1953 University of Michigan Football Team (full Squad)

Top Row: Ted Kress, Dave Williams, William McKinley, Larry Cox, Dave Hill, Dick Kolesar, Van Schoick, Earl Johnson, Bob Ames.

6th Row: Tony Branoff, Ed Hickey, Don Bennett, Dick Vorenkamp, Tom Hendricks, Doug Murray, Charles Ritter, Mike Orend, Carl Kamhout, Jim Kirby, Joe Krahl.

5th Row: Don Dugger, Jack Wheeler, Wilbur Brown, Jerry Gonser, Bob Sriver, Jim Bates, Ray Donohoe, Dick Strozewski, Dave Rentschler, John Kuchka, George Corey, Phil Endres.

4h Row: Gerry Williams, Gordon Barnes, Edgar Meads, Charles Krahnke, Fred Baer, Stanley Knickerbocker, Jim Fox, John Peckham, John Morrow, Dick Rex, Coach J. T. White.

3rd Row: Coach Don Robinson, Don Drake, Joe Shomsky, Lou Baldacci, Salvatore DiMucci, George Dutter, Ray Kenaga, George Muellich, Jim Bowman, Ted Cachey, Coach Bill Orwig.

2nd Row: Cliff Keen, Dean Ludwig, Duncan McDonald, Ken Shields, Peri Gagalis, Pete Wolgast, Bob Milligan, Ron Geyer, Dick Beison, Dan Cline, Art Walker, Coach Matt Patanelli.

Front Row: Wally Weber, John Veselenak, Tad Stanford, Gene Knutson, Dick Balzhiser, Captain Dick O'Shaughnessy; Head Coach Bennie Oosterbaan; Bob Marion, Bob Topp, Ray VanderZeyde, Ron Williams, Jim Balog, Jack Blott.

1953 University of Michigan Football Team (full Squad)

Top Row: Ted Kress, Dave Williams, William McKinley, Larry Cox, Dave Hill, Dick Kolesar, Van Schoick, Earl Johnson, Bob Ames.

6th Row: Tony Branoff, Ed Hickey, Don Bennett, Dick Vorenkamp, Tom Hendricks, Doug Murray, Charles Ritter, Mike Orend, Carl Kamhout, Jim Kirby, Joe Krahl.

5th Row: Don Dugger, Jack Wheeler, Wilbur Brown, Jerry Gonser, Bob Sriver, Jim Bates, Ray Donohoe, Dick Strozewski, Dave Rentschler, John Kuchka, George Corey, Phil Endres.

4h Row: Gerry Williams, Gordon Barnes, Edgar Meads, Charles Krahnke, Fred Baer, Stanley Knickerbocker, Jim Fox, John Peckham, John Morrow, Dick Rex, Coach J. T. White.

3rd Row: Coach Don Robinson, Don Drake, Joe Shomsky, Lou Baldacci, Salvatore DiMucci, George Dutter, Ray Kenaga, George Muellich, Jim Bowman, Ted Cachey, Coach Bill Orwig.

2nd Row: Cliff Keen, Dean Ludwig, Duncan McDonald, Ken Shields, Peri Gagalis, Pete Wolgast, Bob Milligan, Ron Geyer, Dick Beison, Dan Cline, Art Walker, Coach Matt Patanelli.

Front Row: Wally Weber, John Veselenak, Tad Stanford, Gene Knutson, Dick Balzhiser, Captain Dick O'Shaughnessy; Head Coach Bennie Oosterbaan; Bob Marion, Bob Topp, Ray VanderZeyde, Ron Williams, Jim Balog, Jack Blott.

Tales of humour and romance, selected from popular German writers,

Madame de Scuderi, by E.T. Hoffman.--The dishonoured irreclaimable, by F. Schiller.--The death of an angel, by J.P. Richter.--The moon, by J.P. Richter.--The bridegroom's probation, by A.T.[!] E. Langbein.--The broken leg, by A.T.[!] E. Langbein.--The haunted castle. by A. La Fontaine.--Woldemar, by T.C. Körner.--The harp, by T.C. Körner.

Ópera española. Ventajas que la lengua castellana ofrece para el melodrama demostradas con un ejemplo practico en la traduccion de la ópera italiana el Belisario arreglada a la letra y musica del original.

