Diagnosis of limb-girdle muscular dystrophy 2A by immunohistochemical techniques

The Western blot technique is currently the standard detection method for suspected limb girdle muscular dystrophy (LGMD) 2A (calpainopathy). This is the first report in the English literature of the successful application of immunohistochemical techniques to support a diagnosis of LGMD 2A. This approach is straightforward and appears to be reasonably specific. We propose that immunohistochemical methods should be re-evaluated for the screening of undiagnosed patients with suspected LGMD 2A.

Cotas nas universidades e aprendizado escolar: modelo teórico e evidências empíricas

Esse trabalho objetiva avaliar as consequências da adoção de cotas para acesso às universidades públicas sobre o aprendizado em idade escolar. A literatura sobre o tema é controversa; há autores que argumentam teórica e empiricamente que os incentivos ao acumulo de capital humano diminuem com esse tipo de ação afirmativa, mas há também aqueles que sustentam o oposto. No Brasil, há poucos estudos, especialmente teóricos. As evidências empíricas são normalmente restritas a um ou dois estados e esse pode ser um dos motivos que levam a essa divergência. O modelo teórico apresentado neste trabalho explicita condições para que as duas situações (aumento ou diminuição do esforço) ocorram, mostrando ainda que as consequências das cotas podem ser heterogêneas, dependendo das características dos indivíduos afetados. As evidências empíricas apresentadas parecem comprovar essa possibilidade, pois mostram que o desempenho tanto dos negros quanto dos brancos pode melhorar ou piorar.

"Spontaneous overflow of powerful feelings" : romantic imagery in Mary Shelley's Frankstein

Romantic English literature – written at a time when prose fiction was predominantly a medium for sheer entertainment – is rooted in poetry. One or two novelists may exceptionally be granted the adjective “Romantic”, but Mary Shelley is not ranked among them. For centuries, her work has been restricted to that section in handbooks reserved for exotic Gothic literature. This thesis argues that literary criticism has failed to recognize Frankenstein’s obvious relation with the movement. The argument will be fostered by a brief look at such handbooks, and developed through the analysis of the imagery of the novel, so as to trace the Romantic elements there contained. The analysis relies mainly on the frame developed by Northrop Frye concerning the nature and function of imagery in literature. The concept of intertextuality will also be useful as a tool to account for the insertion of images in the novel, and for the novel’s insertion within the Romantic context. The work is divided into three parts. The first contextualizes the main issues set forth by Frankenstein, establishing connections with the life of the author and with the Romantic movement. The second exposes the theoretical basis on which the thesis is grounded. The last presents my reading of the novel’s web of images. In the end, I hope to validate the thesis proposed, that Frankenstein embodies the aesthetic and philosophical assessments of the English Romantic agenda, and therefore deserves to be situated in its due place in the English Literary canon as the legitimate representative of Romanticism in prose form.

A narratological analysis of D. M. Thoma`s: the white hotel (1981)

