Improved endothelial function with simvastatin but unchanged insulin sensitivity with simvastatin or ezetimibe

In addition to their expected effects on lipid profile, lipid-lowering agents may reduce cardiovascular events because of effects on nonclassic risk factors such as insulin resistance and inflammation. Ezetimibe specifically blocks the absorption of dietary and biliary cholesterol as well as plant sterols. Although it is known that an additional reduction of low-density lipoprotein cholesterol (LDL-C) levels can be induced by the combination of ezetimibe with statins, it is not known if this can enhance some pleiotropic effects, which may be useful in slowing the atherosclerotic process. This study assessed the effects of simvastatin and ezetimibe, in monotherapy or in combination, on markers of endothelial function and insulin sensitivity. Fifty prediabetic subjects with normo- or mild-to-moderate hypercholesterolemia were randomly allocated to 2 groups receiving either ezetimibe (10 mg/d) or simvastatin (20 mg/d) for 12 weeks, after which the drugs were combined for both groups for an additional 12-week period. Clinical and laboratory parameters were measured at baseline and after 12 and 24 weeks of therapy. Homeostasis model assessment of insulin resistance index and the area under the curve of insulin were calculated. As expected, both groups receiving drugs in isolation significantly reduced total cholesterol, LDL-C, apolipoprotein B, and triglyceride levels; and additional reductions were found after the combination period (P <.05). After 12 weeks of monotherapy, plasminogen activator inhibitor-1 levels and urinary albumin excretion were lower in the simvastatin than in the ezetimibe group. No change in homeostasis model assessment of insulin resistance index, area under the curve of insulin, and adiponectin levels was observed tiller either the monotherapies or the combined therapy. However, simvastatin combined with ezetimibe provoked significant reductions in E-selectin and intravascular cellular adhesion molecule-1 levels that were independent of LDL-C changes. Our findings support claims that simvastatin may be beneficial in preserving endothelial function in prediabetic subjects with normo- or mild-to-moderate hypercholesterolemia. Alternatively, a deleterious effect of ezetimibe on the endothelial function is suggested, considering the increase in intravascular cellular adhesion molecule I and E-selectin levels. Simvastatin and ezetimibe, in isolation or in combination, do not interfere with insulin sensitivity. (C) 2010 Elsevier Inc. All rights reserved.

High sodium intake enhances insulin-stimulated glucose uptake in rat epididymal adipose tissue

Objective: This study investigated the effect of different sodium content diets on rat adipose tissue carbohydrate metabolism and insulin sensitivity. Methods and Procedures: Male Wistar rats were fed on normal- (0.5% Na+; NS), high- (3.12% Na+; HS), or low-sodium (0.06% Na+; LS) diets for 3, 6, and 9 weeks after weaning. Blood pressure (BP) was measured using a computerized tail-cuff system. An intravenous insulin tolerance test (ivITT) was performed in fasted animals. At the end of each period, rats were killed and blood samples were collected for glucose and insulin determinations. The white adipose tissue (WAT) from abdominal and inguinal subcutaneous (SC) and periepididymal (PE) depots were weighed and processed for adipocyte isolation and measurement of in vitro rates of insulin-stimulated 2-deoxy-d-[H-3]-glucose uptake (2DGU) and conversion of -[U-C-14]-glucose into (CO2)-C-14. Results: After 6 weeks, HS diet significantly increased the BP, SC and PE WAT masses, PE adipocyte size, and plasma insulin concentration. The sodium dietary content did not influence the whole-body insulin sensitivity. A higher half-maximal effective insulin concentration (EC50) from the dose - response curve of 2DGU and an increase in the insulin-stimulated glucose oxidation rate were observed in the isolated PE adipocytes from HS rats. Discussion: The chronic salt overload enhanced the adipocyte insulin sensitivity for glucose uptake and the insulin-induced glucose metabolization, contributing to promote adipocyte hypertrophy and increase the mass of several adipose depots, particularly the PE fat pad.

