964 resultados para Mega-agreements


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[EN] More than 20 mega-landslides have been described in the Canary Islands affecting the flanks of the volcanic edifices. Güímar and La Orotava landslides, in Tenerife, are two exceptional cases due to their huge dimensions and outstanding geomorphological features. The estimated volume of these landslides exceed tens of cubic km. Tsunami deposits have been also identified in some of the islands of the archipelago probably associated to the large landslides of the islands flanks. An investigation has been carried out to explain the causes of these large instability processes and their failure mechanisms.

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Agreed-upon procedures reports on twelve agreements between the Bureau of Nutrition and Health Services of the Iowa Department of Education and child care centers for the period October 1, 2014 through September 30, 2015

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Background - Image blurring in Full Field Digital Mammography (FFDM) is reported to be a problem within many UK breast screening units resulting in significant proportion of technical repeats/recalls. Our study investigates monitors of differing pixel resolution, and whether there is a difference in blurring detection between a 2.3 MP technical review monitor and a 5MP standard reporting monitor. Methods - Simulation software was created to induce different magnitudes of blur on 20 artifact free FFDM screening images. 120 blurred and non-blurred images were randomized and displayed on the 2.3 and 5MP monitors; they were reviewed by 28 trained observers. Monitors were calibrated to the DICOM Grayscale Standard Display Function. T-test was used to determine whether significant differences exist in blurring detection between the monitors. Results - The blurring detection rate on the 2.3MP monitor for 0.2, 0.4, 0.6, 0.8 and 1 mm blur was 46, 59, 66, 77and 78% respectively; and on the 5MP monitor 44, 70, 83 , 96 and 98%. All the non-motion images were identified correctly. A statistical difference (p <0.01) in the blurring detection rate between the two monitors was demonstrated. Conclusions - Given the results of this study and knowing that monitors as low as 1 MP are used in clinical practice, we speculate that technical recall/repeat rates because of blurring could be reduced if higher resolution monitors are used for technical review at the time of imaging. Further work is needed to determine monitor minimum specification for visual blurring detection.

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The first two decades of 21st century were times of great social, economic and political changes in Brazil where sport mega events (FIFA WC 2014, Rio 2016) played a key role in how the nation portrayed and promoted itself in a global scale. Despite the undeniable importance of Presidents Lula da Silva and Dilma Rousseff in attempt to present the country as global protagonist with more political power and social advancements, this works is intended to discuss and extended the discussion upon mega events as different ways of repeating old traditions and practices, (radically) contextualizing the role of other players and agents (sport officials, local politicians, sponsors and local media), their biases and interests, in accordance to traditional colonial processes and the dominant neo-liberal paradigm.

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Nas últimas décadas, muito interesse tem sido focado no potencial biotecnológico das microalgas, principalmente devido à identificação de diversas substâncias bioativas sintetizadas por estas, especialmente ácidos graxos poliinsaturados (PUFAs). PUFAs ômega-3 (PUFAs ω-3) têm sido estudados pela promoção de efeitos benéficos em muitas doenças crônicas, incluindo o câncer, ao contrário de PUFAs ômega-6 (PUFAs ω-6) que, de forma geral, são conhecidos por agravar o desenvolvimento destes quadros. Este estudo objetivou testar a atividade antiproliferativa de extratos lipídicos de duas microalgas marinhas, Isochrysis galbana e Thalassiosira pseudonana, ricas principalmente em PUFAs ω-3, em uma linhagem celular de melanoma, B16F10. Adicionalmente, o efeito dos precursores dos PUFAs ω-3, α-linolênico (ALA), e dos PUFAs ω-6, linoleico (LA) na proliferação celular, foi avaliado nesta linhagem e em uma linhagem melanocítica normal, Melan-A, pelo método MTT. Foi demonstrado que os extratos lipídicos estudados são capazes de induzir inibição de proliferação tempo e concentração dependente na linhagem B16F10 e esta atividade foi também exercida pelo ALA de forma independente das concentrações testadas. Além disso, o extrato lipídico da microalga Thalassiosira pseudonana também induziu citotoxicidade na linhagem B16F10. Desse modo, é possível sugerir que o efeito antiproliferativo dos extratos possa estar relacionado com a alta concentração de ω-3 PUFAs em relação a ω- 6 PUFAs, especialmente para a Thalassiosira pseudonana Adicionalmente, a linhagem Melan-A não foi sensível ao tratamento com o ALA, sugerindo, dessa forma, um efeito antitumoral para este composto. Este estudo ainda indica a possibilidade do uso de microalgas como fontes promissoras de substâncias antitumorais.

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Os nanomateriais de carbono como o fulereno (C60) apresenta comportamentos bioquímicos distintos, podendo atuar como antioxidante ou pró-oxidante em diferentes sistemas biológicos. Outra evidência ao C60 refere-se a sua característica lipofilica, na qual oferece ação mais direta a diferentes tipos de membranas celulares. Do mesmo modo ácidos graxos poliinsaturados (AGPs) como o ômega-3 (DHA) e o ômega-6 (LA) são importantes para funções celulares da membrana, sendo considerados antioxidantes clássicos. Dessa forma este estudo avaliou em suspensões celulares de cérebro da carpa (Cyprinus carpio, Cyprinidae), o efeito de C60 após um pré-tratamento com DHA ou LA. Para tal avaliação os ensaios consistiram em um pré-tratamento com AGPs (48h) e após exposição a C60 (2h). Como resultados observamos que a viabilidade celular e a capacidade antioxidante total não apresentaram diferença (p> 0.05) entre todos os grupos. Em relação a valores de espécies ativas de oxigênio e dano lipídico foi observado redução nos seus valores nos grupos expostos ao C60 pré – tratados com AGPs (p<0.05). Em termos de cisteína, ocorre uma redução da sua concentração em todos os grupos expostos ao C60. Porém para glutationa a exposição ao C60 provoca um aumento de sua concentração nos grupo controle (sem AGPs) e no grupo pré – tratado com DHA. Dessa forma consideramos que o pré – tratamento com AGPs é benéfico às células, uma vez que um aumento nos níveis de glutationa e uma diminuição na concentração de espécies ativas de oxigênio e peroxidação lipídica foram observados nos grupos expostos ao C60. Sendo assim um bom estado nutritivo em termos da concentração de AGPs foi considerado benéfico na exposição ao fulereno.

