Phentolamine bioequivalence study

Objective: To assess the bioequivalence of 2 tablet formulations of phentolamine (Regitine phentolamine 40 mg tablet formulation by Novartis, Brazil, as test formulation, and Vasomax, phentolamine 40 mg tablet formulation by Schering Plough S.A., Brazil, as reference formulation). Methods: A single 40 mg oral dose of each formulation was administered to 36 male healthy volunteers. The study was conducted after screening, using an open, randomized, 2-period crossover design, a 7-day interval between doses, and wash-out period of at least 4 weeks. Plasma samples for determination of phentolarnine were obtained predose and at intervals over 720 min postdose. Plasma concentrations were quantified by reversed-phase liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) with positive ion electrospray ionization using multiple reactions monitoring (MRM) method. Precision of the method was evaluated using calibration curves and plasma quality control samples. The subjects were monitored throughout the study. Systolic and diastolic blood pressure and pulse rate measurement were taken predose and at intervals up to 720 min. Tolerance of both products was good. No serious adverse reactions were reported. The pharmacokinetic parameters calculated for both compounds included: AUC((0-720 min)), AUC((0-infinity)), C-max,C- C-max/AUC((0-720 min),) t(max), t(1/2) and k(c). Results: the maximum concentrations reached (Cmax) were compared. Regitine 40 mg formulation C-max geometric mean ratio was 108.29% (90% Cl = 98.58 - 118.96) of Vasomax 40 mg formulation. The areas under the curve (AUC((0-720 min))) were compared. Regitine 40 formulation (AUC((0-720 min)) geometric mean ratio was 102.33% (90% Cl = 97.21 - 107.72) of Vasomax 40 mg formulation. Conclusion: Since the 90% Cl for both Cmax and AUC ratio where inside the 80 to 125% interval proposed by the Food and Drug Administration, it is concluded that Regitine 40 mg tablet is bioequivalent to Vasomax for the rate and extent of absorption.

GROUND-STATE-ENERGY OF SINGULAR POTENTIALS

It is shown that for singular potentials of the form lambda/r(alpha),the asymptotic form of the wave function both at r --> infinity and r --> 0 plays an important role. Using a wave function having the correct asymptotic behavior for the potential lambda/r(4), it is, shown that it gives the exact ground-state energy for this potential when lambda --> 0, as given earlier by Harrell [Ann. Phys. (NY) 105, 379 (1977)]. For other values of the coupling parameter X, a trial basis;set of wave functions which also satisfy the correct boundary conditions at r --> infinity and r --> 0 are used to find the ground-state energy of the singular potential lambda/r(4) It is shown that the obtained eigenvalues are in excellent agreement with their exact ones for a very large range of lambda values.

HEAT-KERNEL EXPANSION AT FINITE TEMPERATURE

We show how the zero-temperature result for the heat-kernel asymptotic expansion can be generalized to the finite-temperature one. We observe that this general result depends on the interesting ratio square-root tau/beta, where tau is the regularization parameter and beta = 1/T, so that the zero-temperature limit beta --> infinity corresponds to the cutoff limit tau --> 0. As an example, we discuss some aspects of the axial model at finite temperature.

THE EFFECT OF POSITRONIUM FORMATION IN E(+)-LI AND E(+)-NA SCATTERING

We studied e+-Li and e+-Na scattering using the close-coupling approximation in the static and coupled static expansion schemes. The effect of the positronium formation on the elastic channel is found to be strong in both cases. In the case of the lithium atom the effect is dramatic; the inclusion of the positronium formation channel transforms the purely repulsive effective e+-Li S wave (static) potential to a predominantly attractive (coupled static) potential. In this case, in the static model delta(0)-delta(infinity) = 0, whereas in the coupled static model delta(0)-delta(infinity)=pi. According to Levinson's theorem this suggests the presence of a S wave bound or continuum bound state in the e+-Li system.

On the existence of infinite heteroclinic cycles in polynomial systems and its dynamic consequences

In this work we consider the dynamic consequences of the existence of infinite heteroclinic cycle in planar polynomial vector fields, which is a trajectory connecting two saddle points at infinity. It is stated that, although the saddles which form the cycle belong to infinity, for certain types of nonautonomous perturbations the perturbed system may present a complex dynamic behavior of the solutions in a finite part of the phase plane, due to the existence of tangencies and transversal intersections of their stable and unstable manifolds. This phenomenon might be called the chaos arising from infinity. The global study at infinity is made via the Poincare Compactification and the argument used to prove the statement is the Birkhoff-Smale Theorem. (c) 2004 WILEY-NCH Verlag GmbH & Co. KGaA, Weinheim.

