Mechanism of induction of muscle protein degradation by angiotensin II

Angiotensin I and II have been shown to directly induce protein degradation in skeletal muscle through an increased activity and expression of the ubiquitin-proteasome proteolytic pathway. This investigation determines the role of the nuclear transcription factor nuclear factor-κB (NF-κB) in this process. Using murine myotubes as a surrogate model system both angiotensin I and II were found to induce activation of protein kinase C (PKC), with a parabolic dose-response curve similar to the induction of total protein degradation. Activation of PKC was required for the induction of proteasome expression, since calphostin C, a highly specific inhibitor of PKC, attenuated both the increase in total protein degradation and in proteasome expression and functional activity increased by angiotensin II. PKC is known to activate I-κB kinase (IKK), which is responsible for the phosphorylation and subsequent degradation of I-κB. Both angiotensin I and II induced an early decrease in cytoplasmic I-κB levels followed by nuclear accumulation of NF-κB. Using an NF-κB luciferase construct this was shown to increase transcriptional activation of NF-κB regulated genes. Maximal luciferase expression was seen at the same concentrations of angiotensin I/II as those inducing protein degradation. Total protein degradation induced by both angiotensin I and II was attenuated by resveratrol, which prevented nuclear accumulation of NF-κB, confirming that activation of NF-κB was responsible for the increased protein degradation. These results suggest that induction of proteasome expression by angiotensin I/II involves a signalling pathway involving PKC and NF-κB. © 2005 Elsevier Inc. All rights reserved.

Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia

The ability of angiotensin I (Ang I) and II (Ang II) to induce directly protein degradation in skeletal muscle has been studied in murine myotubes. Angiotensin I stimulated protein degradation with a parabolic dose-response curve and with a maximal effect between 0.05 and 0.1 μM. The effect was attenuated by coincubation with the angiotensin-converting enzyme (ACE) inhibitor imidaprilat, suggesting that angiotensin I stimulated protein degradation through conversion to Ang II. Angiotensin II also stimulated protein breakdown with a similar dose-response curve, and with a maximal effect between 1 and 2.5 μM. Total protein degradation, induced by both Ang I and Ang II, was attenuated by the proteasome inhibitors lactacystin (5 μM) and MG132 (10 μM), suggesting that the effect was mediated through upregulation of the ubiquitin-proteasome proteolytic pathway. Both Ang I and Ang II stimulated an increased proteasome 'chymotrypsin-like' enzyme activity as well as an increase in protein expression of 20S proteasome α-subunits, the 19S subunits MSSI and p42, at the same concentrations as those inducing protein degradation. The effect of Ang I was attenuated by imidaprilat, confirming that it arose from conversion to Ang II. These results suggest that Ang II stimulates protein degradation in myotubes through induction of the ubiquitin-proteasome pathway. Protein degradation induced by Ang II was inhibited by insulin-like growth factor and by the polyunsaturated fatty acid, eicosapentaenoic acid. These results suggest that Ang II has the potential to cause muscle atrophy through an increase in protein degradation. The highly lipophilic ACE inhibitor imidapril (Vitor™) (30 mg kg-1) attenuated the development of weight loss in mice bearing the MAC16 tumour, suggesting that Ang II may play a role in the development of cachexia in this model. © 2005 Cancer Research.

Global compilation of benthic data sets I

Approaches to quantify the organic carbon accumulation on a global scale generally do not consider the small-scale variability of sedimentary and oceanographic boundary conditions along continental margins. In this study, we present a new approach to regionalize the total organic carbon (TOC) content in surface sediments (<5 cm sediment depth). It is based on a compilation of more than 5500 single measurements from various sources. Global TOC distribution was determined by the application of a combined qualitative and quantitative-geostatistical method. Overall, 33 benthic TOC-based provinces were defined and used to process the global distribution pattern of the TOC content in surface sediments in a 1°x1° grid resolution. Regional dependencies of data points within each single province are expressed by modeled semi-variograms. Measured and estimated TOC values show good correlation, emphasizing the reasonable applicability of the method. The accumulation of organic carbon in marine surface sediments is a key parameter in the control of mineralization processes and the material exchange between the sediment and the ocean water. Our approach will help to improve global budgets of nutrient and carbon cycles.

