Design and Simulation of Deep Nanometer SRAM Cells under Energy, Mismatch, and Radiation Constraints

La fiabilidad está pasando a ser el principal problema de los circuitos integrados según la tecnología desciende por debajo de los 22nm. Pequeñas imperfecciones en la fabricación de los dispositivos dan lugar ahora a importantes diferencias aleatorias en sus características eléctricas, que han de ser tenidas en cuenta durante la fase de diseño. Los nuevos procesos y materiales requeridos para la fabricación de dispositivos de dimensiones tan reducidas están dando lugar a diferentes efectos que resultan finalmente en un incremento del consumo estático, o una mayor vulnerabilidad frente a radiación. Las memorias SRAM son ya la parte más vulnerable de un sistema electrónico, no solo por representar más de la mitad del área de los SoCs y microprocesadores actuales, sino también porque las variaciones de proceso les afectan de forma crítica, donde el fallo de una única célula afecta a la memoria entera. Esta tesis aborda los diferentes retos que presenta el diseño de memorias SRAM en las tecnologías más pequeñas. En un escenario de aumento de la variabilidad, se consideran problemas como el consumo de energía, el diseño teniendo en cuenta efectos de la tecnología a bajo nivel o el endurecimiento frente a radiación. En primer lugar, dado el aumento de la variabilidad de los dispositivos pertenecientes a los nodos tecnológicos más pequeños, así como a la aparición de nuevas fuentes de variabilidad por la inclusión de nuevos dispositivos y la reducción de sus dimensiones, la precisión del modelado de dicha variabilidad es crucial. Se propone en la tesis extender el método de inyectores, que modela la variabilidad a nivel de circuito, abstrayendo sus causas físicas, añadiendo dos nuevas fuentes para modelar la pendiente sub-umbral y el DIBL, de creciente importancia en la tecnología FinFET. Los dos nuevos inyectores propuestos incrementan la exactitud de figuras de mérito a diferentes niveles de abstracción del diseño electrónico: a nivel de transistor, de puerta y de circuito. El error cuadrático medio al simular métricas de estabilidad y prestaciones de células SRAM se reduce un mínimo de 1,5 veces y hasta un máximo de 7,5 a la vez que la estimación de la probabilidad de fallo se mejora en varios ordenes de magnitud. El diseño para bajo consumo es una de las principales aplicaciones actuales dada la creciente importancia de los dispositivos móviles dependientes de baterías. Es igualmente necesario debido a las importantes densidades de potencia en los sistemas actuales, con el fin de reducir su disipación térmica y sus consecuencias en cuanto al envejecimiento. El método tradicional de reducir la tensión de alimentación para reducir el consumo es problemático en el caso de las memorias SRAM dado el creciente impacto de la variabilidad a bajas tensiones. Se propone el diseño de una célula que usa valores negativos en la bit-line para reducir los fallos de escritura según se reduce la tensión de alimentación principal. A pesar de usar una segunda fuente de alimentación para la tensión negativa en la bit-line, el diseño propuesto consigue reducir el consumo hasta en un 20 % comparado con una célula convencional. Una nueva métrica, el hold trip point se ha propuesto para prevenir nuevos tipos de fallo debidos al uso de tensiones negativas, así como un método alternativo para estimar la velocidad de lectura, reduciendo el número de simulaciones necesarias. Según continúa la reducción del tamaño de los dispositivos electrónicos, se incluyen nuevos mecanismos que permiten facilitar el proceso de fabricación, o alcanzar las prestaciones requeridas para cada nueva generación tecnológica. Se puede citar como ejemplo el estrés compresivo o extensivo aplicado a los fins en tecnologías FinFET, que altera la movilidad de los transistores fabricados a partir de dichos fins. Los efectos de estos mecanismos dependen mucho del layout, la posición de unos transistores afecta a los transistores colindantes y pudiendo ser el efecto diferente en diferentes tipos de transistores. Se propone el uso de una célula SRAM complementaria que utiliza dispositivos pMOS en los transistores de paso, así reduciendo la longitud de los fins de los transistores nMOS y alargando los de los pMOS, extendiéndolos a las células vecinas y hasta los límites de la matriz de células. Considerando los efectos del STI y estresores de SiGe, el diseño propuesto mejora los dos tipos de transistores, mejorando las prestaciones de la célula SRAM complementaria en más de un 10% para una misma probabilidad de fallo y un mismo consumo estático, sin que se requiera aumentar el área. Finalmente, la radiación ha sido un problema recurrente en la electrónica para aplicaciones espaciales, pero la reducción de las corrientes y tensiones de los dispositivos actuales los está volviendo vulnerables al ruido generado por radiación, incluso a nivel de suelo. Pese a que tecnologías como SOI o FinFET reducen la cantidad de energía colectada por el circuito durante el impacto de una partícula, las importantes