“A Narratological Analysis of D. M. Thomas’s The White Hotel (1981)” originated within a seminar on British Postmodernist Literature during the first Master’s Degree in “British and North-American Culture and Literature” (2001-04) at the Universidade da Madeira set up by the Department of English and German Studies. This dissertation seeks to present a narratological analysis of Thomas’s novel. The White Hotel stands as a paradigmatic example of the kind of literature that has dominated the British literary scene in the past three decades, commonly referred to as postmodernist fiction, owing to its formal craftsmanship (multiplicity of narrative voices and perspectives, mixing of differing genres and text types, inclusion of embedded narratives) alongside the handling of what are deemed as postmodernist topoi (the distinction between truth and lies, history and fantasy, fact and fiction, the questioning of the nature of aesthetic representation, the role the author and the reader hold in the narrative process, the instability of the linguistic sign, the notion of originality and the moral responsibility the author has towards his/her work), The narratological approach carried out in this research reveals that Thomas’s text constitutes an aesthetic endeavour to challenge the teleological drive that is inherent in any narrative, i. e., the inevitable progression towards a reassuring end. Hence, the subversion of narrative telling, which is a recurrent feature in Thomas’s remaining literary output, mirrors the contemporary distrust in totalising, hierarchised and allencompassing narratives. In its handling of historical events, namely of the Holocaust, The White Hotel invites us to reassess the most profound beliefs we were taught to take for granted: progress, reality and truth. In their place the novel proposes a more flexible conception of both the world and art, especially of literary fiction. In other terms, the world appears as a brutal chaotic place the subject is forced to adjust to. Accordingly, the literary work is deemed hybrid, fragmented and open. So as to put forth the above-mentioned issues, this research work is structured in three main chapters. The initial chapter – “What is Postmodernism?” – advances a scrutiny not only of the seminal but also of more recent studies on postmodernist literary criticism. Following this, in Chapter II – “Postmodernist British Fiction” – a brief overview of postmodernist British fiction is carried out, focusing on the fictional works that, in my opinion, are fundamental for the periodising of British postmodernism. In addition, I felt the need to include a section – “D. M. Thomas as a Postmodernist Novelist” – in which the author’s remaining literary output is briefly examined. Finally, Chapter III – “A Narratological Analysis of The White Hotel” – proposes a narratological analysis of the novel according to the particular Genettian analytical model. To conclude, my dissertation constitutes an approach to D. M. Thomas’s The White Hotel as a text whose very existence is substantiated in the foregrounding of the contingency of all discourses, meeting the postmodernist precepts of openness and subversion of any narrative that claims to be true, globalising and all-inclusive.

Clinicopathological analysis of head and neck chondrosarcoma: three case reports and literature review

Chondrosarcoma (CHS) is a malignant neoplasm characterized by the formation of cartilaginous matrix by neoplastic cells, with a high propensity for local recurrences. Head and neck CHS is rare, accounting for less than 12% of all cases of CHS, usually affecting the maxilla. The majority of affected patients are in the fourth decade of life, with a slight predilection for male patients. A painless swelling is commonly the most frequent complaint. Surgery with wide en-bloc resection is the preferred treatment for CHS; radiotherapy and chemotherapy are usually palliative options. Owing to its rarity, there are few clinical series evaluating the biological behaviour of head and neck CHS. The aim of this study is to analyse the clinicopathological characteristics of head and neck CHS by reporting 3 new cases of this neoplasia affecting the jaw bones and reviewing the clinical series previously published in the English literature.

The Magic Toyshop: A narrativa imagética como processo de recriação

Because it belongs to a cultural practice, the adaptation of a novel into a feature film will always exist within a context and, for being subject to changes, corresponding modifications in the political sphere and even variations in the meaning of the story may occur. This seems to be precisely the result of the transformation of Angela Carter's second novel, The Magic Toyshop, into the homonymous film, directed by David Whealtey in 1987. Removed from the context of the book's production and publication, a crucial period of questioning about the importance of women in society and culture, the plot created by the English author in the sixties, rewritten two decades later, with the author herself as the script writer, seems to have acquired another meaning during this time. Although the film maintains the same plot of the novel, the political engagement visibly present in the narrative, namely Carter's critical stance about the model of patriarchal society, seems to lose its strength, highlighting now its fantastic character. Briefly discussing issues such as loyalty and betrayal of one gender to another, we seek in this paper to observe the film, based on the re-writers perspective, in other words, the prospects of both writer and director, as a process of rebuilding the story. In this dialogue, the script was also used as an intertext for a better understanding of this process.

Tradição e modernidade em O Senhor dos Anéis

Pós-graduação em Ciências Sociais - FFC

A representação do ato de ensinar: continuidades e rupturas da concepção de ensino na pedagogia tradicional, na psicologia histórico-cultural e na pedagogia histórico-crítica : uma análise a partir das teses e dissertações no Portal da CAPES

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Frankenstein: uma releitura do mito de criação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As manifestações do gótico em Lovecraft: do Castelo de Otranto ao solar de Ward

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Epigramas de Marcial traduzidos por José Feliciano de Castilho: edição, notas e comentários

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A caracterização do feminino em The Silmarillion, de J. R. R. Tolkien

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conduzir o banquete da vida: a presença feminina na obra de Muriel Spark

Pós-graduação em Letras - FCLAS

A independência das adapatações cinematográficas: uma análise de Amor Obsessivo (2004) e Desejo e Reparação (2007)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)