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This article presents part of a larger study on the use of reference sources to perform bibliographical search by graduate students in Education. Data relating to the use of the scientific journals by these students are presented and discussed. Sixty Education graduate students, 28 Master degree and 32 Doctoral, answered an electronic questionnaire. The students indicated the types of articles usually read and the importance attributed to each one. For each of treated themes in the electronic questionnaire, data are initially presented and analyzed in the set of the 60 participants of the study and then compared between master and doctoral students. Were used the Chi-squared (?2) test, the Fisher exact test and the Spearman’s correlation coefficient. Research reports were more frequently pointed out but less valued in comparison to articles referring to critical review and theoretical essay. Methodological articles, appearing in fourth position according to reading frequency and importance attributed, are more valued by doctoral than master students. The students read these articles using different procedures. The possible reasons for the students valorizing the articles of critical review and theoretical essays are discussed. The present study intends to offer a contribution to understand the use of scientific information by students, describing some graduate students’ habits related to information seeking in scientific journals, and reading of the articles published.

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In the context of the studies in the Information Science, the information not just depends on meaning, but the social bows are current of this. The research in development analyse conceptual elements to answer the question about the semiotic foundations of the information mediation processes. This paper aim to know and analyse the semiotic foundations of the information mediation processes in the Information Science context. It presents concepts and reflections regarding the relationship of the information mediation process Charles Peirce's Semiotics, especially, the discussion about the semiotic bases to information mediation process. It discusses the information mediation as a specialization of the communication process, developed, fundamentally, for the human action trying to solve communication and technical problems in sociocultural order.

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The Information and Communication Technologies (ICT) can be combined with the acquisition of academic knowledge and cultural development of students, as they improve their information literacy, and why not say, also digital. Weaim in this research seek references and present experiences that encourage a new concept of school library with the use of ICT in teaching and learning in individual and collective development of the student community. To complement this study we prioritized the following objectives: to insert the technology into the routine of a school library; identify the informational and technological profile of adolescents; understand the needs and technological resources they use to obtain information in daily life and also analyze the importance the effective participation of the school library in the educational context of the school, through greater interaction between the librarian, teacher and pedagogical coordination seeking a cooperative and informal ICT teaching and learning for along with the students, sharing the search for information and knowledge, in a conscious and responsible way. Chosen as theoretical foundation the cognitive studies of Jean Piaget, witch explains how the stages of assimilation and accommodation of knowledge in cooperative practices work. As a methodology was developed a participatory-action research, to learn the behavioral state of young people and adolescents, based on the model of information search for the everyday life (Everyday Life Information Seeking) – ELIS, developed by Finnish researcher Savoleinen (2006), as well as identify the informational and technological profile of adolescents from two selected approaches in the scientific literature (HUGUES-HASSEL; AGOSTO, 2007; UCL, 2008). Thus, came up the initiative to create a Confraternity of the Library in a collaborative digital environment, providing the participants discussion and learning technologies as well as digital information literacy enhancement.

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Como se estivesse tecendo num antigo tear manual, a linha narrativa de El retorno de Eva, da escritora paraguaia Susana Gertopan, vai compondo, com os fios da tradição e da modernidade, memória e história, exílio e retorno, a trajetória de uma jovem mulher em busca de si na condição de cidadã paraguaia e judia. Enquanto a protagonista busca desfazer-se dos diversos nós que a vinculam a uma herança cultural e religiosa que não combina, como ela mesma diz, com o cenário no qual cresce, e nem com a vida moderna de Jerusalém, terra prometida dos seus antepassados para onde emigra, vamos observando a problemática tessitura de sua individualidade entre dois mundos, ambos em crise e transição.

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Discusses some aspects of newspaper hypertextual article in order to find their ideological marks. Assumes that the choice of the element of contact with other texts (links), when producing an article reveals the author's ideology and the institution he represents. Intends to offer the less experienced reader of news, conditions to the development of more fruitful reading. Argues that reading is a process of interaction between reader and text and that requires the presence of an active reader, able to construct new meanings. Establishes as a general objective to identify the ideological marks presents in hypertext and its relation to the critical reading of the media. This theme is treated with special attention to its educational aspects, aiming at understanding the reality that educators must become familiar with, in order to turn more effective the processes of education for the media.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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September 11 has originated a wide range of artistic manifestations which have not only searched for plausible explanations for the tragedy, but also tried to review the events. In this sense, this paper aims at showing how a novel reevaluates this episode. The attacks made the United States experience a strong sense of vulnerability triggering reactions from the American government, whose quick action was translated into a new national security strategy associated with the war on terror. This paper analyzes the narrative strategies employed by the American author Don DeLillo in his novel Falling Man (2007) in order to reevaluate that tragedy. The debate of the topics is based on texts concerning the relationship between literature and history, postmodern fiction and issues on terrorism. This study contributes to enrich the discussion related to the events that led to the catastrophe and its aftermath, examining characters and groups linked to the September 11 terrorist attacks, revealing multiple truths subjected to social, ideological and historical conditions.

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It was observed the metacognitive trajectory of three users from a public university library the state of Sao Paulo to identify the metacognitive strategies that were used during the process of searching for information in a online collective catalog. Its configuration was based on participants' oral reports obtained by the technique of individual verbal protocol to provide an actual configuration of the task ans a closer examination of its natural recovery of information systems. The data collection sessions were recorded, and the recorded data were transcribed and categorized into four units of analyses: 1- expertise, 2-regulation, 3-assessment of knowledge itself and 4- organization of cognitive process. The results showed that knowledge of meta-cognitive strategies affects the quality of the results obtained in the process of searching for information and interferes in the way it implements retrieval on-line catalog, a fact the emphasizes the need for studies to move forward on issues meta-cognition of users of information.

