CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome?

Background: CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, are often located in the 5' end of genes and considered gene markers. Hackenberg et al. ( 2006) recently developed a new algorithm, CpGcluster, which uses a completely diffe

This work was supported by a NIH grant ( LM009598) from the National Library of Medicine, the Thomas F. and Kate Miller Jeffress Memorial Trust Fund, and Institutional Research Grant IRG-73-001-31 from the American Cancer Society.