Spatio-temporal patterns of tuberculosis incidence in Ribeirão Preto, State of São Paulo, southeast Brazil, and their relationship with social vulnerability: a Bayesian analysis

INTRODUCTION: The purpose of this ecological study was to evaluate the urban spatial and temporal distribution of tuberculosis (TB) in Ribeirão Preto, State of São Paulo, southeast Brazil, between 2006 and 2009 and to evaluate its relationship with factors of social vulnerability such as income and education level. METHODS: We evaluated data from TBWeb, an electronic notification system for TB cases. Measures of social vulnerability were obtained from the SEADE Foundation, and information about the number of inhabitants, education and income of the households were obtained from Brazilian Institute of Geography and Statistics. Statistical analyses were conducted by a Bayesian regression model assuming a Poisson distribution for the observed new cases of TB in each area. A conditional autoregressive structure was used for the spatial covariance structure. RESULTS: The Bayesian model confirmed the spatial heterogeneity of TB distribution in Ribeirão Preto, identifying areas with elevated risk and the effects of social vulnerability on the disease. We demonstrated that the rate of TB was correlated with the measures of income, education and social vulnerability. However, we observed areas with low vulnerability and high education and income, but with high estimated TB rates. CONCLUSIONS: The study identified areas with different risks for TB, given that the public health system deals with the characteristics of each region individually and prioritizes those that present a higher propensity to risk of TB. Complex relationships may exist between TB incidence and a wide range of environmental and intrinsic factors, which need to be studied in future research.

The 3C cooperation model applied to the classical requirement analysis

Aspects related to the users' cooperative work are not considered in the traditional approach of software engineering, since the user is viewed independently of his/her workplace environment or group, with the individual model generalized to the study of collective behavior of all users. This work proposes a process for software requirements to address issues involving cooperative work in information systems that provide distributed coordination in the users' actions and the communication among them occurs indirectly through the data entered while using the software. To achieve this goal, this research uses ergonomics, the 3C cooperation model, awareness and software engineering concepts. Action-research is used as a research methodology applied in three cycles during the development of a corporate workflow system in a technological research company. This article discusses the third cycle, which corresponds to the process that deals with the refinement of the cooperative work requirements with the software in actual use in the workplace, where the inclusion of a computer system changes the users' workplace, from the face to face interaction to the interaction mediated by the software. The results showed that the highest degree of users' awareness about their activities and other system users contribute to a decrease in their errors and in the inappropriate use of the system.

Desarrollo de interfaces de usuario para una herramienta de telecontrol y automatización industrial

[ES] Este proyecto de fin de carrera aborda la actualización y refactorización de la aplicación Hecaton. Esta aplicación permite la monitorización y actuación en instalaciones industriales de manera remota a través de un interfaz web. Para ello hace uso de sensores y actuadores que, conectados a través de un equipo de adquisición de datos a un sistema informático servidor, permiten obtener, manipular y almacenar los datos y eventos recibidos. Hecaton ha sido desarrollado enteramente utilizando software libre. Además, el sistema permite ser personalizado, lo que posibilita su uso en todo tipo de escenarios, siendo el usuario quién define las reglas de funcionamiento. Este trabajo se trata del cuarto ciclo de desarrollo, pues la aplicación ha sido crea y ampliada en otros tres proyectos. En este último desarrollo se han actualizado las tecnologías y herramientas que forman parte de la aplicación. Se ha puesto especial énfasis en el rediseño de la interfaz web, adoptando el uso de las últimas tecnologías web que permiten un funcionamiento dinámico de la misma. Por otro lado se han corregido algunos errores de diseño e introducido el uso de nuevas herramientas para la gestión del proyecto software. Se trata por lo tanto de un ejercicio de refactorización software donde se ha puesto especial atención en conseguir un proyecto actualizado y que utilice metodologías de desarrollo actuales y que posibilite que sea actualizado en un futuro.