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O presente trabalho de conclusão de curso reporta os resultados obtidos durante o estágio de Iniciação Científica realizado no Núcleo de Biossíntese, Bioensaios e Ecofisiologia de Produtos Naturais do Departamento de Química Orgânica do Instituto de Química da UNESP-Araraquara. Foram realizados ensaios de triagem de substâncias naturais, semissintéticas e sintéticas com atividade inibitória sobre a protease aspártica pepsina e a protease serínica subtilisina. As amostras foram obtidas de extratos vegetais e de fungos endofíticos e foram testadas tanto substâncias puras naturais como diterpenos clerodânicos, cromenos, peptídeos e amidas bem como derivados sintéticos do ácido caféico, ferúlico, alcalóides piridínicos, entre outros resultantes das pesquisas realizadas por pesquisadores do NuBBE. Resultados mostraram que os ensaios de inibição da pepsina e da subtilisina apresentaram seletividade para os diferentes tipos de substâncias testadas. Ainda mais, foi possível observar diferenças nos resultados obtidos com os enantiômeros dos cromanos e dos cromenos. As substâncias que apresentaram maiores porcentagens de inibição foram os cromenos, os derivados do ácido cafeico, do ácido ferúlico e do ácido benzóico, as amidas, bem como os diterpenos clerodânicos. Alguns destes resultados foram publicados em revistas indexadas (Flausino et al., 2009; López et al., 2010; Oliveira et al., 2011) e outros estão sendo preparados para publicação

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In this work, a tabu search algorithm for solving uncapacitated location problems is presented. The uncapacitated location problem is a classic problem of localization and occurs in many practical situations. The problem consists in determining in a network, at the minimum possible cost, the better localization, in a network, for the installation of facilities in order to attend the customers' associated demands, at the minimum possible cost. One admits that there exists a cost associated with the opening of a facility and a cost of attendance of each customer by any open facilities. In the particular case of the uncapacitated location problem there is no capacity limitation to attend the customers’ demands. There are some parameters in the algorithm that influence the solution’s quality. These parameters were tested and optimal values for them were obtained. The results show that the proposed algorithm is able to find the optimal solution for all small tested problems keeping the compromise between solution’s quality and computational time. However, to solve bigger problems, the structure of the algorithm must be changed in its structure. The implemented algorithm is integrated to a computational platform for solution of logistic problems

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A sociedade contemporânea presencia um momento mundial bastante crítico, no qual se faz presente uma crise sócio-ambiental que tende a se agravar a cada dia devido à exploração e distribuição de recursos naturais inadequadas. Na busca de um modelo que torne viável a sobrevivência das futuras gerações de todas as espécies viventes, faz-se necessária uma alteração do paradigma antropocêntrico vigente, para um paradigma biocêntrico, comprometido com todas as formas de vida do planeta. A mudança dos padrões consumistas presentes no sistema capitalista para padrões permeados pelo consumo sustentável torna-se base essencial para esta mudança de paradigmas. Em tal processo de transição, a educação aparece como uma importante ferramenta para a formação de indivíduos conscientes, criativos e portadores de senso crítico, enfim, indivíduos mais capazes de promover as mudanças de padrões necessárias. Surge então a necessidade de uma educação inovadora, que promova a formação de cidadãos conscientes e atuantes. A partir dessas necessidades, surge o trabalho aqui exposto, com o objetivo de proporcionar uma cartilha de base para iniciativas educacionais voltadas ao consumo responsável.

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A metilação de ilhas CpG em regiões regulatórias de vários genes tem sido descrita como um processo importante no silenciamento de genes supressores de tumor e diretamente envolvida no processo de carcinogênese de uma série de tumores. O estudo desses genes afetados pela metilação em tumores visa identificar possíveis marcadores moleculares para o diagnóstico, prognóstico e tratamento de tumores, além de possibilitar a descoberta de fatores importantes no processo biológico do câncer. Os genes MX1 e ADAM23 foram identificados como diferencialmente metilados em linhagens celulares provenientes de carcinoma de cabeça e pescoço. Neste sentido, ao estudar o perfil diferencial de metilação de genes em carcinomas de células escamosas de cabeça e pescoço, o gene MX1 foi identificado como diferencialmente expresso. Dessa forma, para elucidar a função destes genes no controle da carcinogênese, o presente estudo buscou identificar ligantes celulares das proteínas MX1 e ADAM23 por meio de rastreamentos de duplo-híbrido, usando bibliotecas de cDNA de cérebro fetal humano. Os rastreamentos com a proteína ADAM23 não geraram resultados positivos por isso não são aqui discutidos. Foi realizado rastreamento com a proteína MX1, que resultou em aproximadamente 1,0x106 transformantes, dos quais 74 foram confirmados pelo ensaio de duplo-híbrido e codificam para 9 ligantes já conhecidos e 21novos ligantes prováveis de MX1. Entre esses novos ligantes prováveis estão proteínas que já haviam sido descritas como ligantes de MX1, incluindo a própria proteína MX1, o que valida os resultados obtidos com este rastreamento. Além disso, grande parte dos ligantes identificados são fatores envolvidos no processo de SUMOilação de proteínas, na formação de corpúsculos nucleares denominados PML-NB e uma série de proteínas relacionadas ao controle da transcrição e apoptose... (Resumo completo, clicar acesso eletrônico abaixo)