In Vitro Regulation of CCL3 and CXCL12 by Bacterial By-products Is Dependent on Site of Origin of Human Oral Fibroblasts

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Platelet-Rich Plasma, Low-Level Laser Therapy, or Their Combination Promotes Periodontal Regeneration in Fenestration Defects: A Preliminary In Vivo Study

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Stress distribution on dentin-cement-post interface varying root canal and glass fiber post diameters. A three-dimensional finite element analysis based on micro-C data

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

HMGB1 Localization during Experimental Periodontitis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Biomechanical Loading Modulates Proinflammatory and Bone Resorptive Mediators in Bacterial-Stimulated PDL Cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Morphological traits and type of dairy goats registered in Brazil from 1976 to 2009

Data from 2439 goats of the Saanen, Alpine, Anglo Nubian and Toggenburg breeds recorded from 1976 to 2009 by the Association of Goats and Sheep Breeders of Minas Gerais were used in principal component analysis. After consistency of data, six morphological variables (thorax perimeter, body length, withers height, height, width and length of the rump) and 12 variables related to breed standard score and fitness (breed characteristic, head, palette and topline, feet and legs, dairy type, body capacity, udder, rear and front ligament, udder texture, teat and final score) were analyzed. Based on the magnitude of the eigenvalue (lower than 0.7), eleven variables considered redundant were discarded, resulting in reduced costs of technician labor to evaluate the animals. Maintenance of records on height, length, rump width, breed characteristic, dairy type, front ligament and udder texture is recommended.

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo das células primárias dentais, viabilidade celular e bioatividade de materiais á base de silicato de cálcio

Pós-graduação em Odontologia - FOAR

MTA e hidróxido de cálcio como materiais obturadores de canal radicular em reimplante tardio de dente de macaco

O tratamento endodôntico é uma etapa importante do protocolo de atendimento do reimplante dentário e tem uma relação direta com o aparecimento das reabsorções radiculares, maior causa de perda dos dentes reimplantados. O objetivo do trabalho foi analisar o processo de reparo no reimplante tardio de dente de macaco, utilizando o hidróxido de cálcio (Ca(OH)2) e o MTA como materiais obturadores de canal. Cinco macacos Cebus apella adultos tiveram seus incisivos laterais superiores e inferiores, direito e esquerdo, extraídos e deixados em meio ambiente por 60 minutos. Decorrido esse período, foi realizado o preparo biomecânico dos canais e os dentes foram divididos em dois grupos experimentais: grupo I - canal preenchido com pasta de Ca(OH)2 e grupo II - canal preenchido com MTA (Angelus®). Após o selamento da abertura coronária com ionômero de vidro, o ligamento periodontal foi removido e os dentes imersos em solução de fluoreto de sódio 2%, pH 5,5, por 10 minutos. Em seguida, os alvéolos foram irrigados com soro fisiológico e os dentes reimplantados e contidos por 30 dias com fio de aço e resina composta. A eutanásia dos animais foi realizada 60 dias após o reimplante. Os espécimes de ambos os grupos apresentaram reabsorção por substituição e pontos de anquilose ao longo dos três terços radiculares e ausência de reabsorção inflamatória. Não houve diferença significante entre os dois grupos com relação à reabsorção por substituição, porém a quantidade de anquilose foi significativamente maior no grupo do Ca(OH)2. Baseado nesses resultados conclui-se que o MTA pode ser uma opção clínica viável para a obturação de dentes tardiamente reimplantados que necessitam de um longo período de curativo com hidróxido de cálcio.

