975 resultados para Androstane-3,17-diol -- metabolism


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Der Beitrag gibt einen Überblick über die ikonographische Hintergründe der Ketubim, die für eine feministische Exegese besonders relevant sind.

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Birth defects are a leading cause of infant mortality in the developed countries. They are also of increasing concern in many developing countries, such as China. However, prevalence and causes of birth defects in China are inadequately understood.^ The purpose of the present study was to estimated prevalence of birth defects in surviving children under seven years of age in Tianjin, China and investigate determinants of birth defects in the study area.^ The present study took place in Tianjin, China in 1986, involving 22,081 surviving children under seven years of age. Children with birth defects were ascertained through physical examinations by physicians during household visits and ascertainment of birth defects was verified through multiple sources. Of 22,081 surviving children, 524 had birth defects (23.7 per 1,000). The study noted a striking discrepancy in the prevalence of birth defects between urban and rural area. The prevalence of birth defects was 16.3 per 1,000 in the urban and 33.2 per 1,000 in the rural area.^ Using cases of birth defects ascertained from surviving children, a case-control study was carried out. The study observed that first-trimester maternal flu was associated with increased risk of both major and minor birth defects in children after controlling for other maternal factors (adjusted odds ratio (OR) = 8.7, 95% confidence interval (CI) = 4.3-17.3; OR = 3.6, 95% CI = 1.7-7.5). This association could be biased by different reporting of exposure between mothers of children with birth defects and mothers of children without defects. This study indicated that maternal flu was also associated with congenital heart defects and polydactyly after controlling for other maternal factors (adjusted OR = 32.3, 95% CI = 13.3-78.3; adjusted OR = 5.5, 95% CI = 1.1-27.7). The associations remained when affected controls (children with similar birth defects other than congenital heart defects or polydactyly) were used (adjusted OR = 4.3, 95% CI = 1.2-15.3; OR = 1.4, 95% CI = 1.4-7.9). A weak association between first-trimester vaginal bleeding and selected groups of birth defects was found in this study, but the association may be confounded by other factors. Maternal smoking during pregnancy was modestly associated with cleft lip with or without cleft palate (OR = 1.4, 95% = 0.4-4.9), but the association may be due to chance. Some major limitations in this study warrant caution in interpretation of the findings, especially the causal relation. ^

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Die Auseinandersetzung mit der Trauer und ihren Prozessen eröffnet ein faszinierendes Gebiet. Die Psychologie der Trauer hat in den vergangenen Jahren zahlreiche Erkenntnisse erbracht und vermeintliches Wissen als Meinung entlarvt, das wenig mit der Wirklichkeit, viel aber mit Vorstellungen und kulturellen Überlieferungen zu tun hat. Die einzelnen Kapitel des Buches bauen aufeinander auf und beschäftigen sich mit einzelnen großen Themen wie etwa der allgemeinen Trauer oder der psychologischen Therapie von komplizierter Trauer. Das Buch berücksichtigt die möglichen langfristigen Folgen eines Verlustes und zeigt differentialdiagnostisch auf, welche Störungen mit einer Komplizierten Trauer komorbid sein können.

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BACKGROUND Cytomegalovirus (CMV) replication has been associated with more risk for solid organ graft rejection. We wondered whether this association still holds when patients at risk receive prophylactic treatment for CMV. METHODS We correlated CMV infection, biopsy-proven graft rejection, and graft loss in 1,414 patients receiving heart (n=97), kidney (n=917), liver (n=237), or lung (n=163) allografts reported to the Swiss Transplant Cohort Study. RESULTS Recipients of all organs were at an increased risk for biopsy-proven graft rejection within 4 weeks after detection of CMV replication (hazard ratio [HR] after heart transplantation, 2.60; 95% confidence interval [CI], 1.34-4.94, P<0.001; HR after kidney transplantation, 1.58; 95% CI, 1.16-2.16, P=0.02; HR after liver transplantation, 2.21; 95% CI, 1.53-3.17, P<0.001; HR after lung transplantation, 5.83; 95% CI, 3.12-10.9, P<0.001. Relative hazards were comparable in patients with asymptomatic or symptomatic CMV infection. The CMV donor or recipient serological constellation also predicted the incidence of graft rejection after liver and lung transplantation, with significantly higher rates of rejection in transplants in which donor or recipient were CMV seropositive (non-D-/R-), compared with D- transplant or R- transplant (HR, 3.05; P=0.002 for liver and HR, 2.42; P=0.01 for lung transplants). Finally, graft loss occurred more frequently in non-D- or non-R- compared with D- transplant or R- transplant in all organs analyzed. Valganciclovir prophylactic treatment seemed to delay, but not prevent, graft loss in non-D- or non-R- transplants. CONCLUSION Cytomegalovirus replication and donor or recipient seroconstellation remains associated with graft rejection and graft loss in the era of prophylactic CMV treatment.

