St. Louis, Missouri, 1860 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: City of St. Louis, recompiled & constructed by Julius Hutawa. 9th ed. It was published by Julius Hutawa in 1860. Scale [ca. 1:15,750]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Missouri East State Plane Coordinate System NAD83 (in Feet) (Fipszone 2401). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, horse car tracts, drainage, selected public buildings, city block numbers, property areas, names of selected property owners, and more. Includes street index. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Actinomicose manifestada por febre arrastada

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Construção tridimensional de atlas dos núcleos anteriores do tálamo a partir de cortes de um bloco de encéfalo

Tese de mestrado integrado em Engenharia Biomédica e Biofísica, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2016

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

Decrease in Cdx dosage in an allelic series of mouse Cdx mutants leads to progressively more severe posterior vertebral defects. These defects are corrected by posterior gain of function of the Wnt effector Lef1. Precocious expression of Hox paralogous 13 genes also induces vertebral axis truncation by antagonizing Cdx function. We report here that the phenotypic similarity also applies to patterning of the caudal neural tube and uro-rectal tracts in Cdx and Wnt3a mutants, and in embryos precociously expressing Hox13 genes. Cdx2 inactivation after placentation leads to posterior defects, including incomplete uro-rectal septation. Compound mutants carrying one active Cdx2 allele in the Cdx4-null background (Cdx2/4), transgenic embryos precociously expressing Hox13 genes and a novel Wnt3a hypomorph mutant all manifest a comparable phenotype with similar uro-rectal defects. Phenotype and transcriptome analysis in early Cdx mutants, genetic rescue experiments and gene expression studies lead us to propose that Cdx transcription factors act via Wnt signaling during the laying down of uro-rectal mesoderm, and that they are operative in an early phase of these events, at the site of tissue progenitors in the posterior growth zone of the embryo. Cdx and Wnt mutations and premature Hox13 expression also cause similar neural dysmorphology, including ectopic neural structures that sometimes lead to neural tube splitting at caudal axial levels. These findings involve the Cdx genes, canonical Wnt signaling and the temporal control of posterior Hox gene expression in posterior morphogenesis in the different embryonic germ layers. They shed a new light on the etiology of the caudal dysplasia or caudal regression range of human congenital defects.

Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ

Spinocerebellar ataxia type 1 (SCA1), due to an unstable polyglutamine expansion within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), decreasing motor coordination and causing death within 10-15 years of diagnosis. Currently, there are no therapies available to slow down disease progression. As secondary cellular impairments contributing to SCA1 progression are poorly understood, here, we focused on identifying those processes by performing a PC specific proteome profiling of Sca1154Q/2Q mice at a symptomatic stage. Mass spectrometry analysis revealed prominent alterations in mitochondrial proteins. Immunohistochemical and serial block-face scanning electron microscopy analyses confirmed that PCs underwent age-dependent alterations in mitochondrial morphology. Moreover, colorimetric assays demonstrated impairment of the electron transport chain complexes (ETC) and decrease in ATPase activity. Subsequently, we examined whether the mitochondria-targeted antioxidant MitoQ could restore mitochondrial dysfunction and prevent SCA1-associated pathology in Sca1154Q/2Q mice. MitoQ treatment both presymptomatically and when symptoms were evident ameliorated mitochondrial morphology and restored the activities of the ETC complexes. Notably, MitoQ slowed down the appearance of SCA1-linked neuropathology such as lack of motor coordination as well as preventing oxidative stress-induced DNA / RNA damage and PC loss. Our work identifies a central role for mitochondria in PC degeneration in SCA1 and provides evidence for the supportive use of mitochondria-targeted therapeutics in slowing down disease progression.

Publications.

Some issues are also called Collections, and consist of monographic titles.

An answer to A letter to the Right Honourable the Earl of B*** : in which the false reasoning, and absurd conclusions, in that pamphlet, are fully detected and refuted : addressed to the Right Hon. Earl T-mple.

In defence of William Pitt.

Fabian tract /

Latest issue consulted: 541, published in 1990.

The Round table /

Contitutes no. 11 in a pamphlet collection with binder's title: Tracts. American poetry.

The whole works of John Flavel, late minister of the gospel at Dartmouth, Devon.

I. The life of John Flavel. The fountain of life.--II. The method of in the gospel-redemption. Pneumatologia; a treatise of the soul of man.--III. Pneumatologia (cont.) A practical treatise of fear. The righteous man's refuge. A blow at the root; or, The causes and cure of mental errors. Vindiciarum vindex. The second appendix; of Antinomianism. A sermon on gospel-unity.--England's duty. Mount Pisgah. Divine conduct; or, The mystery of Providence. Wonderful sea-deliverances. Antipharmacum saluberrimum. Tidings from Rome; or, England's alarm.-- V. Husbandry spiritualized; or, The heavenly use of earthly things. Navigation spiritualized; or, A new compass for seamen. [Miscellaneous tracts and sermons]--VI. Preparations for sufferings. The balm of the covenant. An exposition of the Assembly's Shorter catechism. A reply to Mr. Philip Cary's Solemn call. Sacramental meditations. [Miscellaneous tracts and sermons].

Bibliotheca sacra and theological review.

Title from cover.

Cottoni posthuma: divers choice pieces of that renowned antiquary Sir Robert Cotton, knight and baronet, preserved from the injury of time and exposed to publick light for the benefit of posterity

Reprint of the 1679 ed. of the collection of Cotton's tracts made by James Howell, with reproductions of the general t. p. of the collection and of the special title pages preceding each of the 16 tracts except the first.

Chambers' repository of instructive and amusing papers ...

v. 1 includes caption title of 1st edition: Chambers' repository of instructive and amusing tracts.

The works of William Paley, D.D. : with additional sermons ... and a corrected account of the life and writings of the author /

Vols. 2-7 were also published separately.

The works of Francis Bacon, baron of Verulam, viscount St. Alban, and lord high chancellor of England.

Instaurationis magnae, pars V. Opuscula philosophica. Descriptio globi intellectualis. Opera civilia et moralia. Historia regni Henri Septimi.--v.10 Sermones fideles, sive Interiora rerum. De sapientia veterum. Meditationes sacrae. Epistolae. Index rerum in v. 7, 8, 8, et 10. Index to English part, comprised in the six first volumes.