Metodi numerici per lo studio di centri di lavoro ad alta velocità

A Machining Centre is nowadays a complex mechanical, electronic, electrical system that needs integrated design capabilities which very often require a high time-consuming effort. Numerical techniques for designing and dimensioning the machine structure and components usually requires different knowledge according to the system that have to be designed. This Ph. D Thesis is related about the efforts of the Authors to develop a system that allows to perform the complete project of a new machine optimized in its dynamic behaviour. An integration of the different systems developed, each of which respond to specific necessities of designer, is here presented. In particular a dynamic analysis system, based on a lumped mass approach, that rapidly allows to setup the drives of the machine and an Integrated Dynamic Simulation System, based on a FEM approach, that permit a dynamic optimization, are shown. A multilevel Data Base, and an operator interface module provide to complete the designing platform. The proposed approach represents a significant step toward the virtual machining for the prediction of the quality of the worked surface.

Analysis of charge-transport properties in GST materials for next generation phase-change memory devices

The quest for universal memory is driving the rapid development of memories with superior all-round capabilities in non-volatility, high speed, high endurance and low power. The memory subsystem accounts for a significant cost and power budget of a computer system. Current DRAM-based main memory systems are starting to hit the power and cost limit. To resolve this issue the industry is improving existing technologies such as Flash and exploring new ones. Among those new technologies is the Phase Change Memory (PCM), which overcomes some of the shortcomings of the Flash such as durability and scalability. This alternative non-volatile memory technology, which uses resistance contrast in phase-change materials, offers more density relative to DRAM, and can help to increase main memory capacity of future systems while remaining within the cost and power constraints. Chalcogenide materials can suitably be exploited for manufacturing phase-change memory devices. Charge transport in amorphous chalcogenide-GST used for memory devices is modeled using two contributions: hopping of trapped electrons and motion of band electrons in extended states. Crystalline GST exhibits an almost Ohmic I(V) curve. In contrast amorphous GST shows a high resistance at low biases while, above a threshold voltage, a transition takes place from a highly resistive to a conductive state, characterized by a negative differential-resistance behavior. A clear and complete understanding of the threshold behavior of the amorphous phase is fundamental for exploiting such materials in the fabrication of innovative nonvolatile memories. The type of feedback that produces the snapback phenomenon is described as a filamentation in energy that is controlled by electron–electron interactions between trapped electrons and band electrons. The model thus derived is implemented within a state-of-the-art simulator. An analytical version of the model is also derived and is useful for discussing the snapback behavior and the scaling properties of the device.

Lokalisation und Quantifizierung von 4-Hydroxynonenal in der Kochlea des Meerschweinchens nach Applikation von Gentamicin

Einleitung und Literaturdiskussion: Gentamicin ist ein aus Bakterien gewonnenes Aminoglykosid-Antibiotikum, das seit vielen Jahren im klinischen Alltag zur Therapie von bakteriellen Infektionen und zur Behandlung des Morbus Ménière eingesetzt wird. Ein bedeutender, jedoch noch nicht vollständig verstandener, Pathomechanismus ist dabei die Entstehung von 4-HNE durch Lipid Peroxidation und die konsekutive Schädigung durch das gebildete Aldehyd. Ziel dieser Arbeit war es, die Beeinflussung der Expression von 4-HNE in sieben verschiedenen Regionen der Kochlea (SV, SL, CO, NF, LF, IDZ und SGZ) durch Gentamicin zu beschreiben und quantitativ zu ermitteln.rnMaterial und Methoden: Die Meerschweinchen wurden in vier Gruppen unterteilt: eine unbehandelte Kontrollgruppe und je eine Gruppe 1, 2 und 7 Tage nach Gentamicin-Applikation. Nach Ablauf der Inkubationszeit wurden die Kochleae den Tieren entnommen, das Gewebe fixiert, geschnitten und auf Objektträgern aufgebracht. Die Schnitte wurden mit 4-HNE-Antikörpern behandelt und die Immunreaktion mikroskopisch lokalisiert und zelluläre quantitative Unterschiede am Computer berechnet.rnErgebnisse: Die Auswertung der Daten ergab signifikante Anstiege der Immunreaktion auf 4-HNE von der Kontrollgruppe zu allen drei Behandlungsgruppen in vier der sieben untersuchten Regionen (Stria vascularis, Spirales Ligament, Cortisches Organ und Nervenfasern). In zwei Bereichen (Fibrozyten im Limbus und Interdentalzellen) kam es zwischen Kontrollgruppe und nur einer Behandlungsgruppe D (7d) zu einer signifikanten Erhöhung. Lediglich die Spiralganglionzellen erbrachten keine signifikanten Differenzen. Der Vergleich der Einzelwindungen erbrachte für die Stria vascularis, das Spirale Ligament, das Cortische Organ und die Nervenfasern signifikante Anstiege innerhalb der drei Windungen von der Kontrollgruppe zu den drei Behandlungsgruppen. Bei der Stria vascularis zeigte sich als einzige Region eine signifikant erhöhte Immunfärbung in allen drei Einzelwindungen von der Kontrollgruppe zu allen Behandlungsgruppen. Beim Vergleich der Gesamtwindungen ließ sich ausschließlich für die Region der Stria vascularis von der ersten zur dritten Windung ein Anstieg der Braunfärbung feststellen. Zudem konnten Korrelationen der Färbeintensitäten einerseits zwischen den beiden Regionen der Lateralen Wand und andererseits zwischen zwei Zelltypen im Limbus aufgezeigt werden.rnDiskussion: Die durch Gentamicin-gesteigerte 4-HNE-Expression kann durch genomische und nicht-genomische Prozesse hervorgerufen werden.

