Kipus: revista andina de letras. 20 (Reseñas)

Presenta las reseñas de los siguietnes libros: FERNANDO ALBÁN, CRISTINA BURNEO, SANTIAGO CEVALLOS E IVÁN CARVAJAL, LA CUADRATURA DEL CíRCULO. CUATRO ENSAYOS SOBRE LA CULTURA ECUATORIANA Quito: Corporación Cultural Orogenia, 2006, 297 pp. -- JUAN VALDANO, IDENTIDAD y FORMAS DE LO ECUATORIANO Quito: Eskeletra, 2006, 474 pp. -- CECILIA MAFLA BUSTAMANTE, ARí-sí-YES. ANÁLISIS LINGüíSTICO y EVALUACiÓN DE LAS TRADUCCIONES DE HUASIPUNGO AL INGLÉS Quito: Ediciones Abya-Yala, 2004. -- ROBERTO BOLAÑo, 2666 Barcelona: Anagrama, 2005, 1.125 pp. -- LUCRECIA MALDONADO, SALVO EL CALVARIO Quito: Planeta, 2005, 237 pp . -- RAÚL ARIAS, DUENDE ESCAPADO DEL ESPEJO Quito: Machete Rabioso Editores, 2006, 119 pp. -- JORGE ICAZA, TEATRO Quito: Comisión Nacional Permanente de Conmempraciones Cívicas I Libresa, 2006, 119 pp. -- MARíA LEONOR BAQUERIZO, LAs GRANDES COSAS SE PIERDEN EN LA NIEBLA Guayaquil: [s.i.1, 2005, 87 pp. -- RAÚL SERRANO SÁNCHEZ, CATÁLOGO DE ILUSIONES Quito: Eskeletra, 2006, 152 pp. -- CARLOS MARTíNEZ SARASOLA, NUESTROS PAISANOS LOS INDIOS Buenos Aires: Emecé Memoria Argentina, 2005. -- STALIN ALVEAR, EL REINO DE LOS VENCIDOS Quito: Libresa, Colección Crónica de sueños, 2006, 157 pp. -- MARCELO BÁEZ, DALTON OSORNO, EDITS., EL ESCOTE DE LO OCULTO: ANTOLOGÍA DEL RELATO PROHIBIDO Quito: b@ez.editor.es I Libresa, 2006, 183 pp. -- ALEYDA QUEVEDO ROJAS1 SOY MI CUERPO Quito: Libresa, 2006, 89 pp.

Procesos: revista ecuatoriana de historia. 30 (S0LO LIBROS/Reseñas)

Presenta las reseñas de los siguientes libros: GALO GARCÍA IDROVO, EL FERROCARRIL MÁS DIFÍCIL DEL MUNDO, ALAUSÍ-QUITO, INSTITUTO DE INVESTIGACIÓN HISTÓRICA Y CULTURA POPULAR “NUEVO ALAUSÍ”/COMISIÓN NACIONAL PERMANENTE DE CONMEMORACIONES CÍVICAS, 2008, 320 PP. -- RAÚL HERNÁNDEZ ASENSIO, EL MÁTEMÁTICO IMPACIENTE. LA CONDAMINE, LAS PIRÁMIDES DE QUITO Y LA CIENCIA ILUSTRADA, 1740-1751, LIMA, INSTITUTO DE ESTUDIOS PERUANOS/ UNIVERSIDAD ANDINA SIMÓN BOLÍVAR, SEDE ECUADOR, 2009, 316 PP. -- SONIA FERNÁNDEZ RUEDA, COMP., EL FERROCARRIL DE ALFARO. EL SUEÑO DE LA INTEGRACIÓN, QUITO, TALLER DE ESTUDIOS HISTÓRICOS/CORPORACIÓN EDITORA NACIONAL, COLECCIÓN TEMAS, NO. 13, 2008, 290 PP. -- JAIRO GUTIÉRREZ RAMOS, LOS INDIOS DE PASTO CONTRA LA REPÚBLICA (1809-1824), BOGOTÁ, INSTITUTO COLOMBIANO DE ANTROPOLOGÍA E HISTORIA, 2007, 276 PP.

