High Strength Thermoplastic Bonding for Multi-channel, Multi-layer Lab-on-Chip Devices for Ocean and Environmental applications

A solvent-vapour thermoplastic bonding process is reported which provides high strength bonding of PMMA over a large area for multi-channel and multi-layer microfluidic devices with shallow high resolution channel features. The bond process utilises a low temperature vacuum thermal fusion step with prior exposure of the substrate to chloroform (CHCl3) vapour to reduce bond temperature to below the PMMA glass transition temperature. Peak tensile and shear bond strengths greater than 3 MPa were achieved for a typical channel depth reduction of 25 µm. The device-equivalent bond performance was evaluated for multiple layers and high resolution channel features using double-side and single-side exposure of the bonding pieces. A single-sided exposure process was achieved which is suited to multi-layer bonding with channel alignment at the expense of greater depth loss and a reduction in peak bond strength. However, leak and burst tests demonstrate bond integrity up to at least 10 bar channel pressure over the full substrate area of 100 mm x 100 mm. The inclusion of metal tracks within the bond resulted in no loss of performance. The vertical wall integrity between channels was found to be compromised by solvent permeation for wall thicknesses of 100 µm which has implications for high resolution serpentine structures. Bond strength is reduced considerably for multi-layer patterned substrates where features on each layer are not aligned, despite the presence of an intermediate blank substrate. Overall a high performance bond process has been developed that has the potential to meet the stringent specifications for lab-on-chip deployment in harsh environmental conditions for applications such as deep ocean profiling.

Two-Stage Orthogonal Least Squares Methods for Neural Network Construction

A number of neural networks can be formulated as the linear-in-the-parameters models. Training such networks can be transformed to a model selection problem where a compact model is selected from all the candidates using subset selection algorithms. Forward selection methods are popular fast subset selection approaches. However, they may only produce suboptimal models and can be trapped into a local minimum. More recently, a two-stage fast recursive algorithm (TSFRA) combining forward selection and backward model refinement has been proposed to improve the compactness and generalization performance of the model. This paper proposes unified two-stage orthogonal least squares methods instead of the fast recursive-based methods. In contrast to the TSFRA, this paper derives a new simplified relationship between the forward and the backward stages to avoid repetitive computations using the inherent orthogonal properties of the least squares methods. Furthermore, a new term exchanging scheme for backward model refinement is introduced to reduce computational demand. Finally, given the error reduction ratio criterion, effective and efficient forward and backward subset selection procedures are proposed. Extensive examples are presented to demonstrate the improved model compactness constructed by the proposed technique in comparison with some popular methods.

Investigation of Utilizing Single Surface Depressions in Optimization of NLF Aerofoil Design

An environment has been created for the optimisation of aerofoil profiles with inclusion of small surface features. For TS wave dominated flows, the paper examines the consequences of the addition of a depression on the aerodynamic optimisation of an NLF aerofoil, and describes the geometry definition fidelity and optimisation algorithm employed in the development process. The variables that define the depression for this optimisation investigation have been fixed, however a preliminary study is presented demonstrating the sensitivity of the flow to the depression characteristics. Solutions to the optimisation problem are then presented using both gradient-based and genetic algorithm techniques, and for accurate representation of the inclusion of small surface perturbations it is concluded that a global optimisation method is required for this type of aerofoil optimisation task due to the nature of the response surface generated. When dealing with surface features, changes in the transition onset are likely to be of a non-linear nature so it is highly critical to have an optimisation algorithm that is robust, suggesting that for this framework, gradient-based methods alone are not suited.

DEX: self-healing expanders

Using geotechnical and LIDAR spatial monitoring to determine key environmental slope instability thresholds of a Jurassic coastal landslide: Straidkilly Point, Northern Ireland, UK.

