Mikrozystisches Makulaödem bei Optikusatrophie: eine Fallserie Microcystic Macular Edema in Optic Nerve Atrophy: A Case Series.

Background:Microcystic macular edema can occur after optic neuropathies of various etiologies, and is easily demonstrated by OCT. We report a cohort of patients with microcystic macular edema. Patients and Methods: All patients with optic neuropathy and microcystic macular edema were enrolled. Demographics, visual function, retinal angiographies and OCT parameters were studied. Results: Nineteen patients (23 eyes) exhibited microcystic macular edema: 10 men/9 women, aged 17-91 years. Etiologies of optic nerve atrophy were compressive (5), inflammatory (4), glaucoma (3), ischemic (3), trauma (2), degenerative (1), and hereditary (1). Median visual acuity was 4/10 (NLP-12/10). Fluorescein angiography showed no leakage. Topography of the microcystic macular edema correlated with near infrared images but with visual field defects in only 26 %. OCT parameters were all abnormal. Conclusions: Microcystic macular edema is a non-specific manifestation from an optic neuropathy of any etiology. The precise mechanism leading to microcystic macular edema remains unknown but trans-synaptic retrograde degeneration with Müller cells dysfunction is likely. Zusammenfassung Hintergrund: Das mikrozystische Makulaödem kann im Rahmen einer Optikusatrophie jeglicher Ätiologie auftreten und ist leicht mit dem OCT zu erkennen. Wir berichten über eine Patientenkohorte mit mikrozystischem Makulaödem. Patienten und Methoden: Alle Patienten mit einer Optikusneuropathie und einem mikrozystischen Makulaödem wurden in diese Studie eingeschlossen. Die Demografie, die Sehfunktion, die Netzhautangiografie und die OCT-Parameter wurden untersucht. Ergebnisse: Neunzehn Patienten (23 Augen) hatten ein mikrozystisches Makulaödem: 10 Männer/9 Frauen im Alter von 17 bis 91 Jahren. Die Ursachen der Optikusatrophie waren Kompressionen (5), Entzündungen (4), Glaukom (3), Ischämien (3), Traumata (2), Degenerationen (1) und genetisch (1). Der mittlere Visus war 0,4 (keine Lichtwahrnehmung 1,2). In der Fluoreszenzangiografie fand sich keine Leckage. Das OCT des mikrozystischen Makulaödems korrelierte immer mit den Infrarot-Bildern (Nahaufnahme), jedoch nur in 26 % mit den Gesichtsfelddefekten. Alle OCT-Parameter waren abnormal. Schlussfolgerungen: Das mikrozystische Makulaödem ist eine unspezifische Manifestation einer Optikusneuropathie jeglicher Ätiologie. Der genaue Mechanismus, der zu einem mikrozystischen Makulaödem führt, ist unbekannt, eine trans-synaptische retrograde Degeneration mit Dysfunktion der Müller-Zellen ist jedoch wahrscheinlich.

Nuevas series anuales de población de América Latina desde el siglo XIX hasta el 2000

El estudio de la población en América Latina es un tema central en la historiografía de la región, sin embargo, las distintas estimaciones existentes muestran importantes discrepancias para los siglos XIX y XX. A partir del contraste de distintas bases de datos, la principal contribución del artículo consiste en ofrecer nuevas series de población homogéneas para el conjunto de países de América Latina, junto a una detallada explicación de la obtención de los datos, así como un análisis de las discrepancias que las distintas fuentes muestran. Los países que aborda este trabajo son Argentina, Brasil, Bolivia, Chile, Colombia, Costa Rica, Cuba, Guatemala, Ecuador, Haití, Honduras, México, Nicaragua, Panamá, Paraguay, Perú, República Dominicana, Uruguay y Venezuela; a lo que se agrega la suma de todos ellos para obtener la población latinoamericana. Estas nuevas series pueden resultar de gran utilidad para reinterpretar la historia económica de América Latina en el largo plazo. The analysis of population levels in Latin America plays an important role in the regional historiography. The estimated series appeared until now offers huge discrepancies, therefore, we believe essential to provide homogeneous series for the 19th and the 20th centuries. In our work we shed new light on this issue, from an exhaustive study of the existing Latin American historical sources for the region. Along with a detailed explanation of the data collection, we also provide an analysis of the discrepancies and the accuracy of sources. The study offers data from 21 countries in Latin America: Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Cuba, Guatemala, Ecuador, Haiti, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Dominican Republic, Uruguay and Venezuela. This new evidence can be a crucial information to revisit Latin American Economic History in the long run.

