Aspectes metodològics del treball empíric en morfologia verbal

La redacció d'aquest article parteix d'una re flexió de l'autora sobre aspectes metodològics aplicats en els treballs que estudien alguns dels aspectes de la morfologia verbal, a partir de les mancances detectades a l'hora d'iniciar la seva recerca personal en aquest camp. L'objectiu d'aquest article es concreta finalment en tres aspectes. En primer lloc, tenir una idea clara de la complexitat del concepte de verb i les seves implicacions com a objecte de recerca. En segon lloc valorar els avantatges i els desavantatges d'algunes de les tècniques més emprades en els treballs de base empírica en l'anàlisi de la morfologia verbal partint d'exemples reals i, en darrer lloc, apuntar algunes idees sobre qüestions que caldria estudiar de forma conjunta en una dimensió pragmàtica de l'ús verbal.

Maslinic acid-enriched diet decreases intestinal tumorigenesis in ApcMin/+ mice through transcriptomic and metabolomic reprogramming

Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancerrelated death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in ApcMin/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P,0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in ApcMin/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the ApcMin/+ mice model, suggesting its chemopreventive potential against colorectal cancer.

Maslinic acid-enriched diet decreases intestinal tumorigenesis in ApcMin/+ mice through transcriptomic and metabolomic reprogramming

Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancerrelated death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in ApcMin/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P,0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in ApcMin/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the ApcMin/+ mice model, suggesting its chemopreventive potential against colorectal cancer.

Putting the horse before the cart: a pragmatist analysis of knowledge

The definition of knowledge as justified true belief is the best we presently have. However, the canonical tripartite analysis of knowledge does not do justice to it due to a Platonic conception of a priori truth that puts the cart before the horse. Within a pragmatic approach, I argue that by doing away with a priori truth, namely by submitting truth to justification, and by accordingly altering the canonical analysis of knowledge, this is a fruitful definition. So fruitful indeed that it renders the Gettier counterexamples vacuous, allowing positive work in epistemology and related disciplines.

La indeterminación judicial de la responsabilidad extracontractual del estado por <> del servicio en la función administrativa

El trabajo inquiere, examina y condena la concepción bíblico-antigua con el cual se ha pretendido acrisolar a las convenciones jurídicas bajo el estigma de la objetividad, especialmente en el contexto de la Responsabilidad Civil Extracontractual de la Administración Pública, contrastado con el débito acaecido una vez presente un juicio orgánico, esto es, la falla del servicio, supuesto extraído en el interactuar antitético de las autoridades públicas respecto de una obligación primaria de cuidado debido, esto es, una norma legal pre-constituida al momento de la actuación material o acto administrativo. Supuesta tal objetividad en la falla del servicio, una dicotomía se presupone en su contra, la elasticidad con que ésta teoría pretende amalgamar bajo unos mismos y nunca cambiantes elementos de imputación jurídica en manos del juez siempre una única responsabilidad en las autoridades públicas. Y por otro lado, la incidencia de la teoría en la praxis, pragmática que no deja de insinuar lo contrario, esto es, supone desavenencias inexpugnables en la aplicación de tales premisas supuestas objetivas. Luego, resultado de este cisma es la indeterminación en la concepción falla del servicio, como concepto que no conoce contornos definidos, lo cual ofrece como síntoma de su abstrusa constitución una espiritual-subjetiva aplicación, y un cuestionamiento ineludible ¿existen líneas jurisprudenciales cuando de responsabilidad extracontractual se trata, en particular, en la falla del servicio?

