Pas caart van de Oost zee verthoonende alle de ghelegentheyt tusschen't Eylandt Rugen en Wiborg - [Yleisnäkymä - Overview]

Amsterdam 1664

Pas caart van de Oost zee. Detalji.

Amsterdam 1664

Pas-kaart van Europa met een gedeelte van de kust van Africa tot aen Cabo verde - [Yleisnäkymä - Overview]

1 Amsterdam 1665

Nieuwe Paskaert voor een Gedeelte van de Oost Zee ... als mede de Kust van Oost Vinlandt - [Yleiskuva - Overview]

Amsterdam : Johannes van Keulen 1692

Konserttiohjelma 1898-12-05 - Ohjelma

Helsinki 1898

New biogeographical and morphological information on Physaloptera ngoci Le-Van-Hoa, 1961 (Nematoda: Physalopteridae) in South-east Asian rodents

During a study of the helminth fauna of 1,643 rodents trapped along the Mekong River (Thailand, LaoPeople"s Democratic Republic and Cambodia) in 2008-2011, the spirurid nematode Physaloptera ngoci Le-Van-Hoa,1961 was recovered with an overall prevalence of 2.8%. Based on the original description, it was identified in nine of 23 different Murinae host species and is here reported for the first time from these three countries. A scanning electron microscopy study provides additional morphological data.

DOMINIQUE VALÉRIAN (ed.) (Cyrille Aillet, Sophie Gilotte, AnnelieseNef, Christophe Picard, Jean-Pierre Van Staëvel, Élise Voguet):Islamisation et arabisation de l’Occident musulman médiéval (VIIe–XIIesiècle)

This book is the result of a one-year seminar series"Islam médiéval d"Occident (VIIe-XVe)", held at the Colegio de España in Paris in 2006-07 by the Association des doctorants en histoire des mondes musulmans médievaux (Diwan http://diwan.hypotheses.org), and a second volume focusing on Arabization is expected (p. 33). The contributors" experience, alongside their university and research backgrounds, have led to the publication of articles of an outstandingly high level throughout this book. This scholarly achievement is combined with a thought-provoking theoretical framework, where Arabization and Islamization give a common theme to the proceedings, which are developed in four parts.

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.