16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

Background: The 16/6-idiotype (16/6-Id) of the human anti-DNA antibody was found to induce experimental lupus in naive mice, manifested by production of autoantibodies, leukopenia and elevated inflammatory markers, as well as kidney and brain involvement. We assessed behavior and brain pathology of naive mice injected intracerebra-ventricularly (ICV) with the 16/6-Id antibody. Methods: C3H female mice were injected ICV to the right hemisphere with the human 16/6-Id antibody or commercial human IgG antibodies (control). The mice were tested for depression by the forced swimming test (FST), locomotor and explorative activity by the staircase test, and cognitive functions were examined by the novel object recognition and Y-maze tests. Brain slices were stained for inflammatory processes. Results: 16/6-Id injected mice were cognitively impaired as shown by significant differences in the preference for a new object in the novel object recognition test compared to controls (P = 0.012). Similarly, the preference for spatial novelty in the Y-maze test was significantly higher in the control group compared to the 16/6-Id-injected mice (42% vs. 9%, respectively, P = 0.065). Depression-like behavior and locomotor activity were not significantly different between the16/6-Id-injected and the control mice. Immunohistochemistry analysis revealed an increase in astrocytes and microglial activation in the hippocampus and amygdala, in the 16/6-Id injected group compared to the control. Conclusions: Passive transfer of 16/6-Id antibodies directly into mice brain resulted in cognitive impairments and histological evidence for brain inflammation. These findings shed additional light on the diverse mosaic pathophysiology of neuropsychiatric lupus.

Involvement in environmental causes, does the joint effect between subjective income and the performance of the country matter?

Previous research has shown that richer people are more likely to engage in an environmentalcause. We extend it by considering the joint effect between subjective income and a set of macroeconomicvariables. For doing so, we employ the fifth wave of the World Values Survey (WVS).This study provides clear evidence that even when both factors matter, people´s attitudes cruciallydepend on the interaction effect. Hence, those measures that affect the characteristics of thecountry would also change the disposition to be involved.

Primary school : a parent's guide.

Se describe el proceso de elegir una escuela con la comprensión del plan nacional de estudios hasta los once años. Se da una orientación sobre los diferentes tipos de clases disponibles y explica muchas de las siglas utilizadas en el sistema educativo. También informa sobre los tipos de actividades que pueden hacerse con el niño para ayudarle en sus tareas escolares, y dónde acudir para obtener ayuda si el niño tiene dificultades en un tema en particular.

Special educational needs : a parent's guide.

Esta guía proporciona una somera visión de la diversidad de las necesidades educativas especiales más comunes. Contiene información y asesoramiento para que profesores y padres puedan tener las estrategias necesarias para utilizar con los niños en la vida cotidiana, cómo manejar en la escuela y en el hogar comportamientos difíciles, qué hacer o adónde ir para obtener más información y para obtener la mejor educación del niño según sus necesidades especiales.

Validation of the Spanish version of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST)

Resumen tomado de la publicaci??n

Parents??? conceptions of their homework involvement in elementary school

Resumen tomado de la publicaci??n

Connectivity of BA46 involvement in the executive control of language

Resumen tomado de la publicaci??n

Audiologic services: a parent's view

This paper discusses a study to determine desirable characteristics of audiologists who provide services to a pediatric population.

Examination of parent support groups for newly diagnosed hearing-impaired children, birth - 5 years

This paper examines support groups for parents of newly-diagnosed hearing-impaired children and presents an outline for an effective parent support group.

Should homework be required? parent attitudes at Central Institute for the Deaf

This paper discusses a study on parental attitudes towards homework for hearing impaired children.

The importance of parental involvement in language acquisition and activities and techniques to enhance the home-school connection

This study discusses the importance of parental involvement in children’s language development, and the related project offers parents books and activities to assist them in developing their children’s linguistic skills.

A longitudinal demographic study of a parent-infant program for hearing-impaired children

This paper is a longitudinal study of the CID Parent-Infant Program, 1966-1976.