LA MAPOTECA VIRTUAL: UN EJEMPLO DE COLABORACIÓN BAJO UNA PLATAFORMA DE SOFTWARE LIBRE

La Mapoteca Virtual es un sitio web construido sobre la plataforma Joomla, auspiciado por la Escuela de Ciencias Geográfica de la Universidad Nacional, en colaboración con UNA VIRTUAL.Este sitio pretende apoyar la labor docente al permitirle cargar y difundir cartografía digital para los estudiantes, y a los investigadores les facilita la localización de cartografía en línea, necesaria para la realización de sus trabajos en diferentes áreas del conocimiento. Adicionalmente, es un espacio para presentar documentos actuales en relación a la práctica de la cartografía y ciencias conexas, a la vez que fomenta la colaboración y el acceso libre a cartografía digital.Palabras clave: Cartografía, Joomla, Mapas digitales, Herramientas didácticas en líneaAbstractThe Virtual Map Library, www.mapoteca.geo.una.ac.cr, is a website constructed on the Joomla platform and supported by the School of Geographic Sciences at National University, Costa Rica, in collaboration with UNAVIRTUAL. The site intends to support the work of education by allowing the teacher to load and disseminate digital cartography for the students and helping geographic investigators locate cartography needed to accomplish their works in different areas of knowledge.In addition, Mapoteca offers a space to present current  documents relating to the practice of cartography and related sciences that at the same time promotes the contribution and free access to digital cartography.Key Words: Cartography, Mapoteca Virtual, Virtual Map Library, Joomla, digital maps, online teaching tools, School of Geographic Sciences, National University, Costa Rica.

Facebook per promozione turistica: Sviluppo di una piattaforma software per l'analisi delle recensioni

Sviluppo di una piattaforma software per l'estrazione e l'analisi dei dati dalle pagine Facebook ufficiali del turismo delle regioni italiane, per lo studio dell'andamento delle promozioni turistiche.

Studio comparativo di analisi speditive con metodo RE.SIS.TO. e di analisi statiche non lineari eseguite con software 3Muri per la valutazione della fragilità di edifici in muratura nel comune di Maranello (MO)

L’obiettivo della tesi è stato quello di valutare la vulnerabilità sismica di edifici ordinari in muratura tipici del costruito del Comune di Maranello (MO), e di stimare le curve di fragilità. Vengono individuate le tipologie strutturali in muratura tipiche degli edifici del Comune, che viene suddiviso in comparti secondo il metodo CARTIS. Lo scopo è stato di definire quali sono le tipologie in muratura più vulnerabili, e quindi i comparti del Comune costituiti dagli edifici in muratura più fragili dal punto di vista sismico. La valutazione della vulnerabilità sismica di alcuni edifici rappresentativi delle tipologie murarie esistenti nel territorio analizzato è stata eseguita mediante due metodologie: la prima è una metodologia speditiva chiamata RE.SIS.TO., una valutazione semplificata sviluppata dall’Università degli Studi di Bologna, con l’obiettivo di definire lo stato di criticità degli edifici e di definire la priorità di intervento in tempi brevi; la seconda è una metodologia di valutazione più accurata eseguita attraverso l’analisi statica non lineare con il software 3Muri, un programma per il calcolo sismico delle strutture in muratura.

Multi-organ support device for combined extracorporeal carbon dioxide removal and hemofiltration treatments with pump-free solution for ultrafiltration

The use of extracorporeal organ support (ECOS) devices is increasingly widespread, to temporarily sustain or replace the functions of impaired organs in critically ill patients. Among ECOS, respiratory functions are supplied by extracorporeal life support (ECLS) therapies like extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R), and renal replacement therapies (RRT) are used to support kidney functions. However, the leading cause of mortality in critically ill patients is multi-organ dysfunction syndrome (MODS), which requires a complex therapeutic strategy where extracorporeal treatments are often integrated to pharmacological approach. Recently, the concept of multi-organ support therapy (MOST) has been introduced, and several forms of isolated ECOS devices are sequentially connected to provide simultaneous support to different organ systems. The future of critical illness goes towards the development of extracorporeal devices offering multiple organ support therapies on demand by a single hardware platform, where treatment lines can be used alternately or in conjunction. The aim of this industrial PhD project is to design and validate a device for multi-organ support, developing an auxiliary line for renal replacement therapy (hemofiltration) to be integrated on a platform for ECCO2R. The intended purpose of the ancillary line, which can be connected on demand, is to remove excess fluids by ultrafiltration and achieve volume control by the infusion of a replacement solution, as patients undergoing respiratory support are particularly prone to develop fluid overload. Furthermore, an ultrafiltration regulation system shall be developed using a powered and software-modulated pinch-valve on the effluent line of the hemofilter, proposed as an alternative to the state-of-the-art solution with peristaltic pump.

