Growth and puberty after treatment for acute lymphoblastic leukemia

Over the last 20 years, after combining treatment of chemotherapy and radiotherapy, there has been an improvement in the survival rate of acute lymphoblastic leukemia patients, with a current cure rate of around 70%. Children with the disease have been enrolled into international treatment protocols designed to improve survival and minimize the serious irreversible late effects. Our oncology unit uses the international protocol: GBTLI LLA-85 and 90, with the drugs methotrexate, cytosine, arabinoside, dexamethasone, and radiotherapy. However, these treatments can cause gonadal damage and growth impairment. PATIENTS AND METHOD: The authors analyzed 20 children off therapy in order to determine the role of the various doses of radiotherapy regarding endocrinological alterations. They were divided into 3 groups according to central nervous system prophylaxis: Group A underwent chemotherapy, group B underwent chemotherapy plus radiotherapy (18 Gy), and group C underwent chemotherapy plus radiotherapy (24 Gy). Serum concentrations of LH, FSH, GH, and testosterone were determined. Imaging studies included bone age, pelvic ultrasound and scrotum, and skull magnetic resonance imaging. RESULTS: Nine of the patients who received radiotherapy had decreased pituitary volume. There was a significant difference in the response to GH and loss of predicted final stature (Bayley-Pinneau) between the 2 irradiated groups and the group that was not irradiated, but there was no difference regarding the radiation doses used (18 or 24 Gy). The final predicted height (Bayley-Pinneau) was significantly less (P = 0.0071) in both groups treated with radiotherapy. Two girls had precocious puberty, and 1 boy with delayed puberty presented calcification of the epididymis. CONCLUSION: Radiotherapy was been responsible for late side effects, especially related to growth and puberty.

Produtos têxteis inteligentes incorporando filamentos compósitos com nanotubos de carbono

Programa Doutoral em Engenharia Têxtil.

Comportamento de painéis de alvenaria reforçados com FRCM sujeitos a ações no plano: Estudo da interface

O presente trabalho dedica-se à caracterização do comportamento de modelos de alvenaria reforçada com FRCM (fiber reinforced cementitious matrix) quando sujeitos a ações que atuam no plano da parede. O sistema de reforço, composto por uma camada de argamassa cimentícia reforçada com uma malha de CFRP (carbon fiber reinforced polymer), foi aplicado a modelos de alvenaria de tijolo furado. Considerando a importância da interface entre a camada de reforço e o substrato para a eficiência do sistema de reforço, procedeu-se à caracterização do comportamento mecânico da interface por intermédio de ensaios de corte direto, com os quais foi possível definir as superfícies de cedência e de rotura da interface. Os resultados obtidos permitiram a quantificação dos parâmetros que caracterizam a interface entre o material cerâmico e uma argamassa do tipo PFRM (polypropylene fibre reinforced mortar) quando sujeita a cargas de corte combinadas com cargas normais à interface. Através de expressões analíticas e do critério de rotura de Mohr-Coloumb foi analisada a adequação de um critério baseado numa aproximação linear, aos dados obtidos experimentalmente.

Probing dispersion and re-agglomeration phenomena upon melt-mixing of polymer-functionalized graphite nanoplates

A one-step melt-mixing method is proposed to study dispersion and re-agglomeration phenomena of the as-received and functionalized graphite nanoplates in polypropylene melts. Graphite nanoplates were chemically modified via 1,3-dipolar cycloaddition of an azomethine ylide and then grafted with polypropylene-graft-maleic anhydride. The effect of surface functionalization on the dispersion kinetics, nanoparticle re-agglomeration and interface bonding with the polymer is investigated. Nanocomposites with 2 or 10 wt% of as-received and functionalized graphite nanoplates were prepared in a small-scale prototype mixer coupled to a capillary rheometer. Samples were collected along the flow axis and characterized by optical microscopy, scanning electron microscopy and electrical conductivity measurements. The as-received graphite nanoplates tend to re-agglomerate upon stress relaxation of the polymer melt. The covalent attachment of a polymer to the nanoparticle surface enhances the stability of dispersion, delaying the re-agglomeration. Surface modification also improves interfacial interactions and the resulting composites presented improved electrical conductivity.