Integrating Socket Server to the Workstation Environment of Series 40 Platform

Shortening development times of mobile phones are also accelerating the development times of mobile phone software. New features and software components should be partially implemented and tested before the actual hardware is ready. This brings challenges to software development and testing environments, especially on the user interface side. New features should be able to be tested in an environment, which has a look and feel like a real phone. Simulation environments are used to model real mobile phones. This makes possible to execute software in a mobile phone that does not yet exist. The purpose of this thesis is to integrate Socket Server software component to Series 40 simulation environments on Linux and Windows platforms. Socket Server provides TCP/IP connectivity for applications. All other software and hardware components below Socket Server do not exist in simulation environments. The scope of this work is to clarify how that can be done without connectivity problems, including design, implementation and testing phases.

Translations and Translators of English-language Literature in Catalan Literary Publications and Series between 1868 and 1910

Translations into Catalan of English and American authors during the final quarter of the nineteenth century are few and far between. Numerically, English-language literature most likely ranks fifth or sixth among all the translations of this period. We take inventory here of translations found in Catalan magazines from this time (the oldest dates from 1868) and in published series that came out at this time (if these continued until later, we trace them up to their final year). At the same time, the translators are examined, including reference, where available, as to whether the translations are direct or indirect. Finally, we consider some possible causes for the low English-language volume in Catalan translation during the period.

Lapsille suunnatun mainonnan erityispiirteitä ja niiden ilmeneminen tv-mainoksissa

Tämän tutkielman tavoitteena oli perehtyä niihin eri tekijöihin, jotka muokkaavat lapsille suunnattujen mainosten ulkoasua ja sisältöä. Lapsella tässä tutkimuksessa tarkoitetaan alle 12-vuotiasta lasta, tutkimuksen pääpaino oli kuitenkin alle kouluikäisissä, 3-6 -vuotiaissa lapsissa. Tutkimuksen tutkimusmetodologia on kvalitatiivinen haastattelututkimus. Tutkimusta varten haastateltiin 16 alle kouluikäistä lasta, yhdeksää tyttöä ja seitsemää poikaa. Lapsille suunnattujen mainosten sisältöön ja ulkoasuun vaikuttavat muiden muassa. seuraavat tekijät: 1. ulkoinen säätely (lait, asetukset, kuluttaja-asiamiehen ohjeet, EU-direktiivit), 2. sisäinen säätely (mainostajien alan oma eettinen ohjeistus), 3. lapsen ikä ja kehitysaste sekä 4. lapsen mielipiteet. Suunniteltaessa lapsille suunnattua mainontaa, ulkoisen ja sisäisen säätelyn antamien ohjenuorien lisäksi on mainosviestin ymmärtämisen kannalta tärkeää huomioida lapsen kognitiivinen kehitysaste ja sen vaikutus lapsen kykyyn ymmärtää mainoksia. Lapsen mielipiteeseen siitä, millainen on hyvä mainos ja millaisista mainoksista hän ei pidä vaikuttaa iän lisäksi hyvin vahvasti lapsen sukupuoli.

Intraosseous migration of tendinous calcifications: cortical erosions, subcortical migration and extensive intramedullary diffusion, a SIMS series.

Calcium hydroxyapatite crystal deposition is a common disorder, which sometimes causes acute pain as calcifications dissolve and migrate into adjacent soft tissue. Intraosseous calcium penetration has also been described. We illustrate the appearance of these lesions using a series of 35 cases compiled by members of the French Society of Musculoskeletal Imaging (Société d'Imagerie Musculo-Squelettique, SIMS). The first group in our series (7 cases) involved calcification-related cortical erosions of the humeral and femoral diaphyses, in particular at the pectoralis major and gluteus maximus insertions. A second group (28 cases) involved the presence of calcium material in subcortical areas. The most common site was the greater tubercle of the humerus, accompanying a calcifying tendinopathy of the supraspinatus. In addition, an extensive intramedullary diffusion of calcium deposits was observed in four of these cases, associated with cortical erosion in one case and subcortical lesions in three cases. Cortical erosions and intraosseous migration of calcifications associated with calcific tendinitis may be confused with neoplasm or infection. It is important to recognize atypical presentations of hydroxyapatite deposition to avoid unnecessary investigation or surgery.

AA amyloidosis treated with tocilizumab: case series and updated literature review.