Studio di interazione hardware/software tra Raspberry e nanoVNA

L’obiettivo della tesi è quello di realizzare un progetto basato sull’interazione tra Raspberry Pi e NanoVNA, allo scopo di rendere automatico il processo di acquisizione dei dati di questo strumento di misura. A tal fine è stato sviluppato un programma in linguaggio Python, eseguibile dal terminale del Raspberry Pi, che permette all’utente di inserire agevolmente i parametri essenziali, come l’orario di inizio e termine delle misurazioni e l'intervallo di tempo tra una rilevazione e l’altra.

Dashboard per monitorare lo sviluppo software: criticità, vantaggi

Lo scopo di questa tesi e studiare l’uso di ”cruscotti” (in inglese Dashboard) per il monitoraggio dello sviluppo software, approfondendo i metodi di raccolta delle metriche e come esse vengono gestite. Nello specifico, analizzerò l’ambiente di sviluppo Compositional Agile System (CAS), sviluppando un nuovo plugin per l’IDE Microsoft Visual Studio Code, che e open source. Verranno proposti nuovi metodi di implementazione e utilizzo delle Dashboard e possibili miglioramenti dell’ambiente CAS.

Analisi delle prestazioni energetiche di un impianto HVAC basato su un chiller con eiettore a geometria variabile mediante il software TRNSYS

Il lavoro svolto nella seguente Tesi ha avuto come obiettivo principale quello di modificare il precedente modello TRNSYS dell’impianto innovativo solare/biomassa studiato nell’ambito del progetto Hybrid-BioVGE, impianto che utilizza un gruppo chiller VGE con eiettore a geometria variabile, aggiungendo il circuito per la produzione di ACS, composto da un serbatoio di accumulo un campo di collettori solari dedicato ed una pompa di circolazione, modificando la circuitazione idraulica complessiva, modellando la configurazione finale. Sono state modificate e migliorate anche le logiche di controllo dei vari componenti dell’impianto, in particolare della caldaia a biomassa, del connettore tra accumulo caldo da un lato e circuito di riscaldamento ed accumulo per la produzione di ACS dall’altro lato, del gruppo chiller VGE e dell’accumulo di energia frigorifera con PCM. In ultima istanza, è stata implementata per la stagione estiva un’ulteriore logica di controllo che favorisce il funzionamento del gruppo chiller VGE quando è disponibile un alto contributo di energia solare ed in presenza di una temperatura ambiente in condizioni favorevoli. Attraverso il software TRNSYS 18 sono stati riprodotti in maniera fedele e accurata l'edificio, l'impianto innovativo ad esso associato e sono state svolte delle simulazioni in periodi temporali dell'anno precisi. Tali simulazioni hanno mostrato: un miglioramento nell’efficienza dell’impianto durante la stagione di riscaldamento per alimentare i pannelli radianti al servizio dell’edificio e la produzione di ACS, con valori di Solar Fraction pari al 70% e quota di energia rinnovabile del 90%; prestazioni migliori durante la stagione di raffrescamento con incremento dell'energia termica emessa dai fan-coils del 3%, della Solar Fraction pari al 50% e Seasonal Performance Factor di sistema migliori. Annualmente si è vista una quota di energia rinnovabile molto elevata (84.2%).

Analysing Road Barrier using GIS Software: The Case Study of Bologna

The direct attention of this thesis is the maintenance of road elements to improve road safety. The goal of the research is to prioritise maintenance for barriers based on factors such as the terrain of the site, deformations, degradation of the components, and adherence to the original installation. Using these factors, a coefficient is calculated to determine the maintenance priority for each barrier. To ease understanding and visualisation, data was uploaded and processed in a GIS environment to generate analysis and maps. This was done using GIS, a free and open-source GIS software. Information about the features of the barriers was collected through both on-site and online examination. During on-site inspections, a database of geotagged photos was created to aid in the survey. GIS capabilities word fully utilised by using geoprocessing tools for more in-depth analysis.

An Efficient Protocol For The Generation Of Monocyte Derived Dendritic Cells Using Serum-free Media For Clinical Applications In Post Remission Aml Patients.

