Socioeconomic Status and Childhood Leukemia Incidence in Switzerland.

Socioeconomic status (SES) discrepancies exist for child and adult cancer morbidity and are a major public health concern. In this Swiss population-based matched case-control study on the etiology of childhood leukemia, we selected the cases from the Swiss Childhood Cancer Registry diagnosed since 1991 and the controls randomly from census. We assigned eight controls per case from the 1990 and 2000 census and matched them by the year of birth and gender. SES information for both cases and controls was obtained from census records by probabilistic record linkage. We investigated the association of SES with childhood leukemia in Switzerland, and explored whether it varied with different definitions of socioeconomic status (parental education, living condition, area-based SES), time period, and age. In conditional logistic regression analyses of 565 leukemia cases and 4433 controls, we found no consistent evidence for an association between SES and childhood leukemia. The odds ratio comparing the highest with the lowest SES category ranged from 0.95 (95% CI: 0.71-1.26; P trend = 0.73) for paternal education to 1.37 (1.00-1.89; P trend = 0.064) for maternal education. No effect modification was found for time period and age at diagnosis. Based on this population-based study, which avoided participation and reporting bias, we assume the potential association of socioeconomic status and childhood leukemia if existing to be small. This study did not find evidence that socioeconomic status, of Switzerland or comparable countries, is a relevant risk factor or strong confounder in etiological investigations on childhood leukemia.

Prognostic Relevance of Palliative Primary Tumor Removal in 37,793 Metastatic Colorectal Cancer Patients: A Population-Based, Propensity Score-Adjusted Trend Analysis

OBJECTIVE To assess whether palliative primary tumor resection in colorectal cancer patients with incurable stage IV disease is associated with improved survival. BACKGROUND There is a heated debate regarding whether or not an asymptomatic primary tumor should be removed in patients with incurable stage IV colorectal disease. METHODS Stage IV colorectal cancer patients were identified in the Surveillance, Epidemiology, and End Results database between 1998 and 2009. Patients undergoing surgery to metastatic sites were excluded. Overall survival and cancer-specific survival were compared between patients with and without palliative primary tumor resection using risk-adjusted Cox proportional hazard regression models and stratified propensity score methods. RESULTS Overall, 37,793 stage IV colorectal cancer patients were identified. Of those, 23,004 (60.9%) underwent palliative primary tumor resection. The rate of patients undergoing palliative primary cancer resection decreased from 68.4% in 1998 to 50.7% in 2009 (P < 0.001). In Cox regression analysis after propensity score matching primary cancer resection was associated with a significantly improved overall survival [hazard ratio (HR) of death = 0.40, 95% confidence interval (CI) = 0.39-0.42, P < 0.001] and cancer-specific survival (HR of death = 0.39, 95% CI = 0.38-0.40, P < 0.001). The benefit of palliative primary cancer resection persisted during the time period 1998 to 2009 with HRs equal to or less than 0.47 for both overall and cancer-specific survival. CONCLUSIONS On the basis of this population-based cohort of stage IV colorectal cancer patients, palliative primary tumor resection was associated with improved overall and cancer-specific survival. Therefore, the dogma that an asymptomatic primary tumor never should be resected in patients with unresectable colorectal cancer metastases must be questioned.

Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37.

Vitamin D has immunomodulatory properties in the defence against pathogens. Its insufficiency is a widespread feature of cystic fibrosis (CF) patients, which are repeatedly suffering from rhinovirus (RV)-induced pulmonary exacerbations.To investigate whether vitamin D has antiviral activity, primary bronchial epithelial cells from CF children were pre-treated with vitamin D and infected with RV16. Antiviral and anti-inflammatory activity of vitamin D was assessed. RV and LL-37 levels were measured in bronchoalveolar lavage (BAL) of CF children infected with RV.Vitamin D reduced RV16 load in a dose-dependent manner in CF cells (10(-7 )M, p<0.01). The antiviral response mediated by interferons remained unchanged by vitamin D in CF cells. Vitamin D did not exert anti-inflammatory properties in RV-infected CF cells. Vitamin D increased the expression of the antimicrobial peptide LL-37 up to 17.4-fold (p<0.05). Addition of exogenous LL-37 decreased viral replication by 4.4-fold in CF cells (p<0.05). An inverse correlation between viral load and LL-37 levels in CF BAL (r=-0.48, p<0.05) was observed.RV replication in primary CF bronchial cells was reduced by vitamin D through the induction of LL-37. Clinical studies are needed to determine the importance of an adequate control of vitamin D for prevention of virus-induced pulmonary CF exacerbations.