The Antrim Coast Road stretching from the seaport of Larne in the East of Northern Ireland to the famous Giant’s Causeway in the North has a well-deserved reputation for being one of the most spectacular roads in Europe (Day, 2006). At various locations along the route, fluid interactions between the problematic geology, Jurassic Lias Clay and Triassic Mudstone overlain by Cretaceous Limestone and Tertiary Basalt, and environmental variables result in frequent instances of slope instability within the vadose zone. During such instances of instability, debris flows and composite mudflows encroach on the carriageway posing a hazard to road users. This paper examines the site investigative, geotechnical and spatial analysis techniques currently being implemented to monitor slope stability for one site at Straidkilly Point, Glenarm, Northern Ireland. An in-depth understanding of the geology was obtained via boreholes, resistivity surveys and laboratory testing. Environmental variables recorded by an on-site weather station were correlated with measured pore water pressure and soil moisture infiltration dynamic data.
Terrestrial LiDAR (TLS) was applied to the slope for the monitoring of failures, with surveys carried out on a bi-monthly basis. TLS monitoring allowed for the generation of Digital Elevation Models (DEMs) of difference, highlighting areas of recent movement, erosion and deposition. Morphology parameters were generated from the DEMs and include slope, curvature and multiple measures of roughness. Changes in the structure of the slope coupled with morphological parameters are characterised and linked to progressive failures from the temporal monitoring. In addition to TLS monitoring, Aerial LiDARi datasets were used for the spatio-morphological characterisation of the slope on a macro scale. Results from the geotechnical and environmental monitoring were compared with spatial data obtained through Terrestrial and Airborne LiDAR, providing a multi-faceted approach to slope stability characterization, which facilitates more informed management of geotechnical risk by the Northern Ireland Roads Service.

Statistical data correction for unreliable memories

In this paper, we introduce a statistical data-correction framework that aims at improving the DSP system performance in presence of unreliable memories. The proposed signal processing framework implements best-effort error mitigation for signals that are corrupted by defects in unreliable storage arrays using a statistical correction function extracted from the signal statistics, a data-corruption model, and an application-specific cost function. An application example to communication systems demonstrates the efficacy of the proposed approach.

On the performance of LDPC and turbo decoder architectures with unreliable memories

In this paper, we investigate the impact of faulty memory bit-cells on the performance of LDPC and Turbo channel decoders based on realistic memory failure models. Our study investigates the inherent error resilience of such codes to potential memory faults affecting the decoding process. We develop two mitigation mechanisms that reduce the impact of memory faults rather than correcting every single error. We show how protection of only few bit-cells is sufficient to deal with high defect rates. In addition, we show how the use of repair-iterations specifically helps mitigating the impact of faults that occur inside the decoder itself.

Foreword

Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.

Secure key generation from OFDM subcarriers' channel responses

The ability to exchange keys between users is vital in any wireless based security system. A key generation technique which exploits the randomness of the wireless channel is a promising alternative to existing key distribution techniques, e.g., public key cryptography. In this paper, a secure key generation scheme based on the subcarriers' channel responses in orthogonal frequency-division multiplexing (OFDM) systems is proposed. We first implement a time-variant multipath channel with its channel impulse response modelled as a wide sense stationary (WSS) uncorrelated scattering random process and demonstrate that each subcarrier's channel response is also a WSS random process. We then define the X% coherence time as the time required to produce an X% correlation coefficient in the autocorrelation function (ACF) of each channel tap, and find that when all the channel taps have the same Doppler power spectrum, all subcarriers' channel responses has the same ACF as the channel taps. The subcarrier's channel response is then sampled every X% coherence time and quantized into key bits. All the key sequences' randomness is tested using National Institute of Standards and Technology (NIST) statistical test suite and the results indicate that the commonly used sampling interval as 50% coherence time cannot guarantee the randomness of the key sequence.

