O tratamento de metástases ósseas de fração única vs múltiplas frações com 3D CRT ou SBRT: artigo de revisão sistemática

Introdução – A escolha do tratamento depende de vários fatores, incluindo o estado clínico e prognóstico de cada doente. Estes fatores desempenham um papel importante na escolha da intervenção terapêutica em metástases ósseas. A deteção precoce e o tratamento adequado podem melhorar a qualidade de vida e independência funcional dos doentes. Metodologia – Este artigo pretende realizar uma revisão sistemática da literatura dos últimos 15 anos, identificando os diferentes tipos de fracionamentos (fração única versus múltiplas frações) e técnicas utilizadas em radioterapia no tratamento de metástases ósseas. Resultados – Os recentes avanços na tecnologia e nas técnicas de tratamento de radioterapia ajudam na distribuição de doses altamente conformacionais e com orientação por imagem para uma entrega mais precisa do tratamento. A radioterapia estereotáxica corporal (SBRT, do acrónimo inglês stereotactic body radiotherapy) permite delimitar e aumentar a dose nos tumores a irradiar. No caso das metástases ósseas, os resultados de controlo local do tumor e da dor têm-se revelado promissores. A radioterapia convencional de 8Gyx1, no entanto, continua a ser o tratamento mais indicado nos doentes paliativos. Conclusão – O tratamento de metástases ósseas é complexo e uma abordagem multidisciplinar é sempre necessária. O tratamento deve ser individualizado para se adequar aos sintomas e estado clínico de cada doente.

Electrochemical response of 70Co-30Ni highly branched 3D-dendritic structures for charge storage electrodes

A 70Co-30Ni dendritic alloy was produced on stainless steel by pulse electrodeposition in the cathodic domain, and oxidized by potential cycling. X-ray diffraction (XRD) identified the presence of two phases and scanning electron microscopy (SEM) evidenced an open 3D highly branched dendritic morphology. After potential cycling in 1 M KOH, SEM and X-ray photoelectron spectroscopy (XPS) revealed, respectively, the presence of thin nanoplates, composed of Co and Ni oxi-hydroxides and hydroxides over the original dendritic film. Cyclic voltammetry tests showd the presence of redox peaks assigned to the oxidation and reduction of Ni and Co centres in the surface film. Charge/discharge measurements revealed capacity values of 121 mAh g(1) at 1 mA cm(2). The capacity retention under 8000 cycles was above 70%, stating the good reversibility of these redox materials and its suitability to be used as charge storage electrodes. Electrochemical impedance spectroscopy (EIS) spectra, taken under different applied bias, showed that the capacitance increased when the electrode was fully oxidized and decreased when the electrode was reduced, reflecting different states-of-charge of the electrode. (C) 2015 Elsevier Ltd. All rights reserved.

Processing and characterization of 3D dense chitosan pieces, for orthopedic applications, by adding plasticizers

In this work, plasticizer agents were incorporated in a chitosan based formulation, as a strategy to improve the fragile structure of chitosan based-materials. Three different plasticizers: ethylene glycol, glycerol and sorbitol, were blended with chitosan to prepare 3D dense chitosan specimens. The properties of the obtained structures were assessed for mechanical, microstructural, physical and biocompatibility behavior. The results obtained revealed that from the different specimens prepared, the blend of chitosan with glycerol has superior mechanical properties and good biological behavior, making this chitosan based formulation a good candidate to improve robust chitosan structures for the construction of bioabsorbable orthopedic implants.

How to link organizational competences in public organizations?

Comunicação apresentada na 17ª Conferência Anual da Network of Intitutes and Schools of Public Administration (NISPA) em Birdua, Montenegro de 14 a 16 dem Maio de 2009.

Embedded system for individual recognition based on ECG biometrics

Biometric recognition is emerging has an alternative solution for applications where the privacy of the information is crucial. This paper presents an embedded biometric recognition system based on the Electrocardiographic signals (ECG) for individual identification and authentication. The proposed system implements a real-time state-of-the-art recognition algorithm, which extracts information from the frequency domain. The system is based on a ARM Cortex 4. Preliminary results show that embedded platforms are a promising path for the implementation of ECG-based applications in real-world scenario.

Biometric recognition system using low bandwidth ECG signals

Biometric recognition has recently emerged as part of applications where the privacy of the information is crucial, as in the health care field. This paper presents a biometric recognition system based on the Electrocardiographic signal (ECG). The proposed system is based on a state-of-the-art recognition method which extracts information from the frequency domain. In this paper we propose a new method to increase the spectral resolution of low bandwidth ECG signals due to the limited bandwidth of the acquisition sensor. Preliminary results show that the proposed scheme reveals a higher identification rate and lower equal error rate when compared to previous approaches.

