1000 resultados para metabolismo da glicose e lípides
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Agronomia (Horticultura) - FCA
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Pós-graduação em Alimentos e Nutrição - FCFAR
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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In recent years, uremic toxins have been widely investigated as an immunosuppressive factor for nephropathic patients. This study aimed to test the hypothesis that, as it was similarly observed in humans, the rate of apoptosis and superoxide production in polymorphonuclear leukocytes are changed in dogs treated with uremic serum. The superoxide production of polymorphonuclear leukocytes and apoptotic index of 10 healthy dogs incubated with autologous and homologous serum from healthy and uremic dogs was compared. Thus, there was an effect of partial inhibition of oxidative metabolism in uremia without correlation with the acceleration of polymorphonuclear leukocytes apoptosis in dogs.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The increased prevalence of diabetic individuals has become a public health problem. Diabetes Mellitus is a metabolic disorder characterized by an increase in plasma glucose levels. It impairs the physiological equilibrium in utilization of carbohydrate by tissues. The persistent hyperglycemia can produce deleterious effects on bone formation due the microvascular complication. The present paper reviews the bibliography linking the impact of glycemic control at complications associated at diabetes mellitus on osseointegration. In experimental models of diabetes it was observed a reduced level of bone-implant contact. This failure can be reduced by means of hyperglycemia control. Also, several studies point the beneficial effect of coated implant on osseointegration process. It is necessary to take special care into account for the placement of implants in diabetic patient and improve the percentages of implant survival. A rigorous control of plasma glycaemia, together with other measures, like as absence of chronic complications, good oral hygiene and regular medical follow-up has been related to rising the percentages of successful in diabetic patients.
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Obesity is fundamentally a problem of energy balance that develops when the energy intake is greater than the total energy expenditure (TEE). TEE is composed by the sum of resting energy expenditure (REE), thermal effect of foods and thermal effect of physical activity. Many factors can affect energy expenditure and energy homeostasis. Historically, the energy expenditure has been measured by indirect calorimetry. However, more recently, the use of doubly labeled water has allowed the assessment of energy expenditure in a 24 hour period, which expanded the knowledge on energy metabolism. Factors such as gender, age, thyroid disorders, physical activity and body composition affect REE as already established in the literature. However, there has been speculation whether other factors, such as adipocytokines and diet composition, which might be involved in the genesis of obesity by decreasing the REE. So, this paper aims to review the factors that can alter the energy metabolism.
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Leukogram and neutrophil oxidative metabolism from dogs with visceral leishmaniasis (VL) were compared before and after treatment with meglumine antimoniate (AM) and with an association of meglumine antimoniate and allopurinol (AMA). The results obtained demonstrated that neutrophils of dogs with VL do not lose their capacity of reducing NBT and that oxidative metabolism has been more active in the majority of the cases. After treatment with AM and AMA, dogs with VL presented a redution of neutrophils oxidative metabolism, suggesting that this decrease was related with the decrease in the number of parasites and a probable inhibitor effect of these drugs on neutrophils oxidative metabolism.
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O processo de remodelação óssea é regulado por fatores sistêmicos e locais. Estrógeno é o hormônio mais importante na manutenção do turnover ósseo normal, cuja deficiência leva a alterações na remodelação óssea com reabsorção excedendo a formação, como observado em mulheres pós-menopausadas. O tratamento da osteoporose está relacionado com a descoberta de fármacos alternativo à terapia hormonal estrogênica compensando as desvantagens dessa terapêutica. O Raloxifeno (RLX) mimetiza os efeitos benéficos do estrógeno sem estimular tecidos como mama e endométrio. O Fluoreto de sódio (NaF) apresenta-se como agente eficaz no combate às fraturas, conseqüentes da osteoporose.
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Pós-graduação em Agronomia (Horticultura) - FCA
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)