The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Autoria(s): Winkler T.W.; Justice A.E.; Graff M.; Barata L.; Feitosa M.F.; Chu S.; Czajkowski J.; Esko T.; Fall T.; Kilpeläinen T.O.; Lu Y.; Mägi R.; Mihailov E.; Pers T.H.; Rüeger S.; Teumer A.; Ehret G.B.; Ferreira T.; Heard-Costa N.L.; Karjalainen J.; Lagou V.; Mahajan A.; Neinast M.D.; Prokopenko I.; Simino J.; Teslovich T.M.; Jansen R.; Westra H.J.; White C.C.; Absher D.; Ahluwalia T.S.; Ahmad S.; Albrecht E.; Alves A.C.; Bragg-Gresham J.L.; de Craen A.J.; Bis J.C.; Bonnefond A.; Boucher G.; Cadby G.; Cheng Y.C.; Chiang C.W.; Delgado G.; Demirkan A.; Dueker N.; Eklund N.; Eiriksdottir G.; Eriksson J.; Feenstra B.; Fischer K.; Frau F.; Galesloot T.E.; Geller F.; Goel A.; Gorski M.; Grammer T.B.; Gustafsson S.; Haitjema S.; Hottenga J.J.; Huffman J.E.; Jackson A.U.; Jacobs K.B.; Johansson Å.; Kaakinen M.; Kleber M.E.; Lahti J.; Mateo Leach I.; Lehne B.; Liu Y.; Lo K.S.; Lorentzon M.; Luan J.; Madden P.A.; Mangino M.; McKnight B.; Medina-Gomez C.; Monda K.L.; Montasser M.E.; Müller G.; Müller-Nurasyid M.; Nolte I.M.; Panoutsopoulou K.; Pascoe L.; Paternoster L.; Rayner N.W.; Renström F.; Rizzi F.; Rose L.M.; Ryan K.A.; Salo P.; Sanna S.; Scharnagl H.; Shi J.; Smith A.V.; Southam L.; Stančáková A.; Steinthorsdottir V.; Strawbridge R.J.; Sung Y.J.; Tachmazidou I.; Tanaka T.; Thorleifsson G.; Trompet S.; Pervjakova N.; Tyrer J.P.; Vandenput L.; van der Laan S.W.; van der Velde N.; van Setten J.; van Vliet-Ostaptchouk J.V.; Verweij N.; Vlachopoulou E.; Waite L.L.; Wang S.R.; Wang Z.; Wild S.H.; Willenborg C.; Wilson J.F.; Wong A.; Yang J.; Yengo L.; Yerges-Armstrong L.M.; Yu L.; Zhang W.; Zhao J.H.; Andersson E.A.; Bakker S.J.; Baldassarre D.; Banasik K.; Barcella M.; Barlassina C.; Bellis C.; Benaglio P.; Blangero J.; Blüher M.; Bonnet F.; Bonnycastle L.L.; Boyd H.A.; Bruinenberg M.; Buchman A.S.; Campbell H.; Chen Y.D.; Chines P.S.; Claudi-Boehm S.; Cole J.; Collins F.S.; de Geus E.J.; de Groot L.C.; Dimitriou M.; Duan J.; Enroth S.; Eury E.; Farmaki A.E.; Forouhi N.G.; Friedrich N.; Gejman P.V.; Gigante B.; Glorioso N.; Go A.S.; Gottesman O.; Gräßler J.; Grallert H.; Grarup N.; Gu Y.M.; Broer L.; Ham A.C.; Hansen T.; Harris T.B.; Hartman C.A.; Hassinen M.; Hastie N.; Hattersley A.T.; Heath A.C.; Henders A.K.; Hernandez D.; Hillege H.; Holmen O.; Hovingh K.G.; Hui J.; Husemoen L.L.; Hutri-Kähönen N.; Hysi P.G.; Illig T.; De Jager P.L.; Jalilzadeh S.; Jørgensen T.; Jukema J.W.; Juonala M.; Kanoni S.; Karaleftheri M.; Khaw K.T.; Kinnunen L.; Kittner S.J.; Koenig W.; Kolcic I.; Kovacs P.; Krarup N.T.; Kratzer W.; Krüger J.; Kuh D.; Kumari M.; Kyriakou T.; Langenberg C.; Lannfelt L.; Lanzani C.; Lotay V.; Launer L.J.; Leander K.; Lindström J.; Linneberg A.; Liu Y.P.; Lobbens S.; Luben R.; Lyssenko V.; Männistö S.; Magnusson P.K.; McArdle W.L.; Menni C.; Merger S.; Milani L.; Montgomery G.W.; Morris A.P.; Narisu N.; Nelis M.; Ong K.K.; Palotie A.; Pérusse L.; Pichler I.; Pilia M.G.; Pouta A.; Rheinberger M.; Ribel-Madsen R.; Richards M.; Rice K.M.; Rice T.K.; Rivolta C.; Salomaa V.; Sanders A.R.; Sarzynski M.A.; Scholtens S.; Scott R.A.; Scott W.R.; Sebert S.; Sengupta S.; Sennblad B.; Seufferlein T.; Silveira A.; Slagboom P.E.; Smit J.H.; Sparsø T.H.; Stirrups K.; Stolk R.P.; Stringham