variaciones de proceso en los nodos más pequeños va a afectar su inmunidad frente a la radiación. Se demuestra que los errores inducidos por radiación pueden aumentar hasta en un 40 % en el nodo de 7nm cuando se consideran las variaciones de proceso, comparado con el caso nominal. Este incremento es de una magnitud mayor que la mejora obtenida mediante el diseño de células de memoria específicamente endurecidas frente a radiación, sugiriendo que la reducción de la variabilidad representaría una mayor mejora. ABSTRACT Reliability is becoming the main concern on integrated circuit as the technology goes beyond 22nm. Small imperfections in the device manufacturing result now in important random differences of the devices at electrical level which must be dealt with during the design. New processes and materials, required to allow the fabrication of the extremely short devices, are making new effects appear resulting ultimately on increased static power consumption, or higher vulnerability to radiation SRAMs have become the most vulnerable part of electronic systems, not only they account for more than half of the chip area of nowadays SoCs and microprocessors, but they are critical as soon as different variation sources are regarded, with failures in a single cell making the whole memory fail. This thesis addresses the different challenges that SRAM design has in the smallest technologies. In a common scenario of increasing variability, issues like energy consumption, design aware of the technology and radiation hardening are considered. First, given the increasing magnitude of device variability in the smallest nodes, as well as new sources of variability appearing as a consequence of new devices and shortened lengths, an accurate modeling of the variability is crucial. We propose to extend the injectors method that models variability at circuit level, abstracting its physical sources, to better model sub-threshold slope and drain induced barrier lowering that are gaining importance in FinFET technology. The two new proposed injectors bring an increased accuracy of figures of merit at different abstraction levels of electronic design, at transistor, gate and circuit levels. The mean square error estimating performance and stability metrics of SRAM cells is reduced by at least 1.5 and up to 7.5 while the yield estimation is improved by orders of magnitude. Low power design is a major constraint given the high-growing market of mobile devices that run on battery. It is also relevant because of the increased power densities of nowadays systems, in order to reduce the thermal dissipation and its impact on aging. The traditional approach of reducing the voltage to lower the energy consumption if challenging in the case of SRAMs given the increased impact of process variations at low voltage supplies. We propose a cell design that makes use of negative bit-line write-assist to overcome write failures as the main supply voltage is lowered. Despite using a second power source for the negative bit-line, the design achieves an energy reduction up to 20% compared to a conventional cell. A new metric, the hold trip point has been introduced to deal with new sources of failures to cells using a negative bit-line voltage, as well as an alternative method to estimate cell speed, requiring less simulations. With the continuous reduction of device sizes, new mechanisms need to be included to ease the fabrication process and to meet the performance targets of the successive nodes. As example we can consider the compressive or tensile strains included in FinFET technology, that alter the mobility of the transistors made out of the concerned fins. The effects of these mechanisms are very dependent on the layout, with transistor being affected by their neighbors, and different types of transistors being affected in a different way. We propose to use complementary SRAM cells with pMOS pass-gates in order to reduce the fin length of nMOS devices and achieve long uncut fins for the pMOS devices when the cell is included in its corresponding array. Once Shallow Trench isolation and SiGe stressors are considered the proposed design improves both kinds of transistor, boosting the performance of complementary SRAM cells by more than 10% for a same failure probability and static power consumption, with no area overhead. While radiation has been a traditional concern in space electronics, the small currents and voltages used in the latest nodes are making them more vulnerable to radiation-induced transient noise, even at ground level. Even if SOI or FinFET technologies reduce the amount of energy transferred from the striking particle to the circuit, the important process variation that the smallest nodes will present will affect their radiation hardening capabilities. We demonstrate that process variations can increase the radiation-induced error rate by up to 40% in the 7nm node compared to the nominal case. This increase is higher than the improvement achieved by radiation-hardened cells suggesting that the reduction of process variations would bring a higher improvement.