Text of Belisario in Italian and Spanish.

Poesie e lettere edite e di Salvator Rosa /

Mode of access: Internet.

Rehabilitar, castigar o neutralizar. Rupturas y continuidades de la cárcel moderna en Argentina

Enmarcados en las indagaciones preliminares sobre las experiencias de jóvenes en libertad ambulatoria que han atravesado un proceso de prisionización en la provincia de Buenos Aires, nos interrogamos sobre el contexto histórico de la "propuesta" carcelaria y las prácticas penitenciarias en su trayectoria histórica. En tanto institución donde disputaron su lugar ideas positivistas de la criminología cientificista, las propuestas penitenciarias "rehabilitantes", así como concepciones del "otro" como enemigo o desecho social, la prisión-laboratorio de los médicos y la prisión-fábrica de los penitenciarios convivieron en un proyecto común de cárcel-depósito. Miradas superpuestas, disciplinantes algunas, segregacionistas otras, o con la ilusión profiláctica de cárceles que luego fueron "galpones", pugnaron el sentido de la cárcel en forma simultánea desde fines del siglo XIX hasta nuestros días. Resulta evidente, a partir del trabajo de Lila Caimari y Ricardo Salvatore, que estas miradas han sufrido modificaciones durante la primera mitad del siglo XX, aunque no existan trabajos que relacionen este período con la actualidad. Es así que en esta ponencia me propongo analizar algunos cambios en particular que aparecen en la práctica carcelaria actual en relación a los estudios históricos, incorporando al período de la dictadura 1976-1983 como profundo clivaje histórico

Pax9 and Jagged1 act downstream of Gli3 in vertabrate limb development

From early in limb development the transcription factor Gli3 acts to define boundaries of gene expression along the anterior-posterior (AP) axis, establishing asymmetric patterns required to provide positional information. As limb development proceeds, posterior mesenchyme expression of Sonic hedgehog (Shh) regulates Gli3 transcription and post-translational processing to specify digit number and identity. The molecular cascades dependent on Gli3 at later stages of limb development, which link early patterning events with final digit morphogenesis, remain poorly characterised. By analysing the transcriptional consequences of loss of Gli3 in the anterior margin of the E11.5 and E12.5 limb bud in the polydactylous mouse mutant extra-toes (Gli3(Xt/Xt)), we have identified a number of known and novel transcripts dependent on Gli3 in the limb. In particular, we demonstrated that the genes encoding the paired box transcription factor Pax9, the Notch ligand Jagged1 and the cell surface receptor Cdo are dependent on Gli3 for correct expression in the anterior limb mesenchyme. Analysis of expression in compound Shh;Gli3 mutant mouse embryos and in both in vitro and in vivo Shh signaling assays, further defined the importance of Shh regulated processing of Gli3 in controlling gene expression. In particular Pax9 regulation by Shh and Gli3 was shown to be context dependent, with major differences between the limb and somite revealed by Shh bead implantation experiments in the chick. Jagged1 was shown to be induced by Shh in the chick limb and in a C3H10T1/2 cell based signaling assay, with Shh;Gli3 mutant analysis indicating that expression is dependent on Gli3 derepression. Our data have also revealed that perturbation of early patterning events within the Gli3(Xt/Xt), limb culminates in a specific delay of anterior chondrogenesis which is subsequently realised as extra digits. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Enhancement of drug affinity for cell membranes by conjugation with lipoamino acids II. Experimental and computational evidence using biomembrane models

Lipoamino acids (LAAs) are promoieties able to enhance the amphiphilicity of drugs, facilitating their interaction with cell membranes. Experimental and computational studies were carried out on two series of lipophilic amide conjugates between a model drug (tranylcypromine, TCP) and LAA or alkanoic acids containing a short, medium or long alkyl side chain (C-4 to C-16). The effects of these compounds were evaluated by monolayer surface tension analysis and differential scanning calorimetry using dimyristoylphosphatidylcholine nnonolayers and liposomes as biomembrane models. The experimental results were related to independent calculations to determine partition coefficient and blood-brain partitioning. The comparison of TCP-LAA conjugates with the related series of TCP alkanoyl amides confirmed that the ability to interact with the biomembrane models is not due to the mere increase of lipophilicity, but mainly to the amphipatic nature and the kind of LAA residue. (C) 2005 Elsevier B.V. All rights reserved.