THE SOUTHERN BRAZILIAN SHELF: GENERAL CHARACTERISTICS, QUATERNARY EVOLUTION AND SEDIMENT DISTRIBUTION

Extending from latitude 34 degrees S to 22 degrees S the Southern Brazilian shelf constitutes the only part of the Brazilian shelf with a subtropical to temperate environment. The studies on the different geological aspects of the area began in the 1960`s and have recently been reassessed after studies related to the determination of the Economic Exclusive Zone. In terms of morphology, the Southern Brazilian shelf may be divided into three sectors, the Sao Paulo Bight, the Florianopolis-Mostardas Sector and the Rio Grande Cone, characterized by conspicuous differences in terms of geological determining factors, bathymetry, declivities and the presence of canyons and channels. Despite the existence of hundreds of radiocarbon datings the sea level changes curve of southern Brazil during the Last Glacial Cycle is still a matter of debate. A recent controversy on the Middle and late Holocene sea level changes curve raised the question of the amplitude of the oscillations which occurred in the period. Also, a few but relatively consistent radiocarbon datings suggest the occurrence of a high sea level during Isotope Stage 3. In terms of sedimentary cover the Southern Brazilian shelf exhibits a very strong hydrodynamic control, both latitudinal and bathymetrical. The sector southward from 25 degrees S is characterized by the influence of the plume of water carrying sediments originating from the Rio de La Plata. Actually its presence is conspicuous up to 28 degrees S, with the area between this latitude and 25 degrees S constituting a transitional zone. In terms of bathymetry the outer shelf is marked by the ""floor-polisher"" effect of the Brazil Current, which is responsible for the maintenance of a relict facies in areas deeper than 100 meters.

Introdução ao forjamento isotérmico

Pretende este trabalho dar início ao estudo do processo de forjamento isotérmico de uma peça de uma liga de alumínio (Al Mg Sil) através de alguns parâmetros como curva de escoamento, influência de lubrificantes e modelos de cálculo de força. Para a análise da curva de escoamento da liga Al Mg Sil foram realizados testes alterando-se tanto a temperatura de ensaio como a velocidade de prensagem. Os resultados obtidos foram comparados com os resultados de duas referências bibliográficas. Em relação ao forjamento apresenta-se a ferramenta utilizada nos testes e descreve-se sobre as influências de alguns lubrificantes testados. Finalizando, mostra-se os resultados obtidos experimentalmente e os resultados obtidos através da aplicação de três modelos teóricos extraídos da literatura. Conclusões e sugestões para futuros trabalhos são também apresentados.

Terraços da margem leste da Laguna dos Patos, Litoral Médio do Rio Grande do Sul: estratigrafia e evolução holocênica

O presente trabalho discute os terraços lagunares da margem leste da Laguna dos Patos, localizados próximo à cidade de Mostardas. Através desse estudo é apresentado um novo modelo evolutivo para os últimos 5.000 anos no Litoral Médio do Rio Grande do Sul. Novas ferramentas foram utilizadas pela primeira vez no estudo da planície costeira do Rio Grande do Sul. Com respeito a aquisição dos dados de subsuperfície foi utilizado com êxito um GPR (Ground Penetretion Radar). Na análise e interpretação dos dados foi feita uma tentativa de aplicação da estratigrafia de seqüências. Através do uso de um scanner foram elaborados perfis dos testemunhos de sondagem, identificando aspectos distintos na composição e porosidade de diferentes litologias. Outras ferramentas utilizadas constam de sensoriamento remoto, nivelamento altimétrico e batimétrico, vibracore e datação radiométrica. Dessa forma, foram definidas três feições de terraceamento lagunar de idade holocênica na área de estudo, cada uma relacionada a um nível lagunar distinto. Através dos dados obtidos em subsuperfície foi possível traçar um esboço cronoestratigráfico, bem como uma curva de variação relativa do nível lagunar para a região. Também, como resultado dos dados geológicos de superfície, associados a novas interpretações baseadas em fotografias aéreas e imagens de satélite, foi elaborado um mapa geológico atualizado.

O governo Geisel, o II PND e os economistas

Esta pesquisa pretende analisar o Governo Geisel e o II Plano Nacional de Desenvolvimento, verificando se essa política econômica representou a implantação de um novo padrão de acumulação no Brasil ou se trata de uma fase mais avançada do padrão de acumulação de bens duráveis que vigorava no País com os planos anteriores. O II PND aumentou ou diminuiu a dependência brasileira no contexto internacional? Esse plano é tão heterodoxo quanto o I PND ou representa uma guinada ortodoxa? Qual foi o papel e o peso dos gestores econômicos no Governo Geisel?

