894 resultados para Proteômica aplicada


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Nos peixes, durante a vida reprodutiva o desenvolvimento gonadal é cíclico e anual. As alterações estruturais das gônadas de machos e fêmeas provêm parâmetros úteis para a sua classificação macroscópica e microscópica. Porém, o desenvolvimento das células germinativas, nem sempre é consoante com os diferentes tipos de classificação e, machos e fêmeas nem sempre parecem concatenados. Neste estudo, aplicando-se propostas recentes, utilizadas primariamente para peixes derivados, notadamente os Perciformes marinhos, e tomando como modelo experimental representantes da série Otophysi, Hoplias malabaricus (Characiformes), Tanichthys albonubes (Cypriniformes), Sorubim lima (Siluriformes) e Gymnotus sp. (Gymnotiformes), e dos Perciformes Neotropicais, Cichla temensis, foram descritos, comparativamente, os eventos iniciais da oogênese e da espermatogênese, assim como o desenvolvimento oocitário a fim de traçar um paralelo entre grupos basais e derivados. A partir dos resultados, verificou-se que a maioria dos eventos morfológicos durante o desenvolvimento oocitário é similar entre grupos basais e derivados. Os Perciformes de água doce divergem dos grupos basais por duas características: a presença de inclusões lipídicas, que surgem no citoplasma perinuclear após o início da formação dos alvéolos corticais e deposição de vitelo e por uma tênue proteólise do vitelo durante a maturação final. A foliculogênese e espermatogênese não apresentam divergências e parecem ser processos conservados entre os Teleostei. Durante a fase de Regeneração, os eventos iniciais desses processos em fêmeas e machos, respectivamente, são responsáveis por altos índices de proliferação das células germinativas, quando comparado às demais fases. Além disso, analisou-se ...(Resumo completo, clicar acesso eletrônico abaixo)

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This paper focuses on the implementation of a geological and geotechnical mapping to the planning of the region stream Bertini, territorial expansion area of the municipality of Americana (SP), a medium-sized city in the countryside of Sao Paulo state, with great potential for growth industrial and residential. To this end, based on the methodology established by the Institute for Technological Research, the charters geological and geotechnical aimed at exposing the capabilities and limitations of the soil. The analysis of similar soil characteristics such as geology, geomorphology, slope, geotechnical testing and the current use and land cover was possible to recognize four geotechinical units. The units I and III are related to areas of top and concave and convex parts of the study area, shown to be sites of low occupancy restriction. However the units II and IV, respectively allocated in the floodplain of the Piracicaba River and the banks of the stream Bertini and some of its drainage, showed a more restricted area due to proximity to water bodies and drainages that offer higher slopes.

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The proposed of scanning of an electrical industrial substation HV is associated with a segment of the Electrotechnical area and aims the study and preliminary application of digital technologies in the protection, control, measurement and automation maneuvers aimed at a Industrial Electrical System typical High Voltage. Well intended to supervision, protection and control of major electrical and thermal quantities involved in a substation, such as voltage levels, current, temperature, power factor, loads of transformers and circuit feeders, status of interlocking devices, switching equipment maneuvers, etc

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Investigations in ethnomathematics show that there are several cultural forms of mathematics, mathematics different dominant. Currently, most research in ethnomathematics aim an ethnographic study of anthropological or cultural groups. However, there is a strong need for studies in ethnomathematics is to target the pedagogical action, involving the teachinglearning practices. So the big challenge for researchers in ethnomathematics is the development of study and teaching practices in line with the objectives philosophicaltheoretical Program Ethnomathematics

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Nos peixes, durante a vida reprodutiva o desenvolvimento gonadal é cíclico e anual. As gônadas passam por alterações de forma, de tamanho, de cor e de textura que são utilizadas como parâmetros para a sua classificação macroscópica. Porém, o desenvolvimento das células germinativas, nem sempre é consoante com essa classificação e, machos e fêmeas nem sempre parecem concatenados. Novas propostas de classificação vêm surgindo na tentativa de compatibilizar as informações macroscópicas e histológicas, considerando a atividade do epitélio germinativo de machos e fêmeas. Ocorre, no entanto, que essas propostas vêm sendo desenvolvidas em estudos com Perciformes marinhos. Aqui, tomando-se como modelo o Characiformes, Schizodon nasutus e o Perciformes, Plagioscion squamosissimus analisou-se comparativamente o ciclo reprodutivo de ambas as espécies, frente às classificações tradicionais e às novas propostas de classificação adicionadas das características histológicas das gônadas, e pode-se perceber que a análise macroscópica das gônadas, muitas vezes, não corresponde a sua verdadeira fase do ciclo reprodutivo, analisado microscopicamente. Isso se dá porque muitas das características cruciais para distinção das fases não são visíveis a olho nu, como folículos atrésicos, maturação do oócito ou anastomose de túbulos ou lóbulos testiculares. Assim, para determinação das fases reprodutivas, deve-se sempre contar com a análise microscópica e, no presente estudo, foi considerado que a melhor classificação para tal é a proposta de Brown-Peterson e colaboradores (2009), que divide o ciclo reprodutivo em seis fases reprodutivas, bastante detalhadas. A partir da descrição do ciclo reprodutivo feminino e masculino em S. nasutus e P. squamosissimus, os dados foram correlacionados com o índice gonadossomático, determinando, assim, que o período... (Resumo completo, clicar acesso eletrônico abaixo)