Iridaea cordata (Gigartinales, Rhodophyta): responses to artificial UVB radiation

The effects of UVB radiation on the different developmental stages of the carrageenan-producing red alga Iridaea cordata were evaluated considering: (1) carpospore and discoid germling mortality; (2) growth rates and morphology of young tetrasporophytes; and (3) growth rates and pigment content of field-collected plant fragments. Unialgal cultures were submitted to 0.17, 0.5, or 0.83 W m(-2) of UVB radiation for 3 h per day. The general culture conditions were as follows: 12 h light/12 h dark cycles; irradiance of 55 mu mol photon. per square meter per second; temperature of 9 +/- 1 degrees C; and seawater enriched with Provasoli solution. All UVB irradiation treatments were harmful to carpospores (0.17 W m(-2) = 40.9 +/- 6.9%, 0.5 W m(-2) = 59.8 +/- 13.4%, 0.83 W m(-2) = 49 +/- 17.4% mortality in 3 days). Even though the mortality of all discoid germlings exposed to UVB radiation was unchanged when compared to the control, those germlings exposed to 0.5 and 0.83 W m(-2) treatments became paler and had smaller diameters than those cultivated under control treatment. Decreases in growth rates were observed in young tetrasporophytes, mainly in 0.5 and 0.83 W m(-2) treatments. Similar effects were only observed in fragments of adult plants cultivated at 0.83 W m(-2). Additionally, UVB radiation caused morphological changes in fragments of adult plants in the first week, while the young individuals only displayed this pattern during the third week. The verified morphological alterations in I. cordata could be interpreted as a defense against UVB by reducing the area exposed to radiation. However, a high level of radiation appears to produce irreparable damage, especially under long-term exposure. Our results suggest that the sensitivity to ultraviolet radiation decreases with increased algal age and that the various developmental stages have different responses when exposed to the same doses of UVB radiation.

Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells

Aims: The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that play an important role in reverse cholesterol transport. We examined the effects of inhibitors of the cholesterol absorption (ezetimibe) and synthesis (statins) on expression of these transporters in HepG2 cells and peripheral blood mononuclear cells (PBMCs) of individuals with primary (and nonfamilial) hypercholesterolemia (HC). Materials & methods: A total of 48 HC individuals were treated with atorvastatin (10 mg/day/4 weeks) and 23 were treated with ezetimibe (10 mg/day/4 weeks), followed by simvastatin (10 mg/day/8 weeks) and simvastatin plus ezetimibe (10 mg of each/day/4 weeks). Gene expression was examined in statin- or ezetimibe-treated and control HepG2 cells as well as PBMCs using real-time PCR. Results: In PBMCs, statins and ezetimibe downregulated ABCA1 and ABCG1 mRNA expression but did not modulate NR1H2 (LxR-beta) and NR1H3 (LXR-alpha) levels. Positive correlations of ABCA1 with ABCG1 and of NR1H2 with NR1H3 expressions were found in all phases of the treatments. In HepG2 cells, ABCA1 mRNA levels remained unaltered while ABCG1 expression was increased by statin (1.0-10.0 mu M) or ezetimibe (5.0 mu M) treatments. Atorvastatin upregulated NR1H2 and NR1H3 only at 10.0 mu M, meanwhile ezetimibe (1.0-5.0 mu M) downregulated NR1H2 but did not change NR1H3 expression. Conclusion: Our findings reveal that lipid-lowering drugs downregulate ABCA1 and ABCG1 mRNA expression in PBMCs of HC individuals and exhibit differential effects on HepG2 cells. Moreover, they indicate that the ABCA1 and ABCG1 transcript levels were not correlated directly to LXR mRNA expression in both cell models treated with lipid-lowering drugs.

Tight-binding model for carbon nanotubes from ab initio calculations

Here we present a parametrized tight-binding (TB) model to calculate the band structure of single-wall carbon nanotubes (SWNTs). On the basis of ab initio calculations we fit the band structure of nanotubes of different radii with results obtained with an orthogonal TB model to third neighbors, which includes the effects of orbital hybridization by means of a reduced set of parameters. The functional form for the dependence of these parameters on the radius of the tubes can be used to interpolate appropriate TB parameters for different SWNTs and to study the effects of curvature on their electronic properties. Additionally, we have shown that the model gives an appropriate description of the optical spectra of SWNTs, which can be useful for a proper assignation of SWNTs` specific chirality from optical absorption experiments.

Atmospheric effects on extensive air showers observed with the surface detector of the Pierre Auger observatory

Atmospheric parameters, Such as pressure (P), temperature (T) and density (rho proportional to P/T), affect the development of extensive air showers initiated by energetic cosmic rays. We have Studied the impact of atmospheric variations on extensive air showers by means of the surface detector of the Pierre Auger Observatory. The rate of events shows a similar to 10% seasonal modulation and similar to 2% diurnal one. We find that the observed behaviour is explained by a model including the effects associated with the variations of P and rho. The former affects the longitudinal development of air showers while the latter influences the Moliere radius and hence the lateral distribution of the shower particles. The model is validated with full simulations of extensive air showers using atmospheric profiles measured at the site of the Pierre Auger Observatory. (C) 2009 Elsevier B.V. All rights reserved.