Random-modulation cw lidar system for space-borne carbon dioxide remote sensing based on a high-brightness semiconductor laser

In this paper, we report on the progresses of the BRITESPACE Consortium in order to achieve space-borne LIDAR measurements of atmospheric carbon dioxide concentration based on an all semiconductor laser source at 1.57 ?m. The complete design of the proposed RM-CW IPDA LIDAR has been presented and described in detail. Complete descriptions of the laser module and the FSU have been presented. Two bended MOPAs, emitting at the sounding frequency of the on- and off- IPDA channels, have been proposed as the transmitter optical sources with the required high brightness. Experimental results on the bended MOPAs have been presented showing a high spectral purity and promising expectations on the high output power requirements. Finally, the RM-CW approach has been modelled and an estimation of the expected SNR for the entire system is presented. Preliminary results indicate that a CO2 retrieval precision of 1.5 ppm could be achieved with an average output power of 2 W for each channel.

Lewerentz en Malmo: Intersecciones entre arquitectura y paisaje

El Cementerio Este de Malmo (1916-1973) ha sido analizado en el ámbito internacional sólo en contadas ocasiones, aunque en este lugar el arquitecto sueco Sigurd Lewerentz (1885-1975) realizó un proyecto experimental a gran escala, rechazando los trazados de cementerios pintorescos que se habían popularizado en Europa en aquella época y proponiendo una disposición más ortogonal, vinculada con el lugar de distintas maneras. Después de que Lewerentz ganase el concurso, el proyecto se desarrolló durante casi sesenta años. El Cementerio Este de Malmo ofrece una lente única a través de la cual se puede examinar la forma en la que se establecieron relaciones entre el proyecto de arquitectura y diversos aspectos del paisaje: con el entorno urbano y diversas circunstancias del entorno social mediante la vegetación como límite, con la topografía a través de la escala y los materiales de construcción, con la tradición organizando plantas, secciones y construcción, con el ámbito internacional a través de los paramentos constructivos, con las técnicas constructivas habituales en Suecia por medio de materiales cotidianos y con los alrededores a través del planteamiento de los detalles. La hipótesis de trabajo plantea que el concepto de límite en la obra de Lewerentz y en el Cementerio Este de Malmo en particular tiene un carácter dual, produciendo simultáneamente separaciones y relaciones con distintos aspectos del lugar y del tiempo. Esta investigación documenta y examina la construcción del Cementerio Este de Malmo apoyándose en planos y escritos originales de distintos archivos, datos recogidos en el proyecto así como en otros cementerios de la época y en análisis previos ya publicados. Proporcionando un estudio detallado de la evolución del enfoque de Lewerentz respecto a la relación entre arquitectura y paisaje, se define un marco en el que la obra de este arquitecto puede entenderse de una manera más completa. Lewerentz mantuvo una postura crítica con algunos modelos de su época, al tiempo que planteó vínculos con aspectos de la vida cotidiana de las personas. Este conjunto de referencias redefine, un conjunto de circunstancias vinculadas con el proyecto, que redefinen el lugar de forma abstracta. En esta doble cualidad del límite se da lugar a un espacio de intersección, entendido como un lugar de convergencia de personas. En estas relaciones, el usuario siempre es el centro, ya sea para crear un pórtico para resguardar, una avenida de árboles para crear un espacio más tranquilo o una ventana simplificada. Esta tesis contribuye a la investigación en el ámbito de la integración del proyecto de arquitectura en el lugar, describiendo una metodología de proyectar, en la que los elementos que sirven para separar espacios, también se emplean para vincularlos a un conjunto seleccionado de referencias a distintas escalas, lugares y tiempos. Este doble proceso que implica la construcción de los límites permite favorecer la proximidad a algunos aspectos del entorno y al mismo tiempo rechazar otros, permitiendo una perspectiva crítica y pudiendo proponer situaciones alternativas. ABSTRACT Malmó Eastern Cemetery (1916-1973) has received little international attention, despite the fact that Swedish architect Sigurd Lewerentz (1885-1975) led a large-scale experimental project, rejecting picturesque cemetery plans, popular in Europe at that time, and developing a more orthogonal layout, which was linked to the site in different ways. After Lewerentz won first prize in the competition to develop Malmó Eastern Cemetery, the project unfolded over a period of nearly sixty years. Malmó Eastern Cemetery project offers a unique lens through which to examine how different relationships were established between the architectural project and various features of the landscape: with the urban environment and various social circumstances using greenery as a boundary; with topography using the scale of construction and materials; with tradition by designing plans, sections and construction; with the international architectural arena by building walls; with common construction methods in Sweden using ordinary materials and with the surroundings by using detail. The hypothesis of this thesis explores the dual nature of the notion of limit in Lewerentz's work, and in Malmó Eastern Cemetery in particular, through the simultaneous creation of separations and connections with various aspects of place and time. This research documents and examines the construction of Malmó Eastern Cemetery by examining original drawings and writings from various archives, field exploration into the project and other cemeteries of the time, and the existing literature. By providing a detailed study of Lewerentz's evolving approach to the relationship between architecture and landscape, this thesis defines a framework in which Lewerentz's work may be understood in a more comprehensive way. Lewerentz was critical of some of the models of his time, although he established different connections with aspects of people's everyday lives. This set of connections defines a particular setting or set of circumstances for the project, which are more of an abstract notion. Within this double role of limits, a space of intersection is generated, which can be understood as a place of convergence for people. In this set of connections, the user is always at the centre of the design. For example, Lewerentz designed a portico that would provide shelter, an avenue of trees to produce a tranquil space of commemoration or a simplified window. This thesis contributes to research in the field of integration of an architectural project in a site, by describing a methodology of design, in which the elements used to subdivide spaces are also used to connect a set of selected references for different scales, locations and times. The dual process involved in building limits encourages proximity to some aspects of the environment, while rejecting others, thereby allowing for a critical perspective and the proposal of alternative situations.

LogIn Design City

LogIn Design City is a project for the revitalization of public city?s space through the involvement of individuals, collectivities and municipalities, managed by a specific team and structured upon an augmented platform. The management system permits the organization of self-managed events and actions, offering support and assistance for the implementation of these actions in the offered spots of the city. Actions can be of cultural, commercial, educational or leisure-oriented nature and depending on their purpose the spots can be offered free of charge or with fees, creating a possibility for remuneration and providing a tool for development in underprivileged zones of the city. An important aspect is the emphasis on the digital outlook of the city, which is structured as an interface that allows communication with the management system and information upon actual, past and upcoming events.

Producción social, proceso participativo e intervención sostenible en el espacio público de centros históricos

La formación académica de profesionales arquitectos bajo enfoques cientificistas y disciplinares aislados de la realidad espacial y social para la cual proyectan, como modelo de conocimiento y formación da paso al desarrollo de una praxis contemporánea de consulta y creación colectiva, tomada por los diseñadores como punto de partida para la exploración formal de proyectos de diseño urbano concertados y de investigación social. Este proyecto de investigación formativa con iniciativa ciudadana y académica, se basa en un método de diagnóstico y diseño participativo, para la valoración e intervención del patrimonio urbano-arquitectónico de la ciudad de Pamplona, con aplicación específica en el diseño de espacio público en el centro histórico de la ciudad de Pamplona. ABSTRACT Academic formation of professional architects, under the scientific and disciplinary approaches, isolate from space and social reality, as a model of knowledge and formation, leads to the development of a contemporary praxis of consultation and collective creation, taken by the designers as a starting point for the formal exploration of concerted urban design projects and social research. This project of formative research involving civil and academic initiative is based on a diagnostic method and participative design for the evaluation and intervention of Pamplona‘s architectural and urban heritage, specifically applied to the design of public space, in its historical center, based in the relationship that is built between the architects in formation and the community.

