Population dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacement

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

TNFa-e microsatellite, HLA-DRB1 and-DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus

TNF microsatellite and HLA class II polymorphisms were studied in 28 recently diagnosed Brazilian patients presenting type 1 diabetes mellitus (T1DM) and in 120 healthy controls. TNFa-e and HLA-DRB1/DQB1 alleles were identified using sets of sequence-specific primers. Compared to controls, the DRB1* 03 and DQBI*02 allele groups, TNFa1 allele, and the TNFa4-b5-c1-d4-e3 and TNFa10-b5-c1-d4-e3 haplotypes were overrepresented in patients. TNF microsatellite together with HLA polymorphisms is associated with type 1 diabetes in Brazilian patients, corroborating the participation of the MHC genes in disease susceptibility.

Food-web composition affects cross-ecosystem interactions and subsidies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

No more!: the right of women to live a life free of violence in Latin America and the Caribbean

Includes bibliography

Ni una más!. El derecho a vivir una vida libre de violencia en América Latina y el Caribe

Incluye Bibliografía

El trabajo a tiempo parcial en Chile: ¿constituye empleo precario?: reflexiones desde la perspectiva de género

Incluye Bibliografía

Part-time work in Chile: is it precarious employment?: reflections from a gender perspective

Includes bibliography

Violencia contra la mujer en relación de pareja: América Latina y el Caribe. Una propuesta para medir su magnitud y evolución

Incluye Bibliografía

Violence against women in couples: Latin America and the Caribbean. A proposal for measuring its incidence and trends

Includes bibliography

Women's formal education: achievements and obstacles

Includes bibliography

Logros y obstáculos en la educación formal de las mujeres

Incluye Bibliografía

Circulation of Different Lineages of Dengue Virus 2, Genotype American/Asian in Brazil: Dynamics and Molecular and Phylogenetic Characterization

The American/Asian genotype of Dengue virus type 2 (DENV-2) was introduced into the Americas in the 80′s. Although there is no data showing when this genotype was first introduced into Brazil, it was first detected in Brazil in 1990. After which the virus spread throughout the country and major epidemics occurred in 1998, 2007/08 and 2010. In this study we sequenced 12 DENV-2 genomes obtained from serum samples of patients with dengue fever residing in São José do Rio Preto, São Paulo (SJRP/SP), Brazil, in 2008. The whole open reading frame or envelope sequences were used to perform phylogenetic, phylogeographic and evolutionary analyses. Isolates from SJRP/SP were grouped within one lineage (BR3) close to isolates from Rio de Janeiro, Brazil. Isolates from SJRP were probably introduced there at least in 2007, prior to its detection in the 2008 outbreak. DENV-2 circulation in Brazil is characterized by the introduction, displacement and circulation of three well-defined lineages in different times, most probably from the Caribbean. Thirty-seven unique amino acid substitutions were observed among the lineages, including seven amino acid differences in domains I to III of the envelope protein. Moreover, we dated here, for the first time, the introduction of American/Asian genotype into Brazil (lineage BR1) to 1988/89, followed by the introduction of lineages BR2 (1998-2000) and BR3 (2003-05). Our results show a delay between the introduction and detection of DENV-2 lineages in Brazil, reinforcing the importance and need for surveillance programs to detect and trace the evolution of these viruses. Additionally, Brazilian DENV-2 differed in genetic diversity, date of introduction and geographic origin and distribution in Brazil, and these are important factors for the evolution, dynamics and control of dengue. © 2013 Drumond et al.

Compartir las responsabilidades familiares: una tarea para el desarrollo

Documento de Referencia DDR/6

Si no se cuenta, no cuenta: información sobre la violencia contra las mujeres

Incluye Bibliografía

Regional implementation meeting on access rights and sustainable development in the Caribbean. Workshop on enhancing access to information on climate change, natural disasters and coastal vulnerability: leaving no one behind

This document summarizes the regional implementation meeting on access rights and sustainable development in the Caribbean and the workshop on enhancing access to information on climate change, natural disasters and coastal vulnerability: leaving no one behind held in Rodney’s Bay, Saint Lucia, from 24 to 26 August 2015.