Search for first harmonic modulation in the right ascension distribution of cosmic rays detected at the Pierre Auger Observatory

We present the results of searches for dipolar-type anisotropies in different energy ranges above 2.5 x 10(17) eV with the surface detector array of the Pierre Auger Observatory, reporting on both the phase and the amplitude measurements of the first harmonic modulation in the right-ascension distribution. Upper limits on the amplitudes are obtained, which provide the most stringent bounds at present, being below 2% at 99% C.L. for EeV energies. We also compare our results to those of previous experiments as well as with some theoretical expectations. (C) 2011 Elsevier B.V. All rights reserved.

The Crystal Complex of Phosphofructokinase-2 of Escherichia coli with Fructose-6-phosphate KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION

Substrate inhibition by ATP is a regulatory feature of the phosphofructokinases isoenzymes from Escherichia coli (Pfk-1 and Pfk-2). Under gluconeogenic conditions, the loss of this regulation in Pfk-2 causes substrate cycling of fructose-6-phosphate (fructose-6-P) and futile consumption of ATP delaying growth. In the present work, we have broached the mechanism of ATP-induced inhibition of Pfk-2 from both structural and kinetic perspectives. The crystal structure of Pfk-2 in complex with fructose-6-P is reported to a resolution of 2 angstrom. The comparison of this structure with the previously reported inhibited form of the enzyme suggests a negative interplay between fructose-6-P binding and allosteric binding of MgATP. Initial velocity experiments show a linear increase of the apparent K(0.5) for fructose-6-P and a decrease in the apparent k(cat) as a function of MgATP concentration. These effects occur simultaneously with the induction of a sigmoidal kinetic behavior (n(H) of approximately 2). Differences and resemblances in the patterns of fructose-6-P binding and the mechanism of inhibition are discussed for Pfk-1 and Pfk-2, as an example of evolutionary convergence, because these enzymes do not share a common ancestor.

Una memoria consensuada : El Informe Rettig

No cabe duda que hoy día la memoria de la dictadura militar (1973-1990) está presente en la vida cotidiana de Chile más que ningún otro periodo histórico. La razón se encuentra en los trágicos sucesos que se vivieron duran- te esos años en materia de derechos humanos. Don Patricio Aylwin, primer presidente electo democráticamente en tras 17 años de autoritarismo y una figura comprometida con los derechos humanos, era consciente de la necesi- dad de investigar la verdad de los crímenes de lesa humanidad ocurridos en Chile. Para ello creó la Comisión Nacional de Verdad y Reconciliación, aunque consideró menester limitar el contenido de su informe con el fin de no amedrentar a las Fuerzas Armadas, las cuales gozaban todavía de mucho poder. Asimismo, el apoyo electoral de los partidos de derecha fue un factor que logró coartar el contenido del informe de la comisión. En este trabajo se presentan aquellas cuestiones que más relevancia tuvieron en la conformación de la verdad de la represión, tales como sus objetivos, sus integrantes y su metodología.

O poder e as injustiças nas pesquisas em seres humanos

Após considerações gerais sobre a ética na pesquisa envolvendo seres humanos, focaliza-se a possibilidade de ocorrências de injustiças, sob a égide de diversas formas de poder. Exemplificam-se situações concretas. Enfatiza-se a análise das possíveis injustiças à luz da Bioética, com destaque para multi e transdisciplinaridade. O autor se posiciona quanto às características atuais da Bioética, cuja ótica levou à elaboração das Diretrizes éticas para a pesquisa envolvendo seres humanos, no Brasil (Resolução 196/96 e complementares do Conselho Nacional de Saúde). Descreve-se a sistemática das atividades do Grupo Executivo de Trabalho - GET, designado pelo Conselho Nacional de Saúde (órgão de controle social na área da saúde), para elaborar as Diretrizes. É dado destaque à participação dos diversos segmentos da sociedade, evidenciando multi e transdiciplinaridade, sob a coordenação do GET, do qual o autor foi Presidente. Comentam-se os principais tópicos das Diretrizes brasileiras, enfocando-se a sua relação com o tema de poder e injustiça. Salienta-se o papel dos Comitês de Ética em Pesquisa - CEP e da Comissão Nacional de Ética em Pesquisa - CONEP.

Gestión del agua a nivel de cuencas: teoría y práctica

Incluye Bibliografía

Desarrollo competitivo de un clúster biotecnológico: el biopolo de Santiago

Incluye Bibliografía

Financiamiento de la banca comercial a micro, pequeñas y medianas empresas en México

Incluye Bibliografía

Condiciones generales de competencia en Honduras

Incluye Bibliografía

Gasto, inversión y financiamiento para el desarrollo sostenible en Chile

Incluye Bibliografía