CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome?

Background: CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, are often located in the 5' end of genes and considered gene markers. Hackenberg et al. ( 2006) recently developed a new algorithm, CpGcluster, which uses a completely diffe

Diversity and evolution of MicroRNA gene clusters

microRNA (miRNA) gene clusters are a group of miRNA genes clustered within a proximal distance on a chromosome. Although a large number of miRNA clusters have been uncovered in animal and plant genomes, the functional consequences of this arrangement are

Developing a framework for mapping industrial emergence

The industrial landscape is becoming increasingly complex and dynamic, with innovative technologies stimulating the emergence of new industries and business models. This paper presents a preliminary framework for mapping industrial emergence, based on roadmapping principles, in order to understand the nature and characteristics of such phenomena. The focus at this stage is on historical examples of industrial emergence, with the preliminary framework based on observations from 20 'quick scan' maps, one of which is used to illustrate the framework. The learning from these historical cases, combined with further industrial consultation and literature review, will be used to develop practical methods for strategy and policy application. The paper concludes by summarising key learning points and further work needed to achieve these outcomes. © 2009 PICMET.

Roadmapping in industrial companies: Experiences

From its origins in the US electronics sector in the 1970s, technology roadmapping has been adapted (and adopted) widely, for many different innovation, strategy and policy applications. Communication is commonly cited as one of the key benefi ts of roadmapping, particularly in terms of the process that brings different organizational perspectives together, with the roadmap providing a common visual 'language'. There is signifi cant demand for methods that are agile, in the sense of being rapid, flexible and effective to apply, focused on strategic decisions and actions. 'Fast-start' roadmapping workshop techniques enable key stakeholders to address strategic issues efficiently using the visual structure of roadmaps to capture, discuss, prioritize, explore and communicate. This paper presents the learning from a set of five diverse applications of the fast-start approach in the Basque Country, which demonstrate the agility of the technique.

The dynamics of industrial emergence

The need to stimulate, identify and nurture new industries is a prominent challenge in advanced economies. While basic science represents a valuable source of new ideas and opportunities, it can often take decades before this science finally finds application in the market. While numerous studies have to date focused on aspects of industrial evolution, (e.g. innovation, internationalisation, new product introduction, technological lifecycles and emerging technologies), far fewer have focused on technology-based industrial emergence. It is clear that if assistance is to be provided to firms and industrial policymakers attempting to navigate industrial emergence then we need an improved understanding of the characteristics and dynamics of this phenomenon. Accordingly, this paper reviews published work from a range of disparate disciplines - evolutionary theory, social construction of technology (SCOT), complexity science, industrial dynamics and technology management - to identify these dynamics. Through this review we conceptualise industrial emergence as a co-evolutionary process in which nonlinear dynamics operate. Industrial emergence is sensitive to the initial availability of resources and the market applications, with growth dependent on the supply-demand coupling, agents' actions to reduce uncertainty and catalytic events. Through synthesizing these key dynamics we go on to propose a conceptual model for industrial emergence. © 2010 IEEE.

Application of scalar dissipation rate modelling to industrial burners in partially premixed regimes

The objective of this paper is to test various available turbulent burning velocity models on an experimental version of Siemens small scale combustor using the commercial CFD code. Failure of burning velocity model with different expressions for turbulent burning velocity is observed with an unphysical flame flashback into the swirler. Eddy Dissipation Model/Finite Rate Chemistry is found to over-predict mean temperature and species concentrations. Solving for reaction progress equation with its variance using scalar dissipation rate modelling produced reasonably good agreement with the available experimental data. Two different turbulence models Shear Stress Transport (SST) and Scale Adaptive Simulation (SAS) SST are tested and results from transient SST simulations are observed to be predicting well. SAS-SST is found to under-predict with temperature and species distribution.

Implications of the industrial fish processing growth for the commercial fishery and fishers in Uganda

The study was undertaken to generate socio-economic information on fish market systems and performance of the industrial processing industry, which will guide the processes leading to modernization of the fisheries sector and, sustainability of Lake Victoria fisheries. The main objective of this study was to evaluate the socio-economic implications of the fish marketing systems with particular emphasis on fish export market in Uganda. The study thus, analysed the socio-economic characteristics of fishers and examinined fish marketing systems and the impacts on the fishing activities, food security, employment opportunities and incomes of fisher-folk communities.