William H. Seward; an autobiography from 1801 to 1834. With a memoir of his life, and selections from his letters ...

Vol. 1 first published 1877.

Extracts from the second report of (William Crawford and Whitworth Russell, esqs.) the inspectors of prisons for the home district; addressed to the Right Honourable the Secretary of State for the Home Department ...

Mode of access: Internet.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Les moeurs du jour, ou Histoire de Sir William Harrington. Partie 2 / , écrite du vivant de M. Richardson,... revue et retouchée par lui sur le manuscrit de l'auteur

Titre original : The history of sir William Harrington

Les moeurs du jour, ou Histoire de Sir William Harrington. Partie 4 / , écrite du vivant de M. Richardson,... revue et retouchée par lui sur le manuscrit de l'auteur

Titre original : The history of sir William Harrington

Les moeurs du jour, ou Histoire de Sir William Harrington. Partie 3 / , écrite du vivant de M. Richardson,... revue et retouchée par lui sur le manuscrit de l'auteur

Titre original : The history of sir William Harrington

Les moeurs du jour, ou Histoire de Sir William Harrington. Partie 1 / , écrite du vivant de M. Richardson,... revue et retouchée par lui sur le manuscrit de l'auteur

Titre original : The history of sir William Harrington

Indenture of Land Sold by Benjamin Middough to William Woodruff

Indenture stating that Benjamin Middough of Stamford sold a tract of land in the County of Oxford, district of London to William Woodruff of Niagara. The land consisted of 200 acres on lot 34 of the 2nd Concession. This transaction was registered on August 4, 1834 - instrument no. 2413. The date of sale was January 17, 1823.

Agreement (1 page, handwritten note) stating that William Barker of Oxford paid for the broken lots no. 21 and 22 and in the 3rd concession in the County of Oxford

Agreement (1 page, handwritten note) stating that William Barker of Oxford paid for the broken lots no. 21 and 22 and in the 3rd concession in the County of Oxford of Reverend Harris’ land, Nov. 7, 1831.

William Boyce White, Jr. Papers - Accession 1488

The William Boyce White, Jr. Papers consists of his genealogical research as well as his research related to the history of York County and Rock Hill, SC. The papers also include records and manuscripts relating to several of his published works. Mr. White is a Rock Hill native and taught at the Winthrop Training School (WTS) from 1958-1965 and taught at Rock Hill High School following the closing of the high school portion of the WTS. He also taught in Clover before coming to Winthrop. He was the organist at First Presbyterian Church in Rock Hill from 1945 until he moved to Virginia. His interest in local history covers the Rock Hill train depot (included in the collection is a tintype of the original depot ca. 1860s), Colonel William Hill, the Catawba River, Catawba Indians, Rock Hill and York County schools, historic homes (includes several photographs, many of which were used by Elizabeth Reed in her long running series on historic homes in Rock HillEvening Herald), local churches, as well as Rock Hill, Fort Mill, Blackstocks, and York County in general. Of special interest is a copy of the Indian Land Chronicle dated January 21, 1859. Only three copies of the Chronicle are known to exist in the state of South Carolina. The genealogical research conducted by Mr. White covers many of the prominent names of York County and of South Carolina in general. Below is a list of the prominent family names covered in Mr. White’s research: Anderson; Bankhead; Barringer; Bell; Black; Button; Campbell; Carpenter; Coffey; Cowan; Crawford; Culp; Davis; Fennell; Fewell; Graham; Hanna; Hayes; Hill; Hutchison; Irwin/ Erwin; Johnson; Lee; Martin; Massey; McClain; McConnell; McCullough; McFadden; Miller; Mobley; Morrow; Neely; Neil; Patton; Pettus; Plexico/Plaxco; Rives; Robinson; Roddey; Setzer; Stephenson; Strait; Sturgis; Sutton; Templeton; Waggoner; Wallace; Wherry; White; Williams; Williamson; Workman; Wylie.

MS 073 Guide to the William C. Moloney MD papers; 1952-1954

William C. Moloney MD kept a personal journal, with photographs, for much of his two years in Japan with the Atomic Bomb Casualty Commission. In January of 1986, Dr.Moloney donated his journal, correspondence and diary pages to the Harris County Medical Archive. He died in 1998 at the age of 91. His first contribution was a set of ten reprints representing his work with the ABCC from 1952 to 1954. Dr.Moloney's journal is a fine document, one which will be of great use to historians. It is an important record of personal impressions, thoughts and details of events. The journal gives new insights into the work of the ABCC and into the people who participated in that work. Dr. Moloney wrote in his journal from April 1952 to February 1954. The Korean War was on and there was a great deal of military activity in southern Japan. The collection is open for research. The collection consists of a handwritten journal, loose calendar or notebook pages and some reprints. The journal is in generally fair condition. The paper is slightly acidic and the binding is loose. There are numerous photos glued onto the pages. The collection encompasses the years 1952-1954 and is 0.25 cubic feet (1 box).