Valores del capital humano y las competencias del líder que facilitan la implantación de la estrategia organizacional

La obtención de una ventaja competitiva, el desarrollo, el crecimiento, la perdurabilidad, entre otros, son los aspectos que buscan las organizaciones a través de las estrategias que se definen. Sin embargo, no es suficiente con diseñar las metas y los objetivos que se quieren alcanzar, es necesario aterrizar estos propósitos en planes de acción e involucrar a todos los miembros de la organización, lo cual se consigue a través de la implantación de la estrategia. En este sentido, la etapa de implantación de la estrategia en una organización, da curso al camino establecido en la etapa de formulación de la estrategia, por lo tanto, se relaciona directamente con su éxito o su fracaso. No obstante, este proceso no depende de algunos pocos miembros de la organización, de directivos o de funcionarios, sino que depende de la buena sincronización y armonía de todos aquellos que hacen parte de ella. La presente investigación a través de la revisión teórica y de evidencias empíricas, busca poner de manifiesto la incidencia de dos aspectos clave en la organización sobre la implantación de la estrategia, por un lado, los líderes, a partir de sus competencias interpersonales y por otro el capital humano, a partir de sus valores. Los resultados obtenidos muestran que tanto las competencias del líder como los valores del capital humano son determinantes para la adecuada implantación de la estrategia organizacional.

Estrategia organizacional y su relación con la adopción de prácticas saludables

Las organizaciones asumen en el mundo en el que vivimos el reto de transformarse permanentemente para evolucionar y prolongarse en el tiempo, y una alternativa es a través de actividades dirigidas hacia los distintos grupos de interés y hacia la propia organización. Es así, como surge el interés de realizar este estudio analizando la estrategia, desde los conceptos de algunos pensadores representativos, las tipologías y modelos existentes, así como el concepto de organizaciones saludables, las cuales a través de prácticas saludables logran llevar a cabo acciones dirigidas hacia el bienestar de los empleados, el medio ambiente, proveedores, compradores, y la comunidad. Con el propósito de establecer la relación existente entre las prácticas saludables y la estrategia empresarial, se tienen en cuenta algunos estudios académicos y empíricos relacionados con la aplicación de las prácticas saludables para contribuir a la estrategia de la organización. Para estudiar dicha relación, se llevó a cabo un trabajo de campo en una empresa de salud tomando como muestra a 134 empleados de la organización. Los resultados arrojados señalan que tres de las cuatro prácticas saludables, a saber: plan de desarrollo, empleados, medio ambiente, no poseen una relación significativa con la estrategia, siendo la práctica referente a la comunidad, proveedores y compradores la más relacionada con ésta. Resulta importante continuar con otras investigaciones acerca del tema, con el fin de seguir analizando cómo las prácticas saludables están o no relacionadas con la estrategia de la organización.

A importância da revisão estratégia europeia de segurança : desafios pós-2008

O processo de construção de uma comunidade europeia de segurança iniciou-se em 1953. Apenas em 2003 foi adotada uma Estratégia Europeia de Segurança e só em 2010, com a entrada em vigor do Tratado de Lisboa, se criou uma política comum de segurança e defesa. Desde 2003, nestes 10 anos de PESD/PCSD, foram lançadas cerca de 30 missões em regiões diferentes como os Balcãs, a África Subsahariana, o Sahel e o espaço da ex-União Soviética, tocando áreas tão vastas como a reforma do setor da segurança, a formação e controlo alfandegário, o combate à pirataria ou a formação militar. Portugal participou em 11 dessas missões. O elenco de riscos e ameaças constantes da Estratégia Europeia de Segurança, revisto e atualizado em 2008, é exaustivo e mantém-se ajustado à presente situação internacional. As dificuldades da UE, no domínio da PCSD, prendem-se sobretudo com um conjunto de défices, em particular de vontade política e de recursos materiais e finanaceiros e não com a revisão da EES. Uma abordagem pragmática, que passe pela melhor definição de prioridaddes, de estratégias regionais, do reforço das capacidades e das industriais de defesa, seria a melhor orientação que o Conselho EUropeu de Dezembro de 2013 poderia dar às Instituições Europeias e aos Estados membros, no sentido de um esforço conjunto com vista a manter e a reforçar o papel da União Europeia enquanto fornecedor de segurança no sistema internacional.

