Análise baropodométrica do apoio plantar em idosos e sua relação com as quedas

O presente estudo teve como principal objetivo a descrição, a análise e a comparação de parâmetros relacionados com o apoio plantar em idosos, através do método da baropodometria eletrónica, que oferece a avaliação das variáveis temporais e espaciais na postura estática e na marcha. Ademais, teve a finalidade de medir e comparar a distribuição da pressão plantar num grupo de idosos, institucionalizados e não institucionalizados, com e sem historial de quedas nos últimos 12 meses, para verificar se há um padrão comum ou divergente de apoio plantar, aspetos biomecânicos e diferenças significativas na marcha entre estes dois grupos e sua relação com a ocorrência de quedas. A amostra foi composta por 160 idosos, 80 institucionalizados e 80 não institucionalizados, onde foi realizado um levantamento das variáveis sociodemográficas como: idade, género, o índice de massa corporal (IMC), a ocorrência de quedas nos últimos 12 meses, a existência de patologias e a prática de atividade física. Foram analisadas, através da plataforma de pressão, a distribuição das pressões plantares, os picos de pressão plantar média e máxima, área de superfície plantar e a largura da base de sustentação na postura estática e, relativamente às variáveis temporais na postura dinâmica, foram avaliadas a duração do passo e o tempo de contato plantar, no momento da fase de apoio e propulsão da marcha. Foi analisada a correlação destas variáveis com a ocorrência de quedas. Foram identificados maiores valores de pressão média e máxima, na postura estática e dinâmica, nos idosos não institucionalizados. Na comparação entre os grupos, foram encontradas diferenças estatisticamente significativas em grande parte das variáveis na postura estática, especialmente aumento da largura da base (p=0,048) e, na postura dinâmica, a duração do passo e do tempo de contato do pé no solo (p=0,000) foram maiores nos idosos institucionalizados. O avançar da idade, o aumento na duração do passo e do tempo de contato do pé no solo, bem como a diminuição dos valores das pressões plantares apresentaram correlação com a ocorrência de quedas na amostra total de idosos, especialmente nos idosos institucionalizados. Entretanto, as variáveis índice de massa corporal e largura da base de sustentação não influenciaram na ocorrência de quedas na amostra total de idosos. Estes resultados demonstram a importância da análise do apoio plantar em idosos, pois alterações na distribuição das pressões plantares podem constituir um fator de risco para quedas.

Adquisición de habilidades motrices acuáticas en niños de 3 a 11 años

Existe cierta controversia acerca de la adquisición de habilidades motrices acuáticas en niños. Ello conlleva a la necesidad de concretar la edad adecuada para comenzar el aprendizaje. El objetivo del estudio fue evaluar la adquisición de habilidades motrices acuáticas de propulsión, respiración y flotación en niños en función de la edad. 337 alumnos de edades comprendidas entre los 3 y los 11 años fueron evaluados a través de un test ad hoc. Se presenta innovación en la adquisición de las habilidades motrices acuáticas en función de la edad. La mayoría de las variables presentaron una asociación significativa con la edad. Sólo las variables “Flotación estático vertical” (p=0,06), “Propulsión ventral de brazos alternos” (p=0,23), “Propulsión ventral de piernas alternas” (p=0,71), “Propulsión ventral de brazos y piernas alternos” (p=0,07) y “Propulsión dorsal de piernas alternas” (p=0,08) no presentaron una asociación con la edad. Los resultados señalan la necesidad de seguir una evolución proporcional en la metodología de enseñanza en función de la edad, prestando especial interés en las habilidades de propulsión, las cuales requieren un componente coordinativo simultáneo. A modo de conclusión, la adquisición de habilidades motrices acuáticas en niños de 3 a 11 años sigue una evolución motriz acorde a la edad.