On a Microcomputer Implementation of an Intrusion-detection Algorithm

The main objective of this paper is to discuss various aspects of implementing a specific intrusion-detection scheme on a micro-computer system using fixed-point arithmetic. The proposed scheme is suitable for detecting intruder stimuli which are in the form of transient signals. It consists of two stages: an adaptive digital predictor and an adaptive threshold detection algorithm. Experimental results involving data acquired via field experiments are also included.

You Can't Touch This: Touch-free Navigation Through Radiological Images

Keyboards, mice, and touch screens are a potential source of infection or contamination in operating rooms, intensive care units, and autopsy suites. The authors present a low-cost prototype of a system, which allows for touch-free control of a medical image viewer. This touch-free navigation system consists of a computer system (IMac, OS X 10.6 Apple, USA) with a medical image viewer (OsiriX, OsiriX foundation, Switzerland) and a depth camera (Kinect, Microsoft, USA). They implemented software that translates the data delivered by the camera and a voice recognition software into keyboard and mouse commands, which are then passed to OsiriX. In this feasibility study, the authors introduced 10 medical professionals to the system and asked them to re-create 12 images from a CT data set. They evaluated response times and usability of the system compared with standard mouse/keyboard control. Users felt comfortable with the system after approximately 10 minutes. Response time was 120 ms. Users required 1.4 times more time to re-create an image with gesture control. Users with OsiriX experience were significantly faster using the mouse/keyboard and faster than users without prior experience. They rated the system 3.4 out of 5 for ease of use in comparison to the mouse/keyboard. The touch-free, gesture-controlled system performs favorably and removes a potential vector for infection, protecting both patients and staff. Because the camera can be quickly and easily integrated into existing systems, requires no calibration, and is low cost, the barriers to using this technology are low.

An Intelligent Assistant for Public Transport Management

This paper describes the architecture of a computer system conceived as an intelligent assistant for public transport management. The goal of the system is to help operators of a control center in making strategic decisions about how to solve problems of a fleet of buses in an urban network. The system uses artificial intelligence techniques to simulate the decision processes. In particular, a complex knowledge model has been designed by using advanced knowledge engineering methods that integrates three main tasks: diagnosis, prediction and planning. Finally, the paper describes two particular applications developed following this architecture for the cities of Torino (Italy) and Vitoria (Spain).

Hydrologic models for emergency decision support using Bayesian networks

In the presence of a river flood, operators in charge of control must take decisions based on imperfect and incomplete sources of information (e.g., data provided by a limited number sensors) and partial knowledge about the structure and behavior of the river basin. This is a case of reasoning about a complex dynamic system with uncertainty and real-time constraints where bayesian networks can be used to provide an effective support. In this paper we describe a solution with spatio-temporal bayesian networks to be used in a context of emergencies produced by river floods. In the paper we describe first a set of types of causal relations for hydrologic processes with spatial and temporal references to represent the dynamics of the river basin. Then we describe how this was included in a computer system called SAIDA to provide assistance to operators in charge of control in a river basin. Finally the paper shows experimental results about the performance of the model.

