Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.

One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. We used data from 751 studies including 4,372,000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. Wellcome Trust.

Akateemiset urapolut. Humanistisen, yhteiskuntatieteellisen ja kasvatustieteellisen alan generalistien urapolkujen alkuvaiheet 1980- ja 1990-luvuilla

Academic Career Paths. The early career phases of generalists in the fields of humanities, social science and education in the 1980’s and 1990’s This doctoral thesis analyses how generalist graduates of master’s degree have attached to the labour market in two different time periods, and how their career paths in the first eight years following graduation have shaped up. The thesis also analyses the channels of employment through which the generalists have got employed in their early career path. By generalists I am referring to graduates of studies in academic fields which have not qualified the person in a specific profession but rather offered a more general readiness for working life. I address two groups of generalist master’s degree graduates of The University of Turku; one including graduates of the year 1985 and the other consisting of graduates of 1995. All subjects have graduated in the field of humanities, social studies or education. 71 respondents from the group of 1985 and 80 respondents from the group of 1995 answered a survey, which provided the data for the thesis. I interpret the data through the theoretical approaches of changing working life, model of normal employment, transitional labour markets, linear life path, overlapping life courses, hidden labour market and social capital. The conclusion of the thesis is that societal era is connected with employment and career paths of academic generalists. Between the two groups there were differences especially in attachment to labor market, in forms of employment (permanent full-time job vs. temporary job) and in employment channels. Compared to the situation the 1985 group had been in after their graduation, the 1995 group - after getting their degree - became more often unemployed and/or employed in duties below their level of education. Their mobility was also greater and their contracts were often temporary, whereas the graduates of 1985 had been employed in more permanent positions. I demonstrate that the career paths of generalists can be categorized in five career types: steady state, transitory, linear, unsteady and diverging career. Graduates of 1985 have been treading on more stable paths than the latter group. The channels of employment they used were roughly equally divided between formal (e.g. newspaper advertisement and employment office) and informal (e.g. personal contacts and unprompted search for work) channels, whereas amongst the 1995 group employment happened through more varied channels and mostly through informal channels. Regardless of their year of graduation the generalists’ careers had begun to evolve already while they were still in the university and had started working at the same time. The thesis displays how the model of normal employment has weakened and career paths have become unsteady as a consequence of temporary positions. What is also evident in employment when turning from the 1980’s towards the succeeding decade is the rise of significance of the hidden labour market and social capital.

Kansallisten immateriaalioikeuksien vaikutus lääkekeksintöihin Suomessa ja Ruotsissa 1980-90-luvulla

Pro gradu- tutkielman tarkoituksena oli tutkia lääkkeiden immateriaalioikeudellisia suojamuotoja Suomen ja Ruotsin osalta. Tutkimuksessa pyrittiin selvittämään lääkkeiden kansallisen patenttisuojan, lisäsuojatodistuksen ja dokumentaatiosuojan vaikutusta lääkekeksintöihin 1980–90-luvun Suomessa ja Ruotsissa. Lääkkeiden lisäsuojatodistuksella tarkoitetaan ainoastaan lääkeaineille tarkoitettua erillistä immateriaalioikeudellista lisäsuojamuotoa, joka pidentää suoja-aikaa enimmillään viidellä vuodella. Dokumentaatiosuojalla tarkoitetaan suojamuotoa, joka suojaa lääkkeiden kehittämisessä aikaan saatuja tutkimus- ja turvallisuustuloksia rinnakkaisvalmistajilta tietyn määritellyn ajan. Suomen ja Ruotsin kansallisessa lainsäädännössä oli tarkasteluajanjaksolla olennaisia eroja. Rinnakkaisongelmana tutkittiin innovaatio- ja patenttipolitiikan merkitystä lääkekeksintöjen määrään ja laatuun. Tutkimuskysymyksiä lähestyttiin virallislähteiden ja kirjallisuuden lisäksi myös teemahaastatteluin. Haastateltavat olivat alan asiantuntijoita. Tutkimus oli haasteellinen. Oli palkitsevaa saada asiaa koskeva ”hiljainen tieto” kansiin. Suomen ja Ruotsin poliittinen ja lainsäädännöllinen ilmapiiri poikkesivat toisistaan. Suomessa vallitsi protektionistinen ilmapiiri ja se näkyi politiikassa ja vaikutti lainsäädäntöön. Menetelmäpatentista ei haluttu luopua. Menetelmäpatentti on patentti, joka käsittää ainoastaan lääkeaineen valmistusmenetelmän, eikä lopputuotetta. Suomessa sallittiin lääkeaineiden tuotepatentti vasta 1995. Toisin oli Ruotsissa; siellä poliittinen ilmapiiri ja valtion sekä lääketeollisuuden näkemykset johtivat kehitystä niin, että tuotepatenttikielto poistettiin huomattavasti aiemmin kuin Suomessa. Ruotsi oli kaukonäköisempi myös muiden suojamuotojen kohdalla. Lopputuloksena tästä seurasi se, että Ruotsin lääketeollisuus on menestynyt huomattavasti paremmin kuin Suomen. Lääkekeksintöjä tehtiin enemmän. Ruotsin lääkekeksinnöistä suuri osa oli uusia molekyylejä; Suomen vastaava osuus oli selvästi pienempi. Myös Ruotsin lääkevienti oli ja on huomattavasti suurempaa kuin Suomen.

