939 resultados para Time since diagnosis
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Dissertação apresentada à Escola Superior Agrária do Instituto Politécnico de Castelo Branco para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Sistemas de Informação Geográfica - Recursos Agro-Florestais e Ambientais.
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In 2013 the European Council for the first time since long will deal with European defence. An excellent opportunity: to move key Pooling & Sharing projects to the implementation stage in the short term, and to launch a permanent and structured approach to the development of European military capabilities for the long term.
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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014
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In the third quarter of 2012, Ukraine’s economy recorded negative growth (-1.3%) for the first time since its 2009 economic crisis. Q4 GDP is projected to suffer a further decline, bringing Ukraine into formal recession. In addition to the worsening macroeconomic indicators, Ukraine is also facing a series of concomitant economic problems: a growing trade deficit, industrial decline, shrinking foreign exchange reserves, and the weakening of the hryvnia. Poor economic growth is expected to result in lower than projected budget revenues, which in turn could lead to the sequestration of the budget in December. The decline evident across the key economic indicators in the second half of 2012 brings to a close a period of relative economic stability and two years of economic growth, which had been seen as a significant personal achievement of President Viktor Yanukovych and the ruling Party of Regions. The health of the Ukrainian economy largely depends on the state of the country’s export- -oriented industries. The current economic forecasts for foreign markets are not very optimistic. It is impossible to determine whether the current economic downturn is likely to be merely temporary or whether it heralds the onset of a prolonged economic crisis. The limited capacity to deal with the growing economic problems may mean that Kiev will need to seek financial support from abroad. This is particularly significant with regard to external debt servicing, since in 2013 Ukraine will need to pay back around 9 billion USD, including over 5.5 billion USD to the International Monetary Fund. In order to overcome the recession and stabilise public finances, the government may be forced to take a series of unpopular measures, including raising the price of natural gas and utilities. These measures have been stipulated by the IMF as a condition of further financial assistance and the disbursement of the 12 billion USD stabilisation loan granted to Ukraine in July 2010. The only alternative for Western loans and economic reforms appears to be financial support from Russia. The price for Moscow’s help might however turn out to be very high, and precipitate a turn in Kiev’s foreign policy towards a gradual re-integration of former Soviet republics under Moscow-led geopolitical projects.
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2014 was a watershed year for the geopolitical positioning of the European Union. For the first time since the end of the Cold War, Europe is no longer exporting stability but has begun to import instability in an unprecedented way. The neighborhood policy needs a fundamental review as non-European actors pursue policy concepts and strategies that run counter to EU norms and interests. ZEI Director Prof. Dr. Ludger Kühnhardt argues that the values of the Atlantic civilization have come under pressure in a world which tends to be influenced by new conflicts or a secular nature.
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China has just announced that its exports declined on an annual basis last year, for the first time since the country began opening up its economy to the world at the end of the 1970s. And that is not all; in value terms, global trade declined in 2015. The obvious question is why?
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The 7 March EU-Turkey migration crisis summit took place three days after the Turkish authorities seized Feza media group, which includes Turkey’s largest circulation daily Zaman and its English language sister paper Today’s Zaman. The seizure was the latest development in the worst crackdown on fundamental rights and freedoms Turkey has witnessed in decades. Yet because Turkey is vital in dealing with the migration/refugee crisis, the EU’s response was meek to say the least. For the first time since the Cold War – when Turkey was key in shoring up Europe’s security – Ankara has found itself in a particular position of strength. Turkey has skillfully exploited the EU’s and particularly German Chancellor Angela Merkel’s urgent need to find a way out of the crisis.
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The 7 March EU-Turkey migration crisis summit took place three days after the Turkish authorities seized Feza media group, which includes Turkey’s largest circulation daily Zaman and its English language sister paper Today’s Zaman. The seizure was the latest development in the worst crackdown on fundamental rights and freedoms Turkey has witnessed in decades. Yet because Turkey is vital in dealing with the migration/refugee crisis, the EU’s response was meek to say the least. For the first time since the Cold War – when Turkey was key in shoring up Europe’s security – Ankara has found itself in a particular position of strength. Turkey has skillfully exploited the EU’s and particularly German Chancellor Angela Merkel’s urgent need to find a way out of the crisis.