Healthcare providers balancing norms and practice : challenges and opportunities in providing contraceptive counselling to young people in Uganda - a qualitative study

BACKGROUND: Pregnancies among young women force girls to compromise education, resulting in low educational attainment with subsequent poverty and vulnerability. A pronounced focus is needed on contraceptive use, pregnancy, and unsafe abortion among young women. OBJECTIVE: This study aims to explore healthcare providers' (HCPs) perceptions and practices regarding contraceptive counselling to young people. DESIGN: We conducted 27 in-depth interviews with doctors and midwives working in seven health facilities in central Uganda. Interviews were open-ended and allowed the participant to speak freely on certain topics. We used a topic guide to cover areas topics of interest focusing on post-abortion care (PAC) but also covering contraceptive counselling. Transcripts were transcribed verbatim and data were analysed using thematic analysis. RESULTS: The main theme, HCPs' ambivalence to providing contraceptive counselling to sexually active young people is based on two sub-themes describing the challenges of contraceptive counselling: A) HCPs echo the societal norms regarding sexual practice among young people, while at the same time our findings B) highlights the opportunities resulting from providers pragmatic approach to contraceptive counselling to young women. Providers expressed a self-identified lack of skill, limited resources, and inadequate support from the health system to successfully provide appropriate services to young people. They felt frustrated with the consultations, especially when meeting young women seeking PAC. CONCLUSIONS: Despite existing policies for young people's sexual and reproductive health in Uganda, HCPs are not sufficiently equipped to provide adequate contraceptive counselling to young people. Instead, HCPs are left in between the negative influence of social norms and their pragmatic approach to address the needs of young people, especially those seeking PAC. We argue that a clear policy supported by a clear strategy with practical guidelines should be implemented alongside in-service training including value clarification and attitude transformation to equip providers to be able to better cater to young people seeking sexual and reproductive health advice.

Population, social equity and changing production patterns

Includes bibliography

Interações nas danças circulares do Mana-Maní em Belém do Pará

Esta pesquisa prioriza abordagens que estudam a comunicação enquanto interação entre pessoas. O objetivo geral foi identificar, compreender e interpretar as interações que ocorrem nas danças circulares do Mana-Maní em Belém do Pará. Especificamente buscou-se identificar a dimensão comunicativa das ações individuais e coletivas que ocorrem na dança circular e verificar de que maneira a dimensão comunicativa das interações favorecem as interações simbólicas na dança circular, além de descrever as interações comunicativas que ocorrem nas danças circulares do Mana- Maní. O aporte teórico fundamentalmente discutiu dispositivos interacionais em José Luiz Braga; Espírito Comum e Sociedade Midiatizada em Raquel Paiva e Muniz Sodré e Comunidade Emotiva e Percepção do Mundo Sensível em Michel Mafessoli. Desse modo fez-se um tencionamento entre teorias e pesquisa empírica, sobre as observações em um contexto compreendido a partir de interpretações do pesquisador. Ao nível da abordagem metodológica, utilizou-se um enfoque prevalentemente qualitativo (interpretativo), que se pautou na abordagem fenomenológicopragmática, buscando revelar características intrínsecas, ações e reações que ora promovem, ora decorrem das interações observadas no contexto do grupo. Trabalhou-se com pesquisa bibliográfica e de campo, com a observação participante, diário de campo, entrevistas em profundidade e não estruturadas, aplicação de formulário semi-estruturado e coleta de depoimentos de participantes e ex participantes. Quanto às implicações práticas, buscou-se compreender formas de comunicação ocorridas partir de uma vivência sociocultural, dentro de um contexto especificamente observado, reconhecendo influências externas e internas que propiciam interações comunicativas. Quanto aos resultados, compreendeu-se que as interações ocorrem nas danças circulares do Mana-Maní a partir da inter-relação entre cinco elementos: 1) o eu, parte fundamental e insubstituível, que agrega motivações pessoais para vivenciar as danças circulares; 2) o outro – matéria-prima para as diversas interações, sempre de forma assimétrica, conforme o cabedal de conhecimento de cada um. Sem o outro, não há interação; 3) a ritualística das danças circulares no Mana-Maní, inspirada nas matrizes culturais da Amazônia, que com sua filosofia estimula e permite um espírito mais meditativo e interativo entre os participantes; 4) o cotidiano, por conta do reencantamento, a partir do prazer de participar e de ter inspirações para enfrentar dificuldades, desafios, limites físicos, psíquicos e comunicativos do comportamento pessoal; 5) a intersubjetividade, que ocorre de forma relevante e intensa, partir das dimensões simbólica e intersubjetiva, onde cada participante projeta seu mundo, sua subjetividade e entra em contato com a subjetividade dos demais, criando e ressignificando interações.

