Thermal conductivity of ODP Leg 110 holes

Thirty-four sediment and mudline temperatures were collected from six drill holes on ODP Leg 110 near the toe of the Barbados accretionary complex. When combined with thermal conductivity measurements these data delineate the complicated thermal structure on the edge of this convergent margin. Surface heat-flow values from Leg 110 (calculated from geothermal gradients forced through the bottom-water temperature at mudline) of 92 to 192 mW/m**2 are 80% to 300% higher than values predicted by standard heat flow vs. age models for oceanic crust, but are compatible with earlier surface measurements made at the same latitude. Measured heat flow tends to decrease downhole at four sites, suggesting the presence of heat sources within the sediments. These results are consistent with the flow of warm fluid through the complex along sub-horizontal, high-permeability conduits, including thrust faults, the major decollement zone, and sandy intervals. Simple calculations suggest that this flow is transient, occurring on time scales of tens to tens of thousands of years. High heat flow in the vicinity of 15°30'N and not elsewhere along the deformation front suggests that the Leg 110 drill sites may be situated over a fluid discharge zone, with dewatering more active here than elsewhere along the accretionary complex.

A vueltas con la naturaleza del cambio fonético-fonológico: los casos de Nj y Lj

Las etapas del cambio fonético-fonológico han sido descritas desde hace décadas, especialmente desde un punto de vista articulatorio y casi siempre partiendo de los testimonios escritos de que se podía disponer. No obstante, recientemente han ido surgiendo nuevas teorías que defienden que el cambio puede ser explicado a través del estudio de la variación y los procesos fonéticos propios del habla actual, puesto que ambos están relacionados con fenómenos de hipo (e hiper) articulación y, a la postre, de coarticulación. Una de ellas es la Fonología Evolutiva (Blevins 2004), aun cuando no ofrece una explicación satisfactoria para la difusión del cambio. En este estudio, se ha recurrido a estas teorías para esclarecer las causas de la evolución de dos contextos de yod segunda: /nj/ y /lj/, que llevaron a la fonologización de // y //, en un primer estadio de la historia del español.

Resolución 110 del 26 de agosto de 2013: Por la cual se decide un recurso de reposición y en subsidio de apelación

Servicios registrales

2222+2015=110

2222 é a Resolução que o Conselho de Segurança das Nações Unidas adoptou em 27/5/15. 7450 reunião. A Carta das Nações Unidas de 1945 visa a paz internacional, prevenção e resolução dos conflitos. A protecção dos jornalistas e colaboradores é um desiderato que vem sendo reafirmado desde a Resolução 1265, 1999. § 2222 is the Resolution adopted by the United Nations Security Council on 5/27/15. 7450 meeting. The 1945 United Nations Charter aims at international peace, conflict prevention and resolution. The protection of journalists and employees has been reaffirmed since Resolution 1265, 1999.

Riqualificazione energetica di un edificio plurifamiliare nel comune di Castel Maggiore (BO) con applicazione del Superbonus 110

La tesi propone un esempio di riqualificazione energetica di un edificio residenziale sito a Castel Maggiore (Bologna) con l’applicazione della pratica di detrazione fiscale Bonus 110% introdotta nell’anno 2020 con il Decreto Rilancio. Il lavoro segue l’iter burocratico e progettuale alla base di questa pratica, a partire dalle fasi preliminari di studio dello stato di fatto dell’edificio fino alla realizzazione degli interventi proposti. La tesi si sviluppa come segue. I primi due capitoli definiscono alcuni concetti base della termotecnica e le regole per l’applicazione del Bonus 110. I due capitoli successivi forniscono la situazione dell’edificio allo stato di fatto sia per quanto riguarda la struttura e l’impianto termico sia per quanto riguarda le dispersioni termiche e il fabbisogno energetico. Allo stato di fatto il condominio presenta strutture non coibentate, infissi e impianto termico datati. Il quinto capitolo riporta gli interventi previsti: quelli trainanti sono il rifacimento dell’impianto termico e la coibentazione delle pareti esterne e della copertura; quelli trainati sono la sostituzione degli infissi e l’installazione dell’impianto fotovoltaico. Il sesto capitolo presenta il dimensionamento del generatore di calore e dell’impianto fotovoltaico, nonché i risultati ottenuti con l’analisi energetica dell’edificio in seguito all’esecuzione degli interventi proposti. Il settimo capitolo riporta i dimensionamenti dei vari componenti dell’impianto, mentre nell’ottavo capitolo si esegue l’analisi economica complessiva. Gli interventi effettuati comportano un calo drastico delle dispersioni termiche e dell’indice di prestazione energetica, un maggior comfort all’interno dei locali e un notevole aumento nell’uso di energia primaria rinnovabile. L’edificio passa dalla classe energetica F alla classe energetica A4, realizzando così pienamente gli obiettivi di efficientamento energetico e rientrando ampiamente nei requisiti imposti dalla pratica Bonus 110%.