Estabilidade institucional, credibilidade e poupança privada: uma análise de economia política

O objetivo desta pesquisa é mostrar que há uma relação positiva entre a estabilidade política-institucional, a credibilidade e a taxa de poupança privada. Parte da literatura recente sobre disparidades entre taxas de poupança usa um argumento de economia política para explicar como a instabilidade política-institucional pode afetar as decisões públicas que determinam a poupança pública, mas não sugere da mesma forma que tal instabilidade pode atingir negativamente a poupança privada. Analisar-se-á esta lacuna da teoria partindo-se do referencial teórico da Nova Economia Institucional (NEI), onde salienta-se, nos processos de decisão privada de acumulação de ativos, o papel do governo gartantindo (i) a estabilidade das regras de mercado e (ii) os direitos de propriedade. A pesquisa envolverá uma análise teórica microeconômica da determinação da poupança privada usando a visão da NEI. O interesse prático fundamental da pesquisa é tentar justificar, em parte, os baixos níveis de poupança na América Latina usando um argumento institucionalista e, desta forma, propor ações de governo e reformas.

Evolução setorial e trajetórias tecnológicas em nível de empresas na indústria de celulose e papel no Brasil (1970 - 2004): contexto da política de substituição de importações à competição globalizada

Accordingly, a variety of firms's technological capabilities studies, the literature recently is still lacking about the dynamic of sector evolution and technological development in inter-firm and their implication for technical and economical financial performance. More lacking is the research catching up the evolution of industrial sectors after the institutional reforms in the 90. For that, the focus of the dissertation is to analyze the main of the evolution of the pulp and paper industry from 1970 to 2004, using as reference points the import-substitution policy and the economic deregulation of the 1990s. Futhermore, the work tries to evaluate how such changes at industry level have been perceived from a firm point of view in terms of accumulation of technological capabilities and improvement of economic financial performance. This linkage is tested and examined in the following firms: Aracruz (Barra do Riacho establishment ), Klabin (Monte Alegre establishment) e Votorantim Celulose e Papel ¿ VCP (Jacareí establishment), defining the same time period of sectoral level. As far as the industry level study is concerned, it is based on the average rate of annual growth of some selected variables, given that the technological capabilities test is performed according to the methodology already existing in the literature, but properly adapted to the pulp and paper case. Similarly, the analysis regarding the improvement of the economic financial performance is based on a set of industry specific indicators. Hence, the work is built upon multiple case studies, taking into account both the qualitative and quantitative evidence, i.e. interviews, direct observations, as well as firm reports. Finally, it is worth emphasizing as the analysis of the changes in the sector, in conjunction with the above mentioned methodology used to measure the technological capabilities in the context of an evolving industrial regime, is still lacking in emerging economies as well as in Brazil. According to the empirical evidence, the reforms of the 1990s had a positive impact on the industrial development, from both the national and international viewpoint. Such a transformation was evident at firm level in terms of accumulation of technological capabilities and improvement of economic financial indicators. Indeed, the results show that the speed of accumulation of technological capabilities within the firms influences positively the performance indicators. On the other hand, these are also related to external factors, such as the macroeconomic conditions, which as such have not been considered in details.

Acumulação de competências tecnológicas e suas implicações para performance operacional: análise comparativa de duas empresas do grupo Lupatec em Caxias do Sul - RS

This work focuses on the implications of accumulation of technological competences for improvement of operational performance indicators. This relationship is examined in two mechanical industry firms in Caxias do Sul-RS, in the period 1985-2000. Based on a comparative case study, this work finds its ground in both qualitative and quantitative empirical evidences, collected in different sources in the firms, which are being studied. The examination of accumulation of technological competences is done through a structure of analysis existing in literature, which is specifically adapted to the mechanical industry. The examination of performance improvement is based on a set of typical operational indicators pertaining to mechanical industry. Studies of this nature are already found, mainly in Latin American literature, since the eighties. But, the application of these analytic structures in industrializing firms in Brazil is found only in the nineties. This work shows that within a unique enterprise group there is a different accumulation of technological competences, and it demonstrates that this process is not automatic. Moreover, it contributes to explain not only the differences between both firms, in terms of operational performance at some points in time, but also, how both firms got to (or did not get to) improve their performance indicators along time. This conclusion is not different from that of previous studies, but it derives from a study made in a specific industry (mechanical), which has not yet been studied in the south of Brazil.

