Boron mobility in eucalyptus clones

Understanding the magnitude of B mobility in eucalyptus may help to select clones that are more efficient for B use and to design new practices of B fertilization. This study consisted of five experiments with three eucalyptus clones (129, 57 and 58) where the response to and mobility of B were evaluated. Results indicated that clone 129 was less sensitive to B deficiency than clones 68 and 57, apparently due to its ability to translocate B previously absorbed via root systems to younger tissues when B in solution became limiting. Translocation also occurred when B was applied as boric acid only once to a single mature leaf, resulting in higher B concentration in roots, stems and younger leaves. The growth of B-deficient plants was also recovere by a single foliar application of B to a mature leaf. This mobility was greater, when foliar-applied B was supplied in complexed (boric acid + manitol) than in non-complexed form (boric acid alone). When the root system of clone 129 was split in two solution compartments, B supplied to one root compartment was translocated to the shoot and back to the roots in the other compartment, improving the B status and growth. Thus, it appears that B is relatively mobile in eucalyptus, especially in clone 129, and its higher mobility could be due to the presence of an organic compound such as manitol, able to complex B.

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.

Evaluation des campagnes de prévention contre le SIDA en Suisse : Befragung von informellen Meinungsbildnern : janvier 1988

Der Auftrag beinhaltete die Organisation, Durchführung und Auswertung einer Befragung bei insgesamt 50 Pfarrern, Aerzten, Lehrern und Eltern in sechs Gemeinden. Angesprochen werden sollten diese Zielpersonen in ihrer potentiellen Verstärkerfunktion innerhalb der bevorstehenden AIDS-/Kondom- Kampagne des BAG bzw. der AIDS-Hilfe Schweiz, wobei hauptsächlich folgende Fragen interessierten: -> Welches sind die zu erwartenden Spontanreaktionen auf die bevorstehen Kondom-Kampagne -> Wo liegen allfällige - offene oder latente - Abwehrmechanismen oder Aengste hinsichtlich der Präsentierten Informationen ? -> Welches ist der Informationsstand über die Krankheit AIDS und ihre Epidemiologie und wo ist allenfalls mit Wissensdefiziten zu rechnen ? -> Wie gross is die Bereitschaft des eine Verstärkerrolle ausübenden Personenkreises zur aktiven Unterstützung der Kampagne ? [Auteurs, p. 11]

Evaluation des campagnes de prévention contre le SIDA en Suisse : rapport sur la vente des préservatifs : novembre 1987

L'évolution du chiffre de vente des préservatifs et de la structure du marché des préservatifs en Suisse ont été choisis comme mesures des effets des campagnes de prévention de l'OFSP. préservatifs en Suisse.

Evaluation des campagnes de prévention contre le SIDA en Suisse : étude du Groupe "dragueurs(euses)" : janvier 1988

But de la recherche: évaluation semi-quantitative et qualitative concernant le groupe "Dragueurs/Dragueuses" (partainaires multiples et occasionnels) considéré comme pouvant avoir ou ayant des comportements à risques face au Sida. Quatre préoccupations distinctes à savoir : -> 1) Définir, mieux connaître cette population; -> 2) Evaluation semi-quantitative: cette population a-t-elle modifié ses pratiques (safer-sexe) avant et après les campagnes STOP-SIDA/OFSP/ASS ? oui, non, comment et pourquoi ? -> 3) Evaluation semi-qualitative: comment les informations, les thèmes, les émetteurs, les codes utilisés, les objectifs de la campagne ont-ils été reçus, acceptés, mis en pratique; -> 4) Evaluation qualitative: études des résistances aux changements...

Gtdap-1 and the role of autophagy during planarian regeneration and starvation

Planarians have been established as an ideal model organism for stem cell research and regeneration. Planarian regeneration and homeostasis require an exquisite balancing act between cell death and cell proliferation as new tissues are made (epimorphosis) and existing tissues remodeled (morphallaxis). Some of the genes and mechanisms that control cell proliferation and pattern formation are known. However, studies about cell death during remodeling are few and far between. We have studied the gene Gtdap-1, the planarian ortholog of human death-associated protein-1 or DAP-1. DAP-1 together with DAP-kinase has been identified as a positive mediator of programmed cell death induced by gamma-interferon in HeLa cells. We have found that the gene functions at the interface between autophagy and cell death in the remodeling of the organism that occurs during regeneration and starvation in sexual and asexual races of planarians. Our data suggest that autophagy of existing cells may be essential to fuel the continued proliferation and differentiation of stem cells by providing the necessary energy and building blocks to neoblasts.

Universo moral de jovens internos da Febem

Neste estudo, apresentamos elementos do universo moral de jovens internos da Fundação do Bem-Estar do Menor do Estado de São Paulo. Entrevistamos 14 sujeitos sobre o tema do 'Seguro', uma forma de organização criada pelos próprios jovens internos, que está baseada em regras precisas cuja desobediência implica a exclusão do transgressor. Procuramos verificar as formas de legitimação da referida organização, e os valores morais que a sustentam. As categorias de análise dos dados foram: autonomia/heteronomia, virtudes e personalidade moral. Os dados apontam para o predomínio de formas heteronômicas de legitimação das regras, para a valorização de certos traços de caráter (virtudes) como a 'firmeza', a 'virilidade', a 'coragem' e para a franca desvalorização de seus contrários (fraqueza, homossexualidade, medo). Os dados também apontam para a construção de uma identidade que inclui valores do chamado 'mundo do crime' e que se opõe claramente ao 'mundão', que inclui as pessoas que não são os 'malandros'.

Listériose : étude cas témoins en Suisse romande : hiver 1984/85

Le but de cette étude était - d'établir un instrument d'enquête utilisable en cas d'épidémie; - de reconnaître une éventuelle reprise de l'épidémie observée l'hiver précédent, et dans cette hypothèse de récolter des données pour la recherche d'une source.