Le politiche giudiziarie inglesi degli anni 2000: mutamento di paradigma e rafforzamento dell'incisività politica dei giudici

The Ph.D. dissertation analyses the reasons for which political actors (governments, legislatures and political parties) decide consciously to give away a source of power by increasing the political significance of the courts. It focuses on a single case of particular significance: the passage of the Constitutional Reform Act 2005 in the United Kingdom. This Act has deeply changed the governance and the organization of the English judicial system, has provided a much clearer separation of powers and a stronger independence of the judiciary from the executive and the legislative. What’s more, this strengthening of the judicial independence has been decided in a period in which the political role of the English judges was evidently increasing. I argue that the reform can be interpreted as a «paradigm shift» (Hall 1993), that has changed the way in which the judicial power is considered. The most diffused conceptions in the sub-system of the English judicial policies are shifted, and a new paradigm has become dominant. The new paradigm includes: (i) stronger separation of powers, (ii) collective (as well as individual) conception of the independence of the judiciary, (iii) reduction of the political accountability of the judges, (iv) formalization of the guarantees of judicial independence, (v) principle-driven (instead of pragmatic) approach to the reforms, and (vi) transformation of a non-codified constitution in a codified one. Judicialization through political decisions represent an important, but not fully explored, field of research. The literature, in particular, has focused on factors unable to explain the English case: the competitiveness of the party system (Ramseyer 1994), the political uncertainty at the time of constitutional design (Ginsburg 2003), the cultural divisions within the polity (Hirschl 2004), federal institutions and division of powers (Shapiro 2002). All these contributes link the decision to enhance the political relevance of the judges to some kind of diffusion of political power. In the contemporary England, characterized by a relative high concentration of power in the government, the reasons for such a reform should be located elsewhere. I argue that the Constitutional Reform Act 2005 can be interpreted as a result of three different kinds of reasons: (i) the social and demographical transformations of the English judiciary, which have made inefficient most of the precedent mechanism of governance, (ii) the role played by the judges in the policy process and (iii) the cognitive and normative influences originated from the European context, as a consequence of the membership of the United Kingdom to the European Union and the Council of Europe. My thesis is that only a full analysis of all these three aspects can explain the decision to reform the judicial system and the content of the Constitutional Reform Act 2005. Only the cultural influences come from the European legal complex, above all, can explain the paradigm shift previously described.

Educazione alla cittadinanza per cittadini immigrati adulti. Il contributo della formazione linguistico-giuridica all'acquisizione di competenze di cittadinanza in lingua seconda