Progettazione degli interventi di efficientamento energetico di un edificio condominiale con ausilio degli incentivi statali del Superbonus 110%

Il tema centrale di questo elaborato è lo studio completo di un caso di ristrutturazione edilizia le cui spese vengono agevolate mediante l’incentivo denominato “Superbonus 110 %”. Partendo dalla descrizione dello sfondo normativo e legislativo vigente che regola l’applicazione di questa agevolazione (in continuo e costante aggiornamento) si procede all’analisi del caso di ristrutturazione edilizia scelto, ovvero un edificio condominiale, composto da 12 unità immobiliari distinte, sito nel comune di Patti (ME). Verranno studiati in una prima fase gli interventi applicabili all’edificio, ai sensi del DI 06/08/2020, per poi procedere ad una selezione in funzione dei risultati di una diagnosi energetica. Gli interventi scelti verranno poi approfonditi sotto l’aspetto tecnico affinché possano soddisfare i requisiti minimi per accedere all’agevolazione e affinché possano garantire le migliori prestazioni possibili all’edificio in funzione dei suoi parametri energetici. Verrà poi stimato il costo totale della ristrutturazione suddividendo le spese da effettuare nei capitoli degli interventi migliorativi studiati. Verrà redatto l’Attestato di Prestazione Energetica post-intervento e dimostrato il salto di classe necessario per ottenere l’agevolazione del Superbonus 110 %. Infine, verrà redatta l’asseverazione delle spese, la quale attesta la congruità delle spese effettuate e la regolarità degli interventi previsti e mostra il risparmio di energia primaria complessivo conseguito in seguito all’applicazione degli interventi migliorativi effettuati.

Migraine Equivalents In Childhood.

Migraine equivalents are a group of periodic and paroxysmal neurologic diseases. Because headache is not a prominent symptom, the diagnosis might be challenging. The objective of the study was to evaluate the frequency and outcome of migraine equivalents. This was a retrospective study. We included benign paroxysmal torticollis of infancy, benign paroxysmal vertigo of infancy, abdominal migraine, cyclic vomiting, aura without migraine, and confusional migraine. We evaluated the frequency of events, treatment, and outcome. Out of 674 children with headache, 38 (5.6%) presented with migraine equivalents. Twenty-one were boys and the mean age was 6.1 years. Fifteen had abdominal migraine, 12 benign paroxysmal vertigo, 5 confusional migraine, 3 aura without migraine, 2 paroxysmal torticollis, and 1 cyclic vomiting. Prophylactic treatment was introduced in 23 patients; 4 lost follow-up and 19 had significant improvement. We conclude that the correct diagnosis of migraine equivalents enables an effective treatment with an excellent outcome.

A Putative Otu Domain-containing Protein 1 Deubiquitinating Enzyme Is Differentially Expressed In Thyroid Cancer And Identifies Less-aggressive Tumours.

This study aimed to identify novel biomarkers for thyroid carcinoma diagnosis and prognosis. We have constructed a human single-chain variable fragment (scFv) antibody library that was selected against tumour thyroid cells using the BRASIL method (biopanning and rapid analysis of selective interactive ligands) and phage display technology. One highly reactive clone, scFv-C1, with specific binding to papillary thyroid tumour proteins was confirmed by ELISA, which was further tested against a tissue microarray that comprised of 229 thyroid tissues, including: 110 carcinomas (38 papillary thyroid carcinomas (PTCs), 42 follicular carcinomas, 30 follicular variants of PTC), 18 normal thyroid tissues, 49 nodular goitres (NG) and 52 follicular adenomas. The scFv-C1 was able to distinguish carcinomas from benign lesions (P=0.0001) and reacted preferentially against T1 and T2 tumour stages (P=0.0108). We have further identified an OTU domain-containing protein 1, DUBA-7 deubiquitinating enzyme as the scFv-binding antigen using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. The strategy of screening and identifying a cell-surface-binding antibody against thyroid tissues was highly effective and resulted in a useful biomarker that recognises malignancy among thyroid nodules and may help identify lower-risk cases that can benefit from less-aggressive management.