Discovering the preferences of physicians with regards to rank-ordered medical documents

The practice of evidence-based medicine involves consulting documents from repositories such as Scopus, PubMed, or the Cochrane Library. The most common approach for presenting retrieved documents is in the form of a list, with the assumption that the higher a document is on a list, the more relevant it is. Despite this list-based presentation, it is seldom studied how physicians perceive the importance of the order of documents presented in a list. This paper describes an empirical study that elicited and modeled physicians' preferences with regard to list-based results. Preferences were analyzed using a GRIP method that relies on pairwise comparisons of selected subsets of possible rank-ordered lists composed of 3 documents. The results allow us to draw conclusions regarding physicians' attitudes towards the importance of having documents ranked correctly on a result list, versus the importance of retrieving relevant but misplaced documents. Our findings should help developers of clinical information retrieval applications when deciding how retrieved documents should be presented and how performance of the application should be assessed. © 2012 Springer-Verlag Berlin Heidelberg.

Transglutaminase 2 interaction with small heat shock proteins mediate cell survival upon excitotoxic stress

Transglutaminase 2 has been postulated to be involved in the pathogenesis of central nervous system neurodegenerative disorders. However, its role in neuronal cell death remains to be elucidated. Excitotoxicity is a common event underlying neurodegeneration. We aimed to evaluate the protein targets for transglutaminase 2 in cell response to NMDA-induced excitotoxic stress, using SH-SY5Y neuroblastoma cells which express high tranglutaminase 2 levels upon retinoic acid-driven differentiation toward neurons. NMDA-evoked calcium increase led to transglutaminase 2 activation that mediated cell survival, as at first suggested by the exacerbation of NMDA toxicity in the presence of R283, a synthetic competitive inhibitor of transglutaminase active site. Assays of R283-mediated transglutaminase inhibition showed the involvement of enzyme activity in NMDA-induced reduction in protein basal levels of pro-apoptotic caspase-3 and the stress protein Hsp20. However, this occurred in a way different from protein cross-linking, given that macromolecular assemblies were not observed in our experimental conditions for both proteins. Co-immunoprecipitation experiments provided evidence for the interaction, in basal conditions, between transglutaminase 2 and Hsp20, as well as between Hsp20 and Hsp27, a major anti-apoptotic protein promoting caspase-3 inactivation and degradation. NMDA treatment disrupted both these interactions that were restored upon transglutaminase 2 inhibition with R283. These results suggest that transglutaminase 2 might be protective against NMDA-evoked excitotoxic insult in neuronal-like SH-SY5Y cells in a way, independent from transamidation that likely involves its interaction with the complex Hsp20/Hsp27 playing a pro-survival role. © 2011 Springer-Verlag.

Perceiving Spanish in Miami: The Interaction of Dialect and National Labeling

The current study implements a speech perception experiment that interrogates local perceptions of Spanish varieties in Miami. Participants (N=292) listened to recordings of three Spanish varieties (Peninsular, Highland Colombian, and Post-Castro Cuban) and were given background information about the speakers, including the parents’ country of origin. In certain cases, the parents’ national-origin label matched the country of origin of the speaker, but otherwise the background information and voices were mismatched. The manipulation distinguishes perceptions determined by bottom-up cues (dialect) from top-down ones (social information). Participants then rated each voice for a range of personal characteristics and answered hypothetical questions about the speakers’ employment, family, and income. Results show clear top-down effects of the social information that often drive perceptions up or down depending on the traits themselves. Additionally, the data suggest differences in perceptions between Hispanic/non-Hispanic and Cuban/non-Cuban participants, although the Cuban participants do not drive the Hispanic participants’ perceptions.

Recognition and importance of amalgamated sandy meander belts in the continental rock record

Date of Acceptance: 27/05/2015

Fluvial geomorphic elements in modern sedimentary basins and their potential preservation in the rock record : A review

We appreciate very helpful reviews by Dr. Martin Stokes and three anonymous reviewers and editor Dr. Richard Marston. We also appreciate the encouragement for writing this paper from Dr. Timothy Horscroft. We acknowledge support of the sponsors of the Fluvial Systems Research Group consortium, BP, BG, Chevron, ConocoPhillips and Total.