H.M.; Swertz M.A.; Swift A.J.; Syvänen A.C.; Tan S.T.; Thorand B.; Tönjes A.; Tremblay A.; Tsafantakis E.; van der Most P.J.; Völker U.; Vohl M.C.; Vonk J.M.; Waldenberger M.; Walker R.W.; Wennauer R.; Widén E.; Willemsen G.; Wilsgaard T.; Wright A.F.; Zillikens M.C.; van Dijk S.C.; van Schoor N.M.; Asselbergs F.W.; de Bakker P.I.; Beckmann J.S.; Beilby J.; Bennett D.A.; Bergman R.N.; Bergmann S.; Böger C.A.; Boehm B.O.; Boerwinkle E.; Boomsma D.I.; Bornstein S.R.; Bottinger E.P.; Bouchard C.; Chambers J.C.; Chanock S.J.; Chasman D.I.; Cucca F.; Cusi D.; Dedoussis G.; Erdmann J.; Eriksson J.G.; Evans D.A.; de Faire U.; Farrall M.; Ferrucci L.; Ford I.; Franke L.; Franks P.W.; Froguel P.; Gansevoort R.T.; Gieger C.; Grönberg H.; Gudnason V.; Gyllensten U.; Hall P.; Hamsten A.; van der Harst P.; Hayward C.; Heliövaara M.; Hengstenberg C.; Hicks A.A.; Hingorani A.; Hofman A.; Hu F.; Huikuri H.V.; Hveem K.; James A.L.; Jordan J.M.; Jula A.; Kähönen M.; Kajantie E.; Kathiresan S.; Kiemeney L.A.; Kivimaki M.; Knekt P.B.; Koistinen H.A.; Kooner J.S.; Koskinen S.; Kuusisto J.; Maerz W.; Martin N.G.; Laakso M.; Lakka T.A.; Lehtimäki T.; Lettre G.; Levinson D.F.; Lind L.; Lokki M.L.; Mäntyselkä P.; Melbye M.; Metspalu A.; Mitchell B.D.; Moll F.L.; Murray J.C.; Musk A.W.; Nieminen M.S.; Njølstad I.; Ohlsson C.; Oldehinkel A.J.; Oostra B.A.; Palmer L.J.; Pankow J.S.; Pasterkamp G.; Pedersen N.L.; Pedersen O.; Penninx B.W.; Perola M.; Peters A.; Polašek O.; Pramstaller P.P.; Psaty B.M.; Qi L.; Quertermous T.; Raitakari O.T.; Rankinen T.; Rauramaa R.; Ridker P.M.; Rioux J.D.; Rivadeneira F.; Rotter J.I.; Rudan I.; den Ruijter H.M.; Saltevo J.; Sattar N.; Schunkert H.; Schwarz P.E.; Shuldiner A.R.; Sinisalo J.; Snieder H.; Sørensen T.I.; Spector T.D.; Staessen J.A.; Stefania B.; Thorsteinsdottir U.; Stumvoll M.; Tardif J.C.; Tremoli E.; Tuomilehto J.; Uitterlinden A.G.; Uusitupa M.; Verbeek A.L.; Vermeulen S.H.; Viikari J.S.; Vitart V.; Völzke H.; Vollenweider P.; Waeber G.; Walker M.; Wallaschofski H.; Wareham N.J.; Watkins H.; Zeggini E.; CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium; Chakravarti A.; Chakravarti A.; Clegg D.J.; Cupples L.A.; Gordon-Larsen P.; Jaquish C.E.; Rao D.C.; Abecasis G.R.; Assimes T.L.; Barroso I.; Berndt S.I.; Boehnke M.; Deloukas P.; Fox C.S.; Groop L.C.; Hunter D.J.; Ingelsson E.; Kaplan R.C.; McCarthy M.I.; Mohlke K.L.; O'Connell J.R.; Schlessinger D.; Strachan D.P.; Stefansson K.; van Duijn C.M.; Hirschhorn J.N.; Lindgren C.M.; Heid I.M.; North K.E.; Borecki I.B.; Kutalik Z.; Loos R.J.
Data(s)

2015
Resumo

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
Identificador

https://serval.unil.ch/?id=serval:BIB_4635F40FBD19

isbn:1553-7404 (Electronic)

pmid:26426971

doi:10.1371/journal.pgen.1005378

isiid:000364401600002

http://my.unil.ch/serval/document/BIB_4635F40FBD19.pdf

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4635F40FBD199
Idioma(s)

en
Direitos

info:eu-repo/semantics/openAccess
Fonte

Plos Genetics, vol. 11, no. 10, pp. e1005378
Palavras-Chave #Adult; Age Factors; Aged; Body Mass Index; Body Size/genetics; Chromosome Mapping; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Sex Characteristics; Waist-Hip Ratio
Tipo

info:eu-repo/semantics/article

article
Acesso ao item digital