BACKGROUND: In published case reports, tocilizumab (TCZ) has shown good efficacy for AA amyloidosis in almost all patients. We investigated the efficacy and safety of TCZ in AA amyloidosis in a multicentre study of unselected cases. METHODS: We e-mailed rheumatology and internal medicine departments in France, Switzerland and North Africa by using the Club Rhumatismes Inflammation (CRI) network and the French TCZ registry, Registry RoAcTEmra (REGATE), to gather data on consecutive patients with histologically proven AA amyloidosis who had received at least one TCZ infusion. Efficacy was defined as a sustained decrease in proteinuria level and/or stable or improved glomerular filtration rate (GFR) and by TCZ maintenance. RESULTS: We collected 12 cases of AA amyloidosis treated with TCZ as monotherapy (mean age of patients 63 ± 16.2 years, amyloidosis duration 20.6 ± 31.3 months): eight patients had rheumatoid arthritis (RA), six with previous failure of anti-tumor necrosis factor α (anti-TNF-α) therapy. In total, 11 patients had renal involvement, with two already on hemodialysis (not included in the renal efficacy assessment). For the nine other patients, baseline GFR and proteinuria level were 53.6 ± 32.8 mL/min and 5 ± 3.3 g/24 h, respectively. The mean follow-up was 13.1 ± 11 months. TCZ was effective for six of the eight RA patients (87.5%) according to European League Against Rheumatism response criteria (four good and two moderate responders). As expected, C-reactive protein (CRP) level decreased with treatment for 11 patients. Renal amyloidosis (n = 9) progressed in three patients and was stabilized in three. Overall, three patients showed improvement, with sustained decrease in proteinuria level (42%, 82% and 96%). Baseline CRP level was higher in subsequent responders to TCZ than other patients (p = 0.02). Among the six RA patients with previous anti-TNF-α therapy, amyloidosis was ameliorated in one and stabilized in three. Three serious adverse events occurred (two diverticulitis and one major calciphylaxia due to renal failure). Finally, 7 of 12 (58%) patients continued TCZ. CONCLUSIONS: The efficacy of TCZ for AA amyloidosis varies depending on the inflammatory status at treatment onset. Discrepancies between our study of unselected consecutive patients and reported cases may be due to publication bias. These results support further prospective trials of TCZ for AA amyloidosis.

Phenotypic and genotypic characteristics of cryopyrin-associated periodic syndrome: a series of 136 patients from the Eurofever Registry.

OBJECTIVE: To evaluate genetic, demographic and clinical features in patients with cryopyrin-associated periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype-phenotype correlations and predictive disease severity markers. METHODS: A web-based registry retrospectively collected data on patients with CAPS. Experts in the disease independently validated all cases. Patients carrying NLRP3 variants and germline-mutation-negative patients were included. RESULTS: 136 patients were analysed. The median age at disease onset was 9 months, and the median duration of follow-up was 15 years. Skin rash, musculoskeletal involvement and fever were the most prevalent features. Neurological involvement (including severe complications) was noted in 40% and 12% of the patients, respectively, with ophthalmological involvement in 71%, and neurosensory hearing loss in 42%. 133 patients carried a heterozygous, germline mutation, and 3 patients were mutation-negative (despite complete NLRP3 gene screening). Thirty-one different NLRP3 mutations were recorded; 7 accounted for 78% of the patients, whereas 24 rare variants were found in 27 cases. The latter were significantly associated with early disease onset, neurological complications (including severe complications) and severe musculoskeletal involvement. The T348M variant was associated with early disease onset, chronic course and hearing loss. Neurological involvement was less strongly associated with V198M, E311 K and A439 V alleles. Early onset was predictive of severe neurological complications and hearing loss. CONCLUSIONS: Patients carrying rare NLRP3 variants are at risk of severe CAPS; onset before the age of 6 months is associated with more severe neurological involvement and hearing loss. These findings may have an impact on treatment decisions.

Primeros datos cromoestratigráficos de las series evaporíticas del triásico superior de Valencia (España)

El Triásico Superior del sector central valenciano de la Cordillera Ibérica presenta una facies germánica (Keuper) integrada por dos secuencias evaporíticas separadas por un episodio detrítico principal. Los datos preliminares obtenidos de una investigación palinológica en curso revelan una edad Karniense para todos estos materiales.

Primeros datos cromoestratigráficos de las series evaporíticas del triásico superior de Valencia (España)

El Triásico Superior del sector central valenciano de la Cordillera Ibérica presenta una facies germánica (Keuper) integrada por dos secuencias evaporíticas separadas por un episodio detrítico principal. Los datos preliminares obtenidos de una investigación palinológica en curso revelan una edad Karniense para todos estos materiales.

