983 resultados para Barbour, frank
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Thesis (Master's)--University of Washington, 2016-06
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We expressed the full-length CD44v2-10 isoform in SKHep1 cells, a nonmetastatic human hepatocellular carcinoma cell line that does not express any endogenous CD44v isoforms. In SCID mice, expression of CD44v2-10 by SKHep1 cells had no effect on s.c. primary tumor development but caused pulmonary metastases in 41% (7 of 17) of animals compared with control SKHep1 cells (0 of 16; P < 0.01). CD44v2-10 expression by SKHep1 cells resulted in enhanced heparan sulfate (HS) attachment and an enhanced capacity to bind heparin-binding growth factors. Mutation of the v3 domain to prevent HS attachment and growth factor binding abolished the metastatic phenotype, demonstrating that HS modification of CD44v2-10 plays a critical role in the development of metastases in this model. However, in vitro proliferation, motility, and invasion were not altered by CD44v2-10 expression.
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Book review: Frank Hendriks, Oxford University Press, 2010, 256 pp., £47 ($85.00) (hb), ISBN-13: 9780199572786
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Book review: Boons, F. (2009) Creating ecological value. Cheltenham, Edward Elgar
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This qualitative study used critical discourse analysis to highlight how educational stakeholders can examine discourses and react to power in texts using a feminist lens to problematize identity.
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Fil: Zamuner, Amanda. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.
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Fil: Zamuner, Amanda. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.
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Fil: Zamuner, Amanda. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.