Wirkung von mikroiontophoretisch appliziertem Ethosuximid auf thalamische und kortikale Neurone in einem Tiermodell der Absence Epilepsie in vivo

Magdeburg, Univ., Medizin. Fak., Diss., 2002

Diabetes Mellitus and Glucose as Predictors of Mortality in Primary Coronary Percutaneous Intervention

Background: Diabetes mellitus and admission blood glucose are important risk factors for mortality in ST segment elevation myocardial infarction patients, but their relative and individual role remains on debate. Objective: To analyze the influence of diabetes mellitus and admission blood glucose on the mortality of ST segment elevation myocardial infarction patients submitted to primary coronary percutaneous intervention. Methods: Prospective cohort study including every ST segment elevation myocardial infarction patient submitted to primary coronary percutaneous intervention in a tertiary cardiology center from December 2010 to May 2012. We collected clinical, angiographic and laboratory data during hospital stay, and performed a clinical follow-up 30 days after the ST segment elevation myocardial infarction. We adjusted the multivariate analysis of the studied risk factors using the variables from the GRACE score. Results: Among the 740 patients included, reported diabetes mellitus prevalence was 18%. On the univariate analysis, both diabetes mellitus and admission blood glucose were predictors of death in 30 days. However, after adjusting for potential confounders in the multivariate analysis, the diabetes mellitus relative risk was no longer significant (relative risk: 2.41, 95% confidence interval: 0.76 - 7.59; p-value: 0.13), whereas admission blood glucose remained and independent predictor of death in 30 days (relative risk: 1.05, 95% confidence interval: 1.02 - 1.09; p-value ≤ 0.01). Conclusion: In ST segment elevation myocardial infarction patients submitted to primary coronary percutaneous intervention, the admission blood glucose was a more accurate and robust independent predictor of death than the previous diagnosis of diabetes. This reinforces the important role of inflammation on the outcomes of this group of patients.

Beeinflussung von Turingstrukturen in der Chlordioxid-Iod-Malonsäure Reaktion mit elektrischen Feldern : experimentelle und numerische Untersuchungen

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2005

Mensch im Hintergrund? : T-Com und Optimierung kundenrelevanter Prozesse durch Wissensmanagement

Wissensmanagement, Deutsche Telekom, T-Com, Prozessmanagement, Organisation, implizites Wissen, explizites Wissen

Sudden Cardiac Death in Brazil: A Community-Based Autopsy Series (2006-2010)

Background: Sudden cardiac death (SCD) is a sudden unexpected event, from a cardiac cause, that occurs in less than one hour after the symptoms onset, in a person without any previous condition that would seem fatal or who was seen without any symptoms 24 hours before found dead. Although it is a relatively frequent event, there are only few reliable data in underdeveloped countries. Objective: We aimed to describe the features of SCD in Ribeirão Preto, Brazil (600,000 residents) according to Coroners’ Office autopsy reports. Methods: We retrospectively reviewed 4501 autopsy reports between 2006 and 2010, to identify cases of SCD. Specific cause of death as well as demographic information, date, location and time of the event, comorbidities and whether cardiopulmonary resuscitation (CPR) was attempted were collected. Results: We identified 899 cases of SCD (20%); the rate was 30/100000 residents per year. The vast majority of cases of SCD involved a coronary artery disease (CAD) (64%) and occurred in men (67%), between the 6th and the 7th decades of life. Most events occurred during the morning in the home setting (53.3%) and CPR was attempted in almost half of victims (49.7%). The most prevalent comorbidity was systemic hypertension (57.3%). Chagas’ disease was present in 49 cases (5.5%). Conclusion: The majority of victims of SCD were men, in their sixties and seventies and the main cause of death was CAD. Chagas’ disease, an important public health problem in Latin America, was found in about 5.5% of the cases.

Einfluss von Dimensionalität und Struktur auf den Grundzustand und die Thermodynamik von Quantenspinsystemen

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2009

Aerobic Training after Myocardial Infarction: Remodeling Evaluated by Cardiac Magnetic Resonance