Aprendizagem criativa na aula de piano em grupo

The central focus of this thesis was to investigate creative learning in music at piano group lessons. Thus, the theoretical framework adopted was guided by two main principles: (1) creativity in the field of music education and (2) Piano teaching and learning. As a methodological procedure we used a research-action with students of the disciplines Prática de Instrumento Harmônico I e II, at the Music Education Undergraduate Course of Federal University of Rio Grande do Norte (UFRN). This research-action was structured in four phases: 1) the identification of the starting points and the theme of creativity matters in piano group lessons, considering the context of a teacher training course in music; 2) the projection of actions, the definition of the objectives and the organization of instruments of data collection and analysis; 3) the realization of the planned actions; and 4) the evaluation of the results, the transcription, organization and analysis of the data collected through observation and interviews. Given the Creative Learning Cycle in Music, represented by the activities of composing, performing and criticizing Music, defended by Beineke (2009, 2013, 2015), we propose in this thesis a creative cycle of formation in music to promote creative learning in piano group lessons, in which teachers and students teach and learn creatively, expanding training opportunities in the field of Music Education. This was possible due to the joint experience of creative practices related to improvisation, elaboration of arrangements and musical compositions - elements that contributed positively to the learning process of the participants. But for this to occur, the planning, implementation and evaluation of the creative and pedagogical musical procedures adopted were decisive, considering the perspectives of students, their conceptions, musical creations, processes and collaborative exchange.

Aprendizagem criativa na aula de piano em grupo

The central focus of this thesis was to investigate creative learning in music at piano group lessons. Thus, the theoretical framework adopted was guided by two main principles: (1) creativity in the field of music education and (2) Piano teaching and learning. As a methodological procedure we used a research-action with students of the disciplines Prática de Instrumento Harmônico I e II, at the Music Education Undergraduate Course of Federal University of Rio Grande do Norte (UFRN). This research-action was structured in four phases: 1) the identification of the starting points and the theme of creativity matters in piano group lessons, considering the context of a teacher training course in music; 2) the projection of actions, the definition of the objectives and the organization of instruments of data collection and analysis; 3) the realization of the planned actions; and 4) the evaluation of the results, the transcription, organization and analysis of the data collected through observation and interviews. Given the Creative Learning Cycle in Music, represented by the activities of composing, performing and criticizing Music, defended by Beineke (2009, 2013, 2015), we propose in this thesis a creative cycle of formation in music to promote creative learning in piano group lessons, in which teachers and students teach and learn creatively, expanding training opportunities in the field of Music Education. This was possible due to the joint experience of creative practices related to improvisation, elaboration of arrangements and musical compositions - elements that contributed positively to the learning process of the participants. But for this to occur, the planning, implementation and evaluation of the creative and pedagogical musical procedures adopted were decisive, considering the perspectives of students, their conceptions, musical creations, processes and collaborative exchange.

El hermafrodito: a propósito de la monstruosidad en la obra de Cristóbal de Castillejo

En la polifacética y satírica obra de Cristóbal de Castillejo es posible encontrar, entre los numerosos temas, el de la monstruosidad del hermafrodito. El tema, abordado en uno de sus poemas, permite conocer los conceptos y tratados de la época, así como la tradición desde la que se trazan una serie de elementos propios de la literatura, cultura y estética del siglo xvi.

Ruxia i Ruxianos w romansach rycerskich autorstwa Feliciano de Silva

W niniejszym artykule przeanalizowany został sposób wykorzystania przez Feliciano de Silva autentycznego toponimu Ruxia (Ruś) przy konstruowaniu świata przedstawionego w romansie rycerskim. Jak zostaje wykazane, Feliciano de Silva jedynie częściowo wpisuje się w tendencję zaobserwowaną wcześniej m.in. u Garci Rodrigueza de Montalvo, który w swoich dziełach nakreśla jasną opozycję pomiędzy chrześcijańskim światem błędnego rycerstwa a złym i nikczemnym pogaństwem. Autor z Ciudad Rodrigo, chcąc nawiązać do chwały średniowiecznego Konstantynopola, powraca do czasów konfliktu bizantyńsko-ruskiego, który twórczo wykorzystuje w aż trzech księgach Florisel de Niquea. Ruxia, jeden z głównych przeciwników greckiego rodu, przedstawiona zostaje jako pogańska potęga militarna, której przewodzą władcy odważni, lecz zarazem owładnięci żądzą, niemoralni i okrutni.