Pelvic Floor Muscle Training Included in a Pregnancy Exercise Program Is Effective in Primary Prevention of Urinary Incontinence: A Randomized Controlled Trial

AIMS: To investigate the effect of pelvic floor muscle training (PFMT) taught in a general exercise class during pregnancy on the prevention of urinary incontinence (UI) in nulliparous continent pregnant women. METHODS: This was a unicenter two armed randomized controlled trial. One hundred sixty-nine women were randomized by a central computer system to an exercise group (EG) (exercise class including PFMT) (n = 73) or a control group (CG) (n = 96). 10.1% loss to follow-up: 10 from EG and 7 from CG. The intervention consisted of 70-75 sessions (22 weeks, three times per week, 55-60 min/session including 10 min of PFMT). The CG received usual care (which included follow up by midwifes including information about PFMT). Questions on prevalence and degree of UI were posed before (week 10-14) and after intervention (week 36-39) using the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF). RESULTS: At the end of the intervention, there was a statistically significant difference in favor of the EG. Reported frequency of UI [Never: CG: 54/60.7%, EG: 60/95.2% (P < 0.001)]. Amount of leakage [None: CG: 45/60.7%, EG: 60/95.2% (P < 0.001)]. There was also a statistically significant difference in ICIQ-UI SF Score between groups after the intervention period [CG: 2.7 (SD 4.1), EG: 0.2 (SD 1.2) (P < 0.001)]. The estimated effect size was 0.8. CONCLUSION: PFMT taught in a general exercise class three times per week for at least 22 weeks, without former assessment of ability to perform a correct contraction was effective in primary prevention of UI in primiparous pregnant women.

Diseño de un sistema para el manejo a distancia de aeronaves construidas con arduino

El principal objetivo del proyecto es intentar reducir los costes de algunas de las operaciones de vigilancia llevadas a cabo por agencias o instituciones de seguridad. El proyecto consiste en diseñar y desarrollar un sistema informático que permita el manejo a distancia de un cuadricóptero a través de un ordenador, utilizando el teclado y visualizando las imágenes recibidas del módulo de la videocámara. Cada cuadricóptero estará compuesto de diferentes módulos y cada módulo tiene una funcionalidad característica. Se desarrollará un sistema de gestión de aeronaves para poder añadir nuevas unidades de cuadricópteros, así como un sistema de gestión de usuarios para administrar los usuarios en el sistema. Adicionalmente, se construirá un prototipo de cuadricóptero y se implementará su unidad controladora para poder realizar las pruebas del sistema desarrollado con ello. ---ABSTRACT---The aim of this project is to attempt to reduce the costs of some surveillance services offered by security agencies or institutions. The project consists in designing and developing a computer system to remotely control a drone or quad-copter through a computer, manipulating the drone through the keyboard and watching the images captured from the camera module. Each drone is built with one or more modules, and each module has its own functionality. Both new drones and new users can be added to the computer system through the drone management system and the user management system, respectively. Both of management systems are going to be developed. The project also includes the making of a quad-copter prototype and a controller unit implementation.

Sistema para el análisis del consumo eléctrico y optimización en la contratación del suministro

