Sovremennik.

Editors: 1836, A. Pushkin; 1837, P. Vi���a︡zemski��, V. Zhukovski��, et al; 1838-1846, P. Pletnev; 1847-1866, N. Nekrassov (with I. Panaev, 1847-1862).

Bibliografía americana. Estudios i catálogo completo i razonado de la biblioteca americana

"Don Gregorio de Beéche (rasgos biográficos)": p. v-xvi.

Rossiada : poėma v XII-ti [i.e. dvi��enadt͡sati] pi��esni��akh : polnyĭ tekst poėmy : obʺi��asnitelʹnyi��a statʹi /

Mode of access: Internet.

AVALIAÇÃO DA PROPORÇÃO DENTAL DE BOLTON EM INDIVÍDUOS COM OCLUS��O NORMAL NATURAL E MALOCLUS��ES DE CLASSE I E CLASSE II DIVISÃO 1 DE ANGLE.

Introdução: A análise de Bolton, análise que quantifica o tamanho dentário, é uma referência importante para profissionais que buscam finalizações ortodônticas adequadas. Objetivo: O objetivo deste trabalho é verificar se há discrepância entre os indivíduos com oclus��o normal natural e maloclus��es de Classe I e de Classe II divisão 1 de Angle pertencentes a amostra selecionada, em relação aos valores encontrados por Bolton, bem como verificar também se há dimorfismo sexual. Metodologia: 3 grupos contendo 35 pares e modelos em gesso cada, separados pelo tipo de oclus��o, pertencentes ao acervo do programa de pós-graduação em Ortodontia da Universidade Metodista de S��o Paulo foram medidos com paquímetro digital em sua maior distância mésiodistal desde 1º molar direito a 1º molar esquerdo, dos arcos superiores e inferiores, com denti��ão permanente. Os valores foram tabulados e a proporção de Bolton foi aplicada. Resultados: Respectivamente para os grupos 1, 2 e 3, a proporção total encontrada foi de 90,36 (DP±1,70), 91,17 (DP±2,58) e 90,76 (DP±2,45), e a proporção anterior foi de 77,73 (DP±2,39), 78,01 (DP±2,66) e 77,30 (DP±2,65). Conclus��o: não houve dimorfismo sexual nem diferença estatisticamente significante comparando os valores aos sugeridos por Bolton.

MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors

T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in focusing of the response on a limited number of the most dominant epitopes. Such T cell responses may be additionally restricted by particular MHC alleles in preference to others. We have studied this poorly understood phenomenon using Theileria parva, a protozoan parasite that causes an often fatal lymphoproliferative disease in cattle. Despite its antigenic complexity, CD8+ T cell responses induced by infection with the parasite show profound immunodominance, as exemplified by the Tp1(214-224) epitope presented by the common and functionally important MHC class I allele N*01301. We present a high-resolution crystal structure of this pMHC complex, demonstrating that the peptide is presented in a distinctive raised conformation. Functional studies using CD8+ T cell clones show that this impacts significantly on TCR recognition. The unconventional structure is generated by a hydrophobic ridge within the MHC peptide binding groove, found in a set of cattle MHC alleles. Extremely rare in all other species, this feature is seen in a small group of mouse MHC class I molecules. The data generated in this analysis contribute to our understanding of the structural basis for T cell-dependent immune responses, providing insight into what determines a highly immunogenic p-MHC complex, and hence can be of value in prediction of antigenic epitopes and vaccine design.

Nanotechnology in the food industry I: applications

Nanotechnology is a multidisciplinary science that is having a boom today, providing new products with attractive physicochemical properties for many applications. In agri/feed/food sector, nanotechnology offers great opportunities for obtaining products and innovative applications for agriculture and livestock, water treatment and the production, processing, storage and packaging of food. To this end, a wide variety of nanomaterials, ranging from metals and inorganic metal oxides to organic nanomaterials carrying bioactive ingredients are applied. This review shows an overview of current and future applications of nanotechnology in the food industry. Food additives and materials in contact with food are now the main applications, while it is expected that in the future are in the field of nano-encapsulated and nanocomposites in applications as novel foods, additives, biocides, pesticides and materials food contact.

La Naci��n i su Procurador

15 p.

Larval development of Notolopas brasiliensis Miers, 1886 (Brachyura: Majoidea: Pisidae) described from laboratory reared material and a reappraisal of the characters of Pisidae

O completo desenvolvimento larval de Notolopas brasiliensis é descrito, a partir de material criado em laboratório, com ênfase na morfologia externa de Majoidea e comparado aos demais gêneros de Pisidae. O desenvolvimento larval de N. brasiliensis consiste em dois estágios de zoea e um de megalopa. A duração media de cada estágio foi de 4.2 ± 1.0 dias para a Zoea I e 3.8 ± 0.7 dias para a Zoea II, a megalopa aparece entre 8.1 ± 0.4 dias após a eclos��o. Os caracteres previamente utilizados para definir as formas larvais de Pisidae ou s��o simplesiomórficos ou altamente homoplásticos. Foi observado que não existe um conjunto de caracteres capazes de definir Pisidae até o presente.Contudo foi mostrado que uma combinação de caracteres pode ser utilizada para diferenciar Notolopas dos demais gêneros da família.

Genetic diversity and connectivity remain high in Holothuria polii (Delle Chiaje 1823) across a coastal lagoon-open sea environmental gradient

Coastal lagoons represent habitats with widely heterogeneous environmental conditions, particularly as regards salinity and temperature,which fluctuate in both space and time. These characteristics suggest that physical and ecological factors could contribute to the genetic divergence among populations occurring in coastal lagoon and opencoast environments. This study investigates the genetic structure of Holothuria polii at a micro-geographic scale across theMar Menor coastal lagoon and nearbymarine areas, estimating the mitochondrial DNA variation in two gene fragments, cytochrome oxidase I (COI) and 16S rRNA (16S). Dataset of mitochondrial sequences was also used to test the influence of environmental differences between coastal lagoon andmarine waters on population genetic structure. All sampled locations exhibited high levels of haplotype diversity and low values of nucleotide diversity. Both genes showed contrasting signals of genetic differentiation (non-significant differences using COI and slight differences using 16S, which could due to different mutation rates or to differential number of exclusive haplotypes. We detected an excess of recent mutations and exclusive haplotypes, which can be generated as a result of population growth. However, selective processes can be also acting on the gene markers used; highly significant generalized additive models have been obtained considering genetic data from16S gene and independent variables such as temperature and salinity.