Propellantless deorbiting of space debris by bare electrodynamic tethers : final report

A Space tether is a thin, multi-kilometers long conductive wire, joining a satellite and some opposite end mass, and keeping vertical in orbit by the gravity-gradient. The ambient plasma, being highly conductive, is equipotential in its own co-moving frame. In the tether frame, in relative motion however, there is in the plasma a motional electric field of order of 100 V/km, product of (near) orbital velocity and geomagnetic field. The electromotive force established over the tether length allows plasma contactor devices to collect electrons at one polarized-positive (anodic) end and eject electrons at the opposite end, setting up a current along a standard, fully insulated tether. The Lorentz force exerted on the current by the geomagnetic field itself is always drag; this relies on just thermodynamics, like air drag. The bare tether concept, introduced in 1992 at the Universidad Politécnica de Madrid (UPM), takes away the insulation and has electrons collected over the tether segment coming out polarized positive; the concept rests on 2D (Langmuir probe) current-collection in plasmas being greatly more efficient than 3D collection. A Plasma Contactor ejects electrons at the cathodic end. A bare tether with a thin-tape cross section has much greater perimeter and de-orbits much faster than a (corresponding) round bare tether of equal length and mass. Further, tethers being long and thin, they are prone to cuts by abundant small space debris, but BETs has shown that the tape has a probability of being cut per unit time smaller by more than one order of magnitude than the corresponding round tether (debris comparable to its width are much less abundant than debris comparable to the radius of the corresponding round tether). Also, the tape collects much more current, and de-orbits much faster, than a corresponding multi-line “tape” made of thin round wires cross-connected to survive debris cuts. Tethers use a dissipative mechanism quite different from air drag and can de-orbit in just a few months; also, tape tethers are much lighter than round tethers of equal length and perimeter, which can capture equal current. The 3 disparate tape dimensions allow easily scalable design. Switching the cathodic Contactor off-on allows maneuvering to avoid catastrophic collisions with big tracked debris. Lorentz braking is as reliable as air drag. Tethers are still reasonably effective at high inclinations, where the motional field is small, because the geomagnetic field is not just a dipole along the Earth polar axis. BETs is the EC FP7/Space Project 262972, financed in about 1.8 million euros, from 1 November 2010 to 31 January 2014, and carrying out RTD work on de-orbiting space debris. Coordinated by UPM, it has partners Università di Padova, ONERA-Toulouse, Colorado State University, SME Emxys, DLR–Bremen, and Fundación Tecnalia. BETs work involves 1) Designing, building, and ground-testing basic hardware subsystems Cathodic Plasma Contactor, Tether Deployment Mechanism, Power Control Module, and Tape with crosswise and lengthwise structure. 2) Testing current collection and verifying tether dynamical stability. 3) Preliminary design of tape dimensions for a generic mission, conducive to low system-to-satellite mass ratio and probability of cut by small debris, and ohmic-effects regime of tether current for fast de-orbiting. Reaching TRL 4-5, BETs appears ready for in-orbit demostration.

Tether-mission design for multiple flybys of moon Europa

Electrodynamic tape-tethers are shown to allow a cheap, light, fast mission to Jupiter for multiple flybys of moon Europa and close exploration of the Jovian interior. As regards flybys, this mission is similar to the Clipper mission presently considered by NASA, the basic difference (periapsis location) arising from mission-challenge metrics.