On a moment problem associated with Chebyshev polynomials

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Biologia populacional de Pareiorhina rudolphi (Loricariidae, Hypostominae) na microbacia do Ribeirão Grande, serra da Mantiqueira oriental, Estado de São Paulo

Pareiorhina rudolphi was sampled in streams of the Ribeirao Grande system, eastern Serra da Mantiqueira (22[degree]47[minute]08[second]S, 45[degree]28[minute]17[second] W). Samplings were carried out using an electrofishing device, during the months of July/2001, October/2001, February/2002 and April/2002. Sex-ratio diverged significantly from the expected 1: 1 ratio([chi]2 = 6.53; p < 0.05), standing at 1.6:1 (female: male). The spawning period for Pareiorhina rudolphi lasts from spring to summer, with, the highest observed, in October and February by the gonadosomantic index and the relative condition factor coincided with the spawning period. The length at sexual maturity of P. rudolphi is about 4.45 cm for both sexes. The absolute fecundity was low, and ranged from 4 to 11 oocytes. The periphyton was used as a direct food source by the species, which remain attached to the substrate with their large circular lips, and use their conspicuous Slightly Yellowish teeth to graze the periphyton. The growth parameters, natural mortality rate and survival rate for P, rudolphi were respectively: K = 0.35 year-1, L[infinity] = 7.2 cm, tmax = 8.6 years, M = 1.1 year-1, S = 33%. The characteristics presented by P. rudolphi occur in the environment function of a population adjustment, and not of species abundance.

Two-body Dirac equation approach to the deuteron

The two-body Dirac(Breit) equation with potentials associated to one-boson-exchanges with cutoff masses is solved for the deuteron and its observables calculated. The 16-component wave-function for the Jπ = 1+ state contains four independent radial functions which satisfy a system of four coupled differential equations of first order. This system is numerically integrated, from infinity towards the origin, by fixing the value of the deuteron binding energy and imposing appropriate boundary conditions at infinity. For the exchange potential of the pion, a mixture of direct plus derivative couplings to the nucleon is considered. We varied the pion-nucleon coupling constant, and the best results of our calculations agree with the lower values recently determined for this constant.

Improved numerical approach for the time-independent Gross-Pitaevskii nonlinear Schrödinger equation

In the present work, we improve a numerical method, developed to solve the Gross-Pitaevkii nonlinear Schrödinger equation. A particular scaling is used in the equation, which permits us to evaluate the wave-function normalization after the numerical solution. We have a two-point boundary value problem, where the second point is taken at infinity. The differential equation is solved using the shooting method and Runge-Kutta integration method, requiring that the asymptotic constants, for the function and its derivative, be equal for large distances. In order to obtain fast convergence, the secant method is used. © 1999 The American Physical Society.

Scaling limit of virtual states of triatomic systems

Natural scales determine the physics of quantum few-body systems with short-range interactions. Thus, the scaling limit is found when the ratio between the scattering length and the interaction range tends to infinity, while the ratio between the physical scales are kept fixed. From the formal point of view, the relation of the scaling limit and the renormalization aspects of a few-body model with a zero-range interaction, through the derivation of subtracted three-body T-matrix equations that are renormalization-group invariant.

Necessary conditions of optimality for state constrained infinite horizon differential inclusions

This article presents and discusses necessary conditions of optimality for infinite horizon dynamic optimization problems with inequality state constraints and set inclusion constraints at both endpoints of the trajectory. The cost functional depends on the state variable at the final time, and the dynamics are given by a differential inclusion. Moreover, the optimization is carried out over asymptotically convergent state trajectories. The novelty of the proposed optimality conditions for this class of problems is that the boundary condition of the adjoint variable is given as a weak directional inclusion at infinity. This improves on the currently available necessary conditions of optimality for infinite horizon problems. © 2011 IEEE.

Spin and pseudospin symmetries of the Dirac equation with confining central potentials

We derive the node structure of the radial functions which are solutions of the Dirac equation with scalar S and vector V confining central potentials, in the conditions of exact spin or pseudospin symmetry, i.e., when one has V=±S+C, where C is a constant. We show that the node structure for exact spin symmetry is the same as the one for central potentials which go to zero at infinity but for exact pseudospin symmetry the structure is reversed. We obtain the important result that it is possible to have positive energy bound solutions in exact pseudospin symmetry conditions for confining potentials of any shape, including naturally those used in hadron physics, from nuclear to quark models. Since this does not occur for potentials going to zero at large distances, which are used in nuclear relativistic mean-field potentials or in the atomic nucleus, this shows the decisive importance of the asymptotic behavior of the scalar and vector central potentials on the onset of pseudospin symmetry and on the node structure of the radial functions. Finally, we show that these results are still valid for negative energy bound solutions for antifermions. © 2013 American Physical Society.

Peixoto's Theorem for vector fields on S2 with impasse points

The structural stability of vector fields with impasse regular curves on S2 is studied and a version of Peixoto's Theorem is established. Moreover a global analysis of normal forms of the constrained systems. A(x).ẋ=F(x),x∈R3,A∈M(3),F:R3→R3 in the Poincaré ball (i.e. in the compactification of R3 with the sphere S2 of the infinity) is made. © 2013 Elsevier Masson SAS.

Síntese e caracterização de intermetálicos ordenados binários de ouro: potenciais eletrocatalisadores de reações em células à combustível

Pós-graduação em Ciência e Tecnologia de Materiais - FC

A influência dos sistemas de gerenciamento de cores em provas digitais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)