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This paper describes the process of creating a controlled vocabulary which can be used to systematically analyse the copyright transfer agreements (CTAs) of journal publishers with regard to self-archiving. The analysis formed the basis of the newly created Copyright Knowledge Bank of publishers’ self-archiving policies. Self-archiving terms appearing in publishers’ CTAs were identified and classified, with these then being simplified, merged, and discarded to form a definitive list. The controlled vocabulary consists of three categories that describe ‘what’ can be self-archived, the ‘conditions’ of self-archiving and the ‘restrictions’ of self-archiving. Condition terms include specifications such as ‘where’ an article can be self archived, restriction terms include specifications such as ‘when’ the article can be self archived. Additional information on any of these terms appears in ‘free-text’ fields. Although this controlled vocabulary provides an effective way of analysing CTAs, it will need to be continually reviewed and updated in light of any major new additions to the terms used in publishers’ copyright and self-archiving policies.

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Resumen El presente artículo desenmascara la forma en que falazmente las instituciones financieras multilaterales pretenden hacer ver las causas de lo que han dado en llamar “la crisis alimentaria mundial” a partir del incremento de los precios de los alimentos alrededor del mundo. Agrocombustibles, incremento del precio del petróleo, cambio climático en zonas productoras son algunas de las causas que el Banco Mundial pone como justificación al incremento del precio de la mayoría de cereales y granos básicos. La milagrosa solución al hambre en los países pobres: la minería, es lanzada desde este todopoderoso agente financiero, como panacea para la producción de regalías que permitan a muchos países de África y algunos de América Latina y Asia,  para resolver la problemática alimentaria.  ¡Nada más falso! En los siguientes párrafos se describen las verdaderas razones de la crisis del actual modelo económico mundial, y se proponen desde un país en concreto,  propuestas de política pública para su solución.   Abstract The present article unmasks the way in which multilateral financial institutions pretend fallaciously to show the causes of which they have given to call “the world food crisis” since the increasing prices of food around the world. Agrofuels, increase the price of oil, produces climate chance in zones used for production, these are some of the causes that the World Bank uses to justify the increasing prices of the majority of cereals and grains. The miraculous solution for hunger in poor countries: mining, is launched from this all mighty financial agent, as a panacea to produce royalties that will permit many countries in Africa, and in some in Latin American and Asia, to solve their food problematic. Nothing more false than that! In the next paragraphs the true reasons of this crisis of the actual economic world model are described, and from a particular country, proposals of public politics for their solutions.

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Using highly detailed import data for Thailand, this paper examines firm-level trade creation and diversion of regional trade agreements (RTAs). Specifically, by focusing on firm-product pairs in which firms import a particular product from non-members but not from RTA members in the initial year of our sample, we empirically investigate the start of imports from RTA members under RTA schemes and the cessation of imports from non-members at the firm-level. We find that firms are more likely to stop importing products with low RTA tariff rates or high most-favored-nation tariff rates from non-members and to start importing such products from RTA member countries. However, from the quantitative point of view, there are very few firms that switch import sources from non-members to RTA members when facing the introduction of RTA schemes.

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The European Commission has been negotiating Economic Partnership Agreements (EPAs) with Regional Economic Communities of African, Caribbean and Pacific Group of States since 2002. The outcomes have been mixed. The negotiations with the Caribbean Forum (CARIFORUM) concluded rather more quickly than was initially envisaged, whereas negotiations with West African Economic Community (ECOWAS) and the remaining ACP regions have been dragging on for several years. This research consequently addresses the key question of what accounts for the variations in the EPA negotiation outcomes, making use of a comparative research approach. It evaluates the explanatory power of three research variables in accounting for the variation in the EPA negotiations outcomes – namely, Best Alternative to the Negotiated Agreement (BATNA); negotiation strategies; and the issues linkage approach – which are deduced from negotiation theory. Principally, the study finds that, the outcomes of the EPA negotiations predominantly depended on the presence or otherwise of a “Best Alternative” to the proposed EPA; that is then complemented by the negotiation strategies pursued by the parties, and the joint application of issues linkage mechanism which facilitated a sense of mutual benefit from the agreements.

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This thesis collects three independent essays and a literature review. Two of them relate to vertical agreements. The first essay explores a retailer's choice in allocating control rights over the decision of retail prices. Results show that retailers adopt a hybrid configuration as a middle ground between two extremes, where pricing decisions are delegated, for all products, either to retailer or manufacturers. The second essay investigates the make-it-or-license-it choice of a brand owner under the risk of moral hazard when licensing the extension product to a third party. Brand licensing emerges as an equilibrium choice under brand dilution (respectively, enhancement) when the consumer perceives a large (small) distance between the extension product and parent brand. The third essay explores the issue of rating bubbles within online feedback systems by means of a field experiment. The analysis found the presence of positive social influence bias, in that high ratings affect the individual rating behavior in a significant way. The last paper is accompanied by a thorough and deep review of the literature about the consequences of online user ratings on product sales/performance (economic dimension) and product adoption/rating behavior (behavioral dimension). The topic is increasingly investigated by academic researchers and industry professionals alike. This overview presents established results and insights as issues for future research.