Analysis and optimization for a hexapod walking robot for planetary missions

La tecnología de las máquinas móviles autónomas ha sido objeto de una gran investigación y desarrollo en las últimas décadas. En muchas actividades y entornos, los robots pueden realizar operaciones que son duras, peligrosas o simplemente imposibles para los humanos. La exploración planetaria es un buen ejemplo de un entorno donde los robots son necesarios para realizar las tareas requeridas por los científicos. La reciente exploración de Marte con robots autónomos nos ha mostrado la capacidad de las nuevas tecnologías. Desde la invención de la rueda, que esta acertadamente considerado como el mayor invento en la historia del transporte humano, casi todos los vehículos para exploración planetaria han empleado las ruedas para su desplazamiento. Las nuevas misiones planetarias demandan maquinas cada vez mas complejas. En esta Tesis se propone un nuevo diseño de un robot con patas o maquina andante que ofrecerá claras ventajas en entornos extremos. Se demostrara que puede desplazarse en los terrenos donde los robots con ruedas son ineficientes, convirtiéndolo en una elección perfecta para misiones planetarias. Se presenta una reseña histórica de los principales misiones espaciales, en particular aquellos dirigidos a la exploración planetaria. A través de este estudio será posible analizar las desventajas de los robots con ruedas utilizados en misiones anteriores. El diseño propuesto de robot con patas será presentado como una alternativa para aquellas misiones donde los robots con ruedas puedan no ser la mejor opción. En esta tesis se presenta el diseño mecánico de un robot de seis patas capaz de soportar las grandes fuerzas y momentos derivadas del movimiento de avance. Una vez concluido el diseño mecánico es necesario realizar un análisis que permita entender el movimiento y comportamiento de una maquina de esta complejidad. Las ecuaciones de movimiento del robot serán validadas por dos métodos: cinemático y dinámico. Dos códigos Matlab® han sido desarrollados para resolver dichos sistemas de ecuaciones y han sido verificados por un tercer método, un modelo de elementos finitos, que también verifica el diseño mecánico. El robot con patas presentado, ha sido diseñado para la exploración planetaria en Marte. El comportamiento del robot durante sus desplazamientos será probado mediante un código de Matlab®, desarrollado para esta tesis, que permite modificar las trayectorias, el tipo de terreno, y el número y altura de los obstáculos. Estos terrenos y requisitos iniciales no han sido elegidos de forma aleatoria, si no que están basados en mi experiencia como miembro del equipo de MSL-NASA que opera un instrumento a bordo del rover Curiosity en Marte. El robot con patas desarrollado y fabricado por el Centro de Astrobiología (INTA-CSIC), esta basado en el diseño mecánico y análisis presentados en esta tesis. ABSTRACT The autonomous machines technology has undergone a major research and development during the last decades. In many activities and environments, robots can perform operations that are tought, dangerous or simply imposible to humans. Planetary exploration is a good example of such environment where robots are needed to perform the tasks required by the scientits. Recent Mars exploration based on autonomous vehicles has shown us the capacity of the new technologies. From the invention of the wheel, which is rightly regarded as the greatest invention in the history of human transportation, nearly all-planetary vehicles are based in wheeled locomotion, but new missions demand new types of machines due to the complex tasks needed to be performed. It will be proposed in this thesis a new design of a legged robot or walking machine, which may offer clear advantages in tough environments. This Thesis will show that the proposed walking machine can travel, were terrain difficulties make wheeled vehicles ineffective, making it a perfect choice for planetary mission. A historical background of the main space missions, in particular those aimed at planetary exploration will be presented. From this study the disadvantages found in the existing wheel rovers will be analysed. The legged robot designed will be introduced as an alternative were wheeled rovers could be no longer the best option for planetary exploration. This thesis introduces the mechanical design of a six-leg robot capable of withstanding high forces and moments due to the walking motion. Once the mechanical design is concluded, and in order to analyse a machine of this complexity an understanding of its movement and behaviour is mandatory. This movement equation will be validated by two methods: kinematics and dynamics. Two Matlab® codes have been developed to solve the systems of equations and validated by a third method, a finite element model, which also verifies the mechanical design. The legged robot presented has been designed for a Mars planetary exploration. The movement behaviour of the robot will be tested in a Matlab® code developed that allows to modify the trajectories, the type of terrain, number and height of obstacles. These terrains and initial requirements have not been chosen randomly, those are based on my experience as a member of the MSL NASA team, which operates an instrument on-board of the Curiosity rover in Mars. The walking robot developed and manufactured by the Center of Astrobiology (CAB) is based in the mechanical design and analysis that will be presented in this thesis.

The development of architecture and urban design in China and the problem we need to solve = La utilización de la baja tecnología en la arquitectura popular de China y su combinación con el método del diseño arquitectónico moderno

In this article, I will research this topic from these aspects: the material, architectural forms, building technology and space experience, hoping to figure out the characteristic of traditional Chinese architecture and the use of low technology in it, explore a suitable path of the development of Chinese Vernacular Architecture.

Prototipos experimentales modernos: la colonia de Schorlemerallee y las villas Am Rupenhorn de los Luckhardt y Anker. Berlín 1924-1930