Clusters como estratégia de desenvolvimento de pequenas e médias empresas: um estudo exploratório do caso moveleiro do município de Colatina - Es

Esse trabalho tem como objetivo mostrar que a formação de clusters de pequenas e médias empresas na área de móveis pode representar uma futura alternativa econômica para Colatina. o foco principal desse estudo visa, analisar o aglomerado de empresas moveleiras do município de Colatina, localizado no centro-oeste do Espírito Santo. Pretende-se identificar como estas empresas estão organizadas, quais barreiras são enfrentadas por elas ao buscar formas de garantir competitividade, e quais atividades poderiam ser alvos de estímulos por parte das instituições de fomento com vistas a transformar este pólo moveleiro em um cluster dinâmico e iniciar um processo de desenvolvimento local. Observamos que Colatina, constitui um caso interessante de estudo por se tratar de um aglomerado de PMEs que, mesmo tendo que enfrentar alguns obstáculos, está conseguindo dinamizar o sistema produtivo local e atrair investimentos.

Globalização de capacidades tecnológicas inovadoras e o papel de subsidiárias de empresas transnacionais (ETNs) no contexto de países em desenvolvimento: a trajetória de uma empresa do setor de TIC no Brasil

This dissertation seeks to add new evidence to the international debate on globalization of innovation in the developing countries context. Globalization of innovation, in this dissertation, is defined and measured by the types, levels and rate of innovative technological capability accumulation and the underlying technological learning processes (sources of capabilities) at the firm level in late-industrializing countries ¿ or developing countries. This relationship is examined within a large transnational corporation (TNC) subsidiary of the information and communication technology (ICT) sector in Brasil: Motorola do Brasil during over the period from 1996 to 2006. In the international literature there is a strong debate on the extent to which innovative technological capabilities have been spreading internationally. But, the most of the studies are focused on early industrialized countries. In other words, there is still a scarcity of analysis, mainly at the firm level, from the perspective of developing countries. This dissertation supports itself in analytical basis developed in the international literature on accumulation of technological capabilities and learning in the context of developing countries. The learning processes examined in this dissertation are: (i) intra-firm learning processes; (ii) inter-firm learning processes (links between mother and sister companies); and (iii) links between the firm and other organizations of the innovation system (universities, research institutes, among others). Based on first-hand empirical evidence, qualitative and quantitative, collected on the basis of extensive fieldwork, this dissertation examines these issues with adequate level of detail and depth, in this large company in Brazil. The study results suggest that: Concerning the path of the technological capability accumulation, the firm exhibited heterogeneity in the path of accumulation of technological capabilities to distinct functions. For the functions Software Engineering and Process and Management Project the firm reached the Level 6 (Innovative Intermediate Superior), on a scale that ranges from 1 to 7; In relation to technological capability sources, the firm deliberately sought and built sources of knowledge in order to develop and sustain its innovative technological capabilities. The dissertation, thus, contributes to adding new empirical evidence to the debate on globalization of innovative capabilities from a late-industrializing perspective.

Trajetórias De Acumulação De Capacidades Inovadoras, Mecanismos De Aprendizagem E Fatores Organizacionais Relativos A Atividades Em Gestão De Projetos: Estudo De Caso Comparativo Inter-Empresarial Na Indústria De Bens De Capital E De Celulose E Papel No Brasil