Neuromuscular Activity Of Bothrops Fonsecai Snake Venom In Vertebrate Preparations.

The neuromuscular activity of venom from Bothrops fonsecai, a lancehead endemic to southeastern Brazil, was investigated. Chick biventer cervicis (CBC) and mouse phrenic nerve-diaphragm (PND) preparations were used for myographic recordings and mouse diaphragm muscle was used for membrane resting potential (RP) and miniature end-plate potential (MEPP) recordings. Creatine kinase release and muscle damage were also assessed. In CBC, venom (40, 80 and 160μg/ml) produced concentration- and time-dependent neuromuscular blockade (50% blockade in 85±9 min and 73±8 min with 80 and 160μg/ml, respectively) and attenuated the contractures to 110μM ACh (78-100% inhibition) and 40mM KCl (45-90% inhibition). The venom-induced decrease in twitch-tension in curarized, directly-stimulated preparations was similar to that in indirectly stimulated preparations. Venom (100 and 200μg/ml) also caused blockade in PND preparations (50% blockade in 94±13 min and 49±8 min with 100 and 200μg/ml, respectively) but did not alter the RP or MEPP amplitude. In CBC, venom caused creatine kinase release and myonecrosis. The venom-induced decrease in twitch-tension and in the contractures to ACh and K(+) were abolished by preincubating venom with commercial antivenom. These findings indicate that Bothrops fonsecai venom interferes with neuromuscular transmission essentially through postsynaptic muscle damage that affects responses to ACh and KCl. These actions are effectively prevented by commercial antivenom.

Influence Of Substrate Steps On The Catalytic Properties Of Pt Layers: The Ethanol Electrooxidation Reaction.

The ethanol oxidation reaction (EOR) is investigated on Pt/Au(hkl) electrodes. The Au(hkl) single crystals used belong to the [n(111)x(110)] family of planes. Pt is deposited following the galvanic exchange of a previously deposited Cu monolayer using a Pt(2+) solution. Deposition is not epitaxial and the defects on the underlying Au(hkl) substrates are partially transferred to the Pt films. Moreover, an additional (100)-step-like defect is formed, probably as a result of the strain resulting from the Pt and Au lattice mismatch. Regarding the EOR, both vicinal Pt/Au(hkl) surfaces exhibit a behavior that differs from that expected for stepped Pt; for instance, the smaller the step density on the underlying Au substrate, the greater the ability to break the CC bond in the ethanol molecule, as determined by in situ Fourier transform infrared spectroscopy measurements. Also, we found that the acetic acid production is favored as the terrace width decreases, thus reflecting the inefficiency of the surface array to cleave the ethanol molecule.

Nitric Oxide-releasing Poly(vinyl Alcohol) Film For Increasing Dermal Vasodilation.

Pathological conditions associated with the impairment of nitric oxide (NO) production in the vasculature, such as Raynaud's syndrome and diabetic angiopathy, have stimulated the development of new biomaterials capable of delivering NO topically. With this purpose, we modified poly(vinyl-alcohol) (PVA) by chemically crosslinking it via esterification with mercaptosuccinic acid. This reaction allowed the casting of sulfhydrylated PVA (PVA-SH) films. Differential scanning calorimetry and X-ray diffractometry showed that the crosslinking reaction completely suppressed the crystallization of PVA, leading to a non-porous film with a homogeneous distribution of -SH groups. The remaining free hydroxyl groups in the PVA-SH network conferred partial hydrophylicity to the material, which was responsible for a swelling degree of ca. 110%. The PVA-SH films were subjected to an S-nitrosation reaction of the -SH groups, yielding a PVA containing S-nitrosothiol groups (PVA-SNO). Amperometric and chemiluminescence measurements showed that the PVA-SNO films were capable of releasing NO spontaneously after immersion in physiological medium. Laser Doppler-flowmetry, used to assess the blood flow in the dermal microcirculation, showed that the topical application of hydrated PVA-SNO films on the health skin led to a dose- and time-dependent increase of more than 5-fold in the dermal baseline blood flow in less than 10min, with a prolonged action of more than 4h during continuous application. These results show that PVA-SNO films might emerge as a new material with potential for the topical treatment of microvascular skin disorders.