Synthesis of Anisotropic Magnetic Nanoobjects Designed for Locomotion in External Magnetic Fields

The subject of the present work is the synthesis of novel nanoscale objects, designed for self-propulsion under external actuation. The synthesized objects present asymmetric hybrid particles, consisting of a magnetic core and polymer flagella and their hydrodynamic properties under the actuation by external magnetic fields are investigated. The single-domain ferromagnetic cobalt ferrite nanoparticles are prepared by thermal decomposition of a mixture of metalorganic complexes based on iron (III) cobalt (II) in non-polar solvents. Further modification of the particles includes the growth of the silver particle on the surface of the cobalt ferrite particle to form a dumbbell-shaped heterodimer. Different possible mechanisms of dumbbell formation are discussed. A polyelectrolyte tail with ability to adjust the persistence length of the polymer, and thus the stiffness of the tail, by variation of pH is attached to the particles. A polymer tail consisting of a polyacrylic acid chain is synthesized by hydrolysis of poly(tert-butyl acrylate) obtained by atom transfer radical polymerization (ATRP). A functional thiol end-group enables selective attachment of the tail to the silver part of the dumbbell, resulting in an asymmetric functionalization of the dumbbells. The calculations on the propulsion force and the sperm number for the resulting particles reveal a theoretical possibility for the propelled motion. Under the actuation of the particles with flagella by alternating magnetic field an increase in the diffusion coefficient compared to non-actuated or non-functionalized particles is observed. Further development of such systems for application as nanomotors or in drug delivery is promising.

Physicochemical complexity in complex chemical systems

Self-replication and compartmentalization are two central properties thought to be essential for minimal life, and understanding how such processes interact in the emergence of complex reaction networks is crucial to exploring the development of complexity in chemistry and biology. Autocatalysis can emerge from multiple different mechanisms such as formation of an initiator, template self-replication and physical autocatalysis (where micelles formed from the reaction product solubilize the reactants, leading to higher local concentrations and therefore higher rates). Amphiphiles are also used in artificial life studies to create protocell models such as micelles, vesicles and oil-in-water droplets, and can increase reaction rates by encapsulation of reactants. So far, no template self-replicator exists which is capable of compartmentalization, or transferring this molecular scale phenomenon to micro or macro-scale assemblies. Here a system is demonstrated where an amphiphilic imine catalyses its own formation by joining a non-polar alkyl tail group with a polar carboxylic acid head group to form a template, which was shown to form reverse micelles by Dynamic Light Scattering (DLS). The kinetics of this system were investigated by 1H NMR spectroscopy, showing clearly that a template self-replication mechanism operates, though there was no evidence that the reverse micelles participated in physical autocatalysis. Active oil droplets, composed from a mixture of insoluble organic compounds in an aqueous sub-phase, can undergo processes such as division, self-propulsion and chemotaxis, and are studied as models for minimal cells, or protocells. Although in most cases the Marangoni effect is responsible for the forces on the droplet, the behaviour of the droplet depends heavily on the exact composition. Though theoretical models are able to calculate the forces on a droplet, to model a mixture of oils on an aqueous surface where compounds from the oil phase are dissolving and diffusing through the aqueous phase is beyond current computational capability. The behaviour of a droplet in an aqueous phase can only be discovered through experiment, though it is determined by the droplet's composition. By using an evolutionary algorithm and a liquid handling robot to conduct droplet experiments and decide which compositions to test next, entirely autonomously, the composition of the droplet becomes a chemical genome capable of evolution. The selection is carried out according to a fitness function, which ranks the formulation based on how well it conforms to the chosen fitness criteria (e.g. movement or division). Over successive generations, significant increases in fitness are achieved, and this increase is higher with more components (i.e. greater complexity). Other chemical processes such as chemiluminescence and gelation were investigated in active oil droplets, demonstrating the possibility of controlling chemical reactions by selective droplet fusion. Potential future applications for this might include combinatorial chemistry, or additional fitness goals for the genetic algorithm. Combining the self-replication and the droplet protocells research, it was demonstrated that the presence of the amphiphilic replicator lowers the interfacial tension between droplets of a reaction mixture in organic solution and the alkaline aqueous phase, causing them to divide. Periodic sampling by a liquid handling robot revealed that the extent of droplet fission increased as the reaction progressed, producing more individual protocells with increased self-replication. This demonstrates coupling of the molecular scale phenomenon of template self-replication to a macroscale physicochemical effect.