Pathogenèse du cancer de l'endomètre de type I : de l'hyperplasie au cancer [Pathogenesis of type I endometrial carcinoma: From hyperplasia to cancer]

Les carcinomes de l'endomètre sont classés en deux types cliniques (types I et II), cinq types histologiques et quatre types moléculaires. Le type I correspond à l'adénocarcinome endométrioïde de grade 1 ou 2, précédé par des lésions d'hyperplasie atypique. Ce cancer est souvent révélé à un stade précoce par des saignements vaginaux postménopausiques et son pronostic est globalement favorable. Les facteurs de risque à l'origine de la majorité des cas (indice de masse corporelle [IMC] élevé, diabète de type II, traitement hormonal substitutif, tamoxifène) agissent par le biais d'une hyperestrogénie non contrecarrée par la progestérone. Moins de 5 % des cas surviennent dans le contexte d'un syndrome de Lynch (anomalie germinale d'un gène de réparation de l'ADN, à transmission autosomique dominante) chez des femmes plus jeunes dont l'IMC est typiquement bas. Les cancers de l'endomètre de type II (carcinomes séreux, à cellules claires, indifférenciés), plus rares, sont des tumeurs agressives diagnostiquées typiquement chez des femmes plus âgées et à un stade plus avancé, de pronostic défavorable.

Vigilância eletrônica no trabalho bancário: do controle consentido ao totalitarismo corporativo

This dissertation addresses the electronic surveillance theme in the banking context. The research that originated it, which was held in an organization called for the fiction name Banco Total, started from the following driving question: How do workers at a bank perceive electronic surveillance at their process of work? The research s main objective was to comprehend how workers perceive electronic surveillance at their process of work. The study adopted an interdisciplinary perspective, having Management as the original field, establishing a dialogue with others disciplines, like Philosophy and Sociology. About its methodology, it s a qualitative research that addressed its object in oral (interviews with live history elements) way. . Ten individuals were interviewed. The analytical process utilized the hermeneutical-dialectics technique.. From the analyses (hermeneutics) of the data, the following themes have emerged: (i) Acquiescence ; (ii) Monitoring; (iii) Time and Motion; (iv) Fear; (v) Interdiction; and (vi) Resistance . From the discussion (dialectic) of the results, this work presents three synthetic propositions that culminate in the following dimensions (i) control; (ii) acquiescence; (iii) corporative totalitarianism. It can be concluded that electronic surveillance is one mechanism of control emerged from the apply of technology at Total Bank; that information technology has been improving the control mechanisms of management theories; and that the imbrications between management and material technology control mechanisms at a context where there is acquiescence by workers contribute for the emergency of corporative totalitarianism components

O Lúdico como Motivação para a Aprendizagem

O presente relatório de investigação foi desenvolvido no âmbito da Unidade Curricular de Estágio I e II, integrada no Mestrado em Educação Pré-Escolar e Ensino do 1º Ciclo do Ensino Básico, e intitula-se “O Lúdico como Motivação para a aprendizagem”. Esta temática foi investigada no contexto de uma sala de três anos, da educação pré-escolar, e de uma turma de 3º ano do 1º Ciclo do Ensino Básico. Esta investigação teve como objetivos: identificar o tipo de brincadeiras que as crianças mais gostam; identificar o tipo de brincadeiras que contribuem para a aprendizagem; e perceber se as atividades lúdicas que motivam as crianças contribuem para novas aprendizagens. A intervenção realizada despontou interesse em aplicar metodologias que promovessem a aprendizagem através do lúdico, tendo em conta as propostas de atividades elaboradas. Desta forma, foram utilizados como instrumentos de recolha de dados qualitativos, os registos de observação, o portfólio reflexivo da estagiária e o grupo de discussão focalizada. A revisão bibliográfica sobre o tema ajudou a suportar o trabalho elaborado. As observações realizadas durante a prática foram fundamentais, uma vez que através destas foram recolhidos dados, que se tornaram significativos na investigação. Os resultados obtidos demonstraram que a aprendizagem através do lúdico tem um impacto positivo nas crianças, estas ficam mais motivadas e, consequentemente, as aprendizagens realizadas tornam-se significativas.

