Leber's hereditary optic neuropathy (LHON) : involvement of mitochondrial permeability transition in the pathogenesis and protective actions of minocycline

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2008

evaluation framework for software test processes

Magdeburg, Univ., Fak. für Informatik, Diss., 2009

Modulation of the activity of the mitochondrial BK-channel and the permeability transition pore by hypoxia and apoptotic factors

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010

Cardiac Autonomic Adjustments During Baroreflex Test in Obese and Non-Obese Preadolescents

Abstract Background: Recent studies have shown changes in cardiac autonomic control of obese preadolescents. Objective: To assess the heart rate responses and cardiac autonomic modulation of obese preadolescents during constant expiratory effort. Methods: This study assessed 10 obese and 10 non-obese preadolescents aged 9 to 12 years. The body mass index of the obese group was between the 95th and 97th percentiles of the CDC National Center for Health Statistics growth charts, while that of the non-obese group, between the 5th and 85th percentiles. Initially, they underwent anthropometric and clinical assessment, and their maximum expiratory pressures were obtained. Then, the preadolescents underwent a constant expiratory effort of 70% of their maximum expiratory pressure for 20 seconds, with heart rate measurement 5 minutes before, during and 5 minutes after it. Heart rate variability (HRV) and heart rate values were analyzed by use of a software. Results: The HRV did not differ when compared before and after the constant expiratory effort intra- and intergroup. The heart rate values differed (p < 0.05) during the effort, being the total variation in non-obese preadolescents of 18.5 ± 1.5 bpm, and in obese, of 12.2 ± 1.3 bpm. Conclusion: The cardiac autonomic modulation did not differ between the groups when comparing before and after the constant expiratory effort. However, the obese group showed lower cardiovascular response to baroreceptor stimuli during the effort, suggesting lower autonomic baroreflex sensitivity.

Serial High-Sensitivity Troponin T in Post-Primary Angioplasty Exercise Test

Abstract Background: The kinetics of high-sensitivity troponin T (hscTnT) release should be studied in different situations, including functional tests with transient ischemic abnormalities. Objective: To evaluate the release of hscTnT by serial measurements after exercise testing (ET), and to correlate hscTnT elevations with abnormalities suggestive of ischemia. Methods: Patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty were referred for ET 3 months after infarction. Blood samples were collected to measure basal hscTnT immediately before (TnT0h), 2 (TnT2h), 5 (TnT5h), and 8 hours (TnT8h) after ET. The outcomes were peak hscTnT, TnT5h/TnT0h ratio, and the area under the blood concentration-time curve (AUC) for hscTnT levels. Log-transformation was performed on hscTnT values, and comparisons were assessed with the geometric mean ratio, along with their 95% confidence intervals. Statistical significance was assessed by analysis of covariance with no adjustment, and then, adjusted for TnT0h, age and sex, followed by additional variables (metabolic equivalents, maximum heart rate achieved, anterior wall STEMI, and creatinine clearance). Results: This study included 95 patients. The highest geometric means were observed at 5 hours (TnT5h). After adjustments, peak hscTnT, TnT5h/TnT0h and AUC were 59% (p = 0.002), 59% (p = 0.003) and 45% (p = 0.003) higher, respectively, in patients with an abnormal ET as compared to those with normal tests. Conclusion: Higher elevations of hscTnT may occur after an abnormal ET as compared to a normal ET in patients with STEMI.

A Wireless Mesh Network NS-3 Simulation Model: Implementation and Performance Comparison With a Real Test-Bed

Wireless mesh networks present an attractive communication solution for various research and industrial projects. However, in many cases, the appropriate preliminary calculations which allow predicting the network behavior have to be made before the actual deployment. For such purposes, network simulation environments emulating the real network operation are often used. Within this paper, a behavior comparison of real wireless mesh network (based on 802.11s amendment) and the simulated one has been performed. The main objective of this work is to measure performance parameters of a real 802.11s wireless mesh network (average UDP throughput and average one-way delay) and compare the derived results with characteristics of a simulated wireless mesh network created with the NS-3 network simulation tool. Then, the results from both networks are compared and the corresponding conclusion is made. The corresponding results were derived from simulation model and real-worldtest-bed, showing that the behavior of both networks is similar. It confirms that the NS-3 simulation model is accurate and can be used in further research studies.

