Eddy formation and the boundary layer in fish locomotion

Cover title.

Opīsanie rukopiseĭ biblīoteki Viḟanskoĭ dukhovnoĭ seminarīi. (S prilozhenīi︠a︡mi)

The supplements contain congratulatory poems and correspondence between members of the imperial family and the metropolitans Platon and Augustin.

Vozsoedinenīe okrain.

Mode of access: Internet.

[Memorial a Felipe IV exponiendo varias consideraciones en súplica de que S. M. le mande cubrir.]

Mode of access: Internet.

Stikhotvorenii͡a.

Binder's title.

Treatise on gynaecology, medical and surgical,

1892 ed. is issued under title: A system of gynaecology.

Poli︠a︡rnai︠a︡ zvi︠e︡zda.

Editors: Iskander (pseud. A.I. Herzen), N.P. Ogarev.

Ni︠e︡kotoryi︠a︡ dannyi︠a︡ dli︠a︡ kharakteristiki nastroenii︠a︡ bi︠e︡lorusskago obshchestva v ėpokhu chetyrekhli︠e︡tni︠a︡go seĭma, 1788-1792.

Record romanized.

AVALIAÇÃO DO ESPAÇO DISPONÍVEL PARA ERUPÇÃO DOS SEGUNDOS E TERCEIROS MOLARES SUPERIORES PERMANENTES APÓS A DISTALIZAÇÃO DOS PRIMEIROS MOLARES SUPERIORES PERMANENTES

A presente pesquisa tem como objetivo avaliar cefalometricamente, o espaço e po-sicionamento das coroas dos segundos e terceiros molares superiores permanentes não erupcionados na região da tuberosidade maxilar durante a distalização dos pri-meiros molares superiores, além de verificar a correlação entre estas duas variáveis. A amostra foi constituída de 38 telerradiografias em norma lateral direita, obtidas de 19 pacientes, jovens brasileiros, leucodermas e melanodermas, sendo 6 do sexo masculino e 13 do sexo feminino, com idade média de 9 anos 5 meses 13 dias. A metodologia constou inicialmente da divisão dos tempos (T1) inicial, e após a distali-zação do primeiro molar superior permanente em (T2) por um período médio de 10 meses e 23 dias. Para avaliação do espaço e angulação das coroas existente utili-zou-se uma Linha referencial intracraniana (Linha M) sendo esta demarcada, a partir de dois pontos, o ponto SE localizado na sutura esfenoetmoidal, e o ponto Pt locali-zado na parte anterior da fossa pterigopalatina. Esta linha referencial foi transferida até o ponto F, (Linha M ) ponto este localizado na região mais posterio-inferior da tuberosidade maxilar. O espaço avaliado compreendeu entre a Linha M , até a face distal do primeiro molar superior permanente. Na análise estatística usou-se o teste t (Teste t Student) , e na correlação entre espaço e angulação foi utilizado o coefi-ciente de correlação de Pearson. Concluímos que o espaço correspondente entre a distal dos primeiros molares superiores permanentes e extremidade da tuberosidade maxilar, na fase inicial e após a movimentação distal, não é suficiente para a erup-ção dos segundos e terceiros molares superiores permanentes. A angulação das coroas na fase inicial e após a movimentação distal posicionam-se com angulações mais para distal. Quanto à correlação das angulações das coroas dos segundos e terceiros molares superiores permanentes e o espaço para erupção verificamos que quanto maior a angulação das coroas para distal, menor os espaços oferecidos para a erupção.(AU)

A Rapid and Sensitive High-Throughput Screening Method to Identify Compounds Targeting Protein–Nucleic Acids Interactions

DNA-binding and RNA-binding proteins are usually considered ‘undruggable’ partly due to the lack of an efficient method to identify inhibitors from existing small molecule repositories. Here we report a rapid and sensitive high-throughput screening approach to identify compounds targeting protein–nucleic acids interactions based on protein–DNA or protein–RNA interaction enzyme-linked immunosorbent assays (PDI-ELISA or PRI-ELISA). We validated the PDI-ELISA method using the mammalian highmobility- group protein AT-hook 2 (HMGA2) as the protein of interest and netropsin as the inhibitor of HMGA2–DNA interactions. With this method we successfully identified several inhibitors and an activator for HMGA2–DNA interactions from a collection of 29 DNA-binding compounds. Guided by this screening excise, we showed that netropsin, the specific inhibitor of HMGA2–DNA interactions, strongly inhibited the differentiation of the mouse pre-adipocyte 3T3-L1 cells into adipocytes, most likely through a mechanism by which the inhibition is through preventing the binding of HMGA2 to the target DNA sequences. This method should be broadly applicable to identify compounds or proteins modulating many DNA-binding or RNA-binding proteins.