Análise das alterações ao nível da estrutura das explorações agrícolas da Região Algarve e respectivo tecido empresarial, decorrentes da aplicação dos apoiso comunitários, com especial incidência no período 1994/99

Dissertação de mest., Gestão Empresarial, Faculdade de Economia, Univ. do Algarve, 2001

A tradução da Peregrinaçam de Fernão Mendes Pinto em Espanha, França, Inglaterra e Alemanha no século XVII

Este trabalho de investigação comparativista insere-se no âmbito das relações entretecidas pelos Estudos de Tradução e a Literatura Comparada, nomeadamente no que respeita ao conceito de tradução literária na Europa Ocidental do século XVII. Trata-se de um estudo intercultural, atendendo a que a tradução promove a mudança cultural decorrente de um processo de transferência intercultural com implicações literárias e ideológicas. Os textos que constituíram o nosso objeto de trabalho são a Peregrinaçam de Fernão Mendes Pinto (1614) e as primeiras traduções completas ou parciais para espanhol (1620), da autoria de Francisco de Herrera Maldonado, para francês (1628), de Bernard Figuier, para inglês (1653), de Henry Cogan, e para alemão (1671), dos editores Henrich e Dietrich Boom. No decorrer da análise comparativa, procurámos demonstrar o grau de (in)fidelidade de cada tradução, estabelecendo paralelismos e realçando os procedimentos tradutológicos adotados em cada versão, os quais revelam, claramente, contactos entre si e/ou condicionalismos culturais e ideológicos implícitos. Estudámos o modo como cada tradução adaptou a obra original ao gosto e aos códigos linguísticos e literários do seu público-alvo. No desenvolvimento do nosso trabalho, tivemos em mente os códigos tradutológicos do século XVII em Espanha, França, Inglaterra e Alemanha, em virtude de o nosso corpus ser constituído por textos publicados no decorrer desse período. Como metodologia de trabalho, delimitámos cinco momentos narrativos, no interior dos quais foram encontradas e analisadas comparativamente passagens consideradas exemplificativas das principais técnicas tradutivas características de cada texto e das inter-relações estabelecidas entre eles. Por fim, um outro objetivo nosso consistiu na avaliação do significado e da relevância da receção da tradução- -adaptação desta obra portuguesa naqueles contextos de chegada (no momento imediato e para além dele).

Theorising and analysing digital labour: from global value chains to modes of production

This paper considers the following question—where do computers, laptops and mobile phones come from and who produced them? Specific cases of digital labour are examined—the extraction of minerals in African mines under slave-like conditions; ICT manufacturing and assemblage in China (Foxconn); software engineering in India; call centre service work; software engineering at Google within Silicon Valley; and the digital labour of internet prosumers/users. Empirical data and empirical studies concerning these cases are systematically analysed and theoretically interpreted. The theoretical interpretations are grounded in Marxist political economy. The term ‘global value chain’ is criticised in favour of a complex and multidimensional understanding of Marx’s ‘mode of production’ for the purposes of conceptualizing digital labour. This kind of labour is transnational and involves various modes of production, relations of production and organisational forms (in the context of the productive forces). There is a complex global division of digital labour that connects and articulates various forms of productive forces, exploitation, modes of production, and variations within the dominant capitalist mode of production.

Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action.

The mechanisms by which CD4(+)CD25(+)Foxp3(+) T (Treg) cells regulate effector T cells in a transplantation setting and their in vivo homeostasis still remain to be clarified. Using a mouse adoptive transfer model, we analyzed the in vivo expansion, trafficking, and effector function of alloreactive T cells and donor-specific Treg cells, in response to a full-thickness skin allograft. Fluorescent-labeled CD4(+)CD25(-) and antigen-specific Treg cells were transferred alone or co-injected into syngeneic BALB/c-Nude recipients transplanted with skins from (C57BL/6 x BALB/c) F1 donors. Treg cells divided in vivo, migrated and accumulated in the allograft draining lymph nodes as well as within the graft. The co-transfer of Treg cells did not modify the early activation and homing of CD4(+)CD25(-) T cells in secondary lymphoid organs. However, in the presence of Treg cells, alloreactive CD4(+)CD25(-) T cells produced significantly less IFN-gamma and were present in reduced numbers in the secondary lymphoid organs. Furthermore, time-course studies showed that Treg cells were recruited into the allograft at a very early stage after transplantation and effectively prevented the infiltration of effector T cells. In conclusion, suppression of rejection requires the early recruitment to the site of antigenic challenge of donor-specific Treg cells, which then mainly regulate the effector arm of T cell alloresponses.