Protocols for the generation of dendritic cells (DCs) using serum as a supplementation of culture media leads to reactions due to animal proteins and disease transmissions. Several types of serum-free media (SFM), based on good manufacture practices (GMP), have recently been used and seem to be a viable option. The aim of this study was to evaluate the results of the differentiation, maturation, and function of DCs from Acute Myeloid Leukemia patients (AML), generated in SFM and medium supplemented with autologous serum (AS). DCs were analyzed by phenotype characteristics, viability, and functionality. The results showed the possibility of generating viable DCs in all the conditions tested. In patients, the X-VIVO 15 medium was more efficient than the other media tested in the generation of DCs producing IL-12p70 (p=0.05). Moreover, the presence of AS led to a significant increase of IL-10 by DCs as compared with CellGro (p=0.05) and X-Vivo15 (p=0.05) media, both in patients and donors. We concluded that SFM was efficient in the production of DCs for immunotherapy in AML patients. However, the use of AS appears to interfere with the functional capacity of the generated DCs.

Comparison Of The Solution Of Histidine-tryptophan-alfacetoglutarate With Histidine-tryptophan-glutamate As Cardioplegic Agents In Isolated Rat Hearts: An Immunohistochemical Study.

Cardiac arrest during heart surgery is a common procedure and allows the surgeon to perform surgical procedures in an environment free of blood and movement. Using a model of isolated rat heart, the authors compare a new cardioplegic solution containing histidine-tryptophan-glutamate (group 2) with the histidine-tryptophan-alphacetoglutarate (group 1) routinely used by some cardiac surgeons. To assess caspase, IL-8 and KI-67 in isolated rat hearts using immunohistochemistry. 20 Wistar male rats were anesthetized and heparinized. The chest was opened, cardioctomy was performed and 40 ml/kg of the appropriate cardioplegic solution was infused. The hearts were kept for 2 hours at 4ºC in the same solution, and thereafter, placed in the Langendorff apparatus for 30 minutes with Ringer-Locke solution. Immunohistochemistry analysis of caspase, IL-8, and KI-67 were performed. The concentration of caspase was lower in group 2 and Ki-67 was higher in group 2, both P<0.05. There was no statistical difference between the values of IL-8 between the groups. Histidine-tryptophan-glutamate solution was better than histidine-tryptophan-alphacetoglutarate solution because it reduced caspase (apoptosis), increased KI-67 (cell proliferation), and showed no difference in IL-8 levels compared to group 1. This suggests that the histidine-tryptophan-glutamate solution was more efficient than the histidine-tryptophan-alphacetoglutarate for the preservation of hearts of rat cardiomyocytes.

Growth Factor Stimulation Improves The Structure And Properties Of Scaffold-free Engineered Auricular Cartilage Constructs.

The reconstruction of the external ear to correct congenital deformities or repair following trauma remains a significant challenge in reconstructive surgery. Previously, we have developed a novel approach to create scaffold-free, tissue engineering elastic cartilage constructs directly from a small population of donor cells. Although the developed constructs appeared to adopt the structural appearance of native auricular cartilage, the constructs displayed limited expression and poor localization of elastin. In the present study, the effect of growth factor supplementation (insulin, IGF-1, or TGF-β1) was investigated to stimulate elastogenesis as well as to improve overall tissue formation. Using rabbit auricular chondrocytes, bioreactor-cultivated constructs supplemented with either insulin or IGF-1 displayed increased deposition of cartilaginous ECM, improved mechanical properties, and thicknesses comparable to native auricular cartilage after 4 weeks of growth. Similarly, growth factor supplementation resulted in increased expression and improved localization of elastin, primarily restricted within the cartilaginous region of the tissue construct. Additional studies were conducted to determine whether scaffold-free engineered auricular cartilage constructs could be developed in the 3D shape of the external ear. Isolated auricular chondrocytes were grown in rapid-prototyped tissue culture molds with additional insulin or IGF-1 supplementation during bioreactor cultivation. Using this approach, the developed tissue constructs were flexible and had a 3D shape in very good agreement to the culture mold (average error <400 µm). While scaffold-free, engineered auricular cartilage constructs can be created with both the appropriate tissue structure and 3D shape of the external ear, future studies will be aimed assessing potential changes in construct shape and properties after subcutaneous implantation.

Chemical Composition And Free Radical-scavenging, Anticancer And Anti-inflammatory Activities Of The Essential Oil From Ocimum Kilimandscharicum.