Last Interglacial synthesis of high-latitude temperature: temperature anomalies and associated errors for 4 time slices

The Last Interglacial (LIG, 129-116 thousand of years BP, ka) represents a test bed for climate model feedbacks in warmer-than-present high latitude regions. However, mainly because aligning different palaeoclimatic archives and from different parts of the world is not trivial, a spatio-temporal picture of LIG temperature changes is difficult to obtain. Here, we have selected 47 polar ice core and sub-polar marine sediment records and developed a strategy to align them onto the recent AICC2012 ice core chronology. We provide the first compilation of high-latitude temperature changes across the LIG associated with a coherent temporal framework built between ice core and marine sediment records. Our new data synthesis highlights non-synchronous maximum temperature changes between the two hemispheres with the Southern Ocean and Antarctica records showing an early warming compared to North Atlantic records. We also observe warmer than present-day conditions that occur for a longer time period in southern high latitudes than in northern high latitudes. Finally, the amplitude of temperature changes at high northern latitudes is larger compared to high southern latitude temperature changes recorded at the onset and the demise of the LIG. We have also compiled four data-based time slices with temperature anomalies (compared to present-day conditions) at 115 ka, 120 ka, 125 ka and 130 ka and quantitatively estimated temperature uncertainties that include relative dating errors. This provides an improved benchmark for performing more robust model-data comparison. The surface temperature simulated by two General Circulation Models (CCSM3 and HadCM3) for 130 ka and 125 ka is compared to the corresponding time slice data synthesis. This comparison shows that the models predict warmer than present conditions earlier than documented in the North Atlantic, while neither model is able to produce the reconstructed early Southern Ocean and Antarctic warming. Our results highlight the importance of producing a sequence of time slices rather than one single time slice averaging the LIG climate conditions.

A gestão educacional das secretarias municipais de educação de municípios maranhenses a partir do plano de ações articuladas 2007-2011

The main purpose of this thesis was to analyze educational management of Municipal Departments of Education (SEMED’s) of cities in Maranhão inserted in the Plan of Articulated Actions (2007- 2011). We evidence the role of Union in that public policy. The leading argument is that Brazilian federal government is not demos constraining in relation to its national sub-governments, what makes the central government to enforce, primarily, educational politics like PAR. This kind of politics interferes in the educational management by national sub-governments, turning them into mere executors. By turning them into mere executors, PAR limits their autonomy and over imposes the results-based management as a parameter to improve the education quality. In order to develop the hypothesis, we adopted Political Science as theoretical basis, represented by Federalism Theory as pact which premise is the cooperative pattern of federalism as being the best form of government because it allows a joint decision-making process from the idea of no centralization of power. The methodology was historical materialism, which assumes the totality and contradiction as a form to understand the phenomenon that does not express in direct way its existence, but can be analyzed from such categories that made possible to interpret the reality. So, we used as tools the semistructured interview and documental analyses with triangulation of data. The empirical basis of the research is 04 (four) cities in Maranhão that obey the following criteria: 1. The municipality has to be assigned on the FNDE Resolution nº 29/2007; 2. To present the lowest educational management indexes from the diagnosis made in loco by PAR; 3. To present the lowest financial management indexes based on the diagnosis in loco by PAR. The results suggest that PAR does not effect a resultbased management which are proposed in its legal rules neither the SEMEDs can propose their conception of educational management. That situation creates a hybridism that sometimes turns to managerialism and performativity, sometimes to bureaucracy, sometimes to a total uncoordinated and unarticulated action. In relation to SEMEDs management, this thesis shows that these institutions have no own conception about educational management and end up acting in an uncoordinated and unarticulated way. The thesis concludes that PAR is an over imposition by federal government towards national sub-governments that conflicts with management patterns of those institutions that are used to a less managerial logic. This over imposition makes the Central government to be the center of Brazilian federalism, which is in reality an incomplete pact.

Effects of exercise training on intrauterine growth restriction in an animal model

Résumé Selon l'OMS, la retard de croissance intra-utérine (RCIU; 10% en dessous du poids normal pendant la grossesse) affecte 5-10% des grossesses et est une cause principale de la morbidité et de la mortalité périnatales. Dans notre étude précédente sur un modèle de souris transgénique de prééclampsie (R+A+), nous avons constaté que l’entraînement physique (ExT) avant et pendant la grossesse réduisait la pression artérielle maternelle et empêchait la RCIU en améliorant le développement placentaire. Dans le cadre de mon projet, nous avons confirmé les bénifices de l’ExT dans un modèle de RCIU (souris déficiente en p57Kip2 (p57-/+). Ainsi, nous avons observé la présence de RCIU, d’une masse placentaire réduite, d’une augmentation de la pathologie placentaire ainsi qu’une plus petite taille des portées chez les souris p57-/+ sédentaire. L’ExT prévient la RCIU ainsi que tous les paramètres mentionnés ci-haut. Nous avons observé que l'expression du facteur de croissance de l’endothélium vasculaire, un régulateur clé de l'angiogenèse lors de la croissance placentaire, était réduite dans le placenta des souris p57-/+ et normalisée par l’ExT. Nous avons également trouvé que l'expression en ARN dans le placenta de 2 facteurs inflammatoires (interleukine-1β et MCP-1) était augmenté chez les souris sédentaires p57-/+ alors que ceci n’était pas présent chez les souris entraînées, ce qui suggère que l'inflammation placentaire peut contribuer à la pathologie placentaire. Toutefois, contrairement aux souris R+A+, le système rénine-angiotensine placentaire chez les souris p57-/+ était normale et aucun effet de l’ExT a été observé. Ces résultats suggèrent que l’ExT prévient la RCIU en normalisant la pathologie placentaire, l’angiogenèse et l’inflammation placentaire.

Étude de la relation entre le champ visuel et le champ visuel utile chez les personnes atteintes d'hémianopsie

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

L'effet d'une variation du niveau d'activité physique sur les propriétés électrophysiologiques des motoneurones du nerf tibial chez le rat

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.