The research examines which cultural and linguistic instruments can be offered to provide adult migrants with formative access to citizenship competences. Starting from the questions: How can individuals of all community groups present in a nation-state acquire high standards of linguistic, sociolinguistic and discourse competences in order to be fully integrated, that is to participate and be included in social activities in the public domain such as work and institutional environments? How are these competencies developed in an educational context? How do adult migrants behave linguistically in this context, according to their needs and motivations? The research hypothesis aimed at outlining a formative project of citizenship education targeted at adult foreign citizens, where a central role is assigned both to law education and linguistic education. Acoordingly, as the study considered if the introduction of a law programme in a second language course could be conceived as an opportunity to further the access to active citizenship and social participation, a corpus of audiodata was collected in law classes of an Italian adult professional course attended by a 50% of foreign students. The observation was conducted on teacher and learner talk and learner participation in classroom interaction when curriculum legal topics were introduced and discussed. In the classroom law discourse two dimensions were analyzed: the legal knowledge construction and the participants’ interpersonal and identity construction. From the analysis, the understanding is that drawn that law classes seem to represent an educational setting where foreign citizens have an opportunity to learn and practise citizenship. The social and pragmatic approach to legal contents plays a relevant role, in a subject which, in non-academic contexts, loses its technical specificity and refers to law as a product of social representation. In the observed educational environment, where students are adults who bring into the classroom multiple personal and social identities, legal topics have the advantage of increasing adult migrants’ motivation to ‘go back to school’ as they are likely to give hints, if not provide solutions, to problems relating to participation in socio-institutional activities. At the same time, these contents offer an ideal context where individuals can acquire high discourse competences and citizenship skills, such as agency and critical reflection. Besides, the analysis reveals that providing adult learners with materials that focus on rights, politics and the law, i.e. with materials which stimulate discussion on concerns affecting their daily lives, is welcomed by learners themselves, who might appreciate the integration of these same topics in a second language course.

The European External Action Service and the Implementation of the 'Union Method' in European Foreign Policy

The European External Action Service (EEAS or Service) is one of the most significant and most debated innovations introduced by the Lisbon Treaty. This analysis intends to explain the anomalous design of the EEAS in light of its function, which consists in the promotion of external action coherence. Coherence is a principle of the EU legal system, which requires synergy in the external actions of the Union and its Members. It can be enforced only through the coordination of European policy-makers' initiatives, by bridging the gap between the 'Communitarian' and intergovernmental approaches. This is the 'Union method' envisaged by A. Merkel: "coordinated action in a spirit of solidarity - each of us in the area for which we are responsible but all working towards the same goal". The EEAS embodies the 'Union method', since it is institutionally linked to both Union organs and Member States. It is also capable of enhancing synergy in policy management and promoting unity in international representation, since its field of action is delimited not by an abstract concern for institutional balance but by a pragmatic assessment of the need for coordination in each sector. The challenge is now to make sure that this pragmatic approach is applied with respect to all the activities of the Service, in order to reinforce its effectiveness. The coordination brought by the EEAS is in fact the only means through which a European foreign policy can come into being: the choice is not between the Community method and the intergovernmental method, but between a coordinated position and nothing at all.

Opportunistic and systematic screening for chlamydia: a study of consultations by young adults in general practice

BACKGROUND: Opportunistic screening for genital chlamydia infection is being introduced in England, but evidence for the effectiveness of this approach is lacking. There are insufficient data about young peoples' use of primary care services to determine the potential coverage of opportunistic screening in comparison with a systematic population-based approach. AIM: To estimate use of primary care services by young men and women; to compare potential coverage of opportunistic chlamydia screening with a systematic postal approach. DESIGN OF STUDY: Population based cross-sectional study. SETTING: Twenty-seven general practices around Bristol and Birmingham. METHOD: A random sample of patients aged 16-24 years were posted a chlamydia screening pack. We collected details of face-to-face consultations from general practice records. Survival and person-time methods were used to estimate the cumulative probability of attending general practice in 1 year and the coverage achieved by opportunistic and systematic postal chlamydia screening. RESULTS: Of 12 973 eligible patients, an estimated 60.4% (95% confidence interval [CI] = 58.3 to 62.5%) of men and 75.3% (73.7 to 76.9%) of women aged 16-24 years attended their practice at least once in a 1-year period. During this period, an estimated 21.3% of patients would not attend their general practice but would be reached by postal screening, 9.2% would not receive a postal invitation but would attend their practice, and 11.8% would be missed by both methods. CONCLUSIONS: Opportunistic and population-based approaches to chlamydia screening would both fail to contact a substantial minority of the target group, if used alone. A pragmatic approach combining both strategies might achieve higher coverage.