940 resultados para 67-499
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Se presentan los resultados de una investigación exploratoria y descriptiva, cuyo objetivo fue evaluar la calidad ambiental del espacio calle, desde la percepción del usuario, con el fin de recuperar la calle como “espacio para vivir”. Se seleccionó como caso de estudio: la Calle Cecilio Acosta de la ciudad de Maracaibo, caracterizada por su multifuncionalidad. Se aplicaron cuatro (4) procesos metodológicos: análisis urbano, simulación, observación y encuesta, además se propusieron lineamientos ambientales y un plan de gestión para construir la calidad urbana. Los resultados arrojaron que no existe correspondencia entre la percepción del usuario y la calidad ambiental de la calle, evidenciándose la relación entre los aspectos socio-económicos de las personas con su percepción
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Pabellón alemán: EXPO'67, Montreal (Canadá): Frei Otto, Rolf Gutbrod: arquitectura textil, análisis del edificio
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Recurso electrónico. Valencia: BVNP, 2014
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The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter γ-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the β-3 GABAA receptor subunit develop a cleft secondary palate. GABA, the ligand for this receptor, is synthesized by the enzyme glutamic acid decarboxylase. We have disrupted one of the two mouse Gad genes by gene targeting and also find defects in the formation of the palate. The striking similarity in phenotype between the receptor and ligand mutations clearly demonstrates a role for GABA signaling in normal palate development.
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Heterozygous reeler mice (HRM) haploinsufficient for reelin express ≈50% of the brain reelin content of wild-type mice, but are phenotypically different from both wild-type mice and homozygous reeler mice. They exhibit, (i) a down-regulation of glutamic acid decarboxylase 67 (GAD67)-positive neurons in some but not every cortical layer of frontoparietal cortex (FPC), (ii) an increase of neuronal packing density and a decrease of cortical thickness because of neuropil hypoplasia, (iii) a decrease of dendritic spine expression density on basal and apical dendritic branches of motor FPC layer III pyramidal neurons, and (iv) a similar decrease in dendritic spines expressed on the basal dendrite branches of CA1 pyramidal neurons of the hippocampus. To establish whether the defect of GAD67 down-regulation observed in HRM is responsible for neuropil hypoplasia and decreased dendritic spine density, we studied heterozygous GAD67 knockout mice (HG67M). These mice exhibited a down-regulation of GAD67 mRNA expression in FPC (about 50%), but they expressed normal amounts of reelin and had no neuropil hypoplasia or down-regulation of dendritic spine expression. These findings, coupled with electron-microscopic observations that reelin colocalizes with integrin receptors on dendritic spines, suggest that reelin may be a factor in the dynamic expression of cortical dendritic spines perhaps by promoting integrin receptor clustering. These findings are interesting because the brain neurochemical and neuroanatomical phenotypic traits exhibited by the HRM are in several ways similar to those found in postmortem brains of psychotic patients.