El presente trabajo se enmarca en el ámbito de la eficiencia energética y contempla la gestión del consumo eléctrico en hogares. Concretamente, para este proyecto fin de grado se propone el desarrollo de un sistema informático que permita el análisis y monitorización del consumo eléctrico y optimización en la contratación del suministro eléctrico en el hogar. El sistema desarrollado permite la monitorización del consumo eléctrico, expresado en kilovatios-hora (kWh), y la monitorización del coste real de dicho consumo, expresado en euros, en función del tipo de tarifa que se tenga contratada en la modalidad del PVPC1 (Precio Voluntario para el Pequeño Consumidor). También se ha desarrollado una interfaz web a través de la cual el usuario tiene acceso a la información y datos del sistema. En dicha web se muestran gráficas de consumo, potencia, voltaje, corriente y coste de la energía por días. Además, se ha dotado al sistema de un generador de alertas que notifica al usuario, vía web y vía correo electrónico, cuando el consumo sobrepasa los límites fijados por él mismo. El usuario, por tanto, podrá definir los valores de alerta de sobreconsumo y visualizar tanto un histórico de las alertas generadas en el pasado como las alertas activas en ese momento. Las alertas se muestran en la gráfica correspondiente dentro de la aplicación web. Por último, se dispone de la opción de exportar las gráficas que son visualizadas en la aplicación web en formato PNG, JPEG, PDF y SVG, además de la posibilidad de imprimirla.---ABSTRACT---This project belongs to the Energy Efficiency field and is aimed at home energy management. Specifically, for this thesis the development of a computer system that allows monitoring and analysis of energy consumption and contracted power optimization is proposed. The developed system allows energy consumption management within households (expressed in kilowatts per hour, kWh) and real cost monitoring (in euros) according to the contract tariff. A web interface has been developed in order to provide the user with power consumption information and control energy tools. In this web application, electric consumption, power, voltage, current and energy cost by day are shown. Besides, an alert generation system has been implemented so that the user can define maximum power consumption values and be informed through email or web when these values are exceeded. The user will be able to check older power alerts as well as the currently active ones. These alerts are shown in a specific graph within the web application. Finally, the user generated graphs can be exported from the web using PNG, JPEG, PDF or SVG image formats as well as be printed from the web.

Microinformática en entornos profesionales : instalación, configuración, mantenimiento y reparación