Over the last 40 years there has been a profusion of studies about the ccumulation of technological capacities in firms from developing economies. However, there remain few studies that examine, on a combined basis, the relationship among: the trajectories of technological capacities accumulation; the underlying learning mechanisms; and, the implications of organizational factors for these two variables. Still scarcer are the studies that examine the relationship among these variables along time and based on a comparative case study. This dissertation examines the relationship among the trajectory of accumulation of innovative capacities in complex project management, the learning mechanisms underlying these technological capacities and the intra-organizational factors that influence these learning echanisms. That set of relationships is examined through a comparative and a long-term (1988-2008) case study in a capital goods firm (for the pulp and paper industry) and a pulp mill in Brazil. Based on first-hand quantitative and qualitative empiric evidence, gathered through extensive field research, this dissertation found: 1. Both firms accumulated innovative capacity in project management at the international frontier level (Level 6). However, there was variability between the firms in terms of the nature and speed of accumulation of those capacities. It was also observed that, at this level of innovation, the innovative capacities of both firms are not confined to their organizational boundaries, but they are distributed beyond their boundaries. 2. So that these companies could accumulate those levels of innovative capacities it was necessary to manage several learning mechanisms: leveraging of external knowledge and its internalization in terms of internal apacities of the firm. In other words, as the companies accumulated more innovative levels of capacities for project management, it was necessary to manage different cycles of technological learning. 3. Further, the relationship between the ccumulation of technological capacities and learning was affected positively by intra-organizational factors, such as 'authority disposition', 'mutability of work roles' and 'intensity of internal crises', and negatively by the factor 'singularity of goals'. This dissertation revealed divergent results between firms in two of the four factors studied. These results contribute to advance our understanding of the complexity and variability involved in the process of accumulation of innovative capacities in firms from developing economies. This highlights the growing importance of the organizational and the human resource dimensions of innovation and technological capacity as the company approaches the international frontier. The results suggest to managers that: (i) the good performance in project management in the two firms studied did not occur simply as a result of the pulp and paper Brazilian industry growth, rather as a result of the deliberate construction and accumulation of the capacities through an intensive and coordinated cyclical process of technological learning, (ii) to develop innovative capabilities in project management, besides looking for learning mechanisms they should also look at the organizational factors that influence the learning mechanisms directly, (iii) performance of pulp mill¿s projects is better when projects are implemented together with technology suppliers than when performed only by the mill. This dissertation concludes that capital goods firms have been having a fundamental role for the innovative capabilities accumulation in project management of pulp mills in Brazil (and vice-versa) for a long time. This contradicts some authors' propositions that affirm that: a) equipment suppliers for the pulp and paper industry have been creating little, if any, development of processes or engineering projects in Brazil; b) firms in the pulp and paper industry have little capacity for machinery and equipments projects only taking place in few technological activities, being internal or external to the firm. Finally, some studies are proposed for future research.

Globalização de capacidades tecnológicas inovadoras e o papel de subsidiárias de empresas transnacionais( ETNs) No contexto de países em desenvolvimento: a trajetória de uma empresa do setor de TIC no Brasil

This dissertation seeks to add new evidence to the international debate on globalization of innovation in the developing countries context. Globalization of innovation, in this dissertation, is defined and measured by the types, levels and rate of innovative technological capability accumulation and the underlying technological learning processes (sources of capabilities) at the firm level in late-industrializing countries ¿ or developing countries. This relationship is examined within a large transnational corporation (TNC) subsidiary of the information and communication technology (ICT) sector in Brasil: Motorola do Brasil during over the period from 1996 to 2006. In the international literature there is a strong debate on the extent to which innovative technological capabilities have been spreading internationally. But, the most of the studies are focused on early industrialized countries. In other words, there is still a scarcity of analysis, mainly at the firm level, from the perspective of developing countries. This dissertation supports itself in analytical basis developed in the international literature on accumulation of technological capabilities and learning in the context of developing countries. The learning processes examined in this dissertation are: (i) intra-firm learning processes; (ii) inter-firm learning processes (links between mother and sister companies); and (iii) links between the firm and other organizations of the innovation system (universities, research institutes, among others). Based on first-hand empirical evidence, qualitative and quantitative, collected on the basis of extensive fieldwork, this dissertation examines these issues with adequate level of detail and depth, in this large company in Brazil. The study results suggest that: Concerning the path of the technological capability accumulation, the firm exhibited heterogeneity in the path of accumulation of technological capabilities to distinct functions. For the functions Software Engineering and Process and Management Project the firm reached the Level 6 (Innovative Intermediate Superior), on a scale that ranges from 1 to 7; In relation to technological capability sources, the firm deliberately sought and built sources of knowledge in order to develop and sustain its innovative technological capabilities. The dissertation, thus, contributes to adding new empirical evidence to the debate on globalization of innovative capabilities from a late-industrializing perspective.