Abstract Background: Numerous studies show the benefits of exercise training after myocardial infarction (MI). Nevertheless, the effects on function and remodeling are still controversial. Objectives: To evaluate, in patients after (MI), the effects of aerobic exercise of moderate intensity on ventricular remodeling by cardiac magnetic resonance imaging (CMR). Methods: 26 male patients, 52.9 ± 7.9 years, after a first MI, were assigned to groups: trained group (TG), 18; and control group (CG), 8. The TG performed supervised aerobic exercise on treadmill twice a week, and unsupervised sessions on 2 additional days per week, for at least 3 months. Laboratory tests, anthropometric measurements, resting heart rate (HR), exercise test, and CMR were conducted at baseline and follow-up. Results: The TG showed a 10.8% reduction in fasting blood glucose (p = 0.01), and a 7.3-bpm reduction in resting HR in both sitting and supine positions (p < 0.0001). There was an increase in oxygen uptake only in the TG (35.4 ± 8.1 to 49.1 ± 9.6 mL/kg/min, p < 0.0001). There was a statistically significant decrease in the TG left ventricular mass (LVmass) (128.7 ± 38.9 to 117.2 ± 27.2 g, p = 0.0032). There were no statistically significant changes in the values of left ventricular end-diastolic volume (LVEDV) and ejection fraction in the groups. The LVmass/EDV ratio demonstrated a statistically significant positive remodeling in the TG (p = 0.015). Conclusions: Aerobic exercise of moderate intensity improved physical capacity and other cardiovascular variables. A positive remodeling was identified in the TG, where a left ventricular diastolic dimension increase was associated with LVmass reduction.

Protective Effect of Aortic Stenosis on the Coronary Arteries. Hypothetic Considerations to an Old Enigma

Abstract A literature overview of angiographic studies has shown that the prevalence of significant coronary disease in patients with aortic stenosis (AS) varies from 20 to 60%. Early necropsy studies suggested that patients with AS had a lower than expected incidence of coronary artery disease (CAD), originating the concept of a protective effect of AS on the coronary arteries. The myth of AS protection against CAD would be better explained as endothelium-myocardial interaction (crosstalk) protection triggered by left ventricular overload. Therefore, the cGMP/NO pathway induced by the AS overload pressure would explain the low incidence of CAD, which is compatible with the amazing natural long-term evolution of this cardiac valve disease.

ADHS- Das Aufmerksamkeitsdefizit-/Hyperaktivitätssyndrom Kritische Auseinandersetzung mit Diagnostik und Intervention- Förderung von Prävention statt Medikation

Das Aufmerksamkeitsdefizit-/Hyperaktivitätssyndrom, in der Praxis kurz ADHS genannt, istmit einer Prävalenz von 5% seit vielen Jahren eine der häufigsten Störungen im Kindes- undJugendalter. In dieser Arbeit wird das Phänomen ADHS vorgestellt. Aufgrund einerumfassenden Literaturrecherche konnten Informationen und Studien in die Arbeiteinbezogen werden, die es ermöglichen das Störungsbild umfassend zu beschreiben. DieKernsymptomatik ist durch motorische Unruhe, Impulsivität und Aufmerksamkeitsstörungengekennzeichnet. Entsprechende Symptomkriterien werden in den KlassifikationsystemenICD-10 und DSM IV definiert. Die ADHS wird als eine Störung über die Lebensspannebezeichnet, da sie in vielen Fällen chronisch verläuft. In der Diagnostik von ADHS beinhaltenVerfahren vor allem die methodische Erfassung beeinträchtigter Funktionen. DieseVerfahren werden auf dem Erkenntnisgewinn zu charakteristischen Symptomen aufgebaut.Obwohl die ADHS oftmals erfolgreich mit Stimulanzien und anderen Psychopharmakabehandelt wird, ist die Nachhaltigkeit der Wirksamkeitseffekte unklar. Deshalb solltentherapeutische Interventionen in eine „Multimodale Therapie“ einbezogen werden. Auchwenn Experten seit vielen Jahren zum Thema ADHS geforscht haben, ist das Störungsbildund deren Auswirkungen auf sämtliche Funktionsbereiche noch nicht vollständig erklärt.Schlüsselwörter: ADHS-Klassifikation-Symptomatik-Chronifizierung-Diagnostik-MultimodaleTherapie

Ein optimales Steuerungs- und Regelungskonzept für autonome Elektrofahrzeuge

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2013

Ein optimales Steuerungs- und Regelungskonzept für autonome Elektrofahrzeuge

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2013

Storing Data in the Trial of Complex Technical Products

The article considers the ways of organization of databases for the storage of the results obtained during testing. A new variant of the organization of the data to ensure the ability to write to the database different sets of parameters in the form of chronological series. The required set of parameters depends on the modification of the tested technical installation.

Low autocorrelation sequences and flat polynomials

Magdeburg, Univ., Fak. für Mathematik, Habil.-Schr., 2014