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Ausgangslage und Fragestellung In der Forschung zum Selbstgespräch im Sport dominiert die Frage nach dessen Auswir-kungen auf die sprechende Person selber. Gemäss Diaz (1992) besitzt das offene Selbstgespräch aber neben der individuell-regulatorischen auch eine sozial-kommunikative Funktion. Diese sozial-kommunikative Funktion und der damit verbunde-ne Einfluss des Selbstgesprächs auf Beobachter wurden in der Sportwissenschaft bisher nur marginal untersucht (z.B. Gould & Weiss, 1981; Van Raalte, Brewer, Cornelius & Pe-titpas, 2006). Im angestrebten Forschungsvorhaben sollen zwei Fragen geklärt werden: Steht das of-fene, während dem Wettkampf geäusserte Selbstgespräch eines Athleten in Zusammen-hang mit dessen Selbstdarstellung? Beeinflusst das offene Selbstgespräch eines Athle-ten den Dyadenpartner und wie sie sich gegenseitig wahrnehmen? Methode Es werden Doppelpartien im Badminton per Videokamera aufgezeichnet. Mittels einer Korrelationsanalyse soll überprüft werden, ob die so erhobenen Selbstgesprächsaussa-gen mit dem Persönlichkeitsmerkmal „Selbstdarstellung“ der Probanden zusammenhän-gen. Nach Spielschluss werden die Probanden entsprechend eines video-stimulierten Fremdkonfrontationsinterviews mit Spielausschnitten konfrontiert, die offenes Selbstge-spräch ihres Dyadenpartners enthalten. Sie werden dabei nach ihren Kognitionen sowie Emotionen gefragt, die sie während der entsprechenden Spielsituation erlebten. Aktuelle Fragen Welcher Fragebogen zur Erhebung des Persönlichkeitsmerkmals „Selbstdarstellung“ soll Verwendung finden? Zur Auswahl steht ein noch zu übersetzender, validierter, engli-scher und sportspezifischer Fragebogen und die Verwendung eines deutschen Frage-bogens, der habituelle Selbstdarstellungstechniken im Allgemeinen erhebt. Wie soll beim video-stimulierten Fremdkonfrontationsinterview vorgegangen werden? Werden den Probanden z.B. das ganze Spiel oder nur ausgewählte Ausschnitte gezeigt, in denen offenes Selbstgespräch vorkommt? Wie zeitnah muss das Interview durchge-führt werden? Literatur Diaz, R. M. (1992). Methodological Concerns in the Study of Private Speech. In R. M. Diaz & L. E. Berk (Eds.), Private speech. From social interaction to self-regulation (pp. 55-81). Hillsdale, NJ: Lawrence Erlbaum. Gould, D. & Weiss, M. (1981). The effects of model similarity and model talk on self-efficacy and muscular endurance. Journal of Sport Psychology, 3, 17-29. Van Raalte, J. L., Brewer, B. W., Cornelius, A. E. & Petitpas, A. J. (2006). Self-presentational effects of self-talk on perceptions of tennis players. Hellenic Journal of Psychology, 3, 134-149.

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INTRODUCTION The proximity of the roots of the posterior maxillary teeth to the maxillary sinus is a constant challenge to the dental practitioner. Because the majority of studies have assessed the relationship regarding molars, the present study focused on premolars. METHODS Cone-beam computed tomographic images of 192 patients were reconstructed in sagittal, coronal, and axial planes to quantify the distances between the root apices of the maxillary premolars and the adjacent maxillary sinus. Measurements were taken for each root, and data were correlated with age, sex, side, and presence of both or absence of 1 of the 2 premolars. RESULTS A total of 296 teeth (177 first and 119 second premolars) were evaluated. The mean distances from buccal roots of the first premolars to the border of the maxillary sinus in the sagittal, coronal, and axial planes ranged from 5.15 ± 2.99 to 8.28 ± 6.27 mm. From palatal roots, the mean distances ranged from 4.20 ± 3.69 to 7.17 ± 6.14 mm. The mean distances of second premolars were markedly shorter in buccal roots between 2.32 ± 2.19 and 3.28 ± 3.17 mm and in palatal roots between 2.68 ± 3.58 and 3.80 ± 3.71 mm, respectively. The frequency of a premolar root protrusion into the maxillary sinus was very low in first premolars (0%-7.2%) but higher in second premolars (2.5%-13.6%). Sex, age, side, and presence/absence of premolars failed to significantly influence the mean distances between premolar roots and the maxillary sinus. CONCLUSIONS Based on the calculated mean distances of the present study, only few premolars (and if so second premolars) would present a risk of violating the border of the maxillary sinus during conventional or surgical endodontic treatment or in case of tooth extraction.

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