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There are many approaches and techniques about Administration and Management of Projects in order to provide greater agility, efficiency and transparency during the development process of new products. Simultaneously, a pursuit for a management approach more flexible in its planning and strategic changes during the development campaign, such as, comprehend the project's unpredictability level and deal it by monitoring and estimates tools. These features tend to accentuate itself in manufacturers of complex products, as aircraft and other aerospace technologies. By these conditions thus research aims to describe a case when the Agile Management Processing of Project Development Scrum was used in the Test area of an aircraft manufacturer. Focused on the Scrum implementation over the area, its adaptation, evolution and achievements the research proposes to analyze the improvements, indicate the obstacles and discuss solutions, contributing then to the theoretical basis of the considered theme and futures updates applicable to the area. The research is classified as qualitative; furthermore the information and data analyzed were obtained by interviews with professionals and observations of the processes from the major aircraft manufacturer

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The intense urbanization in coastal environments can cause environmental changes due to the susceptibility of these areas. It is therefore of utmost importance to understand the environmental quality of coastal area and the geomorphological features are essential to make it possible, as well as the geomorphological maps that are used as an instrument to analyze the relief. However, there is no standardization among the geomorphological mapping techniques, since the proposals vary according to the taxonomy of the relief, the adopted scale and the objective of the researcher. This paper aims to carry out geomorphological mappings of sectors of the city of Mongaguá, in São Paulo state, according to the conceptions of Verstappen and Zuidam (1975) and Gustavsson, Kolstrup and Seijmonsbergen (2006), seeking to verify the possibilities and constraints that each one can provide for environmental management. Verstappen and Zuidam’s design (1975) is a classical international bibliography proposal indicating the symbols and colors that will be used to represent the relief according to the origin shape of the geomorphological features; Gustavsson, Kolstrup and Seijmonsbergen's conception (2006) is a latest international proposal which also uses symbols and colors that can be combined to represent various forms of relief, coming from different origins. The mappings in this research are although not presented as a mainstream map, but as a cartographic representation in which the symbols are superimposed on the digital ortophoto map to provide the reader an association between symbolism and the relief represented. The result is a comparative analysis among the symbols that were used in each mapping, in which is discussed what design is the most appropriate, considering the adopted scale and the geomorphological features of the mapped area

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Leaking of hydrocarbon in fuel underground storage tanks constitute object of concern for urban environmental management, because therefore they provoke damages to the physical, biological and socioeconomic environment. Though laws that regulate this essential activity exist, aiming at to prevent contamination with hydrocarbon, we observe that this still happens. This fact evidences that the selection of places for installation of gas stations has not considered the characteristics of the natural environment, implying in more critical consequences associated to the leaking. The objective of this work is to elaborate a chart applied to the gas stations in Rio Claro/SP. The determination of the Index of Environmental Sensitivity for elaboration of such chart was carried through breaking the selection of factors of Environmental Sensitivity of physical, biological and socioeconomic environment. The balance of these factors was given by means of Ad hoc consultation. The crossing of the information was carried through using the method of overlapping of overlays. The result is a chart that shows us areas with classes of high, middle and low Environmental Sensitivity. One gives credit that this type of material can be used as criterion in the selection of adjusted areas for installations of new gas stations and management of the already installed gas stations. The diagnosis of the current situation of the gas stations in the area and recommendations had also been elaborated.

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The mathematical models are critical to determine theoretical prices of options and analyze whether they are overrated or underrated. This information strongly influence in operations carried out by the investor. Therefore, it is necessary that the employee model present high degree of reliability and be consistent with the reality of investment to which it is intended. In this sense, this dissertation aims to apply the steps of mathematical modeling in the Pricing of options for decision making in the investment of a hydroelectric power plant. Was used a Monte Carlo simulation, with the Latin Hypercube Method, to determine the volatility of returns of the project. In order to validate the proposed model, compared to the results found by the Binomial Model, which is one of the models most used in this type of investment. The results reinforce the hypothesis that the mathematical modeling with the Binomial Model is critical to investment decision-making in hydroelectric power

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This paper addresses the single stage lot-sizing problem in parallel machines. Each item can be produced on any machine, and incurs a setup time before to start the production. The objective of this paper is to obtain lower bounds of good quality for this problem. A solution method is developed based on a reformulation of the problem and the Lagrangian relaxation of a set of constraints. Some computational results are presented comparing the proposed method with a method from the literature and with a computational package.

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Pós-graduação em Engenharia Elétrica - FEIS