Los sistemas microinformáticos se componen principalmente de hardware y software, con el paso del tiempo el hardware se degrada, se deteriora y en ocasiones se avería. El software evoluciona, requiere un mantenimiento, de actualización y en ocasiones falla teniendo que ser reparado o reinstalado. A nivel hardware se analizan los principales componentes que integran y que son comunes en gran parte estos sistemas, tanto en equipos de sobre mesa como portátiles, independientes del sistema operativo, además de los principales periféricos, también se analizan y recomiendan algunas herramientas necesarias para realizar el montaje, mantenimiento y reparación de estos equipos. Los principales componentes hardware internos son la placa base, memoria RAM, procesador, disco duro, carcasa, fuente de alimentación y tarjeta gráfica. Los periféricos más destacados son el monitor, teclado, ratón, impresora y escáner. Se ha incluido un apartado donde se detallan los distintos tipos de BIOS y los principales parámetros de configuración. Para todos estos componentes, tanto internos como periféricos, se ha realizado un análisis de las características que ofrecen y los detalles en los que se debe prestar especial atención en el momento de seleccionar uno frente a otro. En los casos que existen diferentes tecnologías se ha hecho una comparativa entre ambas, destacando las ventajas y los inconvenientes de unas frente a otras para que sea el usuario final quien decida cual se ajusta mejor a sus necesidades en función de las prestaciones y el coste. Un ejemplo son las impresoras de inyección de tinta frente a las laser o los discos duros mecánicos en comparación con y los discos de estado sólido (SSD). Todos estos componentes están relacionados, interconectados y dependen unos de otros, se ha dedicado un capítulo exclusivamente para estudiar cómo se ensamblan estos componentes, resaltando los principales fallos que se suelen cometer o producir y se han indicado unas serie tareas de mantenimiento preventivo que se pueden realizar para prolongar la vida útil del equipo y evitar averías por mal uso. Los mantenimientos se pueden clasificar como predictivo, perfectivo, adaptativo, preventivo y correctivo. Se ha puesto el foco principalmente en dos tipos de mantenimiento, el preventivo descrito anteriormente y en el correctivo, tanto software como hardware. El mantenimiento correctivo está enfocado al análisis, localización, diagnóstico y reparación de fallos y averías hardware y software. Se describen los principales fallos que se producen en cada componente, cómo se manifiestan o qué síntomas presentan para poder realizar pruebas específicas que diagnostiquen y acoten el fallo. En los casos que es posible la reparación se detallan las instrucciones a seguir, en otro caso se recomienda la sustitución de la pieza o componente. Se ha incluido un apartado dedicado a la virtualización, una tecnología en auge que resulta muy útil para realizar pruebas de software, reduciendo tiempos y costes en las pruebas. Otro aspecto interesante de la virtualización es que se utiliza para montar diferentes servidores virtuales sobre un único servidor físico, lo cual representa un importante ahorro en hardware y costes de mantenimiento, como por ejemplo el consumo eléctrico. A nivel software se realiza un estudio detallado de los principales problemas de seguridad y vulnerabilidades a los que está expuesto un sistema microinformático enumerando y describiendo el comportamiento de los distintos tipos de elementos maliciosos que pueden infectar un equipo, las precauciones que se deben tomar para minimizar los riesgos y las utilidades que se pueden ejecutar para prevenir o limpiar un equipo en caso de infección. Los mantenimientos y asistencias técnicas, en especial las de tipo software, no siempre precisan de la atención presencial de un técnico cualificado, por ello se ha dedicado un capítulo a las herramientas de asistencia remota que se pueden utilizar en este ámbito. Se describen algunas de las más populares y utilizadas en el mercado, su funcionamiento, características y requerimientos. De esta forma el usuario puede ser atendido de una forma rápida, minimizando los tiempos de respuesta y reduciendo los costes. ABSTRACT Microcomputer systems are basically made up of pieces of hardware and software, as time pass, there’s a degradation of the hardware pieces and sometimes failures of them. The software evolves, new versions appears and requires maintenance, upgrades and sometimes also fails having to be repaired or reinstalled. The most important hardware components in a microcomputer system are analyzed in this document for a laptop or a desktop, with independency of the operating system they run. In addition to this, the main peripherals and devices are also analyzed and a recommendation about the most proper tools necessary for maintenance and repair this kind of equipment is given as well. The main internal hardware components are: motherboard, RAM memory, microprocessor, hard drive, housing box, power supply and graphics card. The most important peripherals are: monitor, keyboard, mouse, printer and scanner. A section has been also included where different types of BIOS and main settings are listed with the basic setup parameters in each case. For all these internal components and peripherals, an analysis of their features has been done. Also an indication of the details in which special attention must be payed when choosing more than one at the same time is given. In those cases where different technologies are available, a comparison among them has been done, highlighting the advantages and disadvantages of selecting one or another to guide the end user to decide which one best fits his needs in terms of performance and costs. As an example, the inkjet vs the laser printers technologies has been faced, or also the mechanical hard disks vs the new solid state drives (SSD). All these components are interconnected and are dependent one to each other, a special chapter has been included in order to study how they must be assembled, emphasizing the most often mistakes and faults that can appear during that process, indicating different tasks that can be done as preventive maintenance to enlarge the life of the equipment and to prevent damage because of a wrong use. The different maintenances can be classified as: predictive, perfective, adaptive, preventive and corrective. The main focus is on the preventive maintains, described above, and in the corrective one, in software and hardware. Corrective maintenance is focused on the analysis, localization, diagnosis and repair of hardware and software failures and breakdowns. The most typical failures that can occur are described, also how they can be detected or the specific symptoms of each one in order to apply different technics or specific tests to diagnose and delimit the failure. In those cases where the reparation is possible, instructions to do so are given, otherwise, the replacement of the component is recommended. A complete section about virtualization has also been included. Virtualization is a state of the art technology that is very useful especially for testing software purposes, reducing time and costs during the tests. Another interesting aspect of virtualization is the possibility to have different virtual servers on a single physical server, which represents a significant savings in hardware inversion and maintenance costs, such as electricity consumption. In the software area, a detailed study has been done about security problems and vulnerabilities a microcomputer system is exposed, listing and describing the behavior of different types of malicious elements that can infect a computer, the precautions to be taken to minimize the risks and the tools that can be used to prevent or clean a computer system in case of infection. The software maintenance and technical assistance not always requires the physical presence of a qualified technician to solve the possible problems, that’s why a complete chapter about the remote support tools that can be used to do so has been also included. Some of the most popular ones used in the market are described with their characteristics and requirements. Using this kind of technology, final users can be served quickly, minimizing response times and reducing costs.