Acumulação de competências tecnológicas e os processos subjacentes de aprendizagem na indústria eletrônica de consumo : o caso da SHARP do Brasil S/A

Esta dissertação estuda o relacionamento entre a acumulação de competências tecnológicas e os processos subjacentes de aprendizagem. O estudo desse relacionamento foi examinado na fábrica de eletrônica de consumo Sharp do Brasil S/A, situada na cidade de Manaus, durante o período de 1972 a 2000. A acumulação e sustentação de competências tecnológicas são desenvolvidas através de processos de aprendizagem nas organizações. Os processos de aprendizagem estão relacionados diretamente à taxa de acumulação de competências tecnológicas das organizações. A dissertação, utilizando a estrutura de análise existente na literatura, examina os processos de aprendizagem à luz de quatro características: variedade, intensidade, funcionamento e interação. A acumulação de competências é analisada a partir de duas funções tecnológicas: processo/organização e produtos. Ao longo do periodo analisado, a empresa acumulou diferentes níveis de competências tecnológicas e com velocidades variadas nas funções estudadas. Na década de 80, a empresa através de uma melhor coordenação de esforços, passou a adquirir e converter conhecimentos individuais em conhecimentos organizacionais, acelerando o crescimento da taxa de competências tecnológicas acumuladas. Ainda no final da década 80, a empresa foi capaz de acumular competências inovadoras nas duas funções estudadas. A acumulação de competências tecnológicas é um aspecto importante a competitividades e sobrevivência das organizações. No entanto, somente a acumulação de competências tecnológicas não garante o bom desempenho e a sobrevivência da organização. A empresa estudada, apesar da acumulação de elevados níveis de competências tecnológicas ao longo do periodo, enfrenta uma grande crise financeira. A conclusão desta dissertação sugere que a taxa de acumulação de competências tecnológicas pode ser explicada pela capacidade da empresa em socializar e codificar a aprendizagem individual, adquiridas por processos externos e internos de aprendizagem aplicados de forma contínua e organizada, convertendo em aprendizagem organizacional.

Acumulação tecnológica e aprimoramento de performance competitiva: evidências de diferenças e similaridades e médias empresas do setor metal-mecânico no estado do rio de janeiro

The main objective of this dissertation is to examine the implications of technological capacities in the improvement of technical performance indexes, specifically at the company level. These relationships were examined in a small sample of metal-working enterprises in the state of Rio de Janeiro (1960 to 2006). Although diverse studies on technological competences have been carried out in the last twenty years, a gap in empirical studies still exist that correlate the performance of companies in the context of developing countries, especially in Brazil. Aiming to contribute to a reduction of these gaps, this dissertation examines the questions by the light of available models in literature, which opting themselves to using operational indexes of companies. For drawing the accumulation of technological competences in this study, the metric proposal by Figueiredo (2000) shall be used indicating the levels of technological qualification in process, product, and equipment functions. The empirical evidence examined in this dissertation is both qualitative and quantitative in nature and were collected, first hand, through extensive field research involving informal interviews, meetings, direct-site observation and document analysis. In relation to the results, the evidence suggests that: - In terms of technological accumulation, a company reached Level 5 of technological capacity in process and organization of production as well as product and equipment. Three companies obtained Level 4 in the function process function while two others had reached the same technological level in the functions of product and equipment. Two companies had reached Level 3 in the product and equipment functions and one remained this level in the function of process; - In terms of the rate of accumulation of technological capacities, the observed companies had reached Level 4 needs 29 years in process function, 32 years in product function and 29 years in equipment function; - In terms of improvement performance pointers, a company which reached Level 5 of technological capacity improved in 70% of its indicators of performance, while the company that had achieved Level 4 had raised its pointers 60% and the other companies had gotten improved in the order of 40%. It was evidenced that the majority of the pointers of the companies with higher levels of technological capacities had obtained better performance. This dissertation contributes to advancing the strategic management of companies in metal-working segment to understanding internal accumulation of technological capacity and indicators of performance especially in the field of empirical context studied. This information offers management examples of how to improve competitive performance through the accumulation of technological capacities in the process, product and equipment functions.