Factory Acceptance Test des Prozessleitsystems PCS 7 und Anlagenfeld Simulation mit WinMOD

Das Prozessleitsystem PCS 7 beinhaltet softwaretechnische Lösungen für alle Hierarchieebenen der industriellen Automatisierung von der Unternehmensleitebene bis zur Anlagenfeldebene. Mit der Simulationssoftware WinMOD können Komponenten,Signale und Prozesse einer Industrieanlage nachgebildet werden. Zudem bietet WinMOD Schnittstellenlösungen für gängige Speicherprogrammierbare Steuerungen und eignet sich somit für den Factory Acceptance Test (FAT) von Prozessleitsystemen. Die FATs sollen sich hauptsächlich auf die Überprüfung von Signaladressierungen und von Ursache und Wirkung konzentrieren. Im Rahmen der vorliegenden Arbeit wurden ausgewählte PCS 7–Projekte untersucht und auf deren Grundlage Aussagen getroffen wie zukünftig Simulationen effektiv erstellt werden können. Hierzu wurden mithilfe von WinMOD Simulationsmodule angelegt - welche reale Komponenten des Anlagenfeldes ersetzen – , ihr Aufbau beschrieben und in einer Bibliothek zusammengefasst. Im Anschluss wird auf die Verwendung der Bibliothek für verschiedene Anwendungsfälle eingegangen und eine Lösung präsentiert, welche das Erstellen einer Simulation für spezifische Projekte optimiert. Das Ergebnis zeigt auf, dass WinMOD sowohl neue Möglichkeiten der Durchführung für einen FAT liefert, wobei die Simulationserstellung nur einen geringen Mehraufwand bedeutet und sich die Durchführung der Simulation ergonomischer und kürzer gestaltet.

Efficient query processing in co-processor-accelerated databases

...Diese Dissertation zeigt, wie wir Datenbankmanagementsysteme bauen können, die heterogene Prozessoren effizient und zuverlässig zur Beschleunigung der Anfrageverarbeitung nutzen können. Daher untersuchen wir typische Entwurfsentscheidungen von coprozessorbeschleunigten Datenbankmanagementsystemen und leiten darauf aufbauend eine generische Architektur für solche Systeme ab. Unsere Untersuchungen zeigen, dass eines der wichtigsten Probleme für solche Datenbankmanagementsysteme die Entscheidung ist, welche Operatoren einer Anfrage auf welchem Prozessor ausgeführt werden sollen...

A topological proof that surface relators are test words

Vegeu el resum a l'inici del document del fitxer adjunt.

The black-white test score gap widens with age?

We re-examine the theoretical concept of a production function for cognitive achievement, and argue that an indirect production function that depends upon the variables that constrain parents' choices is both moretractable from an econometric point of view, and more interesting from an economic point of view than is a direct production function that depends upon a detailed list of direct inputs such as number of books in the household. We estimate flexible econometric models of indirect production functions for two achievement measures from the Woodcock-Johnson Revised battery, using data from two waves of the Child Development Supplement to the PSID. Elasticities of achievement measures with respect to family income and parents' educational levels are positive and significant. Gaps between scores of black and white children narrow or remain constant as children grow older, a result that differs from previous findings in the literature. The elasticities of achievement scores with respect to family income are substantially higher for children of black families, and there are some notable difference in elasticities with respect to parents' educational levels across blacks and whites.

Resultados del test de consumidores de manzana del proyecto ISAFRUIT

El IRTA ha coordinado el desarrollo de un test de consumidores de nuevas variedades de manzana que se ha desarrollado dentro el programa de trabajo denominado ‘Implementación de nuevas variedades de manzana en base a las preferencias de los consumidores’ en el marco del proyecto europeo de investigación ISAFRUIT. En este programa de trabajo han participado 14 instituciones de investigación, universidades y empresas de Europa

Markup Test Reader: eina de creació i lectura de formularis de test

El projecte exposat en aquestes pàgines és un document d'estudi, anàlisi, disseny, programació i procés de proves en la confecció d'una aplicació de creació i lectura de formularis de test. Aquesta aplicació parteix de les possibilitats de millora de les prestacions, usabilitat i escalabilitat que poden oferir les tècniques de visió en computador en aquest camp. El projecte s'ha basat en un exemple en concret per tal d'oferir una eina vàlida per a la automatització de les tasques que en una empresa de recursos humans es poden donar a l'hora de gestionar la informació dels test psicotècnics que necessiten gestionar. El projecte parteix d'unes premisses bàsiques tals com: l'ús de tècniques en visió per computador, la modularitat, el compliment d'estàndards, la facilitat d'ús i la facilitat en la gestió de canvis.