1000 resultados para Obispo Manuel González
Resumo:
Poco se ha escrito hasta el momento sobre quien podría ser denominado el traductor más prolífico de la posguerra española: Juan González-Blanco. de Luaces. En la década de los cuarenta publicó más de cien traducciones al español. Biógrafo, novelista y poeta, Luaces fue uno de tantos intelectuales españoles cuya trayectoria profesional se vio truncada por el estallido de la Guerra Civil española y la victoria del bando ¿nacional¿. La imposición de la dictadura franquista y la subsiguiente censura le obligó a dejar de lado su labor de escritor para dedicarse en cuerpo y alma al oficio de la traducción y poder, así, mantener a su familia. El objeto del siguiente artículo es relatar la vida de este personaje abandonado en el olvido con el afán de contribuir a completar, de forma modesta, la memoria histórica de un período de nuestra historia en el que aún quedan muchas ausencias por suplir.
Resumo:
Neurodegeneration is a complex process involving different cell types and neurotransmitters. A common characteristic of neurodegenerative disorders is the occurrence of a neuroinflammatory reaction in which cellular processes involving glial cells, mainly microglia and astrocytes, are activated in response to neuronal death. Microglia do not constitute a unique cell population but rather present a range of phenotypes closely related to the evolution of neurodegeneration. In a dynamic equilibrium with the lesion microenvironment, microglia phenotypes cover from a proinflammatory activation state to a neurotrophic one directly involved in cell repair and extracellular matrix remodeling. At each moment, the microglial phenotype is likely to depend on the diversity of signals from the environment and of its response capacity. As a consequence, microglia present a high energy demand, for which the mitochondria activity determines the microglia participation in the neurodegenerative process. As such, modulation of microglia activity by controlling microglia mitochondrial activity constitutes an innovative approach to interfere in the neurodegenerative process. In this review, we discuss the mitochondrial KATP channel as a new target to control microglia activity, avoid its toxic phenotype, and facilitate a positive disease outcome.
Resumo:
Neurodegeneration is a complex process involving different cell types and neurotransmitters. A common characteristic of neurodegenerative disorders is the occurrence of a neuroinflammatory reaction in which cellular processes involving glial cells, mainly microglia and astrocytes, are activated in response to neuronal death. Microglia do not constitute a unique cell population but rather present a range of phenotypes closely related to the evolution of neurodegeneration. In a dynamic equilibrium with the lesion microenvironment, microglia phenotypes cover from a proinflammatory activation state to a neurotrophic one directly involved in cell repair and extracellular matrix remodeling. At each moment, the microglial phenotype is likely to depend on the diversity of signals from the environment and of its response capacity. As a consequence, microglia present a high energy demand, for which the mitochondria activity determines the microglia participation in the neurodegenerative process. As such, modulation of microglia activity by controlling microglia mitochondrial activity constitutes an innovative approach to interfere in the neurodegenerative process. In this review, we discuss the mitochondrial KATP channel as a new target to control microglia activity, avoid its toxic phenotype, and facilitate a positive disease outcome.
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[Traditions. Europe. Espagne]
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[Traditions. Europe. Espagne]
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[Traditions. Europe. Espagne]
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[Traditions. Europe. Espagne]
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[Traditions. Europe. Espagne]
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[Traditions. Europe. Espagne]