La colonia experimental de Schorlemerallee y las villas Am Rupenhorn son dos proyectos concluidos en 1930 por los hermanos Wassili y Hans Luckhardt con Alfons Anker en Berlín. Ambos proyectos forman parte del mismo proceso, que comienza en la Colonia -una exploración sobre el lenguaje moderno en una serie de fases sucesivas- y culmina con las Villas. Éstas últimas, realizadas inmediatamente después de la Colonia, son la síntesis de esa experiencia, aunque finalmente acabaron trascendiéndola, ya que se convirtieron en un modelo sobre la casa en la naturaleza, sobre la idea de la villa clásica y sobre los nuevos modos de habitar, alcanzando con el tiempo la condición de canon moderno. A pesar de ello, no es esta condición lo más importante. Lo singular en este caso, es el propio proceso de proyecto –Colonia versus Villas- un verdadero experimento en su concepción, método y resultados, a través del cual sus autores investigan nuevas tecnologías aplicadas a nuevas formas de habitar y desarrollan un nuevo lenguaje, cuyo resultado son unos prototipos tecnológicos, con los que pretenden, como diría Mies van der Rohe: “Me he esforzado por construir una arquitectura para una sociedad tecnológica. He intentado que todo resultara razonable y claro.....para que cualquiera pueda hacer arquitectura.” El momento y lugar no pueden ser más propicios: Berlín entre 1924 y 1930, en el mismo origen del Movimiento Moderno. El experimento se plantea con auténtico rigor científico. Los arquitectos diseñan, construyen y financian su proyecto, controlando todas sus variables. Especialmente, por lo insólito, es el control de la variable económica. Porque este factor, la economía, es para ellos una clave fundamental del proceso. Se trataba de demostrar que la Nueva Arquitectura (o Neues Bauen, como les gustaba denominarla) era capaz de construir mejor y más rápido la vivienda para una nueva sociedad. La revolución y la vanguardia van de la mano: son el Zeitgeist o espíritu de la época, un contexto que es parte sustancial del proceso, y como lo calificarían los Smithson, un contexto heroico. El concepto se centra en la tríada Bauhaus: diseño + tecnología x economía. En cuanto al método, se fijan una serie de parámetros –las variables del experimento- que se agrupan en tres categorías distintas: topología, tipología y tecnología. La combinación de las variables de cada categoría dará lugar a un sistema con unas características determinadas: una definición del espacio, una forma, un lenguaje y una tecnología, características que permiten establecer las reglas para su desarrollo. Los sistemas resultantes son tres, denominados según su doble condición tipológica/ tecnológica: 1. Sistema de muro de carga: Viviendas adosadas en zig-zag o Mauerwerksbauten. 2. Sistema de esqueleto de acero: Viviendas aisladas o Stahlskelettbauten 3. Sistema de hormigón armado: Viviendas en hilera recta o Betonbauten Las villas Am Rupenhorn se plantean a continuación como verificación de este proceso: la síntesis de las categorías desarrolladas en la Colonia. Pero llegan en un momento de gracia, justo cuando los Luckhardt y Anker se encuentran profundamente implicados en el proceso de desarrollo de un nuevo lenguaje y con la reciente experiencia de la Colonia, que ha sido un éxito en casi todos los aspectos posibles. “En 1930, están en la cumbre”, como diría su mejor crítico y antiguo colaborador: Achim Wendschuh. En las Villas, los arquitectos integran su lenguaje, ya plenamente moderno, con sus experiencias previas: las que los relacionan con su reciente expresionismo (que se podría calificar como Kunstwollen) y con la tradición clásica de la cultura arquitectónica alemana: el sentido del material que deben a Semper y la sensibilidad hacia el paisaje, que toman de Schinkel. El extraordinario interés de las Villas se debe a factores como el tratamiento de la relación dual, poco habitual en la arquitectura moderna, la síntesis de lenguajes y las circunstancias de su momento histórico, factores que las han convertido en una propuesta única e irrepetible de una de las vías experimentales más interesantes y desconocidas de la Modernidad. ABSTRACT The experimental Housing Estate of Schorlemerallee and the Am Rupenhorn Villas are two projects completed by the brothers Wassili and Hans Luckhardt with Alfons Anker in Berlin in 1930. Both projects are part of the same process, starting with the Housing Estate --an exploration of the modern language in a series of phases- which culminates with the Villas project. The Villas Am Ruperhorn, designed immediately after the Housing development, are the synthesis and crowning point of this experience, even finally over passing it, since they have become a model of the house in nature, related with both the ideal of the classical villa and the new ways of life, reaching the condition of a modern canon. However, this is not its most important issue. The most remarkable condition is the project process itself -Housing versus Villas- a true experiment in concept, method and results, in which the authors research new technologies for new ways of living, developing an innovative language, with results in new prototypes, in the way Mies van der Rohe was looking for: “I have tried to make an architecture for a technological society. I have wanted to keep everything reasonable and clear… to have an architecture that anybody can do." The time and place could not be more favourable: Berlin from 1924 to 1930, in the very origin of Modern Movement. The experiment takes place with genuine scientific accuracy. Architects design, build and finance their own project, controlling all variables. Especially, and quite unusual, the control of the economic variable. Precisely the economic factor is for them a fundamental key to the process. It was shown to prove that the new architecture (or Neues Bauen, as they liked to call it) was able to build not only faster, better and more efficient dwellings for a new society, but also at lower cost. Revolution and Avant-garde use to move forward together, because they share the Zeitgeist --or time's spirit--, a context which is a substantial part of the process, and as the Alison & Peter Smithsons would describe, an heroic context. The concept focuses on the Bauhaus triad: Design + Technology x Economy. For the method, a number of variables are fixed --the experimental parameters-- that are later grouped into three distinct categories: Topology, Typology and Technology. The combination of these variables within each category gives way to several systems, with specific characteristics: a definition of space, a form, a language and a technology, thus allowing to establish the rules for its development: The resulting systems are three, called by double typological / technological issue: 1. Terraced Housing in zig-zag or Mauerwerksbauten (bearing wall system) 2. Detached Housing or Stahlskelettbauten (steel skeleton system) 3. Terraced Housing in one row or Betonbauten (reinforced concrete system) The Am Rupenhorn Villas are planned as the check of this process: the synthesis of the categories developed all through the Housing Estate research. The Am Ruperhorn project is developed in a crucial moment, just as the Luckhardts and Anker are deeply involved in the definition process of a new language after the recent experience of Schorlemerallee, which has been a success in almost all possible aspects. "In 1930, they are on the top” has said his best critic and long-time collaborator, Achim Wendschuh. In the Villas, the authors make up their fully modern language with their own background, related with their recent Expressionist trend (Kunstwollen) and with the classical tradition of the German architectural culture: the notion of material related with Semper and the sensible approach to the landscape, linked with Schinkel. Its extraordinary interest lay on diverse factors, such as dual relationships, unusual in modern architecture, synthesis of languages and circumstances of their historical moment, all factors that have become a unique and unrepeatable proposal in one of the most extraordinary experimental ways of Modernity.

