Usefulness of vaginal cytology tests in women with previous hysterectomy for benign diseases: assessment of 53,891 tests

Objective. To assess the value of vaginal screening cytology after hysterectomy for benign disease.Methods. This cross-sectional study used cytology audit data from 2,512,039 screening tests in the metropolitan region of Campinas from 2000 to 2012; the object was to compare the prevalence of abnormal tests in women who had undergone a hysterectomy for benign diseases (n = 53,891) to that of women who had had no hysterectomy. Prevalence ratios (95% confidence intervals, 95% Cl) were determined, and chi-square analysis, modified by the Cochrane-Armitage test for trend, was used to investigate the effects of age.Results. The prevalence of atypical squamous cells (ASC), low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial lesion or squamous-cell carcinoma (HSIL/SCC) was 0.13%, 0.04% and 0.03%, respectively, in women who had undergone hysterectomy, and 0.93%, 0.51% and 0.26% in women who had not undergone hysterectomy. The prevalence ratios for ASC, LSIL and HSIL/SCC were 0.14(0.11-0.17), 0.08 (0.06-0.13) and 0.13 (0.08-020), respectively, in women with a hysterectomy versus those without. For HSIL/SCC, the prevalence ratios were 0.09 and 029, respectively, for women <50 or >= 50 years. The prevalence rates in women with a previous hysterectomy showed no significant variation with age.Conclusion. The prevalence rates of ASC, LSIL and HSIL/SCC were significantly lower in women with a previous hysterectomy for benign disease compared with those observed in women with an intact uterine cervix. This study reinforces the view that there is no evidence that cytological screening is beneficial for women who have had a hysterectomy for benign disease. (C) 2015 Elsevier Inc. All rights reserved.

LC-MS/MS quantitative determination of tetrapterys mucronata alkaloids, a plant occasionally used in ayahuasca preparation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Different tools to trace geographic origin and seasonality of croaker (Micropogonias furnieri)

The aim of this study was to use proximate chemical composition, macro and trace elements, fatty acid profile and stable isotopes as traceability tools to assess geographic origin and seasonality of croaker (Micropogonicts fumieri). Croaker from Parnaiba contained higher ash in July and lower fat content than croaker from Santos. In contrast, croaker from Santos had statistically higher proportion of 16:1n-9+16:1n-7, 20:1n-11, 20:1n-9, MUFA and n-3/n-6 ratio than croaker from Parnaiba. Concerning seasonality, croaker caught in July had significantly higher amounts of 14:0, 15:0, 16:1n-9+16:1n-7 and saturated fatty acids than fish caught in December. Concerning elements, significant differences were also detected between seasons for Cl, Ca, Fe, Sr and S, whereas differences between geographic origins were only observed with K. delta C-13 and delta N-15 were statistically different between geographic origins, whereas differences between seasons were only detected in delta N-15 ratio of croaker from Santos. Fatty acids, minerals and stable isotope are effective methods to trace geographic origin and seasonality of croaker. Nonetheless, further investigation is still required with larger samples of croaker to enable the implementation of fatty acids, elements or stable isotope as authenticity tools by food control agencies. (C) 2014 Elsevier Ltd. All rights reserved.

Short-term effects of triiodothyronine on thyroid hormone receptor alpha by PI3K pathway in adipocytes, 3T3-L1

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Comparação entre métodos para determinar o período anterior à interferência de plantas daninhas em feijoeiros com distintos tipos de hábitos de crescimento

Beans grain productivity may be reduced by up to 80% and, therefore, knowing the proper time to control weeds becomes fundamental, his research was conducted in order to determine the period prior to interference (PPI) on bean cultivars of different types'plant growth through distinct approaches: arbitrary level of 5% productivity loss; tolerance level (TL), and the Weed Period Prior to Economic Loss (WEEPPEL). Experimental treatments were constituted of ten periods of coexistence, periods of the crop with the weeds: 0-7; 0-14; 0-21; 0-28; 0-35; 0-42; 0-49; 0-56; 0-97 (harvesting) days after emergency (DAE), and a control plot, weed free for the entire period. The experimental design was of the Random Block Design, with four replications. PPI was obtained in all of the different approaches, and the bean plant type II with indeterminate growth had the lowest times of coexistence.

