Five papers on the past proceedings and experience of the Society of Friends, in connexion with the education of youth : read at the meeting of the Friends Educational Society at Ackworth in the years 1838, 1839, 1840, 1841, 1842

Smith

The answer of Mr. Sullivan, to the letter and mis-statements of the Hon. Cadwallader D. Colden, in his "Brief exposition" of himself as the advocate of monopoly. The unconstitutionality or limitation of the monopoly demonstrated. The bad policy and injurious effects of it on the community exposed. The legality of an extension of the term of time of a patent when for the good of a state; and the just views and claims of patentees in steam navigation fully explained.

Pages 29-34 contain "Mr. Duer's opinion on the claim of Mr. Sullivan as a patentee, to navigate with steam boats, the waters of the state of New-York."

The Saginaw River port survey, 1957.

Mode of access: Internet.

Annual report of the Board of Education and the Superintendent of Public Instruction of New Jersey, with accompanying documents, for the school year ending ...

Title varies slightly.

The Stoddard library; a thousand hours of entertainment with the world's great writers,

Mode of access: Internet.

Guide to popular U.S. Government publications.

Mode of access: Internet.

"Sunny memories" : containing personal recollections of some celebrated characters /

Mrs. M. Lloyd supposed author.

Annual statements of the railroad and canal companies of the state of New Jersey.

Vols. for 1867-1915 include report of the state director of the United New Jersey Railroad and Canal Company issued through 1878 under its earlier names: 1867-71, Delaware and Raritan Canal and Camden and Amboy Railroad and Transportation Companies (which continues the reports of the State Directors); 1873-78, United Rail Road and Canal Company of New Jersey.

Program evaluation support for the motor vehicle diagnostic inspection demonstration projects /

Mode of access: Internet.

Farmers' produce markets in the United States.

Pt. 2 issued as U.S. Farm Credit Administration. Cooperative Research and Service Division. Miscellaneous report no. 107 (HD1491.U5A3); pt. 3 as U.S. Dept. of Agriculture. Marketing research report no. 17 (HD1751.A9183)

Dimensional control in precision manufacturing, as applied in production machining to effect higher production and lower unit costs.

Mode of access: Internet.

Epidermal Growth Factor Gene (EGF) Polymorphism and Risk of Melanocytic Neoplasiay

A common single nucleotide polymorphism (SNP) in the 5' untranslated region (5'UTR) of the epidermal growth factor (EGF) gene modulates the level of transcription of this gene and hence is associated with serum levels of EGF. This variant may be associated with melanoma risk, but conflicting findings have been reported. An Australian melanoma case-control sample was typed for the EGF+61A>G transversion (rs4444903). The sample comprised 753 melanoma cases from 738 families stratified by family history of melanoma and 2387 controls from 645 unselected twin families. Ancestry of the cases and controls was recorded, and the twins had undergone skin examination to assess total body nevus count, degree of freckling and pigmentation phenotype. SNP genotyping was carried out via primer extension followed by matrix-assisted laser desorption time of flight (MALDI-TOF) mass spectroscopy. The EGIF+61 SNP was not found to be significantly associated with melanoma status or with development of nevi or freckles. Among melanoma cases, however, G homozygotes had thicker tumors (p=0.05), in keeping with two previous studies. The EGF polymorphism does not appear to predispose to melanoma or nevus development, but its significant association with tumor thickness implies that it may be a useful marker of prognosis.

A major quantitative trait locus for CD4-CD8 ratio is located on chromosome 11

CD4-CD8 ratio is an important diagnostic measure of immune system functioning. In particular, CD4-CD8 ratio predicts the time taken for progression of HIV infection to acquired immune deficiency syndrome (AIDS) and the long-term survival of AIDS patients. To map genes that regulate differences between healthy individuals in CD4-CD8 ratio, we typed 757 highly polymorphic microsatellite markers at an average spacing of similar to5 cM across the genome in 405 pairs of dizygotic twins at ages 12, 14 and 16. We used multipoint variance components linkage analysis to test for linkage between marker loci and CD4-CD8 ratio at each age. We found suggestive evidence of linkage on chromosome 11p in 12-year-old twins (LOD=2.55, P=0.00031) and even stronger evidence of linkage in the same region at age 14 (LOD 3.51, P=0.00003). Possible candidate genes include CD5 and CD6, which encode cell membrane proteins involved in the positive selection of thymocytes. We also found suggestive evidence of linkage at other areas of the genome including regions on chromosomes 1, 3, 4, 5, 6, 12, 13, 15, 17 and 22.

Multivariate QTL linkage analysis suggests a QTL for platelet count on chromosome 19q

Platelet count is a highly heritable trait with genetic factors responsible for around 80% of the phenotypic variance. We measured platelet count longitudinally in 327 monozygotic and 418 dizygotic twin pairs at 12, 14 and 16 years of age. We also performed a genome-wide linkage scan of these twins and their families in an attempt to localize QTLs that influenced variation in platelet concentrations. Suggestive linkage was observed on chromosome 19q13.13-19q13.31 at 12 (LOD=2.12, P=0.0009), 14 (LOD=2.23, P=0.0007) and 16 (LOD=1.01, P=0.016) years of age and multivariate analysis of counts at all three ages increased the LOD to 2.59 (P=0.0003). A possible candidate in this region is the gene for glycoprotein VI, a receptor involved in platelet aggregation. Smaller linkage peaks were also seen at 2p, 5p, 5q, 10p and 15q. There was little evidence for linkage to the chromosomal regions containing the genes for thrombopoietin (3q27) and the thrombopoietin receptor (1q34), suggesting that polymorphisms in these genes do not contribute substantially to variation in platelet count between healthy individuals.