The essential oil from the leaves of Ocimum kilimandscharicum (EOOK), collected in Dourados-MS, was investigated for anticancer, anti-inflammatory and antioxidant activity and chemical composition. The essential oil was extracted by hydrodistillation, and the chemical composition was performed by gas chromatography-mass spectrometry. The essential oil was evaluated for free radical-scavenging activity using the DPPH assay and was tested in an anticancer assay against ten human cancer cell lines. The response parameter (GI50) was calculated for the cell lines tested. The anti-inflammatory activity was evaluated using carrageenan-induced pleurisy in mice. The chemical composition showed 45 components with a predominance of monoterpenes, such as camphor (51.81%), 1,8 cineole (20.13%) and limonene (11.23%). The EOOK exhibited potent free radical-scavenging activity by the DPPH assay with a GI50 of 8.31 μg/ml. The major constituents, pure camphor (IC50=12.56 μg/ml) and mixture of the limonene: 1, 8 cineole (IC50=23.25 μg/ml) displayed a potent activity. The oral administration of EOOK (at 30 and 100 mg kg(-1)), as well as the pure camphor or a mixture of 1,8 cineole with limonene, significantly inhibited the carrageenan (Cg) induced pleurisy, reducing the migration of total leukocytes in mice by 82 ± 4% (30 mg kg(-1) of EOOK), 95 ± 4% (100 mg kg(-1) of EOOK), 83 ± 9% (camphor) and 80 ± 5% (mixture of 1,8 cineole:limonene 1:1). In vitro cytotoxicity screening against a human ovarian cancer cell line displayed high selectivity and potent anticancer activity with GI50=31.90 mg ml(-1). This work describes the anti-inflammatory, anticancer and antioxidant effects of EOOK for the first time. The essential oil exhibited marked anti-inflammatory, antioxidant and anticancer effects, an effect that can be attributed the presence of majorital compounds, and the response profiles from chemical composition differed from other oils collected in different locales.

Analysis Of The Contribution Of Immunologically-detectable Her2, Steroid Receptors And Of The Triple-negative" Tumor Status To Disease-free And Overall Survival Of Women With Epithelial Ovarian Cancer."

We assessed associations between steroid receptors including: estrogen-alpha, estrogen-beta, androgen receptor, progesterone receptor, the HER2 status and triple-negative epithelial ovarian cancer (ERα-/PR-/HER2-; TNEOC) status and survival in women with epithelial ovarian cancer. The study included 152 women with primary epithelial ovarian cancer. The status of steroid receptor and HER2 was determined by immunohistochemistry. Disease-free and overall survival were calculated and compared with steroid receptor and HER2 status as well as clinicopathological features using the Cox Proportional Hazards model. A mean follow-up period of 43.6 months (interquartile range=41.4 months) was achieved where 44% of patients had serous tumor, followed by mucinous (23%), endometrioid (9%), mixed (9%), undifferentiated (8.5%) and clear cell tumors (5.3%). ER-alpha staining was associated with grade II-III tumors. Progesterone receptor staining was positively associated with a Body Mass Index≥25. Androgen receptor positivity was higher in serous tumors. In stand-alone analysis of receptor contribution to survival, estrogen-alpha positivity was associated with greater disease-free survival. However, there was no significant association between steroid receptor expression, HER2 status, or TNEOC status, and overall survival. Although estrogen-alpha, androgen receptor, progesterone receptor and the HER2 status were associated with key clinical features of the women and pathological characteristics of the tumors, these associations were not implicated in survival. Interestingly, women with TNEOC seem to fare the same way as their counterparts with non-TNEOC.

Evaluation Of The Location Of Capsules Swallowed With Food During The Pharyngeal Phase Triggering In Asymptomatic Adults.

To assess the location of hard gelatin capsules in the pharyngeal phase triggering among asymptomatic adults. The location of the bolus during the pharyngeal phase triggering provides information about the sensorimotor model of the beginning of deglutition onset. To evaluate the location of hard gelatin capsules in the pharyngeal phase triggering among asymptomatic adults. A videofluoroscopy swallowing study was carried out in 60 subjects (14 male and 46 female participants) aged between 27 and 55 years, who were evaluated with hard gelatin capsules #00 and #3 containing barium sulfate, swallowed with liquid food and pudding, in free volume. The first laryngeal elevation movement was the criterion to locate the pharyngeal phase triggering. Statistical analysis was based on the McNemar test. Capsule #3 presented higher percentage of location in the tongue dorsum compared to capsule #00, and capsule #00 presented higher percentage of location in the tongue base and vallecula compared to capsule #3. There was a difference between different capsules swallowed with liquid (p=0.016) and pudding (p=0.037). The capsule size influenced the location of the pharyngeal phase triggering. Smaller capsules started pharyngeal phase in the most anterior region (tongue dorsum) compared to larger capsules.

Seven-membered Rings Through Metal-free Rearrangement Mediated By Hypervalent Iodine.

A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether) mediated by the hypervalent iodine reagent HTIB (PhI(OH)OTs). Reaction conditions can be easily adjusted to give ring expansion products bearing different functional groups. A route to medium-ring lactones was also developed.