Metabolism and ruminal parameters of Holstein × Gir heifers fed sugarcane and increasing levels of crude protein

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study

To study racemic bupivacaine, non-racemic bupivacaine and ropivacaine on myocardial contractility. Isolated Wistar papillary muscles were submitted to 50 and 100 mM racemic bupivacaine (B50 and B100), non-racemic bupivacaine (NR50 and NR100) and ropivacaine (R50 and R100) intoxication. Isometric contraction data were obtained in basal condition (0.2 Hz), after increasing the frequency of stimulation to 1.0 Hz and after 5, 10 and 15 min of local anesthetic intoxication. Data were analyzed as relative changes of variation. Developed tension was higher with R100 than B100 at D1 (4.3 ± 41.1 vs -57.9 ± 48.1). Resting tension was altered with B50 (-10.6 ± 23.8 vs -4.7 ± 5.0) and R50 (-14.0 ± 20.5 vs -0.5 ± 7.1) between D1 and D3. Maximum rate of tension development was lower with B100 (-56.6 ± 38.0) than R50 (-6.3 ± 37.9) and R100 (-1.9 ± 37.2) in D1. B50, B100 and NR100 modified the maximum rate of tension decline from D1 through D2. Time to peak tension was changed with NR50 between D1 and D2. Racemic bupivacaine depressed myocardial contractile force more than non-racemic bupivacaine and ropivacaine. Non-racemic and racemic bupivacaine caused myocardial relaxation impairment more than ropivacaine.

Evaluation of the temporal acoustic window for transcranial doppler in a multi-ethnic population in Brazil

The aim of this study was to relate the presence of a temporal acoustic window (TAW) to the variables sex, age and race. This observational study was conducted in patients under etiologic investigation after stroke, sickle-cell anemia and hospitalization in an intensive therapy neurologic unit. TAW presence was confirmed by bilateral assessment by two neurologists via transcranial Doppler (TCD). Multiple logistic regression was performed to explain the presence of the window as a function of sex, age and race. In 20% of the 262 patients evaluated, a TAW was not present. The incidence of TAW presence was greater in men (odds ratio [OR] = 5.4, 95% confidence interval [CI] = 2.5-11.7, p < 0.01); lower with increased age (OR = 0.9, 95% CI = 0.92-0.97, p < 0.01); and lower among those of African and Asian descent (OR = 0.32, 95% CI = 0.14-0.70, p = 0.005). On the basis of the results, more men than women had TAWs, and the decrease in TAWs was associated with increased age and African or Asian descent.

Produção e qualidade de inflorescências de couve-flor em função da densidade de plantio

Cauliflower is one of the most planted vegetable throughout Brazil, being a very profitable crop. The use of denser plantings can increase crop yield and improve financial returns to producers. This study aimed to verify the combination effect of different spacing between plants in row and between rows on the cauliflower 'Piracicaba Precoce’ inflorescences productivity and quality. In the experiment, a randomized block design was used and treatments consisted in three distances between rows (70, 80 and 90 cm) with three distances between plants in row (50, 60 and 70 cm) and four replications. Total productivity and productivity by inflorescences size classes were assessed as well as the quality by checking the inflorescences’ mass. The row density did not change the produced heads quality, although the density between plants reduced the inflorescences size. The spacing 70 x 50 cm, totalizing 28,571 plants per ha, due the higher productivity, greater than 14.0 t ha-1 , and still not compromise the inflorescence size can be recommended to the cauliflower "Piracicaba Precoce” production in the region.

Avaliação do consumo alimentar e percepção da imagem corporal de culturistas

In bodybuilding, sport that emerged in Brazil in the 70s, competitors are judged by physical appearance, size and muscle definition. The present study aimed to assess dietary intake, supplement use, and it also investigated body image perceptions of bodybuilders. Practitioners of three different gyms in the state of São Paulo participated in the study. They filled the anamnesis form containing data on food consumption and intake of supplements and also answered a questionnaire on the perception of body image (Satisfaction Scale with Body Appearance). The study showed a considerable food inadequacy with an average of carbohydrate intake of 41.84% ± 10.88%, of lipid, an average of 18.96% ± 6.40% and of protein 39.20% ± 10.41%. In pre-competition, the average of daily carbohydrate intake is reduced to 22.69% ± 12.34%, the lipid increases to 25.68% ± 14.0% and the protein increases to 51.63% ± 10.28%. It was observed that all individuals take some sort of supplement. Considering the perception of body image 60% of the appraised are fully satisfied with the muscular appearance and 40% has greater risk of developing vigorexia. As the bodybuilder has rigid dietary control, it is important nutritional monitoring. So it is necessary a better identification and guidance of risk groups for the development of body image disturbances through specialized professionals such as dieticians, psychologists and coaches for success training, aiming at physical and mental well being of the athletes.

Reatividade e tolerância ao calor de fêmeas ovinas de diferentes grupos genéticos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comparação entre modelos de análise genômica utilizando dados simulados e dados reais em ovinos

Pós-graduação em Genética e Melhoramento Animal - FCAV

Ex vivo torsional properties of the Targon Vet Nail System in canine femurs: comparison with the 2.4 mm LC-DCP Plate

Pós-graduação em Cirurgia Veterinária - FCAV

Parâmetros hemetológicos da tilápia-do-Nilo: efeito da dieta suplementada com levedura e zinco e do estímulo pelo frio

Fundação de Apoio à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de um sistema de proteção e metodologia para localização de faltas em sistemas de distribuição

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)