Dispersion of graphite nanoplates during melt mixing

Artigo publicado a convite da Society for Polymer Engineers

Producing LFT composite parts for large consumption markets from thermoplastic powder-coated towpregs

Thermoplastic matrix composites are receiving increasing interest in last years. This is due to several advantageous properties and speed of processing of these materials as compared to their thermoset counterparts. Among thermoplastic composites, Long Fibre Thermoplastics (LFTs) have seen the fastest growth, mainly due to developments in the automotive sector. LFTs combine the (semi-)structural material properties of long (>1 cm) fibres, with the ease and speed of thermoplastic processing. This paper reports a study of a novel low-cost LFT technology and resulting composites. A patented powder-coating machine able to produce continuously pre-impregnated materials directly from fibre rovings and polymer powders was used to process glass-fibre reinforced polypropylene (GF/PP) towpregs. Such pre-impregnated materials were then chopped and used to make LFTs in a patented low-cost piston-blender developed by the Centre of Lightweight Structures, TUD-TNO, the Netherlands. The work allowed studying the most relevant towpreg production parameters and establishing the processing window needed to obtain a good quality GF/PP powder coated material. Finally, the processing window that allows producing LFTs of good quality in the piston-blender and the mechanical properties of final stamped GF/PP composite parts were also determined.

Advances in thermoplastic pultruded composites

Pultrusion is a versatile continuous high speed production technology allowing the production of fibre reinforced complex profiles. Thermosetting resins are normally used as matrices in the production of structural constant cross section profiles. Although only recently thermoplastic matrices have been used in long and continuous fibre reinforced composites replacing with success thermosetting matrices, the number of their applications is increasing due to their better ecological and mechanical performance. Composites with thermoplastic matrices offers increased fracture toughness, higher impact tolerance, short processing cycle time and excellent environmental stability. They are recyclable, post-formable and can be joined by welding. The use of long/continuous fibre reinforced thermoplastic matrix composites involves, however, great technological and scientific challenges since thermoplastics present much higher viscosity than thermosettings, which makes much difficult and complex the impregnation of reinforcements and consolidation tasks. In this work continuous fibres reinforced thermoplastic matrix towpregs were produced using equipment developed by the Institute for Polymers and Composites (IPC). The processing of the towpregs was made by pultrusion, in a developed prototype equipment existing in the Engineering School of the Polytechnic Institute of Porto (ISEP). Different thermoplastic matrices and fibres raw-materials were used in this study to manufacture pultruded composites for commercial applications (glass and carbon fibre/ polypropylene) and for advanced markets (carbon fibre/Primospire®). To improve the temperature distribution profile in heating die, different modifications were performed. In order to optimize both processes, towpregs production and pultruded composites profiles were analysed to determine the influence of the most relevant processing arameters in the final properties. The final pultruded composite profiles were submitted to mechanical tests to obtain the relevant properties.

Assessment of the properties to characterize the interface between clay brick substrate and strengthening mortar

The behaviour of masonry elements under in-plane and out-of-plane loads can be improved through the application of strengthening systems based on reinforcing overlays. After strengthening, the transition region between the original substrate and the strengthening layer is especially stressed, and premature failure of the strengthened masonry is reached if insufficient interfacial capacity is assured. Therefore, the assessment of the mechanical behaviour of the interface is critical to the development of the masonry strengthening system based on the application of strengthening overlays. In this research a method for the characterization of the interface behaviour between two different materials, a polypropylene fibre reinforced mortar (PFRM) and a ceramic brick used for masonry construction is presented. Direct shear tests were carried out in couplet specimens. Due to the orthotropic nature of the bricks surface, the shear load was applied along three different directions in order to perform an overall estimation of the interface behaviour. The peak and residual shear stresses, as well as the failure modes, were obtained at different levels of the normal stress. Based on these experimental results constitutive laws were assessed for the simulation of the interface mechanical behaviour based on the Mohr and Mohr-Coulomb failure criteria.

