Seven-membered Rings Through Metal-free Rearrangement Mediated By Hypervalent Iodine.


Autoria(s): Silva, Siguara Bastos Lemos; Torre, Adriana Della; de Carvalho, João Ernesto; Ruiz, Ana Lúcia Tasca Gois; Silva, Luiz F
Contribuinte(s)

UNIVERSIDADE DE ESTADUAL DE CAMPINAS

Data(s)

2015

27/11/2015

27/11/2015

Resumo

A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether) mediated by the hypervalent iodine reagent HTIB (PhI(OH)OTs). Reaction conditions can be easily adjusted to give ring expansion products bearing different functional groups. A route to medium-ring lactones was also developed.

20

1475-94

Identificador

Molecules (basel, Switzerland). v. 20, n. 1, p. 1475-94, 2015.

1420-3049

10.3390/molecules20011475

http://www.ncbi.nlm.nih.gov/pubmed/25599151

http://repositorio.unicamp.br/jspui/handle/REPOSIP/202048

25599151

Idioma(s)

eng

Relação

Molecules (basel, Switzerland)

Molecules

Direitos

aberto

Fonte

PubMed

Tipo

Artigo de periódico