Hs. Rothschild 4° 37 - Bibliothèque de Madame la Baronne Adélaïde de Rothschild [Catalogue]

Vorbesitzer: Adélaïde de Rothschild; Freiherrlich Carl von Rothschild'sche Bibliothek Frankfurt am Main; alte Signatur: 81; Hs in 4° 37; Akzessionsnummer: X19125

Bau- und Wohnungswirtschaft in Palästina 1936/37

Hans Jacobowitz

Ms. Barth. 37 - Decretalium compilatio cum novellis Innocentii IV. papae

Vorbesitzer: Johannes Bretheim; Philippus Berbach; Bartholomaeusstift Frankfurt am Main

Ms. Praed. 139 - [Sammelband in 10 Teilen: Konvolut aus Handschrift und Inkunabeln]

Vorbesitzer: Kartause St. Johannes Baptista in Zeelhem; Petrus Dorlandus; Dominikanerkloster Frankfurt am Main

Ms. Carm. 37 - [Sammelband in 4 Teilen: Konvolut aus Handschriften und Inkunabeln]

Vorbesitzer: Karmeliterkloster Frankfurt am Main

Kundmachung: Johann Urban, von Wien gebürtig, 37 Jahre alt, katholisch ...

Welsch (Projektbearbeiter): Verurteilung des ehemaligen Geschäftsführers einer Textilfabrik und Mitgliedes der Wiener Sicherheitswache Urban (in Umwandlung der zuvor ausgesprochenen Todesstrafe) zu zwölfjähriger Zwangsarbeit wegen Aufruhrs und bewaffneten Widerstands gegen das Militär

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 442 - Manuskript "Declamatio in laudem philosophiae" für die Probevorlesung an der Universität in Berlin

abgedruckt in: Schopenhauer-Jahrbuch 32 (1945/48), S 3-14

Na 1 Nachlass Max Horkheimer, 37 - Korrespondenzen u.a. mit Dorthy I. Mulgrave (p. I 18, 335-517)

1 Brief von Margot von Mendelssohn an Max Horkheimer, 20.05.1948; 6 Briefe zwsichen Charles E. Merriam und Max Horkheimer, 1940-1941; 4 Briefe zwischen Josef Messinger und Max Horkheimer, 1940; 1 Curriculum Vitae von Alfred Meusel an Max Horkheimer; 1 Brief von Max Horkheimer an Gerhard Meyer, 17.10.1938; 3 Briefe zwischen Hans A. Meyer und Max Horkheimer´09.10.1939, 1947; 2 Briefe zwischen Julie Meyer und Max Horkheimer, 12.04.1941, 15.04.1941; 43 Briefe zwischen Hermann Meyer-Lindenberg, Oscar Meyer und Max Horkheimer sowie Briefwechsel mit Hadley Cantril; 2 Briefe zwischen Hadley Cantril und Theodor W. Adorno, 22.05.1941, 28.05.1941; 1 Brief von Jerome Michael an Margot von Mendelssohn, 10.01.1941; 2 Briefe und 2 Beilagen zwischen Joseph Mire und Max Horkheimer, 16.03.1941, 28.03.1941; 6 Briefe zwischen Mitchell, Silberberg & Knupp, Los Angeles und Max Horkheimer, 1942, 1943; 1 Brief von Friedrich Pollock an Wesley C. Mitchell, 06.08.1940; 3 Briefe zwischen Hans Mohr und Max Horkheimer, 29.03.1946, 1946; 1 Brief von Herbert Moeller Morton an Max Horkheimer, 25.02.1940; 1 Brief von Max Horkheimer an den Chairman of the Committee on General Scholarships, Cambridge Massachusetts, 01.03.1940; 2 Briefe von David H. Moses an Max Horkheimer, 1939; 1 Brief von Franz Neumann an Philip Mosley, 28.04.1941; 49 Briefe zwischen Dorthy I. Mulgrave und Max Horkheimer, 1936-1940; 1 Brief von Max Horkheimer an das Municipal Court, San Francisco, 24.12.1948;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 37 - Einladung Schopenhauers nach Zürich

u.a.: Besuch der Tante Frau Wüstenfeld in Frankfurt; Philosophie; Kontakt mit Jörg Herwegh und Richard Wagner; Studium der Rechtswissenschaft, Medizin und Philologie; Buddhismus; Lehrwerk der Tibetischen und Mongolischen Sprache von Isaac Jacob Schmidt in Petersburg; Tranksrit-, Zend-, Parsi- und Tibetische Manuskripte im Britischen Museum; 2. Auflage der "Welt als Wille und Vorstellung" von 1844 in der Stadtbibliothek Zürich; Metaphysik der Geschlechtsliebe; Manuskript "Geschichte der Geschlechtsliebe"; Immanuel Kant; Über die vierfache Wurzel des Satzes vom zureichenden Grunde;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 139 - Kritik an einen Artikel über Schopenhauer in dem Frankfurter Conversions-Blatt

u.a.: Mangelnde Anerkennung Schopenhauers in Frankfurt; Anregung zur Aufnahme weiterer Bibelstellen in "Der Welt als Wille und Vorstellung"; Parerga und Paralipomena; Johann Karl Friedrich Rosenkranz;