Greek by Steven Berkoff (1980): The Risky Transformation of Sophocles’ Oedipus Rex into a Love Story

[eng] Can Sophocles’ Oedipus Rex really be transformed into a love story, as in Steven Berkoff’s drama entitled Greek? This article will show that, although Greek may be viewed by some critics as simply a provocative drama by no means intended to justify incest, directors, actors and critics in the end become enthralled by the powerful love story that ensues between Eddy and his wife and mother. This perspective reveals that Berkoff’s adaptation, intended to portray the social degradation of 1980s Great Britain, is in reality a quite risky proposition since it represents a flat denial of the tragic awareness of contemporary men and women. However, if this is the case, the audience, apart from enjoying the performance of Berkoff’s drama, might question, even from a non-fundamentalist perspective within the classical tradition, to what degree it makes sense to take inspiration from a text by Sophocles that precisely illustrates the great tragic awareness of the ancient Greeks.

Greek de Steven Berkoff (1980): L’arriscada conversió de l’Èdip rei de Sòfocles en una love story

[cat] ¿Podem convertir l’Èdip rei de Sòfocles en una història d’amor com ho fa Berkoff a Greek?. Tot i que alguns crítics llegeixen Greek només com un drama provocador que de cap manera intenta justificar l’incest, directors, actors i crítics resten finalment captivats per la impactant història d’amor entre Eddy i la seva esposa-mare. Això demostraria que l’adaptació de Berkoff, pensada per a il·lustrar la degradació social de la Gran Bretanya dels 80s, esdevé una proposta arriscada, car significa negar de fet la consciència tràgica dels homes i dones contemporanis. Tanmateix, si aquest és el cas, lectors i espectadors, a banda de l’indubtable plaer d’assistir a la representació de Greek, poden preguntar-se, fins i tot des d’una perspectiva no fonamentalista de la tradició clàssica, si té sentit inspirar-se en el text de Sòfocles, el qual mostra precisament la gran consciència tràgica dels grecs.

O ensino da química na Escola Superior de Agricultura "São Bento", Olinda - São Lourenço da Mata - Pernambuco (1912-1936)

The present work proposes the investigation of the role of chemistry in the curriculum of the Higher School of Agriculture "São Bento" (1912-1936) and its function in the education of agronomic engineers. The circumstances under which the Higher Schools of Agriculture and Veterinary Medicine in Olinda were founded at the beginning of the XXth century are discussed. The article further treats the influence of the principles of Justus von Liebig, which were seen at that time as essential for a rational agriculture.

Aspectos históricos dos cursos de licenciatura em química no Brasil nas décadas de 1930 a 1980

This article describes some historical moments in the establishment and development of chemistry teacher's training courses since 1930, with the creation of universities in Brazil, until 1980. Correlations between educational and political questions that influenced the directions taken for the formation of chemistry teachers in Brazil are discussed. From a review of the bibliographical sources available, we revisited stances of discussions on public policies related to science teacher's formation in general and in chemistry, particularly, in order to provoke a reflection on what challenges and prospects exist in the current scenario of undergraduate chemistry education in Brazilian universities and colleges.

Self-condensation of n-(N-propyl)butanimine: NMR and mass spectral analyses and investigation by theoretical calculation

The stability of N-propylbutanimine (1) was investigated under different experimental conditions. The acid-catalyzed self-condensation that produced the E-enimine (4) and Z-inimine (5) was studied by experimental analyses and theoretical calculations. Since the calculations for the energy of 5 indicated that it had a lower energy than 4, yet 4 was the principal product, the self-condensation of 1 must be kinetically controlled.

Resgatando um método eficiente para determinação do ponto de ebulição de substâncias orgânicas: percolador versus Siwoloboff

The aim of this paper was to revive the accurate determination of the boiling point of organic compounds using the percolator technique developed in the 1960s. Although this method is simple, fast and efficient it is omitted from current textbooks. This method has several advantages over Siwoloboff such as high reproducibility and direct measurement of the boiling point of the sample obtained by observing the temperature of the vapor-liquid equilibrium. The experiments were performed in the organic chemistry laboratory but allow interdisciplinary integration with other disciplines of several academic areas.