Analysis of the activation mechanism of Pseudomonas stutzeri cytochrome c peroxidase through an electron transfer chain

J Biol Inorg Chem (2011) 16:881���888 DOI 10.1007/s00775-011-0785-8

Artefacts induced on c-type haem proteins by electrode surfaces

J Biol Inorg Chem (2011) 16:209���215 DOI 10.1007/s00775-010-0717-z

Kinetic, Structural, and EPR Studies Reveal That Aldehyde Oxidoreductase from Desulfovibrio gigas Does Not Need a Sulfido Ligand for Catalysis and Give Evidence for a Direct Mo-C Interaction in a Biological System

J. Am. Chem. Soc., 2009, 131 (23), pp 7990���7998 DOI: 10.1021/ja809448r

Benefits of membrane electrodes in the electrochemistry of metalloproteins: mediated catalysis of Paracoccus pantotrophus cytochrome c peroxidase by horse cytochrome c: a case study

J Biol Inorg Chem. 2008 Jun;13(5):779-87. doi: 10.1007/s00775-008-0365-8

Mediated catalysis of Paracoccus pantotrophus cytochrome c peroxidase by P. pantotrophus pseudoazurin: kinetics of intermolecular electron transfer

J Biol Inorg Chem (2007) 12:691���698 DOI 10.1007/s00775-007-0219-9

A copper protein and a cytochrome bind at the same site on bacterial cytochrome c peroxidase

Biochemistry, 2004, 43 (46), pp 14566���14576 DOI: 10.1021/bi0485833

Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria

Biochemistry, 2003, 42 (10), pp 3070���3080 DOI: 10.1021/bi026979d

A further investigation of the cytochrome b5���cytochrome c complex

J Biol Inorg Chem (2003) 8: 777���786 DOI 10.1007/s00775-003-0479-y

The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774

Eur. J. Biochem. 270, 3904���3915 (2003) doi:10.1046/j.1432-1033.2003.03772.x

Contributo da C.P.R.E./E.T.E. na Terap��utica da Pancreatite Aguda Liti��sica

Na literatura m��dica existem actualmente v��rios trabalhos confirmando o valor da Colangiopancreatografla Retr��gada Endosc��pica (C.P.R.E.) e da Esflncterotomia Endosc��pica (E.T.E.) na terap��utica da Pancreatite Aguda Liti��sica (P.A.L.). E uma t��cnica endosc��pica de primeira linha na actua����o terap��utica na P.A.L. que ao permitir desobstruir as vias biliares de c��lculos elimina o factor etiol��gico desencadeante da doen��a. E a experi��ncia do grupo de C.P.R.E./E.T.E. do Hospital dos Capuchos que iremos dar a conhecer no presente trabalho.

Women's Attachment as a Predictor of Pain During Labour and Post-Delivery: a Prospective Observational Study

INTRODUCTION: Labour is considered to be one of the most painful and significant experiences in a woman's life. The aim of this study was to examine whether women's attachment style is a predictor of the pain experienced throughout labour and post-delivery. MATERIAL AND METHODS:Thirty-two pregnant women were assessed during the third trimester of pregnancy and during labour. Adult attachment was assessed with the Adult Attachment Scale ' Revised. The perceived intensity of labour pain was measured using a visual analogue scale for pain in the early stage of labour, throughout labour and post-delivery. RESULTS:Women with an insecure attachment style reported more pain at 3 cm of cervical dilatation (p < 0.05), before the administration of analgesia (p < 0.01) and post-delivery (p < 0.05) than those securely attached. In multivariate models, attachment style was a significant predictor of labour pain at 3 cm of cervical dilatation and before the first administration of analgesia but not of the perceived pain post-delivery. DISCUSSION: These findings confirm that labour pain is influenced by relevant psychological factors and suggest that a woman's attachment style may be a risk factor for greater pain during labour. CONCLUSION:Future studies in the context of obstetric pain may consider the attachment style as an indicator of individual differences in the pain response during labour. This may have important implications in anaesthesiology and to promote a relevant shift in institutional practices and therapeutic procedures.

An��lise Estrutural do Segmento Anterior por Tomografia de Coer��ncia ��tica no Glaucoma Cong��nito Prim��rio

Objectivo: Analisar a morfologia do segmento anterior por tomografia de coer��ncia ��tica de segmento anterior (OCT-SA) em crian��as com glaucoma cong��nito prim��rio (GCP). Material e m��todos: Realizou-se um estudo caso-controlo, prospetivo, em crian��as com GCP e em crian��as sem glaucoma (grupo controlo), seguidas em Consulta de Oftalmologia Pedi��trica do Hospital Dona Estef��nia, Centro Hospitalar de Lisboa Central. Efectuou-se avalia����o oftalmol��gica completa e OCT-SA utilizando o protocolo A C biometry. Resultados: O estudo incluiu 27 olhos (17 crian��as com OCP) e 22 olhos (11 crian��as sem glaucoma). Detetaram-se valores significativamente superiores de profundidade central e largura da c��mara anterior (CA) (p<0,001) e maiores dist��ncias de abertura do ��ngulo a 500 CP<0,001) e 750��m (p=0,00 l), ��reas de espa��o irido-trabecular a 500 e 750��m (p<0,001) e ��reas do recesso do ��ngulo a 500 (p<0,00l) e 750��m (p=0,001), no grupo GCP. A espessura da ��ris foi significativamente mais fina a 500��m do ��ngulo (p=0,011), no centro da ��ris (p<0,001) e na regi��o mais espessa da mesma (p=0,001) no grupo GCP, assim como o comprimento da ��ris foi superior (p<0,001). A largura de CA e a acuidade visual (logMAR) apresentam correla����o positiva (r=0,688; p<0,001). Outros achados morfol��gicos: anterioriza����o e hipoplasia da ��ris, altera����o da morfologia do ��ngulo no local de interven����o cir��rgica (goniotomia, trabeculotornia, trabeculectomia, v��lvula de Ahmed). Conclus��o: Este primeiro estudo em crian��as com GCP sugere que a OCT-SA �� de aquisi����o relativamente f��cil, poder�� ajudar no seguimento cl��nico e cir��rgico e ser ��til como fator progn��stico destes doentes.

Produ����o de part��culas semelhantes a retrov��rus como candidatas a vacina para a Hepatite C

Disserta����o para obten����o do Grau de Mestre em Gen��tica Molecular e Biomedicina

O Santu��rio de Santa B��rbara de Padr��es ��� uma Perspectiva Religiosa e Art��stica na Lusit��nia dos S��culos I a III d. C.

Disserta����o apresentada para cumprimento dos requisitos necess��rios �� obten����o do grau de Mestre em Hist��ria da Arte ��� ��rea de especializa����o em Hist��ria da Arte da Antiguidade