Estudo das propriedades físicas fundamentais de filmes finos intermetálicos do tipo Ti-Me (Me = Al, Au) na funcionalização de elétrodos - sensores para dispositivos biomédicos

Dissertação de mestrado integrado em Engenharia de Materiais

Estudos de dispersão de nanografite em polipropileno

Dissertação de mestrado integrado em Engenharia de Materiais

Habitar sem ver: a amplificação sensorial ao longo de um percurso entre o Largo Condessa do Juncal e a Veiga de Creixomil

Dissertação de mestrado integrado em Arquitectura (área de especialização em Cultura Arquitetónica)

Desenvolvimento de um sistema fibroso multicamada para reabilitação de edifícios

Dissertação de mestrado Internacional em Sustentabilidade do Ambiente Construído

Susceptibility of Candida biofilms to photodynamic treatment

Dissertação de mestrado em Bioengenharia

Enzymatic hydrophobic modification of jute fibers via grafting to reinforce composites

Horseradish peroxidase (HRP)/H2O2 system catalyzes the free-radical polymerization of aromatic compounds such as lignins and gallate esters. In this work, dodecyl gallate (DG) was grafted onto the surfaces of lignin-rich jute fabrics by HRP-mediated oxidative polymerization with an aim to enhance the hydrophobicity of the fibers. The DG-grafted jute fibers and reaction products of their model compounds were characterized by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The results clearly indicated the grafting of DG to the jute fiber by HRP. Furthermore, the hydrophobicity of jute fabrics was determined by measuring the wetting time and static contact angle. Compared to the control sample, the wetting time and static contact angle of the grated fabrics changed from ~1 s to 1 h and from ~0° to 123.68°, respectively. This clearly proved that the hydrophobicity of jute fabrics improved considerably. Conditions of the HRP-catalyzed DG-grafting reactions were optimized in terms of the DG content of modified jute fabrics. Moreover, the results of breaking strength and elongation of DG-grafted jute/ polypropylene (PP) composites demonstrated improved reinforcement of the composite due to enzymatic hydrophobic modification of jute fibers.

Untersuchung zur Anwendung des Modells "Chemical Leasing" im Vertrieb von Kunststoffgranulat

Der Themenschwerpunkt dieser Arbeit ist das Chemical Leasing. Es wird untersucht, ob dieses Geschäftsmodell auch für den Vertrieb von Kunststoffgranulat genutzt werden kann. Der Fokus liegt auf dem Kunststoff Polypropylen (PP). Der Einsatz des Geschäftsmodell Chemical Leasing wird anhand der Kriterien: Potential des Materials, Wichtigkeit des Prozessschritts, Grad der Spezialisierung und der Verfügbarkeit von geeigneten Partnern vollzogen. Dabeiwird insbesondere aus der Sicht des Rohstoffherstellers berichtet. In dem Verarbeitungsschritt „Compoundieren“ werden bei dem Rohstoffhersteller modifizierte Polypropylene hergestellt. Ist es durch die Compoundveredelung möglich das Potential des Polypropylen zu ändern? Da in dieser Untersuchung der Automobilbau und seine Zulieferstruktur betrachtet werden, wird an den beteiligten Unternehmen dieser Lieferkette geprüft,wo der Grad der Spezialisierung und die Wichtigkeit des Prozessschritts für die jeweiligen Unternehmen liegen. Die gesamte Betrachtung bezieht sich dabei auf den Verarbeitungsschritt Spritzgießen. Die Arbeit zeigt an zwei Praxisbeispielen wie der Grundgedankedes Chemical Leasing (je weniger desto besser)mit den passenden Kunststoffprodukten positiv umgesetzt werden kann. Durch die Analyse der einzelnen Zulieferbetriebe kann schlussendlich festgelegt werden, bei welchen Kunden die Umstellung auf das Chemical Leasing erfolgreich sein wird.Der Vertriebsablauf wird sich durch den Einsatz von Chemical Leasing ändern, es wird aufgezeig twelche Maßnahmen ergriffen werden müssen,um diesem Wandel gewappnet zu sein.Die Arbeit zeigt, dass der Vertrieb von Kunststoffgranulat mit Chemical Leasing möglich ist.