Association of matrix metalloproteinase inducer (EMMPRIN) with the expression of matrix metalloproteinases-1, -2 and -9 during periapical lesion development

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Leptin Effects on the Regenerative Capacity of Human Periodontal Cells

Obesity is increasing throughout the globe and characterized by excess adipose tissue, which represents a complex endocrine organ. Adipose tissue secrets bioactivemolecules called adipokines, which act at endocrine, paracrine, and autocrine levels. Obesity has recently been shown to be associated with periodontitis, a disease characterized by the irreversible destruction of the tooth-supporting tissues, that is, periodontium, and also with compromised periodontal healing. Although the underlying mechanisms for these associations are not clear yet, increased levels of proinflammatory adipokines, such as leptin, as found in obese individuals, might be a critical pathomechanistic link. The objective of this study was to examine the impact of leptin on the regenerative capacity of human periodontal ligament (PDL) cells and also to study the local leptin production by these cells. Leptin caused a significant downregulation of growth (TGF beta 1, and VEGFA) and transcription (RUNX2) factors as well as matrix molecules (collagen, and periostin) and inhibited SMAD signaling under regenerative conditions. Moreover, the local expression of leptin and its full-length receptor was significantly downregulated by inflammatory, microbial, and biomechanical signals. This study demonstrates that the hormone leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing.

Platelet-Rich Plasma Derived From Bone Marrow Aspirate Promotes New Cementum Formation

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Achados radiográficos e ultrassonográficos em equinos com doença do navicular

The distal sesamoid bone, also known as navicular bone, is located inside the hoof, palmar (thoracic limbs) or plantar (pelvic limbs) to distal interphalangeal joint. Its extremities are fixed by collateral medial and lateral sesamoidean ligament and distal impar sesamoidean ligament. Navicular disease diagnostic is made through a thorough clinical exam, nerve blocks and imaging exams. Even though imaging exams are not conclusive, they are essential to evaluate the extension of soft tissue lesions. Radiographic projections used to evaluate navicular bone are lateromedial (LM); dorsoproximal-palmaro/plantarodistal oblíqua (D30Pr-PaDiO); dorsoproximal-palmaro/plantarodistal oblíqua (D60Pr-PaDiO) e a palmaro/plantaroproximal-palmaro/plantarodistal oblíqua (PaPr-PaDiO). This exam allows to identify number and shape alterations of synovial invaginations on the distal (foramem nutricio) in the distal margin of distal sesamoid, osteophytes, enthesophytes and periarticular lesions. There are four ultrasonographic accesses described in literature to evaluate podotroclear apparatus, they are: palmar or plantar distal do the pastern, through the heel bulbs, through coronary band and transcuneal. These images allow a beeter the evaluation of soft tissue next to the distal sesamoid, because it is more sensitive than radiographic exam to evaluate acute lesions in soft tissues and perioesteum

Doença periodontal em cães

Periodontal disease affects the periodontum which are tissues that support and protect the tooth and are composed by the gingiva, alveolar bone, cementum and periodontal ligament. Lesions in the periodontum have as main etiologic agent the presence of plaque or biofilm, which is formed in 24 hours and, basically, it consists of microorganisms surrounded by some bacteria rich matrix products and salivary glycoproteins. Gingivitis is the first clinical manifestation of periodontal disease and it is reversible if the etiologic agent (plaque) is removed. However, if it is not treated or controlled, it will lead to an irreversible periodontitis, and even evolve into alveolar bone, tissue destruction and, eventually, tooth loss

Utilização da ultrassonografia transcuneal como auxílio no diagnóstico da síndrome do navicular em eqüinos

The equine locomotors system alterations are very frequent and corresponds a large portion of cases in equine medicine. The most equine veterinarian’s challenge is to do a precise diagnosis of lameness cause to perform a specific and proper treatment as early as possible. The navicular syndrome is considered responsible for one third of lameness causes and, although much studied, its etiology is still not fully understood. The most varied methods of diagnosis, such as x-ray, magnetic resonance, bursography, scintigraphy, computed tomography and ultrasound, have been used to assess podotrochlear apparatus situation in order to diagnose this syndrome. Among them transcuneal ultrasound can be used to observe some important structures such as the flexor surface of distal sesamoid bone, distal deep digital flexor tendon, distal sesamoid ligament entheses odd and the distal phalanx. The aim of this present paper is provide a brief review on the use and the technique of ultrasonography on third phalanx transcuneal region evaluation and its interpretation on navicular syndrome diagnosis in horses