[Addresses before the Law Association of Philadelphia]

Includes bibliographical references

Philadelphia reports /

Vols. 11-20 compiled by Henry C. Brown.

Grounds and buildings of the Centennial Exhibition, Philadelphia, 1876 /

Binding: brown goatskin, tooled in blind and with seal of the United States Centennial Commission in gilt centered on each board. Edges of boards and turn-ins tooled in gilt. Page edges gilt.

Annual report of the superintendent of public schools of the city of Philadelphia.

Latest issue consulted: 1936/1937.

Annual report of the School Controller of the School District of Philadelphia.

Latest issue consulted: 9th (1920).

Transactions of the College of Physicians of Philadelphia.

Supplements accompany some issues.

History of Philadelphia, 1609-1884 /

Mode of access: Internet.

Secret proceedings and debates of the convention assembled at Philadelphia, in the year 1787,

Mode of access: Internet.

General guide to the collections of the Pennsylvania museum and school of industrial art in Memorial hall, Fairmount park, Philadelphia, Pa.

Preface signed: E. A. B. [i.e. Edwin Atlee Barber]

Comparative vocabulary of Algonquin dialects. From Heckewelder's manuscripts in the collections of the American philosophical society, Philadelphia.

"The manuscript of this work is in the library of the American philosophical society. It is a copy made by Mr. Duponceau, and forms no. xxvii of a collection made by him and recorded in a folio account book, of which it occupies pp. 114-119."--Pilling, Bibl. of the Algonquin languages, p. 227.

An oration, delivered before the American Philosophical Society, held in Philadelphia on the 27th of February, 1786; containing an enquiry into the influence of physical causes upon the moral faculty ...

Microfilmed for preservation

Unraveling the molecular underpinnings of Philadelphia-negative myeloproliferative neoplasms: implications for future therapeutic strategies

The present thesis encompasses the two researches projects I conducted during my PhD program in Molecular Biology and Pathology. The common thread is represented by the analysis of the signaling pathways implicated in the pathophysiology of the two most aggressive Philadelphia-negative myeloproliferative neoplasms, namely, atypical chronic myeloid leukemia (aCML) and primary myelofibrosis (PMF). In the last decade, since the description of the JAK2V617F mutation in 2005, the field of the molecular characterization of Philadelphia-negative myeloproliferative neoplasms has experienced an astonishing implementation that led to the discovery of 16 new mutations involving signal transduction, epigenetic modifiers, cell cycle regulators. Nevertheless, their pathogenetic relevance and whether they could represent good ���druggable��� candidates have to be proved yet. In the first section I provide the first report of the signaling cascade down-stream the rare cytogenetic lesion t(8;9)(p22;p24)/PCM1-JAK2 associated with aCML, finding that it selectively activates the ERK1/2 signaling without affecting JAK/STAT phosphorylation. In the second part, I investigated the implication of the �� isoform of novel Protein kinase Cs (PKCs) in the pathophysiology of the aberrant megakaryocytopoiesis in PMF, concluding that the over-expression of PKC�� detains a crucial relevance in the aberrant behavior of PMF megakaryocytes and its inhibition is capable to restore their normal differentiation and abrogate the anti-apoptotic signaling. Both results are discussed in the view of their therapeutic implications. In case PCM1/JAK2-related hematologic neoplasms, ERK-inhibitors rather than JAK-inhibitors (i.e. ruxolitinib) should be considered as a ���tailored��� drugs. In case of PMF, PKC��-inhibitors (i.e. ��V1-2 peptide) configure as an appealing strategy to re-direct the megakaryocytic neoplastic clone.

Camerawoman at NOW conference, Philadelphia

General note: Title and date provided by Bettye Lane.