Ergociudad: concepción modélica de la calidad de vida urbana desde la perspectiva de la ergonomía y el diseño urbano

Este documento corresponde a la Tesis para optar al grado de Doctor en Arquitectura y Urbanismo en el marco del Programa de Doctorado conjunto de la Universidad Politécnica de Madrid y la Universidad de Chile. La investigación realizada es de carácter exploratorio-descriptivo con el propósito de establecer y relacionar conceptualmente las teorías y principios de la ergonomía y del diseño urbano, para proponer desde un enfoque sistémico criterios de confort en el diseño de la ciudad, que contribuyan a la calidad de vida y la vida urbana, dando a luz lineamientos para la “Ergociudad”; concepto que surge de la unión de las palabras Ergonomía y Ciudad. Al estudiar a diversos autores se concluye en la carencia de referentes de confort y de políticas basados en la relación empírica del ser humano en la ciudad que posibiliten la configuración del medio ambiente urbano a partir de ella. La ciudad se piensa y se construye desde su estructura y no desde una mirada sistémica e integrada de los factores dimensionales, ambientales y psicosociales condicionantes del confort en sus distintas escalas. La mirada respecto del desarrollo de la ciudad es físico constructiva y, por tanto, deja de lado el problema de los estresores o de la percepción de los factores de riesgo en el entorno construido. El tema central de esta tesis es proponer una estructura modélica de calidad de vida urbana denominada Ergociudad en base a los fundamentos teóricos de la Ergonomía y el Diseño Urbano y establecer el “Índice Ergourbano”, como representación de los factores ergonómicos presentes en la ciudad. En este marco, el enfoque de la ergonomía y sus prestaciones han sido trabajados en orden a facilitar mecanismos para disponer de sus procedimientos y de su modelo de análisis relacional a otras escalas. El concepto de “Ergociudad” y su propuesta de exploración desde las personas, postula una mirada sobre los problemas que enfrenta el ser humano en la ciudad considerando la dimensión de lo humano, desde perspectivas psicológicas y sociológicas para establecer y configurar la percepción de estrés y bienestar; la dimensión de lo urbano, representada por los objetos que componen el entorno (en sus distintas escalas); y, la dimensión de lo perceptual, que definiría el concepto de confort en la forma de comprender el mundo sensorial. Los resultados de la investigación confirman la hipótesis de trabajo en términos de demostrar que la percepción de disconfort en la ciudad reflejado en un índice de evaluación perceptual espacial denominado índice Ergourbano obtenido de las mediciones en situ de los factores ergonómicos del entorno. Los resultados finales de la tesis han permitido identificar variables afines en los aspectos espaciales y perceptuales. Ello mediante la exploración de las situaciones urbanas y sus conexiones para establecer el grado de adecuación del espacio urbano a las prácticas, usos y modos de las personas en la ciudad. Una vez aplicado y validado el método desarrollado se ha llegado a obtener información suficiente para aumentar el nivel de conocimiento sobre el espacio urbano con un enfoque relacional que permite entenderlo desde la experiencia de las personas que lo habitan, insistiendo en su aporte metodológico y proyectual considerando la inexistente aplicación de información que vincule la ergonomía a esta escala urbana. ABSTRACT This document corresponds to the thesis to obtain the degree of Doctor of Architecture and Urbanism in the framework of the combined doctorate program of the Technical University of Madrid and the University of Chile. The research carried out is of a descriptive–explanatory nature with the objective of establishing and conceptually relating the theories and principals of ergonomics (or human factors) and urban design. This is done in order to propose, from a systematic focus, comfort criteria in the design of cities that contribute to quality of life and urban life, giving birth to chacteristics for “Ergocity”; concepts that arise from the union of the words ergonomic and city. After studying diverse authors, one concludes the lack of references toward comfort and policies based on the empirical relation of humans in the city that allow for the configuration of the urban environment based on comfort. The city is thought out and built from its structure and not from a systematic and integrated viewpoint of the dimensional, environmental and psychosocial factors, determining factors of comfort in its distinct scales. The view regarding the development of the city is physical constructive and, therefore, leaves aside the problem of the stress factors or the perception of risk factors in the constructed environment. The central theme of this thesis is to propose a quality model of urban life entitled Ergo-city, based on the fundamental theories of the ergonomics and urban design, and to establish an “Ergourban index” as representation of the ergonomic factors present in the city. In this framework, the focus of ergonomics and its services have been used in order to facilitate mechanisms to arrange their procedures and their model of relational analysis on other scales. The concept of “Ergocity”and its offer of exploration from a people perspective, proposes a look at the problems that humans face in the city considering the nonhuman dimension, from psychological and sociological perspectives to establish and configure la perception of stress and well-being: the urban dimension, represented by the objects that the surroundings are made up of (on their distinct scales), and the perceptual dimension, which will define the concept of comfort by means of understanding the sensorial world. The results of the research confirm the working hypothesis in terms of demonstrating the perception of discomfort in the city reflected in an index of perceptual/spatial evaluation named ergo-urban obtained from in situ measurements of the ergonomic factors of the surroundings. The final results of the thesis have permitted the identification the identification of variables related to the spatial and perceptual aspects. All of this through the exploration of the urban situations and their connections in order to establish the level of adaptation of the urban space to the practices, uses and modes of the people in the city. Once applied and validated, the method of development has led to the collection of sufficient information to increase the level of knowledge of the urban space with a relational focus that allows us to understand it from the experience of the people who inhabit said space, persisting with its methodological and projective contribution considering the inexistent application of information that links the ergonomics on an urban scale.