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Enquadramento: A Artrite Reumatóide (AR) é uma patologia com profundas implicações na funcionalidade das pessoas, com efeitos significativos não só ao nível do funcionamento físico, mas também a nível emocional, familiar, social e económico. Objetivos: Avaliar a funcionalidade das pessoas com artrite reumatóide e analisar a sua relação com as variáveis sócio demográficas, clínicas, dor e qualidade do sono. Métodos: Trata-se de um estudo não experimental, transversal, descritivo-correlacional e de caráter quantitativo, que foi realizado numa amostra não probabilística por conveniência, constituída por 75 pessoas com o diagnóstico de artrite reumatóide, acompanhadas na Unidade de Dor, na Consulta de Reumatologia e na Medicina Física de Reabilitação do CHTV, EPE. Para a mensuração das variáveis utilizou-se um instrumento de colheita de dados que integra uma secção de caracterização sócio demográfica e clínica, o Índice da Qualidade de Sono de Pittsburgh – PSQI e o Health Assessment Questionnaire – HAQ. Resultados: Constatou-se que 60,0% dos inquiridos apresenta dificuldades/incapacidades leves no desempenho das atividades da vida diária, 32,0% apresenta já dificuldades moderadas e 8,0% incapacidade grave, sendo que o valor médio da funcionalidade global avaliado por meio do HAQ foi de 1,48, o que revela a existência de uma incapacidade moderada na nossa amostra. Das variáveis sócio demográficas, a idade (p=0,003), a situação laboral (p=0,000), a escolaridade (p=0,006) e os rendimentos mensais (p=0,001) têm influência no estado funcional das pessoas com AR. Das variáveis clínicas, a intensidade da dor (p=0,007) e o tempo de diagnóstico da doença (p=0,013) mostraram relacionarem-se com a funcionalidade. Em relação à qualidade do sono, apenas existem diferenças estatísticamente significativas nas subescalas “levantar-se” (p=0,030) e “caminhar” (p=0,034), sendo que a má qualidade de sono configurou-se em 94,7% dos inquiridos. Conclusão: As evidências encontradas neste estudo referem que a idade, a situação laboral, a escolaridade, os rendimentos mensais, o tempo de diagnóstico, a intensidade da dor e a qualidade do sono, associam-se a uma pior funcionalidade nas pessoas com AR. O diagnóstico precoce, a adoção de medidas para a promoção da boa qualidade do sono, a aplicação de medidas farmacológicas e não farmacológicas para o alívio da dor, e ações de formação direcionadas aos doentes com AR, devem ser estratégias a desenvolver junto desta população, numa tentativa de minimizar o impacto negativo que esta doença acarreta. Palavras-chave: artrite reumatóide, estado funcional, qualidade do sono.
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BACKGROUND Nocardiosis is a rare, life-threatening opportunistic infection, affecting 0.04% to 3.5% of patients after solid organ transplantation (SOT). The aim of this study was to identify risk factors for Nocardia infection after SOT and to describe the presentation of nocardiosis in these patients. METHODS We performed a retrospective case-control study of adult patients diagnosed with nocardiosis after SOT between 2000 and 2014 in 36 European (France, Belgium, Switzerland, Netherlands, Spain) centers. Two control subjects per case were matched by institution, transplant date and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors for nocardiosis. RESULTS One hundred and seventeen cases of nocardiosis and 234 control patients were included. Nocardiosis occurred at a median of 17.5 [range 2-244] months after transplantation. In multivariable analysis, high calcineurin inhibitor trough levels in the month before diagnosis (OR=6.11 [2.58-14.51]), use of tacrolimus (OR=2.65 [1.17-6.00]) and corticosteroid dose (OR=1.12 [1.03-1.22]) at the time of diagnosis, patient age (OR=1.04 [1.02-1.07]) and length of stay in intensive care unit after SOT (OR=1.04 [1.00-1.09]) were independently associated with development of nocardiosis; low-dose cotrimoxazole prophylaxis was not found to prevent nocardiosis. Nocardia farcinica was more frequently associated with brain, skin and subcutaneous tissue infections than were other Nocardia species. Among the 30 cases with central nervous system nocardiosis, 13 (43.3%) had no neurological symptoms. CONCLUSIONS We identified five risk factors for nocardiosis after SOT. Low-dose cotrimoxazole was not found to prevent Nocardia infection. These findings may help improve management of transplant recipients.
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"Reprinted for the first time since the edition dated 1652, from the copy now owned by Mrs. Rosetta E. Clarkson."--T.p. verso.
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"The Itinerary now reprinted in full for the first time since its publication was 'printed by John Beale, dwelling in Aldersgate street', in 1617 ... The book was first written in Latin and then translated into English ... the Latin version, however, was never printed. In 'the table' of the Itinerary, after the contents of the fourth book of the third part there is given a brief summary of twenty-five chapters ... The ms. of these chapters, which were not printed by Moryson, is now in the library of Corpus Christi college, Oxford, and portions of it were edited by Mr. Charles Hughes and published in 1903 under the title of 'Shakespeare's Europe'."--Publishers' note.
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Includes index.
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Goldsmiths'-Kress no. 15910.
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No report was issued for 1913