Kenraaliluutnantti evp. K.L. Oesch 12/12 1974

Kirje 12.12.1974

K. J. Gummerus Osakeyhtiö 10.11.1959 Direktionen

Kirje

Yli-insinööri K. J. Tolonen 9/11 1957

Kirje

K. J. Gummerus Osakeyhtiö 10/11 1959

Kirje 10.11.1959

Pääministeri K.-A. Fagerholm Toukokuussa 1956

Kirje

Calcifications vasculaires et déficit en vitamine K: un facteur de risque modifiable dans l'insuffisance rénale chronique [Vascular calcifications and vitamin K deficiency: a modifiable risk factor in chronic kidney disease].

The mechanisms of vascular calcifications in chronic renal failure are complex. Apart for clotting factors, vitamin K-dependent proteins include matrix Gla protein. Glutamic acid residues in matrix Gla protein are carboxylated by vitamin K-dependent gamma-carboxylase, which enables it to inhibit calcification. The purpose of this review is to discuss available evidence implicating vitamin K as a modifiable risk factor in the pathogenesis of vascular calcification in renal diseases.