Should Koos I Vestibular Schwannomas Be Treated Early with Gamma Knife Surgery? A Prospective Series of 42 Consecutive Cases

Background: Gamma Knife surgery (GKS) for vestibular schwannomas (VS) has a long-term clinical and scientific track record. After a period of de-escalation of dose prescription, results show a high rate of tumor control with improvement of clinical outcome (less than 1% facial palsy, 50-70% hearing preservation). Currently, there is controversial data about the active early treatment of intracanalicular (Koos I) VS. Methods: We prospectively analyzed 208 VS, focusing on 42 Koos I patients treated with GKS as first intention in Lausanne University Hospital, between July 2010 and February 2015. We concentrated on patient, tumor, and dosimetric characteristics. Special attention was given on the dose to the cochlea and its impact in maintaining serviceable hearing. Results: The mean follow-up period was 1.7 years (range 0.6-4.2). Twenty-six (61.9%) were females and 16 (38.1%) males. Preoperative serviceable hearing was present in 33 (78.57%) patients. The mean maximal diameter was 7.7 (5-10). The median target volume at the moment of GKS was 90 mm3 (range 17-317). The median prescription isodose volume was 118 mm3 (range 37-603). The median marginal dose administrated was 12 Gy (range 11-12). The median number of shots was 2 (range 1-9). The median isodose prescription was 50% (range 45-80%). The median maximal dose received by the cochlea in patients in GR class 1 and 2 was 4.2 Gy (mean 4.4 Gy, range 1.8-7.6). Our preliminary results showed 98% tumor control, with 30% shrinkage on MRI. The actuarial probability of keeping the same audition class for those with functional hearing at GKS was 80% at 3 years; the probability of keeping a functional hearing was more than 90%. A paraclinical evolution (on MRI and/or audiometry) at the time diagnosis, before GKS, was associated with a less good prognosis (p < 0.05). Conclusions: Our preliminary data suggest that Koos I patients should be treated early with GKS, before tumor growth, and/or hearing deterioration, as they have the highest probability of hearing preservation. The results in terms of functional outcome seemed comparable to, or even better than, the other Koos classes (i.e., larger lesions).

Series Addicts : Desarrollo de aplicaciones móviles en HTML5

Series Addicts está basada en la necesidad de una aplicación rápida y ligera con la que tener el control de todas las series que seguimos, para poder acceder a las funcionalidades mientras estamos disfrutando de nuestra serie favorita.

Jatkuu ensi viikolla : television draamasarjan tuotantotavat ja tuottajuus

Opinnäytetyö on monimuototyö, joka koostuu kirjallisesta osasta sekä teososasta. Kirjallisessa osassa tutkin television draamasarjan tuotantoa ja tuotantoketjuja Suomessa ja Yhdysvalloissa. Käsiteltävänä on myös tuottajuus Suomessa ja se, miten tuotantotavat ovat muuttuneet viimeisen kymmenen vuoden aikana. Kirjallinen osa taustoittaa aluksi television katsomista Suomessa sekä käy läpi sarjamuotoisen televisiokerronnan synnyn Amerikassa sekä sen tulemisen Suomeen. Kolmannessa luvussa selvitetään amerikkalaista monimutkaista tv-tuotantokulttuuria käymällä läpi tv-sarjan tuotantoketju ideasta televisioensi-iltaan ja selventämällä käsikirjoittajien ja tuottajien työnkuvia sikäläisessä tuotantotiimissä. Neljännessä luvussa käsitellään kotimaisia tuotantokäytäntöjä ja -ketjuja sekä käydään läpi tuottajan roolia ja tehtäviä sekä niissä tapahtuneita kehityksiä ja alan muutoksia. Luvussa viisi pohditaan draamasarjaa sisällöllisesti sekä laadulliselta tasolta että kerronnalliselta kannalta. Kuudennessa luvussa pohditaan voisiko suomalainen ja amerikkalainen tuotantotyyli ottaa jotenkin oppia toisistaan, ja mitkä ovat eri tuotantomallien edut ja haitat. Lopussa tiivistetään opinnäytetyön tärkeimmät havainnot ja pohditaan vielä, mitkä ovat tekijän mahdollisuudet päästä eteenpäin oman sarjaidean kanssa. Lähdemateriaalina on käytetty amerikkalaista tuotantoon ja käsikirjoittamiseen liittyvää kirjallisuutta sekä suomalaista käsikirjoitus- ja mediakulttuurikirjallisuutta. Merkittävinä kotimaisina lähteinä toimivat alan ammattilaisten haastattelut. Työn myötä lukijalle selviää, kuinka suomalainen ja amerikkalainen televisiosarja syntyy. AV-alan työntekijöille ja opiskelijoille kiinnostavana tietona on alalla tapahtuneiden muutosten kartoittaminen sekä erityisesti tuotanto-opiskelijoille tuottajan roolin vahvistuminen. Opinnäytetyön teososa on myyntikansio tekijän omalle kuusiosaiselle tv-draamasarjaidealle.