Bay 41-2272 Activates Host Defence Against Local And Disseminated Candida Albicans Infections.

In our previous study, we have found that 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]-pyrimidin-4-ylamine (BAY 41-2272), a guanylate cyclase agonist, activates human monocytes and the THP-1 cell line to produce the superoxide anion, increasing in vitro microbicidal activity, suggesting that this drug can be used to modulate immune functioning in primary immunodeficiency patients. In the present work, we investigated the potential of the in vivo administration of BAY 41-2272 for the treatment of Candida albicans and Staphylococcus aureus infections introduced via intraperitoneal and subcutaneous inoculation. We found that intraperitoneal treatment with BAY 41-2272 markedly increased macrophage-dependent cell influx to the peritoneum in addition to macrophage functions, such as spreading, zymosan particle phagocytosis and nitric oxide and phorbol myristate acetate-stimulated hydrogen peroxide production. Treatment with BAY 41-2272 was highly effective in reducing the death rate due to intraperitoneal inoculation of C. albicans, but not S. aureus. However, we found that in vitro stimulation of peritoneal macrophages with BAY 41-2272 markedly increased microbicidal activities against both pathogens. Our results show that the prevention of death by the treatment of C. albicans-infected mice with BAY 41-2272 might occur primarily by the modulation of the host immune response through macrophage activation.

Hypobromous Acid, A Powerful Endogenous Electrophile: Experimental And Theoretical Studies.

Hypobromous acid (HOBr) is an inorganic acid produced by the oxidation of the bromide anion (Br(-)). The blood plasma level of Br(-) is more than 1,000-fold lower than that of chloride anion (Cl(-)). Consequently, the endogenous production of HOBr is also lower compared to hypochlorous acid (HOCl). Nevertheless, there is much evidence of the deleterious effects of HOBr. From these data, we hypothesized that the reactivity of HOBr could be better associated with its electrophilic strength. Our hypothesis was confirmed, since HOBr was significantly more reactive than HOCl when the oxidability of the studied compounds was not relevant. For instance: anisole (HOBr, k2=2.3×10(2)M(-1)s(-1), HOCl non-reactive); dansylglycine (HOBr, k2=7.3×10(6)M(-1)s(-1), HOCl, 5.2×10(2)M(-1)s(-1)); salicylic acid (HOBr, k2=4.0×10(4)M(-1)s(-1), non-reactive); 3-hydroxybenzoic acid (HOBr, k2=5.9×10(4)M(-1)s(-1), HOCl, k2=1.1×10(1)M(-1)s(-1)); uridine (HOBr, k2=1.3×10(3)M(-1)s(-1), HOCl non-reactive). The compounds 4-bromoanisole and 5-bromouridine were identified as the products of the reactions between HOBr and anisole or uridine, respectively, i.e. typical products of electrophilic substitutions. Together, these results show that, rather than an oxidant, HOBr is a powerful electrophilic reactant. This chemical property was theoretically confirmed by measuring the positive Mulliken and ChelpG charges upon bromine and chlorine. In conclusion, the high electrophilicity of HOBr could be behind its well-established deleterious effects. We propose that HOBr is the most powerful endogenous electrophile.

Indications For In Vitro Fertilization At A Public Center For Reproductive Health In Campinas, Brazil.

To assess the sociodemographic profile and gynecologic and obstetric characteristics of women referred to a public reference center in Campinas, Brazil, for in vitro fertilization (IVF). Women referred between April 1, 2008, and October 31, 2009, were eligible for inclusion in a cross-sectional study. Participants were interviewed about sociodemographic characteristics, obstetric and gynecologic history, and etiologic factors resulting in the referral. Preliminary clinical examinations performed elsewhere were evaluated. A total of 176 women were included, of whom 129 (73.3%) presented with tubal factor infertility. Tubal ligation had been performed in 66 (37.5%) women. Overall, 121 (68.8%) women were aged 30 years old or less, 110 (62.5%) had received more than 8 years of schooling, 123 (69.6%) had had infertility for up to 5 years, and 99 (56.3%) did not have any children. Moreover, 25 (14.2%) women had endometriosis and 25 (14.2%) had a male factor issue. A previous ectopic pregnancy was reported for 20 (11.4%) women and pelvic inflammatory disease for 49 (27.8%). Tubal factor infertility was the most common indication for IVF. Preventive measures are required, in addition to policies that ensure access to high-complexity treatments in the public sector.