TNFa-e microsatellite, HLA-DRB1 and-DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2006
|
Resumo |
TNF microsatellite and HLA class II polymorphisms were studied in 28 recently diagnosed Brazilian patients presenting type 1 diabetes mellitus (T1DM) and in 120 healthy controls. TNFa-e and HLA-DRB1/DQB1 alleles were identified using sets of sequence-specific primers. Compared to controls, the DRB1* 03 and DQBI*02 allele groups, TNFa1 allele, and the TNFa4-b5-c1-d4-e3 and TNFa10-b5-c1-d4-e3 haplotypes were overrepresented in patients. TNF microsatellite together with HLA polymorphisms is associated with type 1 diabetes in Brazilian patients, corroborating the participation of the MHC genes in disease susceptibility. |
Formato |
300-304 |
Identificador |
http://dx.doi.org/10.1196/annals.1375.045 Immunology of Diabetes Iv: Progress In Our Understanding. Oxford: Blackwell Publishing, v. 1079, p. 300-304, 2006. 0077-8923 http://hdl.handle.net/11449/7654 10.1196/annals.1375.045 WOS:000243126100045 |
Idioma(s) |
eng |
Publicador |
Blackwell Publishing |
Relação |
Immunology of Diabetes Iv: Progress In Our Understanding |
Direitos |
closedAccess |
Palavras-Chave | #type 1 diabetes mellitus #polymorphism #TNF microsatellite #HLA |
Tipo |
info:eu-repo/semantics/article |