Gestão de produto PREMFIRE – sistema de informação geográfica 3D para apoio ao combate a incêndios.

Dissertação apresentada como requisito parcial para obtenção do grau de Mestre em Ciência e Sistemas de Informação Geográfica.

Profissões : sinergias entre o video interactivo e o 3D estereoscópico

Trabalho de Projecto apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Novos Media e Práticas Web

Modelos geológicos estocásticos 3D e interface para modelos de simulação de fluxo: aplicação à área subjacente da antiga fábrica da SPEL

Dissertação para obtenção do grau de Mestre em Engenharia Geológica (Georrecursos)

Concepção de um aparelho de medição 3D da coluna vertebral: Desenvolvimento de um software de detecção de apófises espinhosas e cálculo da distância ântero-posterior

Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia Biomédica

Automatic musical instrument recognition for multimedia indexing

Trabalho apresentado no âmbito do Mestrado em Engenharia Informática, como requisito parcial para obtenção do grau de Mestre em Engenharia Informática

Interacções de proteínas do plasma com potenciais fármacos: estudos 3D a nível molecular

Dissertação para obtenção do Grau de Mestre em Biotecnologia

Functional and therapeutical implications of ligand recognition by the scavenger-like lymphocyte receptors CD5 and CD6

Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina

Smart Plastic Antibody Material (SPAM) tailored on disposable screen printed electrodes for protein recognition: application to Myoglobin detection

This work introduces two major changes to the conventional protocol for designing plastic antibodies: (i) the imprinted sites were created with charged monomers while the surrounding environment was tailored using neutral material; and (ii) the protein was removed from its imprinted site by means of a protease, aiming at preserving the polymeric network of the plastic antibody. To our knowledge, these approaches were never presented before and the resulting material was named here as smart plastic antibody material (SPAM). As proof of concept, SPAM was tailored on top of disposable gold-screen printed electrodes (Au-SPE), following a bottom-up approach, for targeting myoglobin (Myo) in a point-of-care context. The existence of imprinted sites was checked by comparing a SPAM modified surface to a negative control, consisting of similar material where the template was omitted from the procedure and called non-imprinted materials (NIMs). All stages of the creation of the SPAM and NIM on the Au layer were followed by both electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). AFM imaging was also performed to characterize the topography of the surface. There are two major reasons supporting the fact that plastic antibodies were effectively designed by the above approach: (i) they were visualized for the first time by AFM, being present only in the SPAM network; and (ii) only the SPAM material was able to rebind to the target protein and produce a linear electrical response against EIS and square wave voltammetry (SWV) assays, with NIMs showing a similar-to-random behavior. The SPAM/Au-SPE devices displayed linear responses to Myo in EIS and SWV assays down to 3.5 μg/mL and 0.58 μg/mL, respectively, with detection limits of 1.5 and 0.28 μg/mL. SPAM materials also showed negligible interference from troponin T (TnT), bovine serum albumin (BSA) and urea under SWV assays, showing promising results for point-of-care applications when applied to spiked biological fluids.

Ciprofloxacin-imprinted polymeric receptors as ionophores for potentiometric transduction

A 3D-mirror synthetic receptor for ciprofloxacin host–guest interactions and potentiometric transduction is presented. The host cavity was shaped on a polymeric surface assembled with methacrylic acid or 2-vinyl pyridine monomers by radical polymerization. Molecularly imprinted particles were dispersed in 2-nitrophenyl octyl ether and entrapped in a poly(vinyl chloride) matrix. The sensors exhibited a near-Nernstian response in steady state evaluations. Slopes and detection limits ranged from 26.8 to 50.0 mV decade−1 and 1.0 × 10−5 to 2.7 × 10−5 mol L−1, respectively. Good selectivity was observed for trimethoprim, enrofloxacin, tetracycline, cysteine, galactose, hydroxylamine, creatinine, ammonium chloride, sucrose, glucose, sulphamerazine and sulfadiazine. The sensors were successfully applied to the determination of ciprofloxacin concentrations in fish and in pharmaceuticals. The method presented offered the advantages of simplicity, accuracy, applicability to colored and turbid samples and automation feasibility, as well as confirming the use of molecularly imprinted polymers as ionophores for organic ion recognition in potentiometric transduction.