Peptide design by artificial neural networks and computer-based evolutionary search

A technique for systematic peptide variation by a combination of rational and evolutionary approaches is presented. The design scheme consists of five consecutive steps: (i) identification of a “seed peptide” with a desired activity, (ii) generation of variants selected from a physicochemical space around the seed peptide, (iii) synthesis and testing of this biased library, (iv) modeling of a quantitative sequence-activity relationship by an artificial neural network, and (v) de novo design by a computer-based evolutionary search in sequence space using the trained neural network as the fitness function. This strategy was successfully applied to the identification of novel peptides that fully prevent the positive chronotropic effect of anti-β1-adrenoreceptor autoantibodies from the serum of patients with dilated cardiomyopathy. The seed peptide, comprising 10 residues, was derived by epitope mapping from an extracellular loop of human β1-adrenoreceptor. A set of 90 peptides was synthesized and tested to provide training data for neural network development. De novo design revealed peptides with desired activities that do not match the seed peptide sequence. These results demonstrate that computer-based evolutionary searches can generate novel peptides with substantial biological activity.

Computational method to reduce the search space for directed protein evolution

We introduce a computational method to optimize the in vitro evolution of proteins. Simulating evolution with a simple model that statistically describes the fitness landscape, we find that beneficial mutations tend to occur at amino acid positions that are tolerant to substitutions, in the limit of small libraries and low mutation rates. We transform this observation into a design strategy by applying mean-field theory to a structure-based computational model to calculate each residue's structural tolerance. Thermostabilizing and activity-increasing mutations accumulated during the experimental directed evolution of subtilisin E and T4 lysozyme are strongly directed to sites identified by using this computational approach. This method can be used to predict positions where mutations are likely to lead to improvement of specific protein properties.

Persisting to Graduation: A Grounded Theory Exploration of Nontraditional Undergraduate Women's Enrollment

While women maintain a numerical majority in undergraduate college enrollments and degrees earned, they also represent the numerical majority among students over 29 years old, students of color, students who are in the lowest income category, students who are single parents, and students who attend college part-time (Peter & Horn, 2005; Planty, et al., 2008). The National Center for Educational Statistics (NCES) has identified seven characteristics that place students at risk of not completing an undergraduate degree; (a) delayed enrollment between high school and college, (b) part-time enrollment, (c) financial independence, (d) students with dependents, (e) students who are single parents, (f) students who work full-time while enrolled, and (g) students who completed a GED as opposed to earning a high school diploma (Choy, 2002; Dickerson & Stiefer, 2006; Horn & Premo, 1995). The above characteristics overlap with the categories where women have a numerical majority, thereby placing women in greater jeopardy of not completing a bachelor's degree. A review of the existing persistence literature demonstrates a lack of research devoted to understanding the persistence experiences, challenges, strategies, and decisions of nontraditional undergraduate in favor of the "traditional" undergraduate student (Pascarella & Terenzini, 2005; Reason 2003). For this doctoral dissertation, I have based the research on a critical race feminist framework, informed by my experience working with the population of nontraditional undergraduate women at a women's college and employed a critique of the persistence literature as sensitizing concepts. Using a modified grounded theory research design, I collected and analyzed data which led to the development of a grounded theory of nontraditional undergraduate women's persistence. The emergent concepts of commitment, environment, and support interact in a theory of academic momentum and I offer a critical race feminist reading of the findings and theory to expose race neutrality, honor the voices of women of color, and deconstruct the evidence presented. The implications of this research include student, institutional, and inclusive excellence approaches to increasing the persistence of nontraditional undergraduate women and contribute to the success of this unique population of learners.

Design of online practical lessons in colorimetry

Applied colorimetry is an important module in the program of the elective subject "Colour Science: industrial applications”. This course is taught in the Optics and Optometry Degree and it has been used as a testing for the application of new teaching and assessment techniques consistent with the new European Higher Education Area. In particular, the main objective was to reduce the attendance to lessons and encourage the individual and collective work of students. The reason for this approach is based on the idea that students are able to work at their own learning pace. Within this dynamic work, we propose online lab practice based on Excel templates that our research group has developed ad-hoc for different aspects of colorimetry, such as conversion to different colour spaces, calculation of perceptual descriptors (hue, saturation, lightness), calculation of colour differences, colour matching dyes, etc. The practice presented in this paper is focused on the learning of colour differences. The session is based on a specific Excel template to compute the colour differences and to plot different graphs with these colour differences defined at different colour spaces: CIE ΔE, CIE ΔE94 and the CIELAB colour space. This template is implemented on a website what works by addressing the student work at a proper and organized way. The aim was to unify all the student work from a website, therefore the student is able to learn in an autonomous and sequential way and in his own pace. To achieve this purpose, all the tools, links and documents are collected for each different proposed activity to achieve guided specific objectives. In the context of educational innovation, this type of website is normally called WebQuest. The design of a WebQuest is established according to the criteria of usability and simplicity. There are great advantages of using WebQuests versus the toolbox “Campus Virtual” available in the University of Alicante. The Campus Virtual is an unfriendly environment for this specific purpose as the activities are organized in different sectors depending on whether the activity is a discussion, an activity, a self-assessment or the download of materials. With this separation, it is more difficult that the student follows an organized sequence. However, our WebQuest provides a more intuitive graphical environment, and besides, all the tasks and resources needed to complete them are grouped and organized according to a linear sequence. In this way, the student guided learning is optimized. Furthermore, with this simplification, the student focuses on learning and not to waste resources. Finally, this tool has a wide set of potential applications: online courses of colorimetry applied for postgraduate students, Open Course Ware, etc.