Vigilância eletrônica no trabalho bancário: do controle consentido ao totalitarismo corporativo

This dissertation addresses the electronic surveillance theme in the banking context. The research that originated it, which was held in an organization called for the fiction name Banco Total, started from the following driving question: How do workers at a bank perceive electronic surveillance at their process of work? The research s main objective was to comprehend how workers perceive electronic surveillance at their process of work. The study adopted an interdisciplinary perspective, having Management as the original field, establishing a dialogue with others disciplines, like Philosophy and Sociology. About its methodology, it s a qualitative research that addressed its object in oral (interviews with live history elements) way. . Ten individuals were interviewed. The analytical process utilized the hermeneutical-dialectics technique.. From the analyses (hermeneutics) of the data, the following themes have emerged: (i) Acquiescence ; (ii) Monitoring; (iii) Time and Motion; (iv) Fear; (v) Interdiction; and (vi) Resistance . From the discussion (dialectic) of the results, this work presents three synthetic propositions that culminate in the following dimensions (i) control; (ii) acquiescence; (iii) corporative totalitarianism. It can be concluded that electronic surveillance is one mechanism of control emerged from the apply of technology at Total Bank; that information technology has been improving the control mechanisms of management theories; and that the imbrications between management and material technology control mechanisms at a context where there is acquiescence by workers contribute for the emergency of corporative totalitarianism components

Estructuración de las organizaciones comunales de la zona sur de la ciudad de Nueva San Salvador para la gestión de desastres y la gestión de riesgo 2001 2002

En el contenido de la presente investigación se desarrolla el tema: “Estructuración de las Organizaciones Comunales de la Zona sur de la Ciudad de Nueva San Salvador para la Gestión de Desastres y la Gestión de Riesgo 2001 2002”, ha sido elaborado por estudiantes egresados y participantes del Seminario de Proceso de Graduación, impartido por la Escuela de Ciencias Sociales “Licenciado Gerardo Iraheta Rosales” de la Facultad de Ciencias y Humanidades de La Universidad de El Salvador, durante los ciclos I y II de 2002, para optar al grado de Licenciatura en Sociología. El punto de partida es el tema general “Gestión de Riesgos y Reconstrucción por los Terremotos en El Salvador 2001-2002”, tema que fue sugerido por la Escuela de Ciencias Sociales; durante el proceso, se elaboro un diagnostico sobre el tema general, posteriormente el proyecto de investigación que facilito la delimitación del tema: “Estructuración de las Organizaciones Comunales de la Zona sur de la Ciudad de Nueva San Salvador para la Gestión de Desastres y la Gestión de Riesgo” (enero-octubre de 2002) El propósito de esta investigación consistió en analizar la relación y la participación existente entre las organizaciones comunales y otros actores sociales dentro del proceso de gestión de riesgo, como también la estructuración de las organizaciones comunales y sus tendencias transformadoras en función del manejo de desastres, la mitigación y la prevención. Además de proponer elementos teóricos y herramientas que les permitan a las comunidades replantear las concepciones de los desastres y organizarse para transformar sus condiciones de riesgo. La importancia de la investigación radica en el análisis y la reflexión critica, acerca de los procesos de estructuración de las organizaciones comunales en la zona sur de la Ciudad de Nueva San Salvador para la gestión de desastres y del riesgo, dejando en evidencia la necesidad de implantar la gestión de riesgo con participación comunal, enunciando elementos básicos para la formulación de un modelo de gestión del riesgo local con participación comunal, la reconstrucción de algunas definiciones teóricas como por ejemplo: gestión del riesgo, amenazas naturales, amenazas antrópicas y socio-naturales a la vez que proponemos simbología que puede ser utilizada en el análisis de los riesgos nacionales, finalmente presentamos la elaboración de un mapa de Riesgos de la Zona Sur desde una perspectiva sociológica con apoyo de otras ciencias como la geología y de estudios realizados en la Cordillera del Bálsamo.

Rättfärdigade prioriteringar - en kvalitativ analys av hur personal i äldreomsorgen hanterar motstridiga verksamhetslogiker

Tidigare forskning visar att äldreomsorgspersonal kämpar med två typer av logiker: en ekonomisk logik och en omsorgslogik. Även om båda logikerna behövs för att skapa god omsorg så utmanar de varandra. Dessa utmaningar kommer till uttryck i omsorgspraktiken där personalen ställs in för val och måste göra prioriteringar. Denna avhandling syftar till att förstå hur äldreomsorgspersonal beskriver att de arbetar för att finna balans mellan logikerna och hur de rättfärdigar sina prioriteringar i omsorgen om de äldre personerna. Frågeställningen för avhandlingen är att ta reda på hur personal och enhetschef vid ett kommunalt äldreboende förstår och hanterar interaktionen mellan de två logiker som styr omsorgsarbetet för att främja de äldre personernas välbefinnande. Syftet innehåller tre delsyften: 1) att analysera personalens erfarenheter av och meningsskapande kring de äldre personernas välbefinnande och deras reflektioner kring det omsorgsarbete de utför, 2) att belysa och problematiserade logiker som styr omsorgsarbetet samt 3) att analysera hur personalen rättfärdigar sina prioriteringar i rådande kontext och hur deras förklarbarhet påverkar deras professionella identiteter. Målet är att bidra med socialvetenskaplig kunskap om de överväganden personal gör när de ställs inför att göra prioriteringar i äldreomsorgens praktik. Material samlades in genom 12 individuella intervjuer med personal vid ett kommunalt äldreboende, en intervju med personalens enhetschef och en uppföljande gruppintervju med tre personer ur personalgruppen. Materialet analyserades med tre analysmetoder: fenomenologisk analys, reflexiv analys och positioneringsanalys. Resultatet visar att personalen definierar de äldre personernas välbefinnande som ett behov av att känna sig existentiellt berörd. Denna känsla av existentiell beröring delas in i tre delar: känsla av valfrihet, känsla av njutning och känsla av närhet till någon eller något. Arbetet för att uppnå detta välbefinnande beskrivs innebära ett balanserande av tre tvetydigheter: att vilja värna om de äldre personernas valfrihet och samtidigt hantera institutionella begränsningar, de äldre personernas behov av aktivering å ena sidan och att de inte behöver aktiveras å andra sidan samt att förstå de äldre personernas behov av rutiner samtidigt som det är svårt att veta vilka behov de har. Tvetydigheterna kontextualiserades och de två logikerna som styr omsorgsarbetet analyserades. Analysen visar att enhetschefen skapar en hybrid av den ekonomiska logiken och omsorgslogiken; ekonomi är omsorg och vice versa. Denna hybrid möter motstånd från personalen som skiljer på de båda logikerna genom att tala om ”vård och det där andra”. Personalen upplever att den ekonomiska logiken begränsar deras möjligheter att utföra omsorg i linje med omsorgslogiken. Motsättningar mellan de båda logikerna leder till prioriteringar som rättfärdigas av personalen i syfte att behålla de professionella identiteterna. Den teoretiska analysen bygger på teorier om institutionella logiker, förklarbarhet ochprofessionell identitet. Analyserna visar vikten av att väcka dialog mellan enhetschefer och personal där de diskuterar innebörder av olika värdeord som används på politisk nivå. Sådana diskussioner skulle kunna bidra till mindre motstånd och en högre överensstämmelse mellan verksamhetsmål och praktik. Avhandlingen visar även vikten av att förstå logiker som vertikala istället för horisontellt uppdelade. Alltså, att styrande verksamhetslogiker existerar uppifrån och ned i verksamheter (från politisk nivå till chefsnivå och till praktisk nivå) och att de inte kan delas in i exempelvis en professionslogik och en styrningslogik. Den senare synen kan bidra till potentiella missförstånd eftersom det gör att konflikter kan tolkas existera mellan personal och chef, medan de egentligen existerar mellan olika motstridiga värderingssystem. Slutsatsen är att de båda logikerna behövs för att stödja äldre personers välbefinnande. Ibland är logikerna samspelta och ibland är de i konflikt med varandra. När logikerna ställs mot varandra är det av vikt att komma ihåg att den ekonomiska logiken är lika förhandlingsbar som omsorgslogiken. De två logikerna existerar i samspel och om deras motstridigheter inte belyses finns risk att omsorgspraktiken inte stödjer de äldre personernas välbefinnande.

Correlacion entre hemoglobina glicosilada con hallazgos sintax score ii en pacientes con sospecha clínica de enfermedad coronaria, hospitalizados en la unidad coronaria del hospital San José centro en enero a septiembre del año 2015

Se realiza un estudio de corte transversal en el periodo de enero a septiembre del año 2016 en la unidad coronaria del Hospital San José Centro de la Ciudad de Bogotá; en pacientes con sospecha de enfermedad coronaria (Síndrome coronario agudo y angina estable) y antecedente de Diabetes Mellitus Tipo 2, se recolectaron 42 pacientes con los criterios de inclusión a quienes se realizó angiografía coronaria como parte del protocolo de estudio y manejo de la unidad, el objetivo primario fue demostrar la posible correlación entre niveles de hemoglobina glicosilada y la escala de severidad SYNTAX Score I y II de enfermedad coronaria, como objetivos secundarios; caracterizar las variables sociodemográficas, comorbilidades y posible relación con el tipo de presentación de enfermedad coronaria. Como hallazgos relevantes no se encontró correlación importante ni significativa entre niveles de hemoglobina glicosilada y la escala Syntax score II ni Syntax score I, a pesar de que la mayoría de pacientes mostraban mal control crónico de su diabetes mellitus tipo 2, con niveles mayores > 7%, como hallazgo positivo se encontro asociación estadísticamente significativa con niveles de LDL y las diferentes formas de presentación de enfermedad coronaria, a mayor niveles de LDL mayor probabilidad de IAM e IAM con elevación del segmento ST. Se considera que con estudios multicentricos en diferentes ciudades y unidades de cuidado cardiovascular con diferentes niveles de riesgo, se podría demostrar la posible correlación entre niveles de hemoglobina glicosilada y los grados de severidad de enfermedad coronaria representados por las escalas Syntax score I y II.

Formação inicial de pedagogos: a construção dos saberes no âmbito do estágio supervisionado

O espaço da formação docente apresenta-se como um campo de investigação rico de informações frente ao contexto da sociedade contemporânea. Assim, diferentes dimensões do processo formativo vem se destacando no cenário educacional, como é o caso da Formação Inicial de Pedagogo: construção dos saberes no âmbito do Estágio Supervionado, tema desta investigação. Este estudo faz uma abordagem sobre os dois modelos de formação de professores: o racionalismo técnico e o emergente pautado nos princípios do agente social, passando por um breve histórico da pedagogia no Brasil, e avança enfocando as concepções dicotômica e de unidade dos saberes teóricos e práticos, além de analisar a construção e mobilização dos saberes docentes. Destaca-se a relevância do Estágio Supervisionado no processo de formação, o seu papel articulador entre os vários tipos de saberes. Após, contextualiza-se o Curso de Pedagogia da UVA/AP, seus dispositivos legais, enfocando as ementas das disciplinas Estágio Supervisionado I e II contempladas na matriz curricular deste curso. Em seguida faz-se um apanhado da metodologia utilizada nesta investigação, que tem uma natureza descritiva, pautando-se na pesquisa bibliográfica e na pesquisa de campo. Os instrumentos de coleta de dados utilizados foram à entrevista semiestruturada e questionário, com os supervisores de estágios e alunos-estagiários sujeitos desta investigação. Finalizando com o tratamento e análise dos dados, apresentados graficamente das informações dos supervisores de estágios e alunos-estagiários e da análise das compreensões dos alunos-estagiários na entrevista semiestruturada, a qual são interpretadas a luz do referencial teórico utilizado na revisão literária. Os resultados mostraram que a metodologia proposta foi adequada para apreciar sobre a formação inicial do pedagogo e a construção dos saberes no momento do Estágio Supervisionado. ABSTRACT: The sphere of educator training is presented as a rich of information research field in face of the contemporary society context. Thus, different scopes of the training process have been standing out in the educational scenario, as the case of initial educator training: The construction of the knowledge in the scope of the supervised traineeship, topic of this research. This study provides a comprehensive approach about the two models of teacher training: the technical rationalism and the emerging based on the social agent principles, followed by a short historical of the pedagogy in Brazil, right through focusing on dichotomous conceptions and units of the practical and theoretical knowledge, furthermore, analyze the construction and mobilization of the educational knowledge. The relevance of the supervised traineeship stands out in the training process; its role integrates different types of knowledge. After, Put the Pedagogy course: from UVAIAP into context, their legal arrangements, focusing on the subjects "Supervised Traineeship I and II", included in the study programme. Then is made an overview of the methodology used in this research, that is descriptive in nature, also be guided by a bibliographical research and a field research. The data collection resources were semi-structured interview and a questionnaire, with the traineeships supervisor and the trainee-student’s agents of this research. Concluding with the data processing and analysis, graphically presented according to the traineeships supervisor and trainee-students information and also analysis of the trainee-students comprehension in the semi-structured interview, which are interpreted in accordance of the theoretical framework used in the literary review. The results prove that the methodology proposed was appropriated to appreciate about the initial educator training and the construction of knowledge at the moment of the supervised traineeship.