Anti-müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations

STUDY QUESTION Do women with BRCA1 or BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-Müllerian hormone (AMH) concentration?SUMMARY ANSWER Women with a germline mutation in BRCA1 have reduced ovarian reserve as measured by AMH.WHAT IS KNOWN ALREADY The DNA repair enzymes encoded by BRCA1 and BRCA2 are implicated in reproductive aging. Circulating AMH is a biomarker of ovarian reserve and hence reproductive lifespan.STUDY DESIGN, SIZE, DURATION This was a cross-sectional study of AMH concentrations of 693 women at the time of enrolment into the Kathleen Cuningham Foundation Consortium for research in the Familial Breast Cancer (kConFab) cohort study (recruitment from 19 August 1997 until 18 September 2012). AMH was measured on stored plasma samples between November 2014 and January 2015 using an electrochemiluminescence immunoassay platform.PARTICIPANTS/MATERIALS, SETTING, METHODS Eligible women were from families segregating BRCA1 or BRCA2 mutations and had known mutation status. Participants were aged 25–45 years, had no personal history of cancer, retained both ovaries and were not pregnant or breastfeeding at the time of plasma storage. Circulating AMH was measured for 172 carriers and 216 non-carriers from families carrying BRCA1 mutations, and 147 carriers and 158 non-carriers from families carrying BRCA2 mutations. Associations between plasma AMH concentration and carrier status were tested by linear regression, adjusted for age at plasma storage, oral contraceptive use, body mass index and cigarette smoking.MAIN RESULTS AND THE ROLE OF CHANCE Mean AMH concentration was negatively associated with age (P < 0.001). Mutation carriers were younger at blood draw than non-carriers (P ≤ 0.031). BRCA1 mutation carriers had, on average, 25% (95% CI: 5%–41%, P = 0.02) lower AMH concentrations than non-carriers and were more likely to have AMH concentrations in the lowest quartile for age (OR 1.84, 95% CI: 1.11–303, P = 0.02). There was no evidence of an association between AMH concentration and BRCA2 mutation status (P = 0.94).LIMITATIONS, REASONS FOR CAUTION AMH does not directly measure the primordial follicle pool. The clinical implications of the lower AMH concentrations seen in BRCA1 mutation carriers cannot be assessed by this study design.WIDER IMPLICATIONS OF THE FINDINGS Women with a germline mutation in BRCA1 may have reduced ovarian reserve. This is consistent with other smaller studies in the literature and has potential implications for fertility and reproductive lifespan.STUDY FUNDING/COMPETING INTEREST(S) kConFab is supported by a grant from the Australian National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. K.A.P. is an Australian National Breast Cancer Foundation Practitioner Fellow. J.L.H. is a NHMRC Senior Principal Research Fellow. M.H. is a NHMRC Practitioner Fellow. R.A.A. reports personal fees from Roche Diagnostics & Beckman Coulter outside the submitted work and C.S. reports other earnings from Melbourne IVF outside the submitted work. The remaining authors have nothing to declare and no conflicts of interest.

The infant feeding practices of Chinese immigrant mothers in Australia: A qualitative exploration

BACKGROUND: The Australian Infant Feeding Guidelines recommend exclusive breastfeeding until about six months of age when solid foods should be gradually introduced. Evidence indicates that Chinese immigrant mothers in Australia are more likely to use infant formula in combination with breastfeeding and to introduce solids earlier than the general Australian population. This study aimed to explore Chinese immigrant mother's experiences of feeding their infant to gain an insight into the factors shaping their feeding decisions and perceptions of infant growth. METHODS: Semi structured interviews were conducted with 36 Chinese immigrant mothers with children aged 0-12 months, living in Melbourne, Australia. Interviews were conducted either in Chinese, using an interpreter, or in English. All were audio recorded. Recordings were transcribed verbatim and thematically analysed. RESULTS: Eight themes were identified. Chinese immigrant mothers were supportive of exclusive breastfeeding, however breastfeeding problems and conflicting views about infant feeding and infant growth from grandparents reduced many mothers' confidence to breastfeed exclusively. For many new mothers, anxiety that exclusive breastfeeding provided insufficient nourishment led to the introduction of formula before six months of age. Most mothers delayed introducing solid food to five to six months to prevent development of allergic diseases and gastrointestinal problems. Chinese immigrant mothers obtained information and support related to infant feeding from a combination of health professionals, online resources, friends and grandparents. CONCLUSIONS: Chinese immigrant mothers in Australia need support to breastfeed exclusively. In particular maternal confidence to breastfeed exclusively needs to be increased. To achieve this, culturally sensitive guidance is needed and the contradictions in advice given by Chinese grandparents and health professionals on infant feeding practices and healthy infant growth need to be recognised and addressed.

Parent-related mechanisms underlying the social gradient of childhood overweight and obesity: a systematic review

BACKGROUND: Low socio-economic status (SES) is a significant risk factor for childhood overweight and obesity (COWOB) in high-income countries. Parents to young children buffer and accentuate social and cultural influences, and are central to the development of this disease. An understanding of the parent-related mechanisms that underlie the SES-COWOB relationship is needed to improve the efficacy of prevention and intervention efforts. OBJECTIVE: A systematic review of relevant literature was conducted to investigate the mechanisms by which levels of SES (low, middle and high) are associated to COWOB, by exploring mediation and interaction effects. METHOD: Six electronic databases were searched yielding 5155 initial records, once duplicates were removed. Studies were included if they investigated COWOB, SES, parent-related factors and the multivariate relationship between these factors. Thirty studies were included. Factors found to be mediating the SES-COWOB relationship or interacting with SES to influence COWOB were categorized according to an ecological systems framework, at child, parent, household and social system level factors. RESULTS: High parent body mass index, ethnicity, child-care attendance, high TV time (mother and child), breastfeeding (early weaning), food intake behaviours and birthweight potentially mediate the relationship between SES and COWOB. Different risk factors for COWOB in different SES groups were found. For low SES families, parental obesity and maternal depressive symptoms were strong risk factors for COWOB, whereas long maternal working hours and a permissive parenting style were risk factors for higher SES families. None of the studies investigated parental psychological attributes such as attitudes, beliefs, self-esteem and so on as potential mechanisms/risk factors. CONCLUSIONS: Families from different SES groups have different risk and protective factors for COWOB. Prevention and intervention efforts may have improved efficacy if they are tailored to address specific risk factors within SES.

Establishment and development of infant gut microbiota

The nascent gut microbiota at birth is established in concert with numerous developmental parameters. Here, in the INFAMTET study, we chronicled the impact of some factors which are key determinants of the infant gut microbiota, namely; mode of birth, gestational age, and type of feeding. We determined that the aggregated microbiota profile of naturally delivered, initially breastfed infants are relatively stable from one week to six months of age and are not significantly altered by increased duration of breastfeeding. Contrastingly, there is significant development of the microbiota profile of C-section delivered infants, and this development is significantly influenced by breastfeeding duration. Preterm infants, born by either mode of birth, initially have a high proportion of Proteobacteria, and demonstrate significant development of the gut microbiota from week 1 to later time-points. The microbiota is still slightly, but significantly, affected by birth mode at one year of age although no specific genera were found to be significantly altered in relative abundance. By two years of age, there is no effect of either birth mode or gestational age. However this does not preclude the possibility that symptoms developed later in life, which are associated with preterm or C-section birth, are as a result of the early perturbation of the neonatal gut microbiota. It is likely that the combination of relatively low exposure (breast fed), high exposure (formula fed) or delayed exposure (C-section and preterm) to specific antigens and the resulting inflammatory responses, in this crucial window of host-microbiota interaction, influence systemic health of the individual throughout life.

Sjuksköterskans betydelse för viktnedgång hos överviktiga patienter : En litteraturstudie

         Övervikt klassas som en pandemi sedan 2012, och följderna av övervikt är skadliga för hälsan. Patienter söker ofta vården då hälsan börjar svikta till följd av övervikt. Syfte med denna studie var att belysa hur sjuksköterskan i sin yrkesroll och med sin omvårdnadskunskap kan påverka patienter till en livsstilsförändring, vilket en viktnedgång innebär. En litteraturstudie har gjorts, av 10 artiklar som valdes ut från artikelsökningar i CINAHL, PubMed samt PsykInfo. Manuella sökningar har gjorts. Kvalitetsgranskning med granskningsmallar av Polit och Beck (2012) är gjord av artiklar vilka ingår i studien. Resultatet visar att sjuksköterskan har en stor betydelse i patientens viktnedgång. Att stötta patienten till en ökad motivation leder till resultat i form av viktnedgång. Slutsatsen visaratt med utbildning i Motiverande samtal och kunskap om övervikt och dess följdsjukdomar, kan sjuksköterskan göra ett mycket bra och viktigt arbete, som leder till livsstilsförändring och en bestående viktnedgång hos den överviktige patienten.            

Ingestão proteica na infância e risco de obesidade

Trabalho Complementar apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de licenciada em Ciências da Nutrição

Trial for reducing weight retention in new mums: a randomised controlled trial evaluating a low intensity, postpartum weight management programme

BACKGROUND: Failure to return to pregnancy weight by 6 months postpartum is associated with long-term obesity, as well as adverse health outcomes. This research evaluated a postpartum weight management programme for women with a body mass index (BMI) > 25 kg m(-2) that combined behaviour change principles and a low-intensity delivery format with postpartum nutrition information. METHODS: Women were randomised at 24-28 weeks to control (supported care; SC) or intervention (enhanced care; EC) groups, stratified by BMI cohort. At 36 weeks of gestation, SC women received a 'nutrition for breastfeeding' resource and EC women received a nutrition assessment and goal-setting session about post-natal nutrition, plus a 6-month correspondence intervention requiring return of self-monitoring sheets. Weight change, anthropometry, diet, physical activity, breastfeeding, fasting glucose and insulin measures were assessed at 6 weeks and 6 months postpartum. RESULTS: Seventy-seven percent (40 EC and 41 SC) of the 105 women approached were recruited; 36 EC and 35 SC women received a programme and 66.7% and 48.6% completed the study, respectively. No significant differences were observed between any outcomes. Median [interquartile range (IQR)] weight change was EC: -1.1 (9.5) kg versus SC: -1.1 (7.5) kg (6 weeks to 6 months) and EC: +1.0 (8.7) kg versus SC: +2.3 (9) kg (prepregnancy to 6 months). Intervention women breastfed for half a month longer than control women (180 versus 164 days; P = 0.10). An average of 2.3 out of six activity sheets per participant was returned. CONCLUSIONS: Despite low intervention engagement, the high retention rate suggests this remains an area of interest to women. Future strategies must facilitate women's engagement, be individually tailored, and include features that support behaviour change to decrease women's risk of chronic health issues.

2016 West Nile Virus Cases

Most people get infected with West Nile virus by the bite of an infected mosquito. Mosquitoes become infected when they feed on infected birds. Infected mosquitoes can then spread the virus to humans and other animals. In a very small number of cases, West Nile virus has been spread through blood transfusions, organ transplants, and from mother to baby during pregnancy, delivery, or breastfeeding. Recovery from severe disease may take several weeks or months. Some of the neurologic effects may be permanent. About 10 percent of people who develop neurologic infection due to West Nile virus will die.

Déterminants biologiques et maternels des problèmes de comportement chez l’enfant inuit d’âge scolaire

Méthodologie: Corrélations de Pearson, Matrice de Raven

Relação precoce mãe-filho. Revisão dos indicadores pós-parto do projeto Maternidade com Qualidade no CHBM-EPE

O aleitamento materno exclusivo é uma recomendação universal e o contacto pele-a-pele mãe/recém-nascido é fator de desenvolvimento para a díade. O trabalho académico desenvolvido centra-se nos indicadores de medida e evidência - amamentação na 1ª hora de vida & contacto pele a pele entre a díade. Tal enraíza-se no projeto Maternidade com Qualidade, da Ordem dos Enfermeiros Portugueses e em curso no Centro Hospitalar Barreiro-Montijo EPE. O projeto iniciou-se em setembro de 2015, seguindo-se os procedimentos que se relatam no atual documento. No diagnóstico de situação recolheu-se o estado dos indicadores. A vertente de investigação considerou como amostras profissionais e utentes do Centro Hospitalar Barreiro-Montijo e recolheu dados. A intervenção realizada produziu evolução positiva nos indicadores. O bonding em período sensível é reconhecido pelos profissionais como um elemento relevante nos cuidados. Com a implementação deste projeto contribuiu-se para a melhoria da qualidade dos cuidados na área de saúde materna; Mother-Child early relationship. Evaluating postpartum indicators from the Project Maternity with Quality at CHBM-EPE ABSTRACT: Exclusive breastfeeding is a universal recommendation and skin-to-skin mother / newborn is a development factor for the dyad. The academic work focuses on the measurement indicators and evidence - breastfeeding within the 1st hour of life & skin-to-skin between the dyad. This is rooted in the Maternity design with quality, of the Portuguese Nurses and ongoing in-Hospital Center Barreiro Montijo EPE. The project began in September 2015, following the procedures that are reported in the current document. In the situation analysis was collected status indicators. The research strand considers sample practitioners and users Barreiro-Montijo Hospital Center and collects data. The intervention performed produced positive results for these indicators. The bonding in the sensitive period is recognized by professionals as an important element in the care. With the implementation of this project contributed to improving the quality of care in maternal health.

Empoderamento da puérpera para o sucesso no aleitamento materno

São muitas as vantagens do aleitamento materno para a mãe e recém-nascido, havendo consenso de que a sua prática exclusiva deve ser até aos seis meses de vida. A intervenção teve como objetivo empoderar a puérpera para o sucesso no aleitamento materno. Foram aplicados três questionários a duas populações-alvo: um aos enfermeiros do Serviço de Obstetrícia do Centro Hospitalar Barreiro-Montijo, Entidade Pública Empresarial e outros dois às puérperas, que permitiram a recolha de informações sobre os conhecimentos dos enfermeiros acerca das práticas no aleitamento materno e da perceção das puérperas, quanto aos cuidados recebidos durante o internamento. Os resultados apontaram para a necessidade de formação dos enfermeiros sobre o aleitamento materno e a necessidade de empoderamento/acompanhamento no pós-parto. Desenvolveram-se atividades formativas e educacionais, quer para os profissionais, quer para as puérperas. A intervenção profissional revelou-se benéfica para a melhoria contínua dos cuidados de enfermagem na promoção do aleitamento materno exclusivo; EMPOWERMENT OF POSTPARTUM WOMEN FOR SUCCESSFUL BREASTFEEDING ABSTRACT: Breastfeeding presents several advantages to the mother and child, being generally agreed that its practice should be exclusive until six months of age. The goal of this intervention was to empower the puerpera towards breastfeeding success. Three questionnaires were applied to two populations: one to the nurses from the Obstetric Department of the Centro Hospitalar Barreiro-Montijo, Entidade Pública Empresarial and other two to puerperas, which allowed collection of information on the nurses’ knowledge about breastfeeding practices and the puerperas’ perception on received care during hospitalization. The results demonstrated the nurses’ need of training on breastfeeding and the need of empowerment/follow-up during the post-partum period. Educational and training activities, directed to professionals and puerperas, were developed. The professional intervention demonstrated benefits to the improvement of the nursing care in the promotion of exclusive breastfeeding.