The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro.

Herpes simplex virus thymidine kinase (HSV-tk)/ganciclovir (GCV) viral-directed enzyme prodrug gene therapy causes potent, tumor-selective cytotoxicity in animal models in which HSV-tk gene transduction is limited to a minority of tumor cells. The passage of toxic molecules from HSV-tk+ cells to neighboring HSV-tk- cells during GCV therapy is one mechanism that may account for this "bystander" cytotoxicity. To investigate whether gap junction-mediated intercellular coupling could mediate this bystander effect, we used a flow cytometry assay to quantitate the extent of heterocellular coupling between HSV-tk+ murine fibroblasts and both rodent and human tumor cell lines. Bystander tumor cytotoxicity during GCV treatment in a coculture assay was highly correlated (P < 0.001) with the extent of gap junction-mediated coupling. These findings show that gap junction-mediated intercellular coupling contributes to the in vitro bystander effect during HSV-tk/GCV therapy and that retroviral transduction of tumor cells is not required for bystander cytotoxicity.

Desenvolvimento de um controlador preditivo estocástico para processos da indústria química.

O sucesso de estratégias de controle preditivo baseado em modelo (MPC, na sigla em inglês) tanto em ambiente industrial quanto acadêmico tem sido marcante. No entanto, ainda há diversas questões em aberto na área, especialmente quando a hipótese simplificadora de modelo perfeito é abandonada. A consideração explícita de incertezas levou a importantes progressos na área de controle robusto, mas esta ainda apresenta alguns problemas: a alta demanda computacional e o excesso de conservadorismo são questões que podem ter prejudicado a aplicação de estratégias de controle robusto na prática. A abordagem de controle preditivo estocástico (SMPC, na sigla em inglês) busca a redução do conservadorismo através da incorporação de informação estatística dos ruídos. Como processos na indústria química sempre estão sujeito a distúrbios, seja devido a diferenças entre planta e modelo ou a distúrbios não medidos, está técnica surge como uma interessante alternativa para o futuro. O principal objetivo desta tese é o desenvolvimento de algoritmos de SMPC que levem em conta algumas das especificidades de tais processos, as quais não foram adequadamente tratadas na literatura até o presente. A contribuição mais importante é a inclusão de ação integral no controlador através de uma descrição do modelo em termos de velocidade. Além disso, restrições obrigatórias (hard) nas entradas associadas a limites físicos ou de segurança e restrições probabilísticas nos estados normalmente advindas de especificações de produtos também são consideradas na formulação. Duas abordagens foram seguidas neste trabalho, a primeira é mais direta enquanto a segunda fornece garantias de estabilidade em malha fechada, contudo aumenta o conservadorismo. Outro ponto interessante desenvolvido nesta tese é o controle por zonas de sistemas sujeitos a distúrbios. Essa forma de controle é comum na indústria devido à falta de graus de liberdade, sendo a abordagem proposta a primeira contribuição da literatura a unir controle por zonas e SMPC. Diversas simulações de todos os controladores propostos e comparações com modelos da literatura são exibidas para demonstrar o potencial de aplicação das técnicas desenvolvidas.

Perceived emotional intelligence, general intelligence and early professional success: predictive and incremental validity

Although the study of factors affecting career success has shown connections between biographical and other aspects related to ability, knowledge and personality, few studies have examined the relationship be-tween emotional intelligence and professional success at the initial career stage. When these studies were carried out, the results showed significant relationships between the dimensions of emotional intelligence (emotional self-awareness, self-regulation, social awareness or social skills) and the level of professional competence. In this paper, we analyze the relationship between perceived emotional intelligence, measured by the Trait Meta-Mood Scale (TMMS-24) questionnaire, general intelligence assessed by the Cattell factor "g" test, scale 3, and extrinsic indicators of career success, in a sample of 130 graduates at the beginning of their careers. Results from hierarchical regression analysis indicate that emotional intelligence makes a specific contribution to the prediction of salary, after controlling the general intelligence effect. The perceived emotional intelligence dimensions of TMMS repair, TMMS attention and sex show a higher correlation and make a greater contribution to professional success than general intelligence. The implications of these results for the development of socio-emotional skills among University graduates are discussed.

Predictive Models of Alcohol Use Based on Attitudes and Individual Values

Two predictive models are developed in this article: the first is designed to predict people's attitudes to alcoholic drinks, while the second sets out to predict the use of alcohol in relation to selected individual values. University students (N = 1,500) were recruited through stratified sampling based on sex and academic discipline. The questionnaire used obtained information on participants' alcohol use, attitudes and personal values. The results show that the attitudes model correctly classifies 76.3% of cases. Likewise, the model for level of alcohol use correctly classifies 82% of cases. According to our results, we can conclude that there are a series of individual values that influence drinking and attitudes to alcohol use, which therefore provides us with a potentially powerful instrument for developing preventive intervention programs.

Implementation guidelines for actuated controllers in coordinated systems. Final report.

Texas Department of Transportation, Austin

Coordination of actuated controllers on traffic control systems.

Texas Department of Transportation, Austin

Automatic controllers for hydraulically powered deicing chemical spreaders. Final report.

Mode of access: Internet.

Multiple controllers in a CAMAC crate /

Issued March 1978.

ARL, predictive technology /

Mode of access: Internet.

Air traffic controllers and flight service station specialists [microform] : hearings before the Subcommittee on the Civil Service of the Committee on Post Office and Civil Service, House of Representatives, Ninety-sixth Congress, first session ....

Reuse of record except for individual research requires license from Congressional Information Service, Inc.

Siting the Superconducting Super Collider in Illinois : an overview and predictive model of cultural and paleobiological resources in the SSC study area, northern Illinois /

Cover title.

Controllership: its functions and technique; prepared for the Controllers' Institute of America

Mode of access: Internet.

Financial management of the marketing function; a research study and report prepared for the Financial Executives Research Foundation (formerly, Controllers Institute Research Foundation)

Includes bibliography.

DS, GS, and depot maintenance manual : controllers, flight, automatic pilot C-3107/ASW-12(V) and C-3107A/ASW-12(V), and panel, directional control SB-1453/ASW-12(V).

Includes index.

United States Court of Appeals for the District of Columbia Circuit, no. 81-2135, Professional Air Traffic Controllers Organization, petitioner v. Federal Labor Relations Authority, respondent, Federal Aviation Administration, intervenor : petition for review of an order of the Federal Labor